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Keywords: bicarbonate
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Articles
Elinor C. Mannon, P. Robinson Muller, Jingping Sun, Weston B. Bush, Alex Coleman, Hiram Ocasio, Aaron J. Polichnowski, Michael W. Brands, Paul M. O'Connor
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (4): 189–203.
Published: 19 February 2024
...Elinor C. Mannon; P. Robinson Muller; Jingping Sun; Weston B. Bush; Alex Coleman; Hiram Ocasio; Aaron J. Polichnowski; Michael W. Brands; Paul M. O'Connor Sodium bicarbonate (NaHCO 3 ) is commonly utilized as a therapeutic to treat metabolic acidosis in people with chronic kidney disease (CKD...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1433–1437.
Published: 18 October 2022
...) (2022) 136 (8): https://doi.org/10.1042/CS20220095) demonstrate that the alkali sodium bicarbonate protects against loss of renal function in a crystal nephropathy model in mice. Using unbiased approaches in both mice and human tissue, the authors go on to identify two novel mechanisms that may underly...
Articles
Søren Brandt Poulsen, Caralina Marin De Evsikova, Sathish Kumar Murali, Jeppe Praetorius, Yijuang Chern, Robert A. Fenton, Timo Rieg
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1779–1796.
Published: 30 August 2018
... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 adenylyl cyclase acid-base bicarbonate cAMP proton renal physiology In the thick ascending limb (TAL), ~15% of HCO 3 − reabsorption is coupled with NHE3 activity [ 5...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (6): 593–598.
Published: 01 December 1997
...D. J. A. Goldsmith; L. G. Forni; P. J. Hilton 1. The correction of metabolic acidosis with sodium bicarbonate remains controversial. Experiments in vitro have suggested possible deleterious effects after alkalinization of the extracellular fluid. Disequilibrium of carbon dioxide and bicarbonate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (4): 415–419.
Published: 01 October 1994
... of bicarbonate in six healthy adult subjects. MATERIALS AND METHODS Subjects One female and five male subjects were studied (age 29-38 years). All were healthy and were on no routine medication. Informed consent was obtained from each subject, and the experimental protocol was approved by the joint ethics...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (2): 133–139.
Published: 01 February 1993
... was attributed to an additional external Na + -dependent di-isothiocyanatostilbene-disulphonate-sensitive H + efflux. © 1993 The Biochemical Society and the Medical Research Society 1993 amiloride bicarbonate cardiac myocytes pH regulation sodium/proton antiport Clinical Science (1993) 84, 133-139...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (5): 559–564.
Published: 01 May 1992
...Campbell H. Thompson; Paul D. Syme; E. Mark Williams; John G. G. Ledingham; George K. Radda 1. The effect of bicarbonate administration on the intracellular pH of rat skeletal muscle was examined by using 31 P n.m.r. 2. Bicarbonate administered intraperitoneally caused a significant intracellular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (6): 593–599.
Published: 01 December 1988
... transport into bile. By contrast, ursodeoxycholate induces hypercholeresis, partly due to a marked stimulation of biliary bicarbonate secretion. The aim of the present work was to investigate the effect of protoporphyrin IX on ursodeoxycholate-induced choleresis in anaesthetized male Wistar rats. 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (1): 29–34.
Published: 01 July 1988
...Philip A. Lucas; Bernard Lacour; Lydie Comte; Tilman Drüeke 1. We have previously reported reduced blood pH and plasma bicarbonate in young Okamoto–Aoki spontaneously hypertensive rats (SHR) compared with normotensive Wistar–Kyoto rats (WKY). Acid loading with 1.5% (w/v) NH 4 Cl as the sole...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (3): 277–284.
Published: 01 March 1986
... acidosis reduces, whereas acute metabolic alkalosis enhances, magnesium reabsorption. 3. The site within the nephron where absorption of magnesium increases or decreases during acid-base disturbances was beyond the late proximal tubule. 4. Tubular fluid bicarbonate was also measured in these experiments...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (1): 97–100.
Published: 01 January 1985
...U. Gafter; S. Edelstein; J. Levi 1. The effect of bicarbonate (NaHCO 3 ) feeding on intestinal absorption of calcium and phosphorus and vitamin D metabolism was investigated. Gut sac uptake of 45 Ca and [ 32 P]phosphate in vitro , as well as the plasma level of vitamin D metabolites, was determined...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (3): 341–347.
Published: 01 March 1983
... treatment resulted in gastric acid hypersecretion, which was largely abolished by concurrent cimetidine administration. 2. Activities of enzymes implicated in bicarbonate secretion, HCO − 3 -activated ATPase, carbonic anhydrase and Na + + K + -activated ATPase, were measured in the duodenal mucosa...
Articles
The Effect of Potassium and Bicarbonate Ions on the Rise in Blood Pressure Caused by Sodium Chloride
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 407s–409s.
Published: 01 October 1982
...T. O. Morgan 1. A group of eight patients with mild hypertension, sensitive to sodium intake, were studied. 2. Sodium chloride (70 mmol daily) caused their blood pressure to rise by 19/14 mmHg. 3. Sodium bicarbonate (70 mmol daily) caused their blood pressure to rise by 12/5 mmHg. 4. Sodium...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (6): 651–659.
Published: 01 June 1982
... was in fact slightly increased during a prolonged (4 h) perfusion of the bile salt. 4. During bile salt perfusion, basal bicarbonate secretion remained unchanged but caerulein/secretin-stimulated bicarbonate secretion was slightly increased. 5. Plasma levels of pancreatic polypeptide, gastric inhibitory...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (4): 305–312.
Published: 01 October 1979
... bicarbonate and total ammonia than has been reported for faecal dialysate in normal subjects. 2. Total ammonia concentrations in urine– faeces specimens obtained by catheter suggest that urine excreted by the kidneys in these patients becomes increasingly acid with increasing systemic acidosis. The highly...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (2): 139–146.
Published: 01 February 1979
... concentration with increasing exercise, at least to 66% of the maximal O 2 intake. bicarbonate exercise lactate oxygen uptake respiratory exchange ratio work 18 4 1978 29 8 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 Clinical Science (1979) 56,139-146...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (5): 459–466.
Published: 01 November 1977
...K. Sahlin; A. Alvestrand; J. Bergström; E. Hultman 1. A method for measuring intracellular pH and bicarbonate concentration of human muscle is described. 2. Muscle biopsies from the quadriceps muscle of 13 healthy subjects at rest were analysed for acid-labile carbon dioxide and volume of extra...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (6): 859–862.
Published: 01 December 1973
...L. V. Gutierrez; J. H. Baron 1. In twenty-one tests in six subjects without, and three with, pancreatic disease, the maximum volume and bicarbonate output of the duodenal aspirate in response to intravenous infusion of pure ‘GIH’ secretin was significantly higher with 4 than with 2 units kg −1 h −1...
Articles
Journal:
Clinical Science
Clin Sci (1972) 43 (4): 561–567.
Published: 01 October 1972
... hydrogen ion excretion fell sharply during mannitol diuresis. Changes in the excretion of ammonium and titratable acid were small and variable, but in each subject bicarbonate excretion increased markedly. 4. Despite previous conflicting published results urinary acid excretion during mannitol diuresis...
Articles
Journal:
Clinical Science
Clin Sci (1972) 43 (1): 101–114.
Published: 01 July 1972
...P. F. Down; L. Agostini; J. Murison; O. M. Wrong 1. Ammonia, bicarbonate and pH were measured in samples of faecal dialysate from thirteen healthy subjects taking free diets. To observe the effect of marked changes in faecal pH, three subjects were also studied while taking 25 mmol/day of MgCO 3...