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Keywords: autoimmunity
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Clin Sci (Lond) (2023) 137 (23): 1771–1785.
Published: 14 December 2023
...William J. Kalusche; Clinton T. Case; Erin B. Taylor Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that is characterized by B- and T-lymphocyte dysfunction and altered cytokine production, including elevated levels of the adipocytokine leptin. Leptin has various...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (17): 2165–2196.
Published: 17 September 2021
...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...
Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
... on adipokine structure and physiological function, and focus on the known roles of these factors in the modulation of the immune response. I will also discuss adipokines in rheumatic and autoimmune diseases. Correspondence: Erin B. Taylor ( ertaylor@umc.edu ) 21 01 2021 24 02 2021 04 03...
Clin Sci (Lond) (2021) 135 (5): 703–724.
Published: 09 March 2021
... and mechanisms of these and additional cardiovascular toxicities, to be discussed here in further detail. autoimmunity cardiovascular disease heart failure immunomodulation Given that ICIs use will only become increasingly widespread in coming years, it is crucial for all medical care...
Clin Sci (Lond) (2019) 133 (6): 741–760.
Published: 19 March 2019
...Wen-Tao Ma; De-Kun Chen Primary biliary cholangitis (PBC), an autoimmune liver disease occurring predominantly in women, is characterized by high titers of serum anti-mitochondrial antibodies (AMAs) and progressive intrahepatic cholestasis. The immune system plays a critical role in PBC...
Clin Sci (Lond) (2018) 132 (22): 2387–2389.
Published: 19 November 2018
... play an important role in human health and disease, including cardiovascular and autoimmune diseases. Changes in the composition of gut microbiota (dysbiosis) are linked to chronic inflammation, thrombosis, atherogenesis, chronic heart, and kidney disease, as well as to autoimmune diseases like...
Clin Sci (Lond) (2018) 132 (1): 43–67.
Published: 05 January 2018
...Shu-Han Yang; Cai-yue Gao; Liang Li; Christopher Chang; Patrick S.C. Leung; M. Eric Gershwin; Zhe-Xiong Lian Autoimmune diseases can be triggered and modulated by various molecular and cellular characteristics. The mechanisms of autoimmunity and the pathogenesis of autoimmune diseases have been...
Clin Sci (Lond) (2017) 131 (8): 625–634.
Published: 28 March 2017
... characterized. An intricate interplay between both innate and adaptive immune elements exists in protective anti-infective immunity as well as in detrimental autoimmunity. More recently, it has become clear that the innate immune system in this regard not only starts inflammation cascades in SLE leading...
Clin Sci (Lond) (2015) 128 (8): 449–464.
Published: 23 December 2014
... treatment, two challenging issues for decision-making in the clinical setting. Moreover, these cytokines have been related to endothelial damage and vascular repair failure in different autoimmune disorders. Therefore, together with chronic inflammation and disease features, they could probably account...
Clin Sci (Lond) (2014) 126 (1): 1–18.
Published: 12 August 2013
...Abhirup Jayasimhan; Kristy P. Mansour; Robyn M. Slattery T1D (Type 1 diabetes) is an autoimmune disease caused by the immune-mediated destruction of pancreatic β-cells. Studies in T1D patients have been limited by the availability of pancreatic samples, a protracted pre-diabetic phase...
Clin Sci (Lond) (2012) 122 (8): 361–368.
Published: 14 December 2011
... contributes to the pathogenesis of autoimmune disorders. Current challenges in Axl biology are related to the functional interactions of Axl with other members of the TAM family or other tyrosine kinases, mechanisms of ligand-independent activation, inactivation of the receptor and cell–cell interactions...
Clin Sci (Lond) (2006) 110 (6): 627–639.
Published: 15 May 2006
... 1 2006 The Biochemical Society 2006 autoimmunity genetics immunology lymphocytes non-obese diabetic mice pathogenesis Type I diabetes T1DM (Type I diabetes mellitus) results from a chronic autoimmune process directed against the pancreatic β-cells. The onset...
Clin Sci (Lond) (1998) 95 (1): 19–31.
Published: 01 July 1998
... diseases such as rheumatoid arthritis are conventionally thought of as ‘autoimmune'. No convincing candidate autoantigen has yet been identified in rheumatoid arthritis, and recent experiments in transgenic mice indicate that arthritis can be induced by an autoimmune T-cell response which does not target...
Clin Sci (Lond) (1997) 93 (6): 479–491.
Published: 01 December 1997
...Joanne Heward; Stephen C. L. Gough 1. Autoimmune diseases are common conditions which appear to develop in genetically susceptible individuals, with expression of disease being modified by permissive and protective environments. Familial clustering and data from twin studies provided the impetus...
Clin Sci (Lond) (1997) 92 (6): 529–541.
Published: 01 June 1997
...Richard S. McIntosh; M. Suhail Asghar; Anthony P. Weetman 1. The analysis of the antibody response in autoimmune thyroid disease has followed several historical trends. It was the investigation of thyroid-reactive antibody that allowed the initial characterization of the three principle thyroid...
Clin Sci (Lond) (1996) 91 (5): 551–558.
Published: 01 November 1996
...David E. J. Jones 1. Primary biliary cirrhosis is a chronic cholestatic liver disease with an autoimmune aetiology. The classical histopathological lesion, of portal tract biliary epithelial cell damage, is accompanied by a T-cell-rich mononuclear cell infiltrate and upregulation of cell surface...
Clin Sci (Lond) (1992) 83 (3): 281–287.
Published: 01 September 1992
... IgA nephropathy and have now sought evidence for a similar autoimmune component in Henoch—Schoenlein purpura. 2. Sera from 26 patients with Henoch—Schoenlein nephritis and six patients with Henoch—Schoenlein purpura without accompanying nephritis were studied and compared with sera from 20 patients...
Clin Sci (Lond) (1979) 57 (s5): 287s–290s.
Published: 01 December 1979
... whether B15 might serve as predictor for vascular complications. 6. The study adds further support to suggestions of a genetic and possibly HLA-linked connection between essential hypertension, diabetes and autoimmunity. antigen B15 autoantibodies autoimmunity essential hypertension (WHO stage III...
Clin Sci Mol Med (1978) 55 (2): 149–156.
Published: 01 August 1978
... of sustained adrenal hypertrophy indicate that the thymus may contribute to the production of hypertensive vascular disease. 12 9 1977 13 3 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 autoimmunity hypertensive vascular disease renal hypertension thymus...
Clin Sci Mol Med (1973) 45 (s1): 141s–144s.
Published: 01 August 1973
... Society and the Medical Research Society 1994 spontaneous hypertension thymus autoimmunity Clinical Science and Molecular Medicine (1973) 45, 141s-144s. THE THYMUS OF SPONTANEOUSLY HYPERTENSIVE RATS: LIGHT- A N D ELECTRON-MICROSCOPIC STUDIES J . M. R O J O - O R T E G A , E. Y E G H I A Y A N...
Clin Sci (1972) 42 (5): 591–605.
Published: 01 May 1972
...; blood glycerol remained elevated and lactate response to glucose was excessive. 6. It is suggested that in active chronic hepatitis there might be pancreatic dysfunction on an autoimmune basis. 22 10 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 active...