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Keyword: atrial natriuretic peptide
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Articles
Clin Sci (Lond) (2016) 130 (18): 1655–1664.
Published: 08 August 2016
...Liang Dong; Hao Wang; Ningzheng Dong; Ce Zhang; Boxin Xue; Qingyu Wu Atrial natriuretic peptide (ANP)-mediated natriuretic response is a well-established cardiac endocrine function. Corin is a transmembrane protease that activates ANP in the heart. Corin expression has been detected in non-cardiac...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (1): 1–13.
Published: 10 March 2014
...Speranza Rubattu; Sebastiano Sciarretta; Massimo Volpe ANP (atrial natriuretic peptide), discovered 30 years ago in rat cardiac atria, has been extensively investigated with regard to physiology, pathophysiology, cardiovascular disease therapeutics and molecular genetic aspects. Besides its...
Articles
Clin Sci (Lond) (2013) 124 (12): 709–717.
Published: 26 February 2013
... ningzheng_dong@yahoo.com.cn .). 21 9 2012 16 1 2013 18 1 2013 18 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 atrial natriuretic peptide chronic kidney disease (CKD) corin protease urine • The membrane protease corin regulates sodium...
Articles
Clin Sci (Lond) (2007) 112 (9): 485–491.
Published: 02 April 2007
... to nitroprusside-induced hypotension. However, compared with the rise observed on the control day, plasma ANP (atrial natriuretic peptide; P =0.043), BNP (brain natriuretic peptide; P =0.038) and endothelin-1 ( P =0.011) levels were reduced following Ucn1 administration. Associated with this...
Articles
Clin Sci (Lond) (2005) 108 (1): 23–36.
Published: 15 December 2004
...Miriam T. RADEMAKER; A. Mark RICHARDS The cardiac natriuretic peptides, ANP (atrial natriuretic peptide) and BNP (brain natriuretic peptide), are secreted by the heart in proportion to cardiac transmural pressures. They possess a wide range of effects in multiple tissues facilitating overall...
Articles
Clin Sci (Lond) (2004) 107 (3): 297–302.
Published: 24 August 2004
... septal defect atrial natriuretic peptide right atrium ASD (atrial septal defect) is the most common form of congenital heart disease presenting in adulthood after bicuspid aortic valve and mitral valve prolapse [ 1 , 2 ]. The true incidence, however, remains undetermined as it is often...
Articles
Clin Sci (Lond) (2003) 104 (3): 303–312.
Published: 17 February 2003
...Hans BENTZEN; Robert S. PEDERSEN; Henrik B. PEDERSEN; Ole NYVAD; Erling B. PEDERSEN The purpose of this study was to clarify whether the secretions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are pulsatile in patients with chronic heart failure (CHF), and whether the...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 102S–106S.
Published: 01 September 2002
...) and increases in plasma atrial natriuretic peptide (ANP) concentrations respectively, in conscious rats. Thirty and 120min after the administration of vehicle, big ET-1 (0.3nmol/kg, intravenously; i.v.) produced pressor responses of approximately 800mmHg·min (area under the curve for change in MAP...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 249S–253S.
Published: 01 September 2002
...Sebastian PHILIPP; Jan MONTI; Ines PAGEL; Thomas LANGENICKEL; Thomas NOTTER; Frank RUSCHITZKA; Thomas LÜSCHER; Rainer DIETZ; Roland WILLENBROCK In heart failure, the cGMP to natriuretic peptide ratio is decreased and infusion of atrial natriuretic peptide (ANP) induces less cGMP generation. The...
Articles
Clin Sci (Lond) (2000) 99 (4): 343–348.
Published: 07 September 2000
...Kohichi TAMURA; Shinzo TAKAMORI; Hiroharu MIFUNE; Akihiro HAYASHI; Kazuo SHIROUZU Atrial natriuretic peptide (ANP) is a cardiac hormone which affects endothelial cell function through a receptor-mediated process. Pneumonectomy is a common thoracic surgical procedure that can cause pulmonary oedema...
Articles
Clin Sci (Lond) (1999) 97 (2): 201–206.
Published: 29 June 1999
...Erling B. PEDERSEN; Henrik B. PEDERSEN; Kaare T. JENSEN Both atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are involved in sodium and water homoeostasis in healthy humans. The plasma concentrations of the natriuretic peptides can be used to differentiate between dyspnoea of...
Articles
Clin Sci (Lond) (1998) 96 (1): 5–15.
Published: 01 January 1999
... angiotensin II arginine vasopressin atrial natriuretic peptide brain natriuretic peptide cyclic GMP glomerular filtration rate heart failure lithium renal plasma flow renin sodium 5Clinical Science (1999) 96, 5 15 (Printed in Great Britain) Renal effects of brain natriuretic peptide in patients...
Articles
Clin Sci (Lond) (1998) 96 (1): 33–39.
Published: 01 January 1999
... ;=-0.63, P < 0.01), total pulmonary resistance ( r ;= ;0.60, P < 0.01), mean pulmonary arterial pressure ( r ;= ;0.37, P < 0.05), and the natural logarithm of plasma atrial natriuretic peptide ( r ;= ;0.63, P < 0.01). Plasma levels of adrenomedullin did not change significantly after nitric...
Articles
Clin Sci (Lond) (1998) 95 (6): 701–708.
Published: 01 December 1998
...Christopher J. CHARLES; Eric A. ESPINER; M. Gary NICHOLLS; Miriam T. RADEMAKER; A. Mark RICHARDS 1. The circulating cardiac hormones atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have similar bioactivity, as judged by comparative short-term studies. However, no study has...
Articles
Clin Sci (Lond) (1998) 95 (5): 595–602.
Published: 01 November 1998
... between natriuretic peptides and urinary endothelin-1 was further investigated. Six healthy volunteers received, on three different occasions, increasing doses of atrial or C-type natriuretic peptide (0, 2 and 4 ;pmol·min -1 ·kg -1 for 1 ;h each), or placebo. 2. Atrial natriuretic peptide caused...
Articles
Clin Sci (Lond) (1998) 95 (3): 235–239.
Published: 01 September 1998
... 1998 atrial natriuretic peptide brain natriuretic peptide cardiac function stability room temperature molecular forms 235Clinical Science (1998) 95, 235 239 (Printed in Great Britain) Prolonged stability of brain natriuretic peptide: importance for non-invasive assessment of cardiac...
Articles
Clin Sci (Lond) (1998) 94 (4): 359–365.
Published: 01 April 1998
... remain to be established. Like atrial natiuretic peptide adrenomedullin is expressed in the left ventricle. Ventricular expression of atrial natriuretic peptide is known to be markedly increased by volume or pressure overload. In this study we investigated whether ventricular expression of adrenomedullin...
Articles
Clin Sci (Lond) (1998) 94 (2): 135–139.
Published: 01 February 1998
... adrenomedullin, atrial natriuretic peptide and brain natriuretic peptide in the right atrium, pulmonary artery and aorta. 3. Plasma levels of adrenomedullin in the right atrium (mean ± SEM) were significantly increased on admission (4.2 ± 2.6 h) in patients with acute myocardial infarction (10.6 ± 1.0 pmol/l...
Articles
Clin Sci (Lond) (1998) 94 (1): 21–28.
Published: 01 January 1998
... = 0.575, P < 0.0001), but no correlation between plasma levels of adrenomedullin and atrial natriuretic peptide, brain natriuretic peptide and noradrenaline. 5. Our results indicate that adrenomedullin may play an important role to maintain haemodynamics in patients with hypertrophic cardiomyopathy...
Articles
Clin Sci (Lond) (1997) 93 (6): 527–533.
Published: 01 December 1997
...Robert A. Clayton; Jane E. Nally; Neil C. Thomson; John C. McGrath 1. The aim of this study was to compare the ability of four different bronchodilators (atrial natriuretic peptide, salbutamol, sodium nitroprusside and isosorbide dinitrate) to reverse and also to protect against contractions evoked...
Articles
Clin Sci (Lond) (1997) 92 (4): 397–407.
Published: 01 April 1997
... 11 1996 11 12 1996 © 1997 The Biochemical Society and the Medical Research Society 1997 atrial natriuretic peptide lithium clearance sodium urodilatin Clinical Science (1997) 92, 397-407 (Printed in Great Britain) 397 Effect of urodilatin infusion on renal haemodynamics...
Articles
Clin Sci (Lond) (1997) 92 (3): 255–260.
Published: 01 March 1997
... sodium/creatinine ratio, P < 0.02) occurred with the higher dose. Blood pressure, haematocrit, plasma cGMP, atrial natriuretic peptide and aldosterone were unaffected by either dose. 3. Compared with brain natriuretic peptide (0.5 pmol min −1 kg −1 ) alone, SCH 32615 pretreatment increased peak plasma...
Articles
Clin Sci (Lond) (1996) 91 (3): 293–298.
Published: 01 September 1996
.../ml; after infusion, 2.4±0.1 fmol/ml) or hypertensive (before infusion, 3.0±0.1 fmol/ml; after infusion, 2.9 ± 0.2 fmol/ml) group, while renin was suppressed and atrial natriuretic peptide was markedly increased. Plasma endothelin was not affected either. 3. In the chronic salt load study, seven...
Articles
Clin Sci (Lond) (1996) 90 (3): 197–204.
Published: 01 March 1996
...Hideo Kawakami; Hideki Okayama; Mareomi Hamada; Kunio Hiwada 1. We assessed the changes of atrial natriuretic peptide and brain natriuretic peptide gene expression associated with progression and regression of cardiac hypertrophy in renovascular hypertensive rats (RHR). 2. Two-kidney, one-clip...
Articles
Clin Sci (Lond) (1996) 90 (2): 87–89.
Published: 01 February 1996
...C. B. Nielsen; J. N. Bech; E. B. Pedersen 1. In a placebo-controlled, randomized dose—response study the effect of the prostaglandin analogue epoprostenol (Flolan R ) on the plasma level of atrial natriuretic peptide has been investigated in 14 healthy control subjects. 2. During epoprostenol...
Articles
Clin Sci (Lond) (1996) 90 (1): 31–36.
Published: 01 January 1996
.... Chlorothiazide raised haematocrit and plasma renin activity equally in rats with and without infarction, although exchangeable body sodium, plasma vasopressin and plasma osmolality were not changed by the treatment. Plasma atrial natriuretic peptide was 2-fold higher in rats with infarction and this response was...
Articles
Clin Sci (Lond) (1995) 88 (5): 551–556.
Published: 01 May 1995
... quantitative assessment of the acute myocardial perfusion defect. 3. Plasma levels of atrial natriuretic peptide increased from 21.3 ± 3.8 to 72.2 ± 26.7 pg/ml ( P < 0.01) in the angina pectoris group, and increased from 19.4 ± 2.4 to 36.4 ± 17.4 pg/ml ( P < 0.01) in the control group during dynamic...
Articles
Clin Sci (Lond) (1995) 88 (2): 165–172.
Published: 01 February 1995
.... Haemodynamic variables, and plasma concentrations of atrial natriuretic peptide, arginine vasopressin, adrenaline and noradrenaline were measured. 3. Right atrioventricular pacing at a rate of 150 impulses/min resulted in disparate responses in right atrial pressure (slight decrease) and pulmonary capillary...
Articles
Clin Sci (Lond) (1995) 88 (1): 81–86.
Published: 01 January 1995
...Robert I. Cargill; Allan D. Struthers; Brian J. Lipworth 1. Atrial natriuretic peptide and brain natriuretic peptide have similar vasodilator and natriuretic properties, although little information is available regarding their relative effects as antagonists of the renin—angiotensin—aldosterone...
Articles
Clin Sci (Lond) (1994) 87 (6): 671–677.
Published: 01 December 1994
.... In each case, plasma atrial natriuretic peptide was measured in parallel with plasma brain natriuretic peptide. 2. Similarly to plasma atrial natriuretic peptide, plasma brain natriuretic peptide was elevated in patients with mitral stenosis (32 ± 2.9 and 32 ± 2.8 pg/ml in the upright and supine...
Articles
Clin Sci (Lond) (1994) 87 (6): 679–684.
Published: 01 December 1994
...John C. Corboy; Robert J. Walker; Mark B. Simmonds; Gerard T. Wilkins; A. Mark Richards; Eric A. Espiner 1. Plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptides (BNP) were measured, along with left and right atrial and left ventricular volumes, in eight patients with...
Articles
Clin Sci (Lond) (1994) 87 (4): 383–387.
Published: 01 October 1994
... side-effects in cyclosporin therapy, such as hypertension and nephrotoxicity. Atrial natriuretic peptide has been shown to inhibit this effect as well as the cyclosporin-stimulated transmembrane calcium influx in smooth muscle cells. 2. The present study, therefore, was designed to examine the effect...
Articles
Clin Sci (Lond) (1994) 87 (3): 311–317.
Published: 01 September 1994
...M. G. Buckley; N. D. Markandu; G. A. Sagnella; G. A. MacGregor 1. The aim of this study was to determine plasma levels of N-terminal atrial natriuretic peptide and atrial natriuretic peptide in normal subjects and in patients with essential hypertension, cardiac transplant and chronic renal failure...
Articles
Clin Sci (Lond) (1994) 87 (3): 319–322.
Published: 01 September 1994
...-type natriuretic peptide levels were compared with the levels of atrial natriuretic peptide and brain natriuretic peptide. 3. Plasma immunoreactive C-type natriuretic peptide concentrations were greatly elevated in patients with chronic renal failure [non-dialysed, 13.0 ± 4.2 pmol/l (mean ± SEM), n = 9...
Articles
Clin Sci (Lond) (1994) 87 (1): 109–114.
Published: 01 July 1994
..., 7 and 14, and n =8 for day 10) were killed. Hearts were dissected and weighed for determination of ventricular ratios, lungs were perfused with formol saline for histological examination of the pulmonary vasculature, and blood was collected for measurement of plasma atrial natriuretic peptide level...
Articles
Clin Sci (Lond) (1994) 86 (6): 723–730.
Published: 01 June 1994
...B. M. Y. Cheung; J. E. C. Dickerson; M. J. Ashby; M. J. Brown; J. Brown 1. Brain natriuretic peptide, closely related to atrial natriuretic peptide in structure, may be an important circulating hormone. Its physiological role is unclear. First, we studied the effects of incremental infusions of...
Articles
Clin Sci (Lond) (1994) 86 (3): 291–295.
Published: 01 March 1994
...Robert M. Angus; Jane E. Nally; Raymond McCall; Louise C. Young; John C. McGrath; Neil C. Thomson 1. We have previously shown that atrial natriuretic peptide causes bronchodilatation and reduces bronchial reactivity when administered intravenously or by inhalation to asthmatic patients. We wished...
Articles
Clin Sci (Lond) (1993) 85 (5): 643–649.
Published: 01 November 1993
...Gabriele Kaczmarczyk; Dinah Jörres; Rolf Rossaint; Martin Krebs; Volker Unger; Konrad Falke 1. This study in conscious dogs examined the effects of extracellular volume expansion on plasma antidiuretic hormone, atrial natriuretic peptide and aldosterone concentrations, plasma renin activity, and...
Articles
Clin Sci (Lond) (1993) 85 (4): 411–416.
Published: 01 October 1993
... brain natriuretic peptide-32-like immunoreactivity (hBNP-32-li) were measured by radioimmunoassay in 11 healthy subjects and 20 patients with essential hypertension after 15 min supine, 15 min sitting and 15 min with the legs raised at 60°, together with plasma atrial natriuretic peptide concentration...
Articles
Clin Sci (Lond) (1993) 85 (1): 1–4.
Published: 01 July 1993
...Art Ationu; Keld Sorensen; Bruce Whitehead; Donald Singer; Nicholas Carter 1. Dynorphin, an endogenous opioid peptide, acts on specific κ-opioid receptors in the rat heart for the local regulation of atrial natriuretic peptide release. No known study has examined the expression of dynorphin in the...
Articles
Clin Sci (Lond) (1993) 85 (1): 13–17.
Published: 01 July 1993
...G. A. Sagnella; N. D. Markandu; M. G. Buckley; D. R. J. Singer; G. A. MacGregor 1. The present study was designed to investigate the relationships between circulating atrial natriuretic peptide, plasma and urinary cyclic GMP and sodium excretion under basal conditions and in response to changes in...
Articles
Clin Sci (Lond) (1993) 85 (1): 19–26.
Published: 01 July 1993
...Janice E. O'Connell; Alan G. Jardine; David L. Davies; James McQueen; John M. C. Connell 1. Acute pharmacological inhibition of the enzyme neutral endopeptidase (EC 3.4.24.11), which cleaves the cardiac hormone atrial natriuretic peptide, raises endogenous levels of the hormone. Short-term...
Articles
Clin Sci (Lond) (1992) 83 (6): 723–729.
Published: 01 December 1992
... response to atrial natriuretic peptide, were studied isometrically in a small-vessel myograph. Resting tensions were set to simulate transmural pressures of 17.5 mmHg or 35 mmHg. 2. There were no significant differences between intergroup internal vessel diameters or maximal contractile responses to either...
Articles
Clin Sci (Lond) (1992) 83 (5): 529–533.
Published: 01 November 1992
...Chim C. Lang; Wendy J. Coutie; Allan D. Struthers; D. Paul Dhillon; John H. Winter; Brian J. Lipworth 1. Studies in vitro have recently shown that both atrial natriuretic peptide and brain natriuretic peptide have pulmonary vasorelaxant activity. The purpose of the present study was to evaluate for...
Articles
Clin Sci (Lond) (1992) 83 (5): 519–527.
Published: 01 November 1992
...Chim C. Lang; Anna-Maria J. Choy; Allan D. Struthers © 1992 The Biochemical Society and the Medical Research Society 1992 atrial natriuretic peptide brain natriuretic peptide blood pressure congestive heart failure sodium excretion Clinical Science (1992) 83, 519-527 (Printed in...
Articles
Clin Sci (Lond) (1992) 83 (4): 445–451.
Published: 01 October 1992
... clearance studies (continuous infusion of [ 125 I]-iothalamate and 131 I-hippuran as markers for glomerular filtration rate and renal plasma flow, respectively) and was subsequently analysed in relation to individual variation in plasma concentrations of atrial natriuretic peptide, arginine vasopressin...
Articles
Clin Sci (Lond) (1992) 83 (4): 437–444.
Published: 01 October 1992
...M. G. Buckley; D. Sethi; N. D. Markandu; G. A. Sagnella; D. R. J. Singer; G. A. MacGregor 1. We have developed a radioimmunoassay for the measurement of immunoreactive brain natriuretic peptide (1–32) in human plasma. Simultaneous measurements of atrial natriuretic peptide have also been carried...
Articles
Clin Sci (Lond) (1992) 83 (2): 143–147.
Published: 01 August 1992
... placebo in a single-blind manner. Plasma hBNP-li, atrial natriuretic peptide-like immunoreactivity (ANP-li) and angiotensin II-like immunoreactivity (ANG II-li) levels and blood pressure were measured. 3. Baseline plasma hBNP-li and ANP-li levels in these patients with mild to moderate congestive heart...
Articles
Clin Sci (Lond) (1992) 83 (2): 247–253.
Published: 01 August 1992
..., plasma atrial natriuretic peptide and urinary dopamine, in 165 Chinese patients with non-insulin-dependent diabetes mellitus controlled by diet or oral hypoglycaemic agents on two occasions over a 6-week period. Patients were divided into three groups based on the mean value of two 24 h urinary albumin...
Articles
Clin Sci (Lond) (1992) 83 (1): 35–39.
Published: 01 July 1992
...Louise M. Burrell; J. M. Palmer; P. H. Baylis 1. The effect of atrial natriuretic peptide on osmotically stimulated thirst appreciation and consequent fluid intake was investigated in healthy man. 2. Six seated male subjects were studied on two occasions: synthetic α-human atrial natriuretic...