... of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels...

...Karl-Heinz Wagner; Marlies Wallner; Christine Mölzer; Silvia Gazzin; Andrew Cameron Bulmer; Claudio Tiribelli; Libor Vitek Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging biomarker of disease resistance, which may be related to several recently documented...

.... The relationship of HO with atherosclerotic vascular disease was suggested initially in 1994 by an observational study reporting that low serum concentrations of bilirubin (converted from biliverdin) were associated with an increased risk of CAD (coronary artery disease) [ 8 ]. As a result, over the last decade...

...Maria E. Muñoz; Alejandro Esteller; Javier González 1. The effect of high bilirubin loads (60 μmol/kg twice daily for 2 days) on glucuronosyltransferase activity and biliary excretion of bilirubin was studied in Wistar rats. 2. The concentration of bilirubin in serum increased from 1.1 μmol/l...

...Sandro Gentile; Marcello Persico; Giulia Baldini; Giancarlo Lunazzi; Claudio Tiribelli; Gian Luigi Sottocasa 1. The plasma disappearance rate and the increment in plasma unconjugated bilirubin after intravenous administration of 5.9 μmol of rifamycin SV (RSV)/kg body wt. were investigated in 51...

...Jannis Kountouras; Peter J. Scheuer; Barbara H. Billing 1. In order to investigate the effect of extra-hepatic biliary obstruction on bilirubin transport, bile flow was re-established after 5, 10, 15 and 28 days when the mean (± sem ) plasma bilirubin concentrations of the four groups of five rats...

...J. J. García-Marín; A. Esteller 1. The interference between biliary phospholipid and bilirubin secretion was investigated in rats with bile fistulae, under conditions of normal and maximal bilirubin secretion. The enterohepatic circulation of bile salts was interrupted and the animals received...

...James S. Dooley; Carl Bartholomew; John A. Summerfield; Barbara H. Billing 1. The biliary excretion of total bilirubin and bile acids, and the fate of tracer doses of radioactive sulphated and non-sulphated bile acids, were studied in patients with percutaneous transhepatic bile drainage. 2. Non...

...Klaus Kutz; Harald Kandler; Roland Gugler; Johan Fevery 1. Clofibrate (20 mg day −1 kg −1 body weight) given orally for 2 weeks to 18 subjects with Gilbert's syndrome reduced the total serum bilirubin concentration from 44.4 (22.1–71.7) μmol/l (median, range) to 15.0 (7.9–28.9) μmol/l, mainly...

...Chantal Celier; Armelle Foliot 1. The purpose of this study was to determine whether the hepatic content of bilirubin could influence liver 4-nitrophenolglucuronosyltransferase (4-NP-GT) in the Gunn rat. 2. In animals fed on a 45% lipid diet, compared with rats fed on a normal lipid diet (3...

.... During duodenal perfusion with sodium taurocholate alone, both basal and caerulein/secretin-stimulated bilirubin secretion were suppressed. A successive perfusion with a mixture of the bile salt and essential amino acids in combination overcame the biliary suppression and biliary secretion rose above...

...Maria Monica Elias; E. J. Comin; Susana Galeazzi; E. A. Rodriguez Garay 1. the interaction of unconjugated bilirubin with peritubular cell membranes of the rat kidney was studied by means of an isolated rat-kidney preparation applying the multiple-indicator-dilution technique. 2. Inulin was used...

...C. A. Goresky; Ellen R. Gordon; E. A. Shaffer; P. Paré; D. Carassavas; A. Aronoff 1. Intravenous doses of bilirubin (3.4 μmol/kg) were given to normal subjects and patients with Gilbert's syndrome. Both groups displayed an identical initial disappearance of a substantial proportion of the bilirubin...

...L. Okolicsanyi; O. Ghidini; R. Orlando; S. Cortelazzo; G. Benedetti; R. Naccarato; P. Manitto 1. The kinetics of the plasma disappearance of bilirubin (2 mg/kg intravenously) were studied in 106 patients with Gilbert's syndrome and in 13 normal subjects. 2. All patients had significant decreases...

...R. E. Cowan; R. P. H. Thompson; J. P. Kaye; Gillian M. Clark 1. The concentrations of plasma total and unconjugated bilirubin and of serum non-esterified fatty acids (NEFA) have been measured in two healthy subjects during fasts of up to 21 h. 2. Fasting was either continuous or interrupted...

...María Mónica Elías; E. J. Comin; E. A. Rodriguez Garay 1. Unbound or diffusible bilirubin in serum and urine was measured in rats with bile-duct ligation or after continuous infusion of unconjugated bilirubin. 2. The glomerular filtration rate was estimated by measuring the endogenous creatinine...

...D. Owens; E. A. Jones; E. R. Carson 1. The kinetics of unconjugated [ 14 C]-bilirubin metabolism have been investigated and analysed in terms of a three-pool model in a group of seven normal subjects and in a group of eight cirrhotic patients who had appreciable impairment of liver cell function. 2...

...G. Paumgartner; J. Reichen 1. The uptake of bilirubin was studied in the perfused rat liver by a multiple-indicator dilution technique employing the three-compartment model of Goresky. 2. The kinetics of hepatic bilirubin uptake could be described by the Michaelis—Menten equation. 3. The maximal...

...P. D. Berk; B. F. Scharschmidt; Jeanne G. Waggoner; S. C. White 1. A multicompartmental model of erythrokinetics and bilirubin production has been developed to predict the consequences of chronic phlebotomy on daily bilirubin turnover. 2. Control values for four physiological variables including...

...M. L'E. Orme; L. Davies; A. Breckenridge 1. Antipyrine in a dose of 3·2 mmol (600 mg) daily for 6 weeks produced a significant fall in both total and unconjugated serum bilirubin concentrations in six patients with Gilbert's syndrome. The maximum reduction in serum bilirubin concentration was seen...