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1-7 of 7
Keywords: arrhythmias
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Articles
The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype
Available to PurchaseMaria Vitoria da Silva, Artur Santos-Miranda, Julliane V. Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (5): 329–343.
Published: 02 March 2022
... and Ranolazine ameliorated the phenotype. Understanding the insecticides’ impacts upon electromechanical properties of the heart is important for the development of therapeutic approaches to treat cases of pesticides intoxication. β-Cyfluthrin arrhythmias INa-L insecticide pyrethroid ranolazine...
Includes: Supplementary data
Articles
Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure
Available to PurchaseDavid C. Andrade, Camilo Toledo, Hugo S. Díaz, Claudia Lucero, Alexis Arce-Álvarez, Luiz M. Oliveira, Ana C. Takakura, Thiago S. Moreira, Harold D. Schultz, Noah J. Marcus, Julio Alcayaga, Rodrigo Del Rio
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (3): 393–405.
Published: 05 February 2019
...-C1 neurons were selectively ablated using cell-specific immunotoxin (dopamine-β hydroxylase saporin [DβH-SAP]) and measures of cardiac autonomic tone, function, and arrhythmia incidence were evaluated. Cardiac autonomic imbalance, arrhythmogenesis and cardiac dysfunction were present in HF rats...
Includes: Supplementary data
Articles
Effects of the Ca2+ sensitizer EMD 57033 on intracellular Ca2+ in rat ventricular myocytes: relevance to arrhythmogenesis during positive inotropy
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (6): 547–554.
Published: 23 November 2000
... to troponin C, secondary to cross-bridge formation. Thus, during positive inotropy, EMD 57033 is unlikely to provoke arrhythmias due to effects on SR Ca 2+ handling. In intact cells, its effects on Ca 2+ handling would be expected to protect against arrhythmias. Correspondence : Dr J. A. Lee (e...
Articles
Exercise training reduces the sympathetic component of the blood pressure-heart rate baroreflex in man
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (4): 357–362.
Published: 01 April 1992
... of training may be of relevance to individuals with elevated sympathetic activity who may be at risk of myocardial ischaemia, serious ventricular arrhythmias or sudden cardiac death. Clinical Science (1992) 82,357-362 (Printed in Great Britain) Exercise training reduces the sympathetic component of the blood...
Articles
Monophasic action potential recordings in response to rapid transient elevation of extracellular potassium and their modification by β -adrenoceptor blockade in the anaesthetized dog
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (1): 17–24.
Published: 01 January 1990
... by an effect on MAP duration rather than on local conduction time. After /3-adrenoceptor blockade the effect of a bolus injection of potassium chloride on MAP duration was greater and conduction time was increased. Key words: arrhythmias, electrocardiogram, hyper- kalaemia, intraventricular conduction...
Articles
Within-Breath Modulation of the Triggering of Extrasystoles in Man
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1984) 67 (2): 225–227.
Published: 01 August 1984
... when breaths were shorter: always at about 2 s after the start of inspiration. 4. An autonomic reflex mechanism, equivalent to that causing sinus arrhythmia, appears to be the most likely explanation. 12 12 1983 7 2 1984 © 1984 The Biochemical Society and the Medical Research Society...
Articles
The Effect of Adrenaline-Induced Endogenous Lipolysis upon the Mechanical and Metabolic Performance of Ischaemically Perfused Rat Hearts
Available to Purchase
Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (6): 513–521.
Published: 01 December 1977
... ischaemic perfusion such hearts showed a more marked rise in resting tension and decline in heart rate than hearts from normally fed animals. Such hearts also had an increased incidence of arrhythmias and a slight reduction in developed tension. The initial responses of these hearts from fat-fed rats...