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Keywords: autophagy
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Articles
Clin Sci (Lond) (2021) 135 (15): 1873–1895.
Published: 06 August 2021
... in vivo . Moreover, BRG1 activated the Wnt/β-catenin pathway, which further inhibited autophagy. Pharmacologic inhibition of the Wnt/β-catenin pathway (ICG-001) or rapamycin (RAPA)-mediated activation of autophagy effectively blocked BRG1-induced tubular senescence and fibrotic responses, while...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Autophagy Hepatic fibrosis NADPH oxidase...
Articles
Clin Sci (Lond) (2020) 134 (11): 1255–1258.
Published: 05 June 2020
...Qingzhang Zhu Unfolded protein response (UPR) often coordinates with autophagy to maintain cellular proteostasis. Disturbance of proteostasis correlates with diseases including diabetes and neurological complications. In a recent article in Clinical Science, Kong et al. highlighted the critical...
Articles
Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
... (ALA) protects against fibrosis by counteracting Ang II via the MAS-related G-protein coupled (MrgD) receptor, though the effects of alamandine on hepatic fibrosis remain unknown. Autophagy activated by reactive oxygen species (ROS) is a novel mechanism of hepatic fibrosis. However, whether autophagy...
Articles
Clin Sci (Lond) (2019) 133 (18): 1993–2004.
Published: 24 September 2019
... (autophagy activators), or n-saline (sham control) once a day on days 7–9 after the septic insult. Cognitive impairment was assessed by inhibitory avoidance and object recognition tests. Animals were killed 24 h, 3 and 10 days after sepsis with the hippocampus and prefrontal cortex removed to determine...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (15): 1759–1777.
Published: 14 August 2019
... complications. Despite adverse consequences of autophagy impairment on macrophage inflammation, the regulation of macrophage autophagy under hyperglycemic conditions is incompletely understood. Here, we report that the autophagy–lysosome system and mitochondrial function are impaired in streptozotocin (STZ...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (9): CS20190008.
Published: 02 May 2019
... HUVECs (AGEs-sEVs) could inhibit collagen synthesis by activating autophagy of human skin fibroblasts. Additionally, treatment with AGEs-sEVs could delay the wound healing process in Sprague–Dawley (SD) rats. Further analysis indicated that miR-106b-5p was up-regulated in AGEs-sEVs and importantly...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (7): 805–819.
Published: 02 April 2019
...Amalia Forte; Marilena Cipollaro; Marisa De Feo; Alessandro Della Corte Autophagy is a conserved process by which cytoplasmatic elements are sequestered in vesicles and degraded after their fusion with lysosomes, thus recycling the precursor molecules. The autophagy-mediated removal of redundant...
Articles
Clin Sci (Lond) (2019) 133 (3): 515–530.
Published: 12 February 2019
... levels in human amnion fibroblasts. These reductions were completely blocked only with inhibition of both matrix metalloproteases (MMPs) and autophagy. Consistently, SAA1 increased MMP-2/9 abundance and the markers for autophagic activation including autophagy related (ATG) 7 (ATG7) and the microtubule...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (21): 2299–2322.
Published: 02 November 2018
...Jinfang Bao; Yingfeng Shi; Min Tao; Na Liu; Shougang Zhuang; Weijie Yuan Autophagy has been identified as a cellular process of bulk degradation of cytoplasmic components and its persistent activation is critically involved in the renal damage induced by ureteral obstruction. However, the role...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (16): 1725–1739.
Published: 22 August 2018
... an important role. The activation of TLRs results in production of several inflammatory cytokines leading to further renal damage. In contrast, TLRs are key players on autophagy induction, which is associated with a protective function on cisplatin-induced AKI. Hence, the present study aimed to evaluate...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (15): 1645–1667.
Published: 14 August 2018
...Jing Li; Chuxiong Zeng; Beishi Zheng; Chun Liu; Min Tang; Yan Jiang; Yizhong Chang; Weiping Song; Yingxin Wang; Changqing Yang High-mobility group box-1 (HMGB1) plays a context-dependent role in autophagy, which is required for hepatic stellate cells (HSCs) activation. However, the significance...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (1): 111–125.
Published: 11 January 2018
..., the underlying mechanisms are yet to be fully determined. Both endoplasmic reticulum (ER) stress and autophagy have been reported to modulate neuronal survival and death and be associated with several neurodegenerative diseases. Here, a streptozotocin-induced diabetic mouse model and primary cultured mouse...
Articles
Clin Sci (Lond) (2017) 131 (11): 1161–1178.
Published: 22 May 2017
.... We hypothesized that decreased cardiac expression of DJ-1, a positive modulator of autophagy, compromises the effectiveness of IPO-induced cardioprotection in diabetic rats. Diabetic rats subjected to myocardial IR (30 min of coronary artery occlusion followed by 120 min of reperfusion) exhibited...
Articles
Clin Sci (Lond) (2017) 131 (8): 673–687.
Published: 28 March 2017
...Bárbara Maiztegui; Verónica Boggio; Carolina L. Román; Luis E. Flores; Héctor Del Zotto; Alejandro Ropolo; Daniel Grasso; María I. Vaccaro; Juan J. Gagliardino The aim of the present study was to demonstrate the role of autophagy and incretins in the fructose-induced alteration of β-cell mass...
Articles
Clin Sci (Lond) (2017) 131 (5): 381–394.
Published: 15 February 2017
...) infection and has a context-dependent role in autophagy, a highly conserved self-digestive process in response to environmental stress. Recent mouse studies indicate that autophagy is highly active in regulatory T (Treg)-cells. In the present study, we evaluated spontaneous and induced autophagy...
Articles
Clin Sci (Lond) (2017) 131 (1): 37–47.
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (18): 1665–1675.
Published: 08 August 2016
... the ability of small compounds in preventing and reversing TTR V30M deposition in transgenic mice gastrointestinal (GI) tract as well as lowering biomarkers associated with cellular stress and apoptotic mechanisms. In the present study we aimed to study TTR V30M aggregates effect in autophagy, a cellular...
Articles
Clin Sci (Lond) (2016) 130 (18): 1641–1653.
Published: 08 August 2016
... on myocardial I/R injury and autophagy. C57BL/6 mice underwent left coronary artery (LCA) occlusion and cultured neonatal rat cardiomyocytes (NRCs) subjected to hypoxia were treated with vehicle or PD during reperfusion or re-oxygenation. We noted that PD enhanced autophagy and decreased apoptosis during I/R...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (15): 1285–1305.
Published: 29 June 2016
... healthspan. Correspondence: Miguel A. Aon (email miguel.aon@nih.gov ). 14 1 2016 15 4 2016 3 5 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 acetylation aging autophagy biogenesis caloric restriction...
Articles
Clin Sci (Lond) (2016) 130 (8): 625–641.
Published: 08 March 2016
... and FGF21-KO diabetic mice. Mechanistically, FF treatment prevented diabetes-impaired autophagy, reflected by increased microtubule-associated protein 1A/1B-light chain 3, in the wild-type diabetic mice but not in the FGF21-KO diabetic mice. Studies with H9C2 cells in vitro demonstrated that exposure...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (10): 851–862.
Published: 28 August 2015
... of the existing strong associations between iron overload and iron deficiency with cardiomyopathy. Correspondence: Dr Gary Sweeney ( gsweeney@yorku.ca ). 26 1 2015 8 6 2015 14 7 2015 © 2015 Authors; published by Portland Press Limited 2015 24p3 autophagy cardiomyopathy ER...
Articles
Clin Sci (Lond) (2015) 128 (7): 387–403.
Published: 09 December 2014
... pathways and regulate physiological cellular functions. It is now well-established that ROS regulate autophagy, an intracellular degradation process. However, the signalling mechanisms through which ROS modulate autophagy in a regulated manner have only been minimally clarified. NADPH oxidase (Nox) enzymes...
Articles
Clin Sci (Lond) (2014) 126 (8): 529–536.
Published: 17 December 2013
... in Xenopus and Drosophila have revealed an essential role of this association to promote the canonical and non-canonical Wnt signalling pathways, whereas studies with tissue-specific gene deletion have pointed out a role in autophagy. The present review aims to summarize recent findings on the cellular...
Articles
Clin Sci (Lond) (2013) 124 (3): 203–214.
Published: 17 October 2012
...Bo-Shi Wang; Yi-Zhen Liu; Yang Yang; Yu Zhang; Jia-Jie Hao; Hai Yang; Xiao-Min Wang; Zi-Qiang Zhang; Qi-Min Zhan; Ming-Rong Wang There have been multiple lines of evidence suggesting that autophagy selectively targets signalling proteins and regulates cancer cell signalling in addition to bulk...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 124 (1): 1–15.
Published: 07 September 2012
... their viability as therapeutic targets for the antioxidant effects of vitamins C and E plus n −3 PUFAs (polyunsaturated fatty acids). antioxidant apoptosis autophagy ischaemia/reperfusion necrosis oxidative stress ROS can be generated in a variety of ways in cardiac myocytes. The greatest...
Articles
Clin Sci (Lond) (2012) 123 (2): 93–98.
Published: 23 March 2012
... of AMPK (AMP-activated protein kinase) activity and the consequent down-regulation of mTOR (mammalian target of rapamycin), which may finally influence autophagy and preserve the energy state of the cell. I/R (ischaemia/reperfusion) injury, inherent in LT (liver transplantation), is the main cause...
Articles
Clin Sci (Lond) (2012) 122 (12): 555–573.
Published: 05 March 2012
...)/redox balance, autophagy, cell proliferation, cell apoptosis, cellular polarity, mitochondrial function and genotoxic response, either directly or indirectly via numerous downstream pathways under physiological and pathological conditions. In addition to allosteric regulation, AMPK is significantly...
Articles
Clin Sci (Lond) (2010) 118 (3): 173–181.
Published: 26 October 2009
...Marc Germain; Ruth S. Slack BCL-2 homologues are major regulators of apoptosis and, as such, play an active role in the survival of adult neurons following injury. In recent years, these proteins have also been associated with the regulation of autophagy, a catabolic process involved...
Articles
Clin Sci (Lond) (2009) 116 (9): 697–712.
Published: 02 April 2009
...Wim Martinet; Patrizia Agostinis; Barbara Vanhoecke; Michael Dewaele; Guido R. Y. de Meyer Autophagy is a catabolic trafficking pathway for bulk destruction and turnover of long-lived proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy occurs constitutively...