... treatment with the Foresaid X receptor (FXR) agonist obeticholic acid (OCA), which inhibits oxidative stress-related pathogenesis, in ascitic cirrhotic rats with hepatorenal syndrome (HRS) developed 6 weeks after bile duct ligation (BDL). Methods: Systemic, splanchnic, and renal hemodynamics and pathogenic...

... of dilutional hyponatraemia, but ADH V 2 receptor antagonists are not beneficial in long-term treatment of ascites. To test the hypothesis that water retention in experimental ascitic cirrhosis might depend primarily on adrenergic hyper-function, hormonal status, renal function and tubular free-water...

... ). 19 5 2003 11 7 2003 23 7 2003 23 7 2003 © 2004 The Biochemical Society 2004 ascites cirrhosis diuretics platelet aggregation prostaglandin renal function thromboxane Clinical Science (2004) 106, 27 34 (Printed in Great Britain) 27 Effects of dietary...

... remains unclear. Correspondence: Dr S. S. Lee (e-mail [email protected] ). 1 Present address: Department of Physiology and Biophysics, Mayo Clinic, Rochester, MN, U.S.A. The Biochemical Society and the Medical Research Society © 2002 2002 ascites carbon monoxide cGMP cirrhotic...

.... Correspondence: Dr Giovanni Sansoè, Divisione di Gastroenterologia, Ospedale Gradenigo, C.so Regina Margherita 10, 10153 Torino, Italy (e-mail [email protected] ). 9 4 2001 24 8 2001 21 9 2001 The Biochemical Society and the Medical Research Society © 2002 2002 ascites cimetidine...

... is facilitated by plasmin. In the ascitic fluid of patients with cirrhosis, there is massive cleavage of high- M r kininogen and activation of fibrinolysis, but bradykinin has never been measured directly. In the ascitic fluid of 24 patients with cirrhosis, we measured bradykinin-(1-9)-nonapeptide levels by RIA...

... volume restitution, the haemodynamic values returned to baseline. In particular, an increase in HVPG was shown in four out of the twelve patients (two with ascites and two without), which was small in three of them. However, HVPG remained the same as or lower than the baseline in the other eight patients...

... cirrhotic patients with refractory ascites treated with a transjugular intrahepatic porto-systemic shunt (TIPS). Eight cirrhotic patients with refractory ascites without TIPS placement served as controls for the sodium handling effects of ursodeoxycholic acid. From 1 month post TIPS, seven patients were...

... may be a treatable precipitant of renal failure in cirrhosis. Renal perfusion should be optimized by ensuring that the blood pressure and systemic haemodynamics are adequate, and that if renal venous pressure is elevated, due to tense ascites, it is alleviated. 4. The prognosis of hepatorenal syndrome...

...David P. Nelson; Eugene D. Robin; Ronald J. Wong; Mark E. Morin; Klaus G. Bensch; Brian J. Murphy; James Theodore 1. Four groups of mice were subjected to controlled fatal head trauma and then evaluated for the presence of ascites (neurogenic hyperacute ascites, NHA). The animals died virtually...

... activity (PRA) and plasma aldosterone were also evaluated. 2. Patients without ascites and ascitic patients without renal failure showed increased urinary excretion of immunoreactive 6-ketoprostaglandin F 1α (i6-keto-PGF 1α ), prostaglandin E 2 (iPGE 2 ) and thromboxane B 2 (iTXB 2 ) when compared...

...S. M. Shasha; O. S. Better; C. Chaimovitz; J. Doman; Y. Kishon 1. Dogs with bile-duct ligation retain salt and water and form ascites. The present study was undertaken to examine the role of haemodynamic factors in the aetiology of this sodium retention. 2. Haemodynamic studies were performed...