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Articles

Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis

Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1209.
https://doi.org/10.1042/CS-2019-0281C_COR
Published: 16 August 2023
... Targeting immune mechanisms in T2 and non-T2 inflammation Target Approach Name Company Patients Status/clinical phase IgE IgE (Cε3 domain-site involved in binding to FcRI) humanized IgG1 MoAb omalizumab Novartis Asthma urticaria CRSwNP approved IgE (Cε3 domain) humanized MoAb...
View article titled, Correction: New insights into the pathophysiology and therapeutic targets of <span class="search-highlight">asthma</span> and comorbid chronic rhinosinusitis with or without nasal polyposis
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Articles

Circadian regulation of pulmonary disease: the importance of timing

Peter S. Cunningham, Callum Jackson, Amlan Chakraborty, Jafar Cain, Hannah J. Durrington, John F. Blaikley
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (11): 895–912.
https://doi.org/10.1042/CS20220061
Published: 14 June 2023
... findings from these two approaches in the context of four common respiratory diseases (asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and respiratory infection). Potential methods used to identify and measure human circadian oscillations are also discussed as these will be useful...
View article titled, Circadian regulation of pulmonary disease: the importance of timing
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Articles

New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis

Ilja Striz, Kornel Golebski, Zuzana Strizova, Stelios Loukides, Petros Bakakos, Nicola A. Hanania, Milos Jesenak, Zuzana Diamant
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (9): 727–753.
https://doi.org/10.1042/CS20190281
Published: 18 May 2023
...Ilja Striz; Kornel Golebski; Zuzana Strizova; Stelios Loukides; Petros Bakakos; Nicola A. Hanania; Milos Jesenak; Zuzana Diamant Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) or without (CRSsNP) are chronic respiratory diseases. These two disorders often co-exist based on common...
View article titled, New insights into the pathophysiology and therapeutic targets of <span class="search-highlight">asthma</span> and comorbid chronic rhinosinusitis with or without nasal polyposis
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Articles

Asthma and obesity: endotoxin another insult to add to injury?

Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2729–2748.
https://doi.org/10.1042/CS20210790
Published: 17 December 2021
...Nikita Lad; Alice M. Murphy; Cristina Parenti; Carl P. Nelson; Neil C. Williams; Graham R. Sharpe; Philip G. McTernan Low-grade inflammation is often an underlying cause of several chronic diseases such as asthma, obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). Defining...
View article titled, <span class="search-highlight">Asthma</span> and obesity: endotoxin another insult to add to injury?
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Articles

Accelerating the transition of clinical science to translational medicine

Stephen T. Holgate
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2423–2428.
https://doi.org/10.1042/CS20210846
Published: 28 October 2021
... and diagnostics [ 30 ]. 14 09 2021 05 10 2021 06 10 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 asthma interdisciplinary pathology personalized medicine translational science Having experienced the horrendous...
View article titled, Accelerating the transition of clinical science to translational medicine
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Articles

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production

Lin Yuan, Xun Zhang, Ming Yang, Xizi Du, Leyuan Wang, Shuangyan Wu, Mengping Wu, Zhen Duan, Gelei Xiao, Yizhou Zou, Yang Xiang, Xiangping Qu, Huijun Liu, Ling Qin, Qingwu Qin, Xiaoqun Qin, Chi Liu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1735–1749.
https://doi.org/10.1042/CS20191188
Published: 10 July 2020
...Lin Yuan; Xun Zhang; Ming Yang; Xizi Du; Leyuan Wang; Shuangyan Wu; Mengping Wu; Zhen Duan; Gelei Xiao; Yizhou Zou; Yang Xiang; Xiangping Qu; Huijun Liu; Ling Qin; Qingwu Qin; Xiaoqun Qin; Chi Liu Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4...
View article titled, Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production
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Includes: Supplementary data
Articles

Back to the future: re-establishing guinea pig in vivo asthma models

Mikael Adner, Brendan J. Canning, Herman Meurs, William Ford, Patricia Ramos Ramírez, Mariska P.M. van den Berg, Mark A. Birrell, Eva Stoffels, Lennart K.A. Lundblad, Gunnar P. Nilsson, Henric K. Olsson, Maria G. Belvisi, Sven-Erik Dahlén
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1219–1242.
https://doi.org/10.1042/CS20200394
Published: 05 June 2020
...Mikael Adner; Brendan J. Canning; Herman Meurs; William Ford; Patricia Ramos Ramírez; Mariska P.M. van den Berg; Mark A. Birrell; Eva Stoffels; Lennart K.A. Lundblad; Gunnar P. Nilsson; Henric K. Olsson; Maria G. Belvisi; Sven-Erik Dahlén Research using animal models of asthma is currently...
View article titled, Back to the future: re-establishing guinea pig in vivo <span class="search-highlight">asthma</span> models
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Includes: Supplementary data
Articles

Bidirectional interaction of airway epithelial remodeling and inflammation in asthma

Asoka Banno, Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (9): 1063–1079.
https://doi.org/10.1042/CS20191309
Published: 05 May 2020
...Asoka Banno; Aravind T. Reddy; Sowmya P. Lakshmi; Raju C. Reddy Asthma is a chronic disease of the airways that has long been viewed predominately as an inflammatory condition. Accordingly, current therapeutic interventions focus primarily on resolving inflammation. However, the mainstay of asthma...
View article titled, Bidirectional interaction of airway epithelial remodeling and inflammation in <span class="search-highlight">asthma</span>
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Articles

Independent and combined effects of airway remodelling and allergy on airway responsiveness

Kimberley C.W. Wang, Timothy D. Le Cras, Alexander N. Larcombe, Graeme R. Zosky, John G. Elliot, Alan L. James, Peter B. Noble
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (3): 327–338.
https://doi.org/10.1042/CS20171386
Published: 02 February 2018
...Kimberley C.W. Wang; Timothy D. Le Cras; Alexander N. Larcombe; Graeme R. Zosky; John G. Elliot; Alan L. James; Peter B. Noble Airway remodelling and allergic inflammation are key features of airway hyperresponsiveness (AHR) in asthma; however, their interrelationships are unclear. The present...
View article titled, Independent and combined effects of airway remodelling and allergy on airway responsiveness
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Articles

Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner

Kimberley C.W. Wang, Alexander N. Larcombe, Luke J. Berry, Jude S. Morton, Sandra T. Davidge, Alan L. James, Peter B. Noble
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (2): 273–284.
https://doi.org/10.1042/CS20171554
Published: 25 January 2018
...Kimberley C.W. Wang; Alexander N. Larcombe; Luke J. Berry; Jude S. Morton; Sandra T. Davidge; Alan L. James; Peter B. Noble Epidemiological studies demonstrate an association between intrauterine growth restriction (IUGR) and asthma; however the underlying mechanism is unknown. We investigated...
View article titled, Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner
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Articles

Role of human metapneumovirus and respiratory syncytial virus in asthma exacerbations: where are we now?

Penny A. Rudd, Belinda J. Thomas, Ali Zaid, Martin MacDonald, Keiko Kan-o, Michael S. Rolph, Anand R. Soorneedi, Philip G. Bardin, Suresh Mahalingam
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1713–1721.
https://doi.org/10.1042/CS20160011
Published: 30 June 2017
..., second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway...
View article titled, Role of human metapneumovirus and respiratory syncytial virus in <span class="search-highlight">asthma</span> exacerbations: where are we now?
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Articles

Pathogenesis of asthma: implications for precision medicine

Richard J. Russell, Christopher Brightling
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1723–1735.
https://doi.org/10.1042/CS20160253
Published: 30 June 2017
...Richard J. Russell; Christopher Brightling The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse range of underlying dominant disease processes and pathways despite apparent similarities in clinical expression. Here, we present the current understanding of asthma...
View article titled, Pathogenesis of <span class="search-highlight">asthma</span>: implications for precision medicine
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Articles

A new approach to the classification and management of airways diseases: identification of treatable traits

Rahul Shrimanker, Xue Ning Choo, Ian D. Pavord
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (10): 1027–1043.
https://doi.org/10.1042/CS20160028
Published: 09 May 2017
... settings. Correspondence: Ian Pavord ( [email protected] ) 18 10 2016 14 12 2016 26 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 airways disease asthma chronic obstructive pulmonary disease...
View article titled, A new approach to the classification and management of airways diseases: identification of treatable traits
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Articles

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

Simon G. Royce, Anna M. Tominaga, Matthew Shen, Krupesh P. Patel, Brooke M. Huuskes, Rebecca Lim, Sharon D. Ricardo, Chrishan S. Samuel
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (23): 2151–2165.
https://doi.org/10.1042/CS20160328
Published: 20 October 2016
...Simon G. Royce; Anna M. Tominaga; Matthew Shen; Krupesh P. Patel; Brooke M. Huuskes; Rebecca Lim; Sharon D. Ricardo; Chrishan S. Samuel Current asthma therapies primarily target airway inflammation (AI) and suppress episodes of airway hyperresponsiveness (AHR) but fail to treat airway remodelling...
View article titled, Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease
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Articles

Translational models of lung disease

Paul F. Mercer, Katharine Abbott-Banner, Ian M. Adcock, Richard G. Knowles
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (4): 235–256.
https://doi.org/10.1042/CS20140373
Published: 17 October 2014
... of the models currently used in the settings of asthma, idiopathic pulmonary fibrosis and COPD. The ultimate hope is that this will contribute to a more rational, efficient and sustainable development of a range of new treatments for respiratory diseases that continue to cause substantial morbidity...
View article titled, Translational models of lung disease
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Articles

The inverse agonist propranolol confers no corticosteroid-sparing activity in mild-to-moderate persistent asthma

William J. Anderson, Philip M. Short, Peter A. Williamson, Arvind Manoharan, Brian J. Lipworth
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (11): 635–643.
https://doi.org/10.1042/CS20140249
Published: 29 July 2014
...William J. Anderson; Philip M. Short; Peter A. Williamson; Arvind Manoharan; Brian J. Lipworth The murine asthma model shows that switching off airway β 2 receptors with an inverse agonist may confer anti-inflammatory effects as well as corticosteroid-sparing activity. We have assessed for any...
View article titled, The inverse agonist propranolol confers no corticosteroid-sparing activity in mild-to-moderate persistent <span class="search-highlight">asthma</span>
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Articles

Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma

Rylie P. Flesher, Cristan Herbert, Rakesh K. Kumar
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (11): 805–818.
https://doi.org/10.1042/CS20130623
Published: 21 February 2014
... of chronic allergic asthma in mice. Animals sensitized to OVA (ovalbumin) received controlled low-level challenge with aerosolized antigen for 4 weeks, followed by a single moderate-level challenge to simulate an allergen-induced exacerbation of asthmatic inflammation. Induction of an exacerbation...
View article titled, Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic <span class="search-highlight">asthma</span>
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Includes: Supplementary data
Articles

Development of a mouse model mimicking key aspects of a viral asthma exacerbation

Deborah L. Clarke, Nicola H. E. Davis, Jayesh B. Majithiya, Sian C. Piper, Arthur Lewis, Matthew A. Sleeman, Dominic J. Corkill, Richard D. May
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (8): 567–580.
https://doi.org/10.1042/CS20130149
Published: 08 December 2013
...Deborah L. Clarke; Nicola H. E. Davis; Jayesh B. Majithiya; Sian C. Piper; Arthur Lewis; Matthew A. Sleeman; Dominic J. Corkill; Richard D. May Viral respiratory tract infections are known triggers of asthma exacerbations in both adults and children. The current standard of care, inhaled CS...
View article titled, Development of a mouse model mimicking key aspects of a viral <span class="search-highlight">asthma</span> exacerbation
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Articles

Proof-of-concept evaluation of trough airway hyper-responsiveness following regular racemic or levosalbutamol in genotype-stratified steroid-treated persistent asthmatic patients

William J. Anderson, Philip M. Short, Peter A. Williamson, Ashley E. Morrison, Colin Palmer, Roger Tavendale, Brian J. Lipworth
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (1): 75–83.
https://doi.org/10.1042/CS20130213
Published: 09 September 2013
... be detrimental in asthma. The isomeric formulation of salbutamol and the B2ADR (β 2 adrenoceptor) 16 genotype may also influence this phenomenon. We performed a randomized, double-blind, placebo-controlled, triple crossover, proof of concept trial comparing 2 weeks of regular therapy with inhaled racemic...
View article titled, Proof-of-concept evaluation of trough airway hyper-responsiveness following regular racemic or levosalbutamol in genotype-stratified steroid-treated persistent asthmatic patients
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Articles

Longitudinal characterization of a model of chronic allergic lung inflammation in mice using imaging, functional and immunological methods

Kumar Changani, Catherine Pereira, Simon Young, Robert Shaw, Simon P. Campbell, Kashmira Pindoria, Steve Jordan, Katherine Wiley, Sarah Bolton, Tony Nials, Michael Haase, Mike Pedrick, Richard Knowles
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (12): 555–564.
https://doi.org/10.1042/CS20130086
Published: 02 August 2013
... 86/609/EEC and the GlaxoSmithKline Policy on the Care, Welfare and Treatment of Animals. All animal studies performed at AstraZeneca were carried out under licences issued under the Animals (Scientific Procedures) Act 1986 following local ethical committee review. asthma computed tomography (CT...
View article titled, Longitudinal characterization of a model of chronic allergic lung inflammation in mice using imaging, functional and immunological methods
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Includes: Supplementary data
Articles

Differences in respiratory syncytial virus and influenza infection in a house-dust-mite-induced asthma mouse model: consequences for steroid sensitivity

Hiroki Mori, Nicole S. Parker, Deborah Rodrigues, Kathryn Hulland, Deborah Chappell, Jennifer S. Hincks, Helen Bright, Steven M. Evans, David J. Lamb
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (12): 565–574.
https://doi.org/10.1042/CS20130098
Published: 02 August 2013
...Hiroki Mori; Nicole S. Parker; Deborah Rodrigues; Kathryn Hulland; Deborah Chappell; Jennifer S. Hincks; Helen Bright; Steven M. Evans; David J. Lamb A significant number of clinical asthma exacerbations are triggered by viral infection. We aimed to characterize the effect of virus infection...
View article titled, Differences in respiratory syncytial virus and influenza infection in a house-dust-mite-induced <span class="search-highlight">asthma</span> mouse model: consequences for steroid sensitivity
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Articles

Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo : a model of relevance to asthma

Jason P. Riley, Barbara Fuchs, Lisa Sjöberg, Gunnar P. Nilsson, Lars Karlsson, Sven-Erik Dahlén, Navin L. Rao, Mikael Adner
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (11): 533–542.
https://doi.org/10.1042/CS20130092
Published: 25 July 2013
...Jason P. Riley; Barbara Fuchs; Lisa Sjöberg; Gunnar P. Nilsson; Lars Karlsson; Sven-Erik Dahlén; Navin L. Rao; Mikael Adner One feature of allergic asthma, the EAR (early allergic reaction), is not present in the commonly used mouse models. We therefore investigated the mediators involved in EAR...
View article titled, Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo : a model of relevance to <span class="search-highlight">asthma</span>
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Articles

A tailored approach to asthma management: Arg 16 holds the key?

Ian Sayers
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (8): 517–519.
https://doi.org/10.1042/CS20120640
Published: 08 January 2013
...Ian Sayers Asthma is heterogeneous with respect to clinical presentation, underlying disease mechanisms and response to existing drugs making tailored therapy desirable. Pharmacogenetics, the study of the influence of genetic polymorphisms on drug efficacy and/or adverse effects, is relatively...
View article titled, A tailored approach to <span class="search-highlight">asthma</span> management: Arg 16 holds the key?
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Articles

Tailored second-line therapy in asthmatic children with the Arg 16 genotype

Brian J. Lipworth, Kaninika Basu, Helen P. Donald, Roger Tavendale, Donald F. Macgregor, Simon A. Ogston, Colin N. A. Palmer, Somnath Mukhopadhyay
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (8): 521–528.
https://doi.org/10.1042/CS20120528
Published: 08 January 2013
...). We therefore evaluated using montelukast as an alternative to salmeterol as tailored second-line asthma controller therapy in children expressing this susceptible genotype. A total of 62 persistent asthmatic children with the homozygous Arg 16 genotype were randomized to receive salmeterol (50 μg...
View article titled, Tailored second-line therapy in asthmatic children with the Arg 16 genotype
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Articles

Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease

Simon G. Royce, Amelia Sedjahtera, Chrishan S. Samuel, Mimi L. K. Tang
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (1): 41–51.
https://doi.org/10.1042/CS20120024
Published: 07 September 2012
...Simon G. Royce; Amelia Sedjahtera; Chrishan S. Samuel; Mimi L. K. Tang Although CSs (corticosteroids) demonstrate potent effects in the control of airway inflammation in asthma, many patients continue to experience symptoms and AHR (airway hyper-responsiveness) despite optimal treatment...
View article titled, Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease
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Articles

Mast cells in health and disease

Charlotte L. Weller, Sarah J. Collington, Tim Williams, Jonathan R. Lamb
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (11): 473–484.
https://doi.org/10.1042/CS20100459
Published: 15 February 2011
... at the present address: Novartis Pharmaceuticals UK Limited, Horsham, West Sussex RH125 AB, U.K. (email [email protected] ). 27 9 2010 17 11 2010 25 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 asthma atherosclerosis autoimmune disease host...
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Articles

Think the impossible: β-blockers for treating asthma

Brian J. LIPWORTH, Peter A. WILLIAMSON
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (2): 115–120.
https://doi.org/10.1042/CS20090398
Published: 15 January 2010
...Brian J. LIPWORTH; Peter A. WILLIAMSON Asthma was originally thought to be associated with an intrinsic defect in β 2 ADR ( β 2 -adrenoceptor) function, tipping the balance towards parasympathetic bronchoconstriction. Hence β -blocking drugs (such as β 2 ADR antagonists and inverse agonists) may...
View article titled, Think the impossible: β-blockers for treating <span class="search-highlight">asthma</span>
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Articles

A new look at the pathogenesis of asthma

Stephen T. Holgate, Hasan S. Arshad, Graham C. Roberts, Peter H. Howarth, Philipp Thurner, Donna E. Davies
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (7): 439–450.
https://doi.org/10.1042/CS20090474
Published: 23 December 2009
...Stephen T. Holgate; Hasan S. Arshad; Graham C. Roberts; Peter H. Howarth; Philipp Thurner; Donna E. Davies Asthma is an inflammatory disorder of the conducting airways that has strong association with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2)-type T-cell...
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Articles

TNF-α as a target for anti-asthma therapy

Colleen T. Bruce, Paul S. Thomas
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 265.
https://doi.org/10.1042/CS20050289
Published: 17 January 2006
...Colleen T. Bruce; Paul S. Thomas Correspondence: Dr Paul S. Thomas (email [email protected] ). 21 9 2005 14 10 2005 14 10 2005 The Biochemical Society 2006 asthma cytokine etanercept inflammation tumour necrosis factor-α (TNF-α) We read the review...
View article titled, TNF-α as a target for anti-<span class="search-highlight">asthma</span> therapy
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Articles

Clinical relevance of the neurotrophins and their receptors

Shelley J. Allen, David Dawbarn
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 175–191.
https://doi.org/10.1042/CS20050161
Published: 17 January 2006
... disease states, including Alzheimer's disease, depression, pain and asthma. In addition, the role of BDNF (brain-derived neurotrophic factor) in synaptic plasticity and memory formation is discussed. Unlike the other neurotrophins, BDNF is secreted in an activity-dependent manner that allows the highly...
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Articles

TNF-α as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis

Cristina Russo, Riccardo Polosa
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (2): 135–142.
https://doi.org/10.1042/CS20050038
Published: 25 July 2005
... and have proved to be safe and effective in the treatment of patients with RA, Crohn's disease and psoriasis refractory to conventional treatments. Biological therapies blocking TNF-α are likely to constitute a considerable advance in the management of those difficult cases of asthma that are particularly...
View article titled, TNF-α as a promising therapeutic target in chronic <span class="search-highlight">asthma</span>: a lesson from rheumatoid arthritis
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Articles

Structural changes in the airways in asthma: observations and consequences

Tony R. BAI, Darryl A. KNIGHT
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (6): 463–477.
https://doi.org/10.1042/CS20040342
Published: 24 May 2005
..., whereas the importance of structural changes to the phenomenon of airways hyperresponsiveness may be dependent on the specific clinical phenotype of asthma evaluated. Reduced compliance of the airway wall secondary to enhanced matrix deposition may protect against airway narrowing. Conversely, in severe...
View article titled, Structural changes in the airways in <span class="search-highlight">asthma</span>: observations and consequences
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Articles

Perception of bronchoconstriction in obstructive pulmonary diseases (disease-specific dyspnoea)

Aydanur EKICI, Sevda YILMAZ, Mehmet EKICI, Füsun KALPAKLIOĞLU, Yasemin KARADENIZ, Mesut ARSLAN, Ahmet ITEGINLI, Turkan KARA, Ercan KURTIPEK
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (2): 181–185.
https://doi.org/10.1042/CS20020364
Published: 01 August 2003
... are different. We investigated the perception of bronchoconstriction in subjects with bronchiectasis, asthma and chronic bronchitis and possible contributing factors. Forty-seven non-smoking subjects with bronchiectasis, 50 subjects with asthma and 31 with chronic bronchitis were challenged with histamine...
View article titled, Perception of bronchoconstriction in obstructive pulmonary diseases (disease-specific dyspnoea)
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Articles

New insights into the relationship between airway inflammation and asthma

A.J. WARDLAW, C.E. BRIGHTLING, R. GREEN, G. WOLTMANN, P. BRADDING, I.D. PAVORD
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (2): 201–211.
https://doi.org/10.1042/cs1030201
Published: 17 July 2002
...A.J. WARDLAW; C.E. BRIGHTLING; R. GREEN; G. WOLTMANN; P. BRADDING; I.D. PAVORD Asthma is a condition characterized by variable airflow obstruction, airway hyper-responsiveness (AHR) and airway inflammation which is usually, but not invariably, eosinophilic. Current thoughts on the pathogenesis...
View article titled, New insights into the relationship between airway inflammation and <span class="search-highlight">asthma</span>
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Articles

Effects of angiotensin II on remodelling of the airway and the vasculature in the rat

Scott G. RAMSAY, Christopher J. KENYON, Niall WHYTE, Ian C. MCKAY, Neil C. THOMSON, George B. M. LINDOP
Journal: Clinical Science
Clin Sci (Lond) (2000) 98 (1): 1–7.
https://doi.org/10.1042/cs0980001
Published: 19 November 1999
...Scott G. RAMSAY; Christopher J. KENYON; Niall WHYTE; Ian C. MCKAY; Neil C. THOMSON; George B. M. LINDOP Airway remodelling occurs in chronic asthma. Angiotensin II promotes growth in cardiovascular remodelling. Since the renin–angiotensin system is activated in acute severe asthma, we hypothesized...
View article titled, Effects of angiotensin II on remodelling of the airway and the vasculature in the rat
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Articles

β 2 -Adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting β 2 -agonist therapy

B. J. LIPWORTH, I. P. HALL, I. AZIZ, K. S. TAN, A. WHEATLEY
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (3): 253–259.
https://doi.org/10.1042/cs0960253
Published: 01 March 1999
...-eight patients with stable mild to moderate asthma and receiving inhaled corticosteroids were randomized in a parallel group, double-blind, double-dummy fashion to receive 2 weeks of treatment with either formoterol (12 μ g once daily, 6 μ g twice daily or 24 μ g twice daily) or terbutaline (500 μ g...
View article titled, β 2 -Adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting β 2 -agonist therapy
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Articles

Lack of interaction of hyperpnoea with methacholine and histamine in asthma

Suree SOMPRADEEKUL, Rana HEJAL, Melissa McLANE, K. A. LENNER, J. A. NELSON, E. R. McFADDEN, Jr.
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (5): 611–619.
https://doi.org/10.1042/cs0950611
Published: 01 November 1998
...Suree SOMPRADEEKUL; Rana HEJAL; Melissa McLANE; K. A. LENNER; J. A. NELSON; E. R. McFADDEN, Jr. 1. The thermal precipitants of asthma (exercise and hyperventilation) appear to have a unique pathogenesis that does not alter bronchial responsiveness. In the present work, we tested whether hyperpnoea...
View article titled, Lack of interaction of hyperpnoea with methacholine and histamine in <span class="search-highlight">asthma</span>
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Articles

Inhaled corticosteroid therapy reduces the early morning peak in cortisol and aldosterone

Andrew M. WILSON, Erika J. SIMS, Allan D. STRUTHERS, Brian J. LIPWORTH
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (4): 513–517.
https://doi.org/10.1042/cs0950513
Published: 01 October 1998
... was suppressed by inhaled corticosteroid therapy. 2. Ten normotensive patients with mild–moderate asthma, mean age 24.0 (S.D. 9.8) years and mean arterial pressure 90.7 (9.8) mmHg, were studied in a double-blind, randomized crossover design comparing placebo with fluticasone propionate, 1000 ; μ g administered...
View article titled, Inhaled corticosteroid therapy reduces the early morning peak in cortisol and aldosterone
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Articles

Possible interaction between exposure to environmental tobacco smoke and therapy in children with asthma

Jean-Christophe DUBUS, Christiane ODDOZE, Monique BADIER, Chantal GUILLOT, Bernard BRUGUEROLLE
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (2): 143–149.
https://doi.org/10.1042/cs0950143
Published: 01 August 1998
... or several direct interactions between tobacco smoke compounds and albuterol. Correspondence : Professor B. Bruguerolle. 4 12 1997 18 2 1998 26 3 1998 © 1988 The Biochemical Society and the Medical Research Society 1988 albuterol asthma bronchial reactivity carbachol...
View article titled, Possible interaction between exposure to environmental tobacco smoke and therapy in children with <span class="search-highlight">asthma</span>
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Articles

Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma

Ligia J. DOMINGUEZ, Mario BARBAGALLO, Gabriele Di LORENZO, Agata DRAGO, Santi SCOLA, Giuseppina MORICI, Calogero CARUSO
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (2): 137–142.
https://doi.org/10.1042/cs0950137
Published: 01 August 1998
...Ligia J. DOMINGUEZ; Mario BARBAGALLO; Gabriele Di LORENZO; Agata DRAGO; Santi SCOLA; Giuseppina MORICI; Calogero CARUSO 1. Increased bronchial smooth muscle contractility with consequent bronchial hyperreactivity are characteristic physiopathological events of asthma. Since magnesium intervenes...
View article titled, Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in <span class="search-highlight">asthma</span>
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Articles

Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms

Peter J. Barnes
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (6): 557–572.
https://doi.org/10.1042/cs0940557
Published: 01 June 1998
...Peter J. Barnes 1. Glucocorticoids are widely used for the suppression of inflammation in chronic inflammatory diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease and autoimmune diseases, all of which are associated with increased expression of inflammatory genes...
View article titled, Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms
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Articles

Effects of Skin Cooling on Airway Reactivity in Asthma

M. E. Skowronski, R. Ciufo, J. A. Nelson, E. R. McFadden, Jr.
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (5): 525–529.
https://doi.org/10.1042/cs0940525
Published: 01 May 1998
... the exposed skin respectively. It is now known that skin chilling does not amplify the effects of breathing cold air, but it is not established if this lack of interaction is unique, or applies to other forms of airway constrictors. 2. To provide data on this issue, 10 subjects with atopic asthma underwent...
View article titled, Effects of Skin Cooling on Airway Reactivity in <span class="search-highlight">Asthma</span>
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Articles

Influence of Treatment with Beclomethasone, Cromoglycate and Theophylline on Perception of Bronchoconstriction in Patients with Bronchial Asthma

C. M. B. Higgs, G. Laszlo
Journal: Clinical Science
Clin Sci (Lond) (1996) 90 (3): 227–234.
https://doi.org/10.1042/cs0900227
Published: 01 March 1996
...C. M. B. Higgs; G. Laszlo 1. Perception of asthma by patients can be assessed from the relationship between symptom scores and peak expiratory flows. This study was designed to investigate the possibility that medication can affect perception of the sensation of asthma independently of changes...
View article titled, Influence of Treatment with Beclomethasone, Cromoglycate and Theophylline on Perception of Bronchoconstriction in Patients with Bronchial <span class="search-highlight">Asthma</span>
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Articles

Effect of Ozone Exposure on Maximal Airway Narrowing in Non-Asthmatic and Asthmatic Subjects

T. J. N. Hiltermann, J. Stolk, P. S. Hiemstra, P. H. B. Fokkens, P. J. A. Rombout, J. K. Sont, P. J. Sterk, J. H. Dijkman
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (6): 619–624.
https://doi.org/10.1042/cs0890619
Published: 01 December 1995
... levels and hospital admissions for asthma. 17 8 1995 23 8 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 asthma bronchial hyper-reactivity inflammation neutrophils ozone respiratory system sputum Clinical Science (1995) 89, 61%24 (Printed...
View article titled, Effect of Ozone Exposure on Maximal Airway Narrowing in Non-Asthmatic and Asthmatic Subjects
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Articles

Sympathoadrenal Responses to Bronchoconstriction in Asthma: An Invasive and Kinetic Study of Plasma Catecholamines

Kjell Larsson, Per Carlens, Sture Bevegård, Paul Hjemdahl
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (4): 439–446.
https://doi.org/10.1042/cs0880439
Published: 01 April 1995
... adrenaline asthma bronchoconstriction neuropeptide Y noradrenaline sympathetic nervous system Clinical Science (1995) I, 439446 (Printed in Great Britain) 439 Sympathoadrenal responses to bronchoconstriction in asthma: an invasive and kinetic study of plasma catecholamines Kjell LARSSON, Per CARLENS...
View article titled, Sympathoadrenal Responses to Bronchoconstriction in <span class="search-highlight">Asthma</span>: An Invasive and Kinetic Study of Plasma Catecholamines
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Articles

Airway Re-Modelling in Asthma: Role of Airway Smooth Muscle

Alan J. Knox
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (6): 647–652.
https://doi.org/10.1042/cs0860647
Published: 01 June 1994
...Alan J. Knox © 1994 The Biochemical Society and the Medical Research Society 1994 airway smooth muscle asthma Clinical Science (1994) 86, 64Y-652 (Printed in Great Britain) Editorial Review MY Airway remodelling in asthma: role of airway smooth muscle Alan J. KNOX Respiratory Medicine...
View article titled, Airway Re-Modelling in <span class="search-highlight">Asthma</span>: Role of Airway Smooth Muscle
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Articles

Rates of Change in Peak Expiratory Flow and in Diurnal Variation in Peak Flow in Patients Recovering from Acute Severe Asthma

G. E. Packe, W. Freeman, Ruth M. Cayton
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (1): 59–65.
https://doi.org/10.1042/cs0860059
Published: 01 January 1994
...G. E. Packe; W. Freeman; Ruth M. Cayton 1. The rates of change in mean peak expiratory flow and in diurnal variation in peak flow were compared in 14 patients recovering from acute severe asthma. 2. Peak expiratory flow was measured on hospital admission, and at 6-hourly intervals for the next 3...
View article titled, Rates of Change in Peak Expiratory Flow and in Diurnal Variation in Peak Flow in Patients Recovering from Acute Severe <span class="search-highlight">Asthma</span>
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Articles

Acetyl-CoA:lyso-Platelet-Activating Factor Acetyltransferase Activity in Neutrophils from Asthmatic Patients and Normal Subjects

Neil L. A. Misso, Robyn L. Gillon, Marcia L. Taylor, Geoffrey A. Stewart, Philip J. Thompson
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (4): 455–463.
https://doi.org/10.1042/cs0850455
Published: 01 October 1993
...Neil L. A. Misso; Robyn L. Gillon; Marcia L. Taylor; Geoffrey A. Stewart; Philip J. Thompson 1. Platelet-activating factor is a putative mediator of inflammation in asthma and the enzyme acetyl-CoA:lyso-platelet-activating factor acetyltransferase appears to be important in regulating platelet...
View article titled, Acetyl-CoA:lyso-Platelet-Activating Factor Acetyltransferase Activity in Neutrophils from Asthmatic Patients and Normal Subjects
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Articles

Validity of Peak Expiratory Flow Rate Variability for the Diagnosis of Asthma

J. P. Jamison, R. K. McKinley
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (3): 367–371.
https://doi.org/10.1042/cs0850367
Published: 01 September 1993
...J. P. Jamison; R. K. McKinley 1. The aim of this study was to determine the validity of various numerical indices of peak flow variability as tests for asthma. 2. Normal ( n = 24) and asthmatic ( n = 123) subjects aged 10-70 years were recruited from the community. Asthma was diagnosed by full...
View article titled, Validity of Peak Expiratory Flow Rate Variability for the Diagnosis of <span class="search-highlight">Asthma</span>
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Articles

Effect of Glucocorticosteroid Treatment on β -Adrenoceptor Subtype Function in Adipocytes from Patients with Asthma

Signy Reynisdottir, Hans Wahrenberg, Gunnar Bylin, Peter Arner
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (2): 237–244.
https://doi.org/10.1042/cs0850237
Published: 01 August 1993
...Signy Reynisdottir; Hans Wahrenberg; Gunnar Bylin; Peter Arner 1. Adrenoceptor subtype function was studied in isolated adipocytes obtained by subcutaneous fat biopsies from nine patients with mild asthma. The biopsies were taken before and after 7 days treatment with 25 mg of prednisolone given...
View article titled, Effect of Glucocorticosteroid Treatment on β -Adrenoceptor Subtype Function in Adipocytes from Patients with <span class="search-highlight">Asthma</span>
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