... role in the vascular dysfunction of diabetic patients. Furthermore, epidemiological observations indicate a beneficial effect of an increased dietary intake of antioxidants. The present study tested the hypothesis that the antioxidant ascorbic acid influences microcirculatory function in patients...

... demonstrated NEFA-induced endothelial dysfunction of large conduit arteries, reversible by the antioxidant ascorbic acid. We therefore investigated the effect of NEFAs on carbachol-induced endothelium-dependent vasodilation of rat resistance arteries in vitro using the technique of wire myography. In addition...

... antioxidant systems (mainly glutathione, α-tocopherol and ascorbic acid), we have assessed whether, as well as restoring hepatic glutathione content, SAMe has any effect on liver α-tocopherol and ascorbic acid levels in CCl 4 -injured rats. Four groups of seven male Wistar rats treated for 9 weeks were...

...% higher in sportsmen than in controls ( P < 0.005). Accordingly, plasma hydrosoluble antioxidant levels (ascorbic acid and uric acid) were found to be significantly elevated in the soccer players ( P < 0.005). In addition, these subjects showed high concentrations of α-tocopherol in plasma compared...

...B. J. Rathbone; A. W. Johnson; Judith I. Wyatt; J. Kelleher; R. V. Heatley; M. S. Losowsky 1. Concentrations of ascorbic acid (ascorbic and dehydro-ascorbic; A+D; measured by the 2,4-dinitrophenylhydrazine method) of nearly three times those of plasma are present in gastric juice samples from...

...M. Gleeson; J. D. Robertson; R. J. Maughan 1. The response of circulating leucocytes with regard to changes in number, proportion of granulocytes and lymphocytes, as well as changes in the ascorbic acid (AA) concentration of plasma and isolated lymphocytes, were studied in nine men who ran a 21 km...

... in inflammatory joint disease. 26 3 1981 1 5 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 ascorbic acid caeruloplasmin catalase hyaluronic acid hydrogen peroxide rheumatoid arthritis superoxide synovial fluid Clinical Science (1981) 61,483486 483...

... either as an antioxidant or as a pro-oxidant, the direction of its effect depending mainly on the degree of iron overload. This has therapeutic implications. 24 6 1980 13 10 1980 © 1981 The Biochemical Society and the Medical Research Society 1981 ascorbic acid iron overload...

...J. Dow; N. Krasner; A. Goldberg 1. Hepatic alcohol dehydrogenase activity and leucocyte ascorbic acid content were measured in thirty-five patients with liver disease and in ten control subjects with duodenal ulcer. The patients with liver disease were divided into three groups consisting of non...

... ascorbic acid blood sugar metabolism Clinical Science and Molecular Medicine (1974) 47, 63-72. PERIPHERAL VITAMIN C METABOLISM I N DIABETICS A N D NON-DIABETICS EFFECT O F INTRA-ARTERIAL INSULIN B. D. COX, MARGARET J. WHICHELOW, W. J. H. BUTTERFIELD'l) AND P . NICHOLAS Department of Medicine, Guy's...

... vigorous exercise, correlating with a decrease in leucocyte ascorbic acid content. 22 10 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 potassium ascorbic acid whole-body counting Clinical Science and Molecular Medicine (1974) 46,449456. TOTAL BODY, PLASMA...

... Research Society 1972 alcohol dehydrogenase ascorbic acid ethanol redox ratio guinea-pigs Clinical Science (1972) 42, 781-784. S H O R T C O M M U N I C A T I O N ELEVATION OF ALCOHOL DEHYDROGENASE ACTIVITY I N THE SUBCLINICALLY SCORBUTIC GUINEA-PIG MAUREEN O'KEANE, M. R. MOORE AND A. GOLDBERG...