..., reflected by increases in diastolic blood pressure and of the veins reflected by measurements of reduction in venous diameter during intravenous noradrenaline infusions. 2. Compared with 27 healthy subjects, patients with diffuse autonomic insufficiency showed striking supersensitivity in diastolic blood...

..., either by desipramine in normal subjects, or in patients with sympathetic nerve dysfunction (autonomic insufficiency). 3. In 10 of 41 hypertensive patients the t 1 1/2 similarly was prolonged, presumptive evidence of a defect in neuronal noradrenaline uptake. Endogenous noradrenaline escaping uptake...

... stores cannot explain the low PRA found in our patients with autonomic failure. 26 11 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 dopamine noradrenaline renin Parkinson's disease Shy—Drager syndrome autonomic insufficiency Clinical Science...