...William J. Kalusche; Clinton T. Case; Erin B. Taylor Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that is characterized by B- and T-lymphocyte dysfunction and altered cytokine production, including elevated levels of the adipocytokine leptin. Leptin has various...

...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...

... on adipokine structure and physiological function, and focus on the known roles of these factors in the modulation of the immune response. I will also discuss adipokines in rheumatic and autoimmune diseases. Figure 3 Immunomodulatory effects of leptin Created with Biorender.com. Correspondence...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 autoimmunity cardiovascular disease heart failure immunomodulation Adaptive immune responses are key contributors to both anti-tumor and autoimmune immune responses that are triggered by cancer...

...Wen-Tao Ma; De-Kun Chen Primary biliary cholangitis (PBC), an autoimmune liver disease occurring predominantly in women, is characterized by high titers of serum anti-mitochondrial antibodies (AMAs) and progressive intrahepatic cholestasis. The immune system plays a critical role in PBC...

... play an important role in human health and disease, including cardiovascular and autoimmune diseases. Changes in the composition of gut microbiota (dysbiosis) are linked to chronic inflammation, thrombosis, atherogenesis, chronic heart, and kidney disease, as well as to autoimmune diseases like...

...Shu-Han Yang; Cai-yue Gao; Liang Li; Christopher Chang; Patrick S.C. Leung; M. Eric Gershwin; Zhe-Xiong Lian Autoimmune diseases can be triggered and modulated by various molecular and cellular characteristics. The mechanisms of autoimmunity and the pathogenesis of autoimmune diseases have been...

... characterized. An intricate interplay between both innate and adaptive immune elements exists in protective anti-infective immunity as well as in detrimental autoimmunity. More recently, it has become clear that the innate immune system in this regard not only starts inflammation cascades in SLE leading...

... treatment, two challenging issues for decision-making in the clinical setting. Moreover, these cytokines have been related to endothelial damage and vascular repair failure in different autoimmune disorders. Therefore, together with chronic inflammation and disease features, they could probably account...

...Abhirup Jayasimhan; Kristy P. Mansour; Robyn M. Slattery T1D (Type 1 diabetes) is an autoimmune disease caused by the immune-mediated destruction of pancreatic β-cells. Studies in T1D patients have been limited by the availability of pancreatic samples, a protracted pre-diabetic phase...

... contributes to the pathogenesis of autoimmune disorders. Current challenges in Axl biology are related to the functional interactions of Axl with other members of the TAM family or other tyrosine kinases, mechanisms of ligand-independent activation, inactivation of the receptor and cell–cell interactions...

... Diabetes Research Centre, The University of Calgary, Faculty of Medicine, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1 (email [email protected] ). 1 11 2005 12 12 2005 5 1 2006 autoimmunity genetics immunology lymphocytes non-obese diabetic mice pathogenesis...

... diseases such as rheumatoid arthritis are conventionally thought of as ‘autoimmune'. No convincing candidate autoantigen has yet been identified in rheumatoid arthritis, and recent experiments in transgenic mice indicate that arthritis can be induced by an autoimmune T-cell response which does not target...

...Joanne Heward; Stephen C. L. Gough 1. Autoimmune diseases are common conditions which appear to develop in genetically susceptible individuals, with expression of disease being modified by permissive and protective environments. Familial clustering and data from twin studies provided the impetus...

...Richard S. McIntosh; M. Suhail Asghar; Anthony P. Weetman 1. The analysis of the antibody response in autoimmune thyroid disease has followed several historical trends. It was the investigation of thyroid-reactive antibody that allowed the initial characterization of the three principle thyroid...

...David E. J. Jones 1. Primary biliary cirrhosis is a chronic cholestatic liver disease with an autoimmune aetiology. The classical histopathological lesion, of portal tract biliary epithelial cell damage, is accompanied by a T-cell-rich mononuclear cell infiltrate and upregulation of cell surface...

... IgA nephropathy and have now sought evidence for a similar autoimmune component in Henoch—Schoenlein purpura. 2. Sera from 26 patients with Henoch—Schoenlein nephritis and six patients with Henoch—Schoenlein purpura without accompanying nephritis were studied and compared with sera from 20 patients...

...’ and ‘e’ mitochondrial autoantigens, respectively. 12 6 1989 7 7 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 antimitochondrial antibodies autoimmunity primary biliary cirrhosis pyruvate dehydrogenase complex Clinical Science (1989) 77,365-368 365...

... for the bile duct damage and extrahepatic lesions of PBC. 2. Previous studies have demonstrated autoimmune reactions in PBC against normal human biliary tract antigens. To equate these findings with the above hypothesis, it has been suggested that the biliary antigens are related to the HLA system...

... whether B15 might serve as predictor for vascular complications. 6. The study adds further support to suggestions of a genetic and possibly HLA-linked connection between essential hypertension, diabetes and autoimmunity. © 1979 The Biochemical Society and the Medical Research Society 1979 antigen...

... of sustained adrenal hypertrophy indicate that the thymus may contribute to the production of hypertensive vascular disease. 12 9 1977 13 3 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 autoimmunity hypertensive vascular disease renal hypertension thymus...

... Society and the Medical Research Society 1994 spontaneous hypertension thymus autoimmunity Clinical Science and Molecular Medicine (1973) 45, 141s-144s. THE THYMUS OF SPONTANEOUSLY HYPERTENSIVE RATS: LIGHT- A N D ELECTRON-MICROSCOPIC STUDIES J . M. R O J O - O R T E G A , E. Y E G H I A Y A N...

...; blood glycerol remained elevated and lactate response to glucose was excessive. 6. It is suggested that in active chronic hepatitis there might be pancreatic dysfunction on an autoimmune basis. 22 10 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 active...