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Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

Lingling Shu, Ling Zhong, Yang Xiao, Xiaoping Wu, Yang Liu, Xue Jiang, Tao Tang, RubyLaiChong Hoo, Zhiguang Zhou, Aimin Xu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1679–1696.
https://doi.org/10.1042/CS20200021
Published: 07 July 2020
... destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with β-cell autoimmunity in patients with Type 1 diabetes. The present study aims to investigate the impact of NE inhibition on development of autoimmune diabetes in NOD mice...
View article titled, Neutrophil elastase triggers the development of <span class="search-highlight">autoimmune</span> <span class="search-highlight">diabetes</span> by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice
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Includes: Supplementary data