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1-31 of 31
Keywords: bile acids
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André A. Santos, David Pires, Vanda Marques, Nicole Alesina, Elisa Herraez, Pavel Roudnický, Pedro M. Rodrigues, Ana Godinho-Santos, Ana Catarina Bravo, Catarina Gouveia, Susana Saraiva, Luís Correia, Ricardo Crespo, João Pereira da Silva, Marília Cravo, David Potesil, Zbyněk Zdráhal, Jesus M. Banales, Jose J.G. Marin, Joana Torres, Cecília M.P. Rodrigues
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (12): 703–716.
Published: 23 June 2025
... compared with IBD alone. A case–control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls. Serum bile acid profile, proteomic analysis, and immune-related gene expression in the colon tissue were examined. Colonic tissue...
Includes: Supplementary data
Articles
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (1): 61–64.
Published: 10 January 2024
...Justine Gillard; Isabelle A. Leclercq Bile acids are signaling mediators, enabling intricate communication between tissues and the gut microbiota, and are involved in the pathophysiology of several immune and metabolic disorders. In this commentary, we discuss the importance of the gut microbiota...
Articles
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Esther Verkade, Wenqiang Shen, Milaine V. Hovingh, Niels L. Mulder, Krisztina de Bruyn, Martijn Koehorst, Hilde D. de Vries, Vincent W. Bloks, Folkert Kuipers, Jan Freark de Boer
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1637–1650.
Published: 10 November 2023
...Esther Verkade; Wenqiang Shen; Milaine V. Hovingh; Niels L. Mulder; Krisztina de Bruyn; Martijn Koehorst; Hilde D. de Vries; Vincent W. Bloks; Folkert Kuipers; Jan Freark de Boer Cyp2c70 -deficient mice have a human-like bile acid (BA) composition due to their inability to convert chenodeoxycholic...
Includes: Supplementary data
Articles
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Wilhelm Sjöland, Annika Wahlström, Kassem Makki, Marc Schöler, Antonio Molinaro, Lisa Olsson, Thomas Uwe Greiner, Robert Caesar, Jan Freark de Boer, Folkert Kuipers, Fredrik Bäckhed, Hanns-Ulrich Marschall
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (13): 995–1011.
Published: 14 July 2023
...Wilhelm Sjöland; Annika Wahlström; Kassem Makki; Marc Schöler; Antonio Molinaro; Lisa Olsson; Thomas Uwe Greiner; Robert Caesar; Jan Freark de Boer; Folkert Kuipers; Fredrik Bäckhed; Hanns-Ulrich Marschall Mice with deletion of Cyp2c70 have a human-like bile acid composition, display age- and sex...
Includes: Supplementary data
Articles
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (1): 65–85.
Published: 05 January 2023
...Justine Gillard; Isabelle A. Leclercq Bile acids synthesized within the hepatocytes are transformed by gut microorganisms and reabsorbed into the portal circulation. During their enterohepatic cycling, bile acids act as signaling molecules by interacting with receptors to regulate pathways involved...
Articles
Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1689–1706.
Published: 20 July 2021
...Lele Cheng; Tao Chen; Manyun Guo; Peining Liu; Xiangrui Qiao; Yuanyuan Wei; Jianqing She; Bolin Li; Wen Xi; Juan Zhou; Zuyi Yuan; Yue Wu; Junhui Liu Recent studies reveal that bile acid metabolite composition and its metabolism are changed in metabolic disorders, such as obesity, type 2 diabetes...
Includes: Supplementary data
Articles
Chronic microaspiration of bile acids induces lung fibrosis through multiple mechanisms in rats
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Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (10): 951–963.
Published: 04 May 2017
...Bi Chen; Wen Jie You; Xue Qing Liu; Shan Xue; Hui Qin; Han Dong Jiang Gastroesophageal reflux (GER) and microaspiration of duodenogastric refluxate have been recognized as a risk factor for pulmonary fibrosis. Recent evidence suggests that bile acid microaspiration may contribute to the development...
Includes: Supplementary data
Articles
Plasma alkaline phosphodiesterase I in intrahepatic cholestasis induced by α -naphthylisothiocyanate in rats
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Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (1): 13–20.
Published: 01 July 1988
...Julie A. Quayle; Alison Capstick; Anthony I. Morris; David Billington 1. Administration of α-naphthylisothiocyanate (ANIT) to rats produced dose-dependent increases in plasma bile acid and bilirubin concentrations. Similar increases in plasma bile acid and bilirubin concentrations were evident...
Articles
Effect of albumin on taurocholate uptake kinetics in rat liver
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Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (1): 11–17.
Published: 01 January 1987
... lower than in the other experiments. 4. These data suggest that taurocholate uptake shows saturation in the absence of albumin and that albumin reduces taurocholate uptake. 24 6 1986 15 7 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 albumin bile acids...
Articles
Bile Lipid Secretion in Obese and Non-Obese Individuals with and without Gallstones
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Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (1): 71–79.
Published: 01 July 1985
... obese gallstone patients receiving high-dose chenodeoxycholic acid therapy (16-22 mg day −1 kg −1 ). 2. Bile acid secretion rates in the non-obese patients with cholesterol gallstones (563+sem 70 μmol/h, n = 6) were significantly lower than in the non-obese controls (1078 + 210 μmol/h, n = 10, P...
Articles
Enhancement of the Urinary Excretion of Non-Sulphated and Sulphated Radioactive Bile Acids by Sodium Acetate in the Bile Duct Obstructed Rat
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Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (1): 63–70.
Published: 01 January 1985
...A. Chitranukroh; G. Taggart; B. H. Billing 1. The renal clearances of [ 14 C]glycocholate, [ 14 C]taurocholate and [ 3 H]glycochenodeoxycholate-3-sulphate were determined in bile duct obstructed rats. 2. Comparisons of the bile acid clearances with glomerular filtration rates (GFR) indicate...
Articles
The Biliary Excretion of Sulphated and Non-Sulphated Bile Acids and Bilirubin in Patients with External Bile Drainage
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Journal:
Clinical Science
Clin Sci (Lond) (1984) 67 (1): 61–68.
Published: 01 July 1984
...James S. Dooley; Carl Bartholomew; John A. Summerfield; Barbara H. Billing 1. The biliary excretion of total bilirubin and bile acids, and the fate of tracer doses of radioactive sulphated and non-sulphated bile acids, were studied in patients with percutaneous transhepatic bile drainage. 2. Non...
Articles
Inhibition of Partially Purified Rat Brain Na + , K + - Dependent Atpase by Bile Acids, Phenolic Acids and Endotoxin
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Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (4): 415–420.
Published: 01 April 1984
... 1983 © 1984 The Biochemical Society and the Medical Research Society 1984 brain Na + ,K + -ATPase bile acids endotoxin fulminant hepatic failure phenolic acids CIinical Science (1984) 66, 415-420 415 Inhibition of partially purified rat brain Na', K+- dependent ATPase by bile acids...
Articles
The Importance of Conjugation in Biliary Secretion of Ursodeoxycholate and 7-Ketolithocholate in the Rat
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Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (4): 487–491.
Published: 01 April 1984
... was more than three times that of unconjugated 7-ketolithocholate. The SR max. of 7-ketolithocholate infused with taurine (to avoid depletion of the taurine pool) was still significantly lower than that of exogenous tauro-7-ketolithocholate. 3. These data support the hypothesis that, for bile acids...
Articles
Direct Measurement of Hepatic Extraction of Chenodeoxycholic Acid and Ursodeoxycholic Acid in Man
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Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (2): 197–203.
Published: 01 August 1982
... than that of cholic acid and glycocholic acid, but higher than that of ursodeoxycholic acid, (c) progressive impairment of the extraction ratios of these two bile acids occurs as the severity of liver disease increases, and (d) the ratios are correlated with indocyanine green extraction ratios. 15...
Articles
Bile Acid Profiles of Human Serum and Skin Interstitial Fluid and Their Relationship to Pruritus Studied by Gas Chromatography–Mass Spectrometry
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Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (1): 65–73.
Published: 01 July 1982
...T. C. Bartholomew; J. A. Summerfield; B. H. Billing; A. M. Lawson; K. D. R. Setchell 1. Pruritus was assessed in 19 patients by measurement of nocturnal limb movement. 2. Serum (nine pruritic, ten non-pruritic) and interstitial fluid (five pruritic, three non-pruritic) bile acids were fractionated...
Articles
Abnormalities of Bile Acids in Serum and Bile from Patients with Myotonic Muscular Dystrophy
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Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (6): 627–642.
Published: 01 June 1982
...Kaoru Tanaka; Kenzo Takeshita; Minoru Takita 1. Serum bile acids in seven patients with adult type myotonic dystrophy and 22 normal persons were quantitatively analysed by gas—liquid chromatography and gas chromatography—mass spectrometry for cholesterol, γ-glutamyltransferase and bilirubin...
Articles
The Effect of Intrarenal Infusion of Bile on Kidney Function in the Dog
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Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (4): 431–433.
Published: 01 April 1982
... intrarenal infusion of bilirubin did not cause any change in the excretion of electrolytes. 4. It is concluded that increase in circulating bile acids rather than hyperbilirubinaemia may alter kidney function during obstructive jaundice. Acute cholaemia may cause volume depletion by increasing urinary salt...
Articles
Urinary Excretion of Bile Acids in Cholestasis: Evidence for Renal Tubular Secretion in Man
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Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (6): 773–780.
Published: 01 December 1981
..., [ 3 H]chenodeoxycholate-3-sulphate appears in the urine mainly as the result of tubular secretion. 4. Probenecid, ethacrynic acid, frusemide and bendrofluazide decreased the clearance of both bile acids, implying competition for secretion via the proximal tubular organic acid secretory pathway between...
Articles
Effects of a Meal on Plasma Clearance of [ 14 C]Glycocholic Acid and Indocyanine Green in Man
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Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (3): 325–330.
Published: 01 September 1981
... is probably due to an increase in liver blood flow, and suggests that in health this part of the enterohepatic circulation of bile acids also varies with meals. 19 3 1981 26 3 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 bile acids glycocholic acid...
Articles
Direct Measurement of Hepatic Extraction of Bile Acids in Subjects with and without Liver Disease
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Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (1): 65–72.
Published: 01 January 1981
...I. T. Gilmore; R. P. H. Thompson 1. The hepatic extraction ratio of 14 C-labelled bile acids has been measured directly by hepatic vein catheterization in five patients without liver disease (glycocholic acid, three; cholic acid, two) and in 16 patients with histologically confirmed liver disease...
Articles
Structural and Functional Alterations in the Mucosa of Self-Filling Intestinal Blind Loops in Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (2): 121–131.
Published: 01 February 1979
... and deconjugated bile acids play a role in the development of the hyperplastic changes of the blind-loop mucosa, but that another factor might also be involved: as a possible candidate, stasis of the intestinal contents was considered. 5. To test this hypothesis, loops of rat colon were transposed into the jejunum...
Articles
Effects of Ileal and Caecal Resection on the Colon of the Rat
Available to Purchase
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (3): 241–249.
Published: 01 March 1978
... at various levels in the remaining gut of intestinal weight, mucosal thickness, mucosal adenosine 3′:5′-phosphate (cyclic AMP) concentration and the water and bile acid content of luminal material. 2. Rapid adaptation, in terms of growth and the production of formed stools, was seen after ile-ectomy...
Articles
Evidence for Renal Control of Urinary Excretion of Bile Acids and Bile Acid Sulphates in the Cholestatic Syndrome
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Journal:
Clinical Science
Clin Sci Mol Med (1977) 52 (1): 51–65.
Published: 01 January 1977
...J. A. Summerfield; Julia Cullen; S. Barnes; Barbara H. Billing 1. The bile acids and bile acid sulphates in the urine, serum and bile of eight cholestatic patients were studied quantitatively by gas-liquid chromatography and gas-liquid chromatography/mass spectrometry. 2. The primary bile acids...
Articles
Kinetics of Hepatic Uptake of Unconjugated Bilirubin
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Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (2): 169–176.
Published: 01 August 1976
... not compete with bilirubin for hepatic uptake. 5. These findings are consistent with the concept that carrier-mediated transport is responsible for hepatocellular uptake of bilirubin and that bilirubin and bile acids enter the hepatocyte via separate pathways. 10 12 1975 © 1976 The Biochemical...
Articles
Relationships between Ion and Water Movement in the Human Jejunum, Ileum and Colon during Perfusion with Bile Acids
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Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (5): 593–606.
Published: 01 November 1973
...D. L. Wingate; E. Krag; H. S. Mekhjian; S. F. Phillips 1. Perfusion of the human jejunum with low concentrations of glycine-conjugated bile acids in physiological solutions induced net fluid flow that varied between absorption and secretion, with only slight variation of the luminal osmotic...
Articles
The Effect of Conjugated and Unconjugated Bile Acids on Water and Electrolyte Absorption in the Human Jejunum
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Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (3): 301–311.
Published: 01 September 1973
...R. I. Russell; J. G. Allan; V. P. Gerskowitch; K. M. Cochran 1. The effect of conjugated and unconjugated bile acids in various concentrations on the absorption of water, sodium and chloride in the proximal jejunum in man has been studied using a perfusion system incorporating a proximal occluding...
Articles
Bile Acid Synthesis in the Developing Sheep Liver
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Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (3): 403–406.
Published: 01 September 1973
...R. A. Smallwood; P. Jablonski; J. McK. Watts 1. [ 14 C]Cholesterol was administered intravenously via the umbilical vein to foetal sheep in the latter half of gestation, and the incorporation of radioactive label into foetal bile acids was assessed. 2. After 4 days, 0·5–2% of the radioactive label...
Articles
Factors Affecting Plasma Clearance of [ 14 C]Cholic Acid in Patients with Cirrhosis
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Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (2): 147–161.
Published: 01 August 1973
... of radioactivity from the serum during the first 100 min after [ 14 C]cholic acid injection was double-exponential in form. During the early phase, clearance was significantly more rapid, and concentrations of conjugated and free bile acid were significantly lower, in normals than in cirrhotics. 2. Radioactivity...
Articles
Altered Bile Acid Metabolism during Treatment with Phenobarbitone
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Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (2): 257–262.
Published: 01 August 1973
...N. E. Miller; P. J. Nestel 1. The effects of phenobarbitone on cholesterol and bile acid metabolism have been examined in healthy humans. 2. In three of four subjects the faecal excretion of bile acids was increased by phenobarbitone. This was associated with an increased pool size and turnover...
Articles
A Direct Enzymic Assay for 7α-Hydroxy Bile Acids and Their Conjugates
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Journal:
Clinical Science
Clin Sci Mol Med (1973) 44 (1): 95–98.
Published: 01 January 1973
...G. A. D. Haslewood; G. M. Murphy; Judith M. Richardson 1. A 7α-hydroxysteroid dehydrogenase preparation isolated from a strain of Escherichia coli provides a specific and rapid means for the determination of 7α-hydroxy bile acids and their conjugates. 2. When used in conjunction with 3α...
