...Colleen S. Deane; Matthew Piasecki; Philip J. Atherton Periods of skeletal muscle disuse lead to rapid declines in muscle mass (atrophy), which is fundamentally underpinned by an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The complex interplay of molecular...

..., with potential bone fractures, thereby also increasing the burden on family and society. Skeletal muscle wasting is characterized by a reduced number of myoblasts, impaired muscle regeneration and increased muscle atrophy markers (Atrogin-1, MuRF-1). Endothelin-1 (ET-1) is a potent vasoconstrictor peptide...

...Ester Puig-Vilanova; Juana Martínez-Llorens; Pilar Ausin; Josep Roca; Joaquim Gea; Esther Barreiro The study reports novel findings on the associations of muscle weakness and atrophy with a differential expression profile of epigenetic events in the quadriceps of patients with advanced COPD, which...

...Franco Cisternas; María Gabriela Morales; Carla Meneses; Felipe Simon; Enrique Brandan; Johanna Abrigo; Yaneisi Vazquez; Claudio Cabello-Verrugio Skeletal muscle atrophy is a pathological condition characterized by the loss of strength and muscle mass, an increase in myosin heavy chain (MHC...

...), and was used to compare differences observed before and after compared with control SkM. For the comparison of before compared with after EM images, a Student's t test was used. Statistical significance was defined when P <0.05. atrophy dystrophin mitochondrion myofibre skeletal muscle Type 2...

... 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 β-agonists atrophy meniscectomy muscle strength rehabilitation Clinical Science (1993) 84, 651-654 (Printed in Great Britain) 651 Clenbuterol, a p;ldrenoceptor agonist, increases relative muscle strength...

... voluntary contraction (MVC) was also reduced, by 50%, but calf circumference and CSA were only 5% and 16% respectively lower in the injured leg. 3. It was concluded that the changes in contractile speed may indicate a relatively greater atrophy of slow (type I) muscle fibres. 4. The relationship between CSA...

... fibre area is a function of the number of fibres it contains. The ratio varied considerably from patient to patient but there was close agreement between the values obtained for the two limbs of each patient. 5. The quadriceps wasting produced by knee injury was due to muscle fibre atrophy...

... programmes there was a significant depletion of type II fibres. 3. Subjects with a relatively large reduction in strength or a small number of type I fibres demonstrated more depletion of these fibres than other subjects. 4. In patients with moderately reduced muscle strength and muscle fibre atrophy static...

...A. J. Sargeant; C. T. M. Davies 1. Six patients were studied after prolonged immobilization of an injured leg resulting in muscle atrophy. 2. The forces exerted by the atrophied and normal legs during continuous dynamic exercise (one- and two-leg cycling) were examined by a specially adapted...

... area). 3 5 1976 24 9 1976 © 1977 The Biochemical Society and the Medical Research Society 1977 atrophy muscle oxygen uptake Clinical Science and Molecular Medicine (1977) 52, 337-342. Functional and structural changes after disuse of human muscle A. J. SARGEANT,* C. T. M...