... on the contribution of bile salt signaling in the pathogenesis of CMD and the potential of bile salt-based therapies for the treatment of CMD. The TGR5 or G-protein-coupled bile acid receptor-1 (GPBAR1) is the most studied bile salt-responsive G-protein coupled receptor (GPCR). The TGR5 receptor was first...

..., and even to extrahepatic ones. Such versatility is the result of its multiple mechanisms of action. UDCA stabilizes plasma membranes against cytolysis by tensioactive bile acids accumulated in cholestasis. UDCA also halts apoptosis by preventing the formation of mitochondrial pores, membrane recruitment...

...Gustavo Castaño; Silvia Lucangioli; Silvia Sookoian; Marcelo Mesquida; Abraham Lemberg; Mirta Di Scala; Paula Franchi; Clyde Carducci; Valeria Tripodi ICP (intrahepatic cholestasis of pregnancy) is characterized by pruritus and biochemical cholestasis, including raised SBAs (serum bile acids...

... of serum bile acids (BAs) and of progesterone plus progesterone metabolites could be investigated in the absence of overt impairment of hepatobiliary function. Cholanaemia and serum concentrations of progesterone were assayed by an enzymic technique and by ELISA respectively, while BA molecular species...

...Barbro Leijd 1. The present study was undertaken to determine the influence of obesity on bile acid kinetics and cholesterol balance in man. 2. Fourteen obese and normolipidaemic patients (160 ± 6% of ideal body weight, mean ± sem ) were studied under standardized dietary conditions. Bile acid...

...L. R. Engelking; S. Barnes; C. A. Dasher; D. C. Naftel; B. I. Hirschowitz 1. The serum bile acid disappearances of tracer doses of [24- 14 C]cholic acid and [1- 14 C]-glycocholic acid were studied in eight normal subjects and 11 patients with chronic liver disease (with or without cholestasis...

...%; lithocholic acid and ursodeoxycholic acid increased significantly. 4. Bile saturation with cholesterol decreased and correlated negatively with the proportion of chenodeoxycholic acid in biliary bile acids but positively with serum triglycerides. 5. It is concluded that chenodeoxycholic acid treatment...

...J. Ahlberg; B. Angelin; K. Einarsson; K. Hellström; B. Leijd 1. The duodenal bile acid composition was analysed in 24 control subjects and 107 patients with various types of hyperlipoproteinaemia. A highly significant negative correlation was observed between the proportions of deoxycholic acid...

...P. Clifton-Bligh; N. E. Miller; P. J. Nestel 1. Seven patients with type II hyperlipoproteinaemia were treated with the bile acid-sequestering resin, colestipol (5 g three times daily), after a prolonged period of taking placebo. 2. After 8–9 weeks of treatment, the plasma concentration of the non...