...M. Loudon; R. F. Bing; J. D. Swales; H. Thurston 1. To assess the relative importance of vascular as opposed to plasma renin, groups of conscious rats received a single intravenous injection of partially purified rat renin 18 h after bilateral nephrectomy. Blood pressure was monitored continuously...

...J. D. Swales; H. Thurston 1. In the early phase of hypertension produced by renal artery constriction with the opposite kidney intact, infusion of the angiotensin antagonist Sar 1 -Ala 8 -angiotensin II or bilateral nephrectomy lowered blood pressure. However, the extent of the fall was variable...

... remained elevated 6 h after bilateral nephrectomy. 3. The residual hypertension found during antagonist infusion and after bilateral nephrectomy is not maintained by the renin—angiotensin system or sodium retention. © 1976 The Biochemical Society and the Medical Research Society 1976 angiotensin II...

...J. D. Swales; H. Thurston 1. When the renin-angiotensin system of rats had been suppressed by a high salt diet or by bilateral nephrectomy, large doses of angiotensin II antiserum were required to block the pressor action of exogenous angiotensin II. Infusion of renin profoundly lowered...