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Keywords: bilirubin
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Articles
Clin Sci (Lond) (2019) 133 (1): 117–134.
Published: 11 January 2019
... of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 120 (12): 493–504.
Published: 01 March 2011
... 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis atherosclerosis bilirubin cardiovascular disease haem oxygenase-1 (HO-1) vascular repair HO (haem oxygenase) was first discovered in the late 1960s to catalyse the rate-limiting step...
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Clin Sci (Lond) (1987) 73 (4): 371–375.
Published: 01 October 1987
...Maria E. Muñoz; Alejandro Esteller; Javier González 1. The effect of high bilirubin loads (60 μmol/kg twice daily for 2 days) on glucuronosyltransferase activity and biliary excretion of bilirubin was studied in Wistar rats. 2. The concentration of bilirubin in serum increased from 1.1 μmol/l...
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Clin Sci (Lond) (1985) 68 (6): 675–680.
Published: 01 June 1985
...Sandro Gentile; Marcello Persico; Giulia Baldini; Giancarlo Lunazzi; Claudio Tiribelli; Gian Luigi Sottocasa 1. The plasma disappearance rate and the increment in plasma unconjugated bilirubin after intravenous administration of 5.9 μmol of rifamycin SV (RSV)/kg body wt. were investigated in 51...
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Clin Sci (Lond) (1985) 68 (3): 341–347.
Published: 01 March 1985
...Jannis Kountouras; Peter J. Scheuer; Barbara H. Billing 1. In order to investigate the effect of extra-hepatic biliary obstruction on bilirubin transport, bile flow was re-established after 5, 10, 15 and 28 days when the mean (± sem ) plasma bilirubin concentrations of the four groups of five rats...
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Clin Sci (Lond) (1984) 67 (5): 499–504.
Published: 01 November 1984
...J. J. García-Marín; A. Esteller 1. The interference between biliary phospholipid and bilirubin secretion was investigated in rats with bile fistulae, under conditions of normal and maximal bilirubin secretion. The enterohepatic circulation of bile salts was interrupted and the animals received...
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Clin Sci (Lond) (1984) 66 (4): 481–486.
Published: 01 April 1984
...Chantal Celier; Armelle Foliot 1. The purpose of this study was to determine whether the hepatic content of bilirubin could influence liver 4-nitrophenolglucuronosyltransferase (4-NP-GT) in the Gunn rat. 2. In animals fed on a 45% lipid diet, compared with rats fed on a normal lipid diet (3...
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Clin Sci (Lond) (1982) 62 (6): 651–659.
Published: 01 June 1982
.... During duodenal perfusion with sodium taurocholate alone, both basal and caerulein/secretin-stimulated bilirubin secretion were suppressed. A successive perfusion with a mixture of the bile salt and essential amino acids in combination overcame the biliary suppression and biliary secretion rose above...
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Clin Sci (Lond) (1981) 61 (6): 765–771.
Published: 01 December 1981
...Maria Monica Elias; E. J. Comin; Susana Galeazzi; E. A. Rodriguez Garay 1. the interaction of unconjugated bilirubin with peritubular cell membranes of the rat kidney was studied by means of an isolated rat-kidney preparation applying the multiple-indicator-dilution technique. 2. Inulin was used...
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Clin Sci Mol Med (1978) 54 (5): 539–547.
Published: 01 May 1978
...L. Okolicsanyi; O. Ghidini; R. Orlando; S. Cortelazzo; G. Benedetti; R. Naccarato; P. Manitto 1. The kinetics of the plasma disappearance of bilirubin (2 mg/kg intravenously) were studied in 106 patients with Gilbert's syndrome and in 13 normal subjects. 2. All patients had significant decreases...
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Clin Sci Mol Med (1977) 53 (2): 155–163.
Published: 01 August 1977
...R. E. Cowan; R. P. H. Thompson; J. P. Kaye; Gillian M. Clark 1. The concentrations of plasma total and unconjugated bilirubin and of serum non-esterified fatty acids (NEFA) have been measured in two healthy subjects during fasts of up to 21 h. 2. Fasting was either continuous or interrupted...
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Clin Sci Mol Med (1977) 53 (2): 193–196.
Published: 01 August 1977
...María Mónica Elías; E. J. Comin; E. A. Rodriguez Garay 1. Unbound or diffusible bilirubin in serum and urine was measured in rats with bile-duct ligation or after continuous infusion of unconjugated bilirubin. 2. The glomerular filtration rate was estimated by measuring the endogenous creatinine...
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Clin Sci Mol Med (1976) 51 (2): 169–176.
Published: 01 August 1976
...G. Paumgartner; J. Reichen 1. The uptake of bilirubin was studied in the perfused rat liver by a multiple-indicator dilution technique employing the three-compartment model of Goresky. 2. The kinetics of hepatic bilirubin uptake could be described by the Michaelis—Menten equation. 3. The maximal...
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Clin Sci Mol Med (1974) 46 (4): 511–518.
Published: 01 April 1974
...M. L'E. Orme; L. Davies; A. Breckenridge 1. Antipyrine in a dose of 3·2 mmol (600 mg) daily for 6 weeks produced a significant fall in both total and unconjugated serum bilirubin concentrations in six patients with Gilbert's syndrome. The maximum reduction in serum bilirubin concentration was seen...