... and enhanced systolic function with no evidence of arrhythmia in IGF1R model, as well as ventricular hypertrophy and decreased systolic function with intermittent atrial fibrillation in DCM-dnPI3K model. Novel findings obtained from the left atrial (LA) characterization of female mice revealed...

...Huaxin Sun; Jie Song; Kai Li; Yao Li; Luxiang Shang; Qina Zhou; Yanmei Lu; Yazhen Zong; Xiuyuan He; Muzappar Kari; Hang Yang; Xianhui Zhou; Ling Zhang; Baopeng Tang Background: Autoimmune disorder is the emerging mechanism of atrial fibrillation (AF). The β1-adrenergic receptor antibody (β1-AAb...

... against Ca 2+ -handling. Atrial remodeling due to fibrosis and abnormal intracellular Ca 2+ activities contributes to initiation and persistence of atrial fibrillation (AF). The present study investigated the effect of isorhamnetin on angiotensin II (AngII)-induced AF in mice. Wild-type male mice (C57BL...

...Dasom Mun; Hyoeun Kim; Ji-Young Kang; Nuri Yun; Young-Nam Youn; Boyoung Joung Small extracellular vesicles (sEVs) are nanometer-sized membranous vesicles that contribute to the pathogenesis of atrial fibrillation (AF). Here, we investigated the role of sEVs derived from patients with persistent AF...

... of atrial fibrillation (AF). However, the effects of the xanthine oxidase (XO) inhibition for AF remain to be fully elucidated. We investigated the effects of a novel XO inhibitor febuxostat on AF compared with allopurinol in hypertension rat model. Five-week-old Dahl salt-sensitive rats were fed either low...

...Jianqing She; Manyun Guo; Hongbing Li; Junhui Liu; Xiao Liang; Peining Liu; Bo Zhou; Simin Liu; Yangyang Deng; Bowen Lou; Chaofeng Sun; Zuyi Yuan; Yue Wu Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia whose incidence is on the rise globally. However, the pathophysiologic...

... implicated in atrial and ventricular arrhythmogenesis and in setting the vascular tone. Furthermore, the association of genetic alterations in K 2P 3.1 channels with atrial fibrillation, cardiac conduction disorders and pulmonary arterial hypertension demonstrates the relevance of the channels...

...Yen-Yu Lu; Yung-Kuo Lin; Zhi-Hong Wen; Yao-Chang Chen; Shih-Ann Chen; Yi-Jen Chen AF (atrial fibrillation) is the most common sustained arrhythmia, and the PVs (pulmonary veins) play a critical role in triggering AF. Stretch causes structural remodelling, including cytoskeleton rearrangement, which...

... at either the vascular or cardiac level. Among others, the 2238T>C exon 3 variant has been associated with endothelial cell damage and dysfunction and with an increased risk of acute cardiovascular events, a frameshift mutation within exon 3 has been related to increased risk of atrial fibrillation...

... appendage of subjects with resistant atrial fibrillation, and the preliminary observation of significantly higher Ang-(1–12) expression in human left atrial appendages. angiotensin-(1–7) angiotensin-(1–12) angiotensin-converting enzyme (ACE) atrial fibrillation chymase pro-angiotensin-12 renin...

...Giovanni Targher; Alessandro Mantovani; Isabella Pichiri; Riccardo Rigolon; Marco Dauriz; Giacomo Zoppini; Giovanni Morani; Corrado Vassanelli; Enzo Bonora NAFLD (non-alcoholic fatty liver disease) and AF (atrial fibrillation) are two pathological conditions that are highly prevalent in developed...

...Antonio Pinto; Antonino Tuttolomondo; Alessandra Casuccio; Domenico Di Raimondo; Riccardo Di Sciacca; Valentina Arnao; Giuseppe Licata The aim of the present study was to determine the rates of stroke in patients with chronic NVAF (non-valvular atrial fibrillation), evaluating the relationship...

... artery pressure. N-ANP levels were normalized following septal closure in most patients, except in those with atrial fibrillation attacks following corrective surgery. In conclusion, we have shown correlations among variables indicating changes in the architecture of the right atrium along with temporal...

...Nidal MAAROUF; Gavin ARNO; Nicholas D. CARTER; Petros SYRRIS; Shamil YUSUF; John A. CAMM; Jan POLEINIKI; Naab M. Al-SAADY Supraventricular tachycardias, including AF (atrial fibrillation), and mtDNA (mitochondrial DNA) deletions may lead to dilated cardiomyopathy. It is unknown whether mtDNA...

...Maarten P. Van Den Berg; Harry J. G. M. Crijns; Jaap Haaksma; JAN Brouwer; Kong I. Lie Clinical Science (1994) 86, 531-535 (Printed in Great Britain) 53 I Analysis of vagal effects on ventricular rhythm in patients with atrial fibrillation Maarten P. VAN DEN BERG, Harry J. G. M. CRIJNS, Jaap...

...John M. Rawles; G. R. Pai; Susan R. Reid 1. In 50 subjects with atrial fibrillation we have attempted to demonstrate variation of ventricular rate with respiration, as evidence of cardioregulatory reflex activity. 2. The electrocardiogram was recorded for 3 min during spontaneous respiration...

...S. M. Pomfret; C. R. W. Beasley; V. Challenor; S. T. Holgate 1. The efficacy of verapamil alone, or in combination with digoxin, was compared with digoxin alone in eight patients with chronic atrial fibrillation in this double-blind placebo-controlled study. 2. After 2 weeks on each treatment...

...Georg Ertl; Malte Meesmann; Klaus Krumpiegel; Kurt Kochsiek 1. Atrial fibrillation may impair coronary blood flow by tachycardia and reflex vasoconstriction. It has not been documented, however, whether in the presence of coronary stenosis atrial fibrillation exceeds the effects of rhythmic atrial...