... ], and both classes act primarily on the functioning of the voltage-gated sodium channels (NaVs). Pyrethroids bind to NaVs and disrupt the biophysical properties of the insect sodium channel, although interaction with mammal sodium channel also occurs [ 4 ]. β-Cyfluthrin arrhythmias INa-L insecticide...

...-C1 neurons were selectively ablated using cell-specific immunotoxin (dopamine-β hydroxylase saporin [DβH-SAP]) and measures of cardiac autonomic tone, function, and arrhythmia incidence were evaluated. Cardiac autonomic imbalance, arrhythmogenesis and cardiac dysfunction were present in HF rats...

... to troponin C, secondary to cross-bridge formation. Thus, during positive inotropy, EMD 57033 is unlikely to provoke arrhythmias due to effects on SR Ca 2+ handling. In intact cells, its effects on Ca 2+ handling would be expected to protect against arrhythmias. Correspondence : Dr J. A. Lee (e-mail...

... of training may be of relevance to individuals with elevated sympathetic activity who may be at risk of myocardial ischaemia, serious ventricular arrhythmias or sudden cardiac death. 21 10 1991 15 10 1991 © 1992 The Biochemical Society and the Medical Research Society 1992 arrhythmias...

... by an effect on MAP duration rather than on local conduction time. After β-adrenoceptor blockade the effect of a bolus injection of potassium chloride on MAP duration was greater and conduction time was increased. arrhythmias electrocardiogram hyperkalemia intraventricular conduction monophasic action...

... when breaths were shorter: always at about 2 s after the start of inspiration. 4. An autonomic reflex mechanism, equivalent to that causing sinus arrhythmia, appears to be the most likely explanation. 12 12 1983 7 2 1984 © 1984 The Biochemical Society and the Medical Research Society...

... ischaemic perfusion such hearts showed a more marked rise in resting tension and decline in heart rate than hearts from normally fed animals. Such hearts also had an increased incidence of arrhythmias and a slight reduction in developed tension. The initial responses of these hearts from fat-fed rats...