... consecutive occasions), without any other signs of renal disease and whose blood pressure was persistently below 140/90 mmHg, were studied. 3. In a randomized sequence and in a double-blind fashion, after a 2-month run-in period, patients were allocated to receive 5 mg of enalapril or 50 mg of atenolol daily...

... the alterations of prostaglandin generation in the kidney and in the aorta when spontaneously hypertensive rats were treated with atenolol for 2 weeks. 2. The blood pressure reduction was associated with an increase in urinary sodium excretion and urinary prostaglandin E 2 excretion. The sodium excretion...

...Hiroyuki Shimamoto; Yoriko Shimamoto; Shogo Sakata 1. The influence of long-acting propranolol and of atenolol on the circadian rhythm of heart rate was assessed using 24 h electrocardiographic recordings in elderly patients with essential hypertension. Eighteen elderly patients were investigated...

...F. Sau; A. Cherchi; C. Seguro 1. Fifteen patients with essential hypertension, class I, II WHO, nine males and six females, whose mean age was 46 years, were given atenolol, 100 mg a day, for 1 year. 2. After 1 month, compared with control, systolic and diastolic blood pressures, heart rate...

...S. E. Kjeldsen; I. Eide; P. Leren; O. P. Foss 1. Nineteen healthy men aged 50 years, with untreated, mild essential hypertension WHO group I, were randomized into two groups to study the effect of treatment (18 weeks) with oxprenolol ( n = 10) and atenolol ( n = 9) on serum cholesterol fractions...

...M. Mohsen Ibrahim; M. Aziz Madkour; Ragaa Mossallam 1. Seventeen male patients with essential hypertension were studied after 4 weeks of placebo and after 8 weeks of β-adrenoceptor-blockade therapy with atenolol (100 mg/day). 2. The influence of the following factors on left ventricular wall...

...M. Mohsen Ibrahim; M. Aziz Madkour; Ragaa Mossallam 1. Atenolol (100 mg/day) was given to 12 hypertensive patients for 8 weeks, and its effects on mean arterial pressure, cardiac index and ejection phase indices of myocardial performance were examined by echocardiography. 2. Echocardiographic...

...M. Velasco; J. Guevara; J. Morillo; A. Ramírez; A. Urbina-Quintana; O. Hernández-Pieretti 1. The effect of the cardioselective β-adrenoreceptor antagonist atenolol on blood pressure, heart rate, systolic time interval, limb blood flow and limb vascular resistance was studied, both when the drug...

... attention to times of retiring to bed, and times of waking in the morning. 3. All subjects were treated with a single daily dose of atenolol (50 to 200 mg) for between 2 and 9 months, and then underwent a second 24 h blood pressure study. 4. Arterial blood pressure was lowered significantly throughout...

...J. D. F. England; A. S. P. Hua; J. Shaw 1. Chlorothiazide twice a day plus atenolol, metoprolol, pindolol and propranolol in single daily doses administered to patients with essential hypertension achieved effective control of blood pressure. 2. Each β-adrenoreceptor-blocking drug was associated...

...R. Fagard; A. Amery; J. F. Deplaen; P. Lijnen; A. Missotten 1. The anti-hypertensive effect of atenolol was greater than that of bendrofluazide. 2. The change in systolic blood pressure caused by bendrofluazide showed a significant inverse correlation with the plasma renin concentration ( r = −0·47...

...L. Hansson; B. E. Karlberg; H. Åberg; A. Westerlund; N. C. Henningsen; S. Jameson 1. Atenolol (ICI 66.082, Tenormin) is a new β-adrenoreceptor-blocking agent, devoid of intrinsic sympathomimetic and membrane-stabilizing properties. It does not cross the blood—brain barrier. 2. Atenolol given...

...H. Æ. Jensen; K. Rasmussen; N. Mosbæk 1. The β 1 -adrenoreceptor-blocking agent atenolol was studied in the treatment of twelve out-patients with essential hypertension. 2. With a mean dose of 110 mg of atenolol daily (range 75–200 mg/day) we observed a pronounced decrease in blood pressure. 3...

...P. Lund-Johansen; O. J. Ohm 1. Oxygen consumption and central haemodynamics were recorded at rest and during exercise in fifty-one men with essential hypertension (W.H.O. stage I) and repeated after 1 year on a single drug: alprenolol ( n = 10), atenolol (13) metoprolol (12) and timolol (16). 2...