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Keywords: biomarker
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Clin Sci (Lond) (2023) 137 (5): 353.
Published: 01 March 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker cell-free DNA cGAS-STING DNA damage mitochondria...
Clin Sci (Lond) (2023) 137 (2): 163–180.
Published: 24 January 2023
... level of cell-free DNA (cfDNA), a result of mitochondrial and/or genomic DNA damage, as a biomarker for atherosclerosis. Cigarette smoke extract (CSE) increased DNA damage in the nucleus and mitochondria in human endothelial cells. Mitochondrial damage induced minority mitochondrial outer membrane...
Includes: Supplementary data
Clin Sci (Lond) (2022) 136 (12): 953–971.
Published: 22 June 2022
.... All participants were informed of the process and purpose of this research and signed informed consent. In addition, this project was approved by the Medical Ethics Committee of Guangxi University of Traditional Chinese Medicine. biomarker circUSP36 ischemic stroke miR-139-3p SMAD3...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (20): 2741–2754.
Published: 28 October 2020
... on behalf of the Biochemical Society 2020 biomarker extracellular vesicles glomerular diseases mechanism therapy Under stressed conditions, EVs can be increasingly released from different kidney cells, including glomerular cells, tubular epithelial cells (TECs) and infiltrating cells...
Clin Sci (Lond) (2018) 132 (21): 2285–2298.
Published: 02 November 2018
... be reversed by down-regulation of DNMT1. Hsa_circ_0012919 regulated KLF13 and RANTES by miR-125a . Conclusion: Hsa_circ_0012919 could be regarded as a biomarker for SLE and hsa_circ_0012919 was the competitive endogenous RNA (ceRNA) for miR-125a-3p . Accumulating evidence has implicated epigenetic factors...
Clin Sci (Lond) (2018) 132 (14): 1565–1580.
Published: 31 July 2018
... actin (αSMA)-positive myofibroblasts is important in the progression of idiopathic pulmonary fibrosis (IPF), few biomarkers reflecting the fibrotic process have been discovered. We performed microarray analyses between FACS-sorted steady-state fibroblasts (lineage (CD45, TER-119, CD324, CD31, LYVE-1...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (15): 1971–1987.
Published: 13 July 2017
... Press Limited on behalf of the Biochemical Society 2017 acute liver injury biomarker chronic liver injury liver fibrosis ischemia-reperfusion miR-223 The term ‘liver disease’ comprises various medical conditions of different underlying aetiologies (infections, metabolic conditions...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (7): 553–566.
Published: 17 March 2017
...Yasbanoo Moayedi; Heather J. Ross The purpose of this review is to provide an overview of diagnosis, prognosis and management of heart failure (HF) with reduced ejection fraction (HFrEF). Specifically, this review is divided into three sections. The first section will address biomarkers...
Clin Sci (Lond) (2015) 129 (1): 1–25.
Published: 01 April 2015
...Karl-Heinz Wagner; Marlies Wallner; Christine Mölzer; Silvia Gazzin; Andrew Cameron Bulmer; Claudio Tiribelli; Libor Vitek Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging biomarker of disease resistance, which may be related to several recently documented...
Clin Sci (Lond) (2015) 128 (8): 449–464.
Published: 23 December 2014
... presentation and outcome, thereby highlighting the need for new predictive biomarkers. In this sense, several studies have recently revealed a role for type I IFNs (interferons), mainly IFNα, in the pathogenesis of a subset of RA patients. Genetic variants associated with the type I IFN pathway have been...
Clin Sci (Lond) (2014) 127 (5): 341–350.
Published: 15 May 2014
... (Crohn's disease) that may mandate surgical resection. Accurate biomarkers that reflect the relative contribution of fibrosis to an individual stricture are an unmet need in managing patients with CD. The miRNA-29 ( miR-29 ) family has been implicated in cardiac, hepatic and pulmonary fibrosis...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (4): 209–216.
Published: 10 April 2014
... some of the underlying mechanisms of OSA. The section on diabetes discusses current evidence in both humans and animal models demonstrating that intermittent hypoxia and sleep fragmentation has a negative impact on glucose tolerance. Finally, the section on cardiovascular biomarkers reviews...
Clin Sci (Lond) (2014) 127 (3): 149–161.
Published: 03 April 2014
... sequentially to the innate immune response evoked by MI. Emerging evidence on the role of MIF in myocardial ischaemia and infarction highlights a significant potential for the clinical use of MIF agonists or antagonists and as a unique cardiac biomarker. 1 These authors contributed equally...
Clin Sci (Lond) (2014) 127 (2): 77–89.
Published: 17 March 2014
...Amutha Selvamani; Madison H. Williams; Rajesh C. Miranda; Farida Sohrabji Small non-coding RNA [miRNA (microRNA)] found in the circulation have been used successfully as biomarkers and mechanistic targets for chronic and acute disease. The present study investigated the impact of age and sex...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (6): 377–400.
Published: 15 November 2013
...Hardip Sandhu; Helen Maddock Development of reliable biomarkers for early clinical assessment of drug-induced cardiotoxicity could allow the detection of subclinical cardiac injury risk in vulnerable patients before irreversible damage occurs. Currently, it is difficult to predict who will develop...
Clin Sci (Lond) (2014) 126 (2): 95–110.
Published: 13 September 2013
... of disease, thus improving management of diabetes and its associated complications. Not only are miRNAs displaying promise as an early biomarker for disease, but a number of these miRNAs are displaying therapeutic potential with several in pre-clinical development. The present review aims to highlight our...
Clin Sci (Lond) (2013) 124 (7): 423–441.
Published: 07 December 2012
... among others. Accordingly, they have been considered biomarkers of vascular injury and pro-thrombotic or pro-inflammatory conditions. In addition to this, emerging evidence suggests that microparticles are not simply a consequence of disease, but that they themselves may contribute to pathological...
Clin Sci (Lond) (2013) 124 (6): 389–390.
Published: 27 November 2012
... practice. Correspondence: Professor Visith Thongboonkerd (e-mail thongboonkerd@dr.com or vthongbo@yahoo.com ) 16 10 2012 19 10 2012 22 10 2012 22 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 body fluid biomarker diagnostics...
Clin Sci (Lond) (2013) 124 (5): 289–306.
Published: 12 November 2012
... and lipid complement respectively, of a given system. Their application to ischaemic heart disease has demonstrated utilities in population profiling, identification of multivariate biomarkers and in monitoring of therapeutic response, as well as in basic mechanistic studies. Although advances in magnetic...
Clin Sci (Lond) (2011) 121 (2): 79–89.
Published: 04 April 2011
... stratification enabling more accurate identification of high-risk individuals. Correspondence: Dr Hafid Narayan (email hn31@le.ac.uk ). 22 11 2010 9 2 2011 10 2 2011 10 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 biomarker copeptin Global...
Clin Sci (Lond) (2011) 120 (5): 183–193.
Published: 19 November 2010
...Junhao Gui; Yaping Tian; Xinyu Wen; Wenhui Zhang; Pengjun Zhang; Jing Gao; Wei Run; Liyuan Tian; Xingwang Jia; Yanhong Gao Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate the feasibility of using...
Includes: Supplementary data
Clin Sci (Lond) (2011) 120 (2): 81–89.
Published: 08 October 2010
... evidence suggests that sRAGE may be a potential biomarker of RAGE-mediated pathology. The present study aimed to examine the relationship between RAGE expression in peripheral blood monocytes and circulating sRAGE and esRAGE (endogenous sRAGE, a splice variant of sRAGE) in Type 2 diabetes. Protein...
Clin Sci (Lond) (2011) 120 (2): 51–63.
Published: 24 September 2010
... diseases. The revisited concept of a potential use of endogenous EPO levels as a predictor of CHF severity, as well as in the monitoring of responses to treatment, deserves appropriate investigation, as this may identify EPO as a useful biomarker in the clinical management of cardiovascular diseases...
Clin Sci (Lond) (2010) 119 (5): 203–205.
Published: 02 June 2010
... A. Giannitis E. Katus H. A. Meyer F. J. High-sensitive troponin T: a novel biomarker for prognosis and disease severity in patients with pulmonary arterial hypertension Clin. Sci. 2010 119 207 213 8 Warwick G. Thomas P. S. Yates D. H. Biomarkers in pulmonary hypertension...
Clin Sci (Lond) (2010) 119 (5): 207–213.
Published: 02 June 2010
... (N-terminal pro-brain natriuretic protein). Moreover, hsTnT predicted a WHO (World Health Organization) functional class >II better than NT-proBNP or hFABP. In conclusion, in PAH patients, the novel biomarker hsTnT is associated with death and advanced WHO functional class, and is related...
Clin Sci (Lond) (2010) 119 (2): 87–95.
Published: 20 April 2010
..., the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI. AMI, IP and I/R injury...
Clin Sci (Lond) (2010) 118 (12): 717–725.
Published: 30 March 2010
... need to develop biomarkers for earlier detection of ovarian cancer. In the present study, we demonstrate for the first time that the previously reported metastasis-inducing protein AGR2 (anterior gradient protein 2) can be detected in the blood of ovarian cancer patients. Using a newly developed ELISA...
Clin Sci (Lond) (2008) 114 (11): 661–677.
Published: 01 May 2008
... signalling pathways and control of the vessel wall matrix will be as important as those involved in the renin–angiotensin system, adrenergic and other vasoactive systems. Identifying the genes involved is important, since it may suggest new biomarkers as well as provide novel drug targets to reduce arterial...
Clin Sci (Lond) (2005) 109 (5): 421–430.
Published: 24 October 2005
..., a major priority is the identification of disease-associated biomarkers. Proteomics, with its high-throughput and unbiased approach to the analysis of variations in protein expression patterns (actual phenotypic expression of genetic variation), promises to be the most suitable platform for biomarker...