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Keywords: biomarker
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Clin Sci (Lond) (2022) 136 (12): 953–971.
Published: 22 June 2022
... time that circUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis, which make circUSP36 a potential therapeutic target for IS. biomarker circUSP36 ischemic stroke miR-139-3p SMAD3 Correspondence: Aruo Nan ( nanaruo@163.com ) or Li Su ( suli2018...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (20): 2741–2754.
Published: 28 October 2020
... 2020 biomarker extracellular vesicles glomerular diseases mechanism therapy In the midst of EV research, the methods for EV collection are of particular importance. At present, although different collection methods have been developed, there is no standard consensus, with special...
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Clin Sci (Lond) (2017) 131 (15): 1971–1987.
Published: 13 July 2017
... Press Limited on behalf of the Biochemical Society 2017 acute liver injury biomarker chronic liver injury liver fibrosis ischemia-reperfusion miR-223 The term ‘liver disease’ comprises various medical conditions of different underlying aetiologies (infections, metabolic conditions...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (1): 1–25.
Published: 01 April 2015
...Karl-Heinz Wagner; Marlies Wallner; Christine Mölzer; Silvia Gazzin; Andrew Cameron Bulmer; Claudio Tiribelli; Libor Vitek Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging biomarker of disease resistance, which may be related to several recently documented...
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Clin Sci (Lond) (2015) 128 (8): 449–464.
Published: 23 December 2014
... presentation and outcome, thereby highlighting the need for new predictive biomarkers. In this sense, several studies have recently revealed a role for type I IFNs (interferons), mainly IFNα, in the pathogenesis of a subset of RA patients. Genetic variants associated with the type I IFN pathway have been...
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Clin Sci (Lond) (2014) 127 (4): 209–216.
Published: 10 April 2014
... some of the underlying mechanisms of OSA. The section on diabetes discusses current evidence in both humans and animal models demonstrating that intermittent hypoxia and sleep fragmentation has a negative impact on glucose tolerance. Finally, the section on cardiovascular biomarkers reviews...
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Clin Sci (Lond) (2014) 127 (3): 149–161.
Published: 03 April 2014
... sequentially to the innate immune response evoked by MI. Emerging evidence on the role of MIF in myocardial ischaemia and infarction highlights a significant potential for the clinical use of MIF agonists or antagonists and as a unique cardiac biomarker. Coronary plaque destabilization and rupture are key...
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Clin Sci (Lond) (2014) 126 (2): 95–110.
Published: 13 September 2013
... of disease, thus improving management of diabetes and its associated complications. Not only are miRNAs displaying promise as an early biomarker for disease, but a number of these miRNAs are displaying therapeutic potential with several in pre-clinical development. The present review aims to highlight our...
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Clin Sci (Lond) (2013) 124 (7): 423–441.
Published: 07 December 2012
... among others. Accordingly, they have been considered biomarkers of vascular injury and pro-thrombotic or pro-inflammatory conditions. In addition to this, emerging evidence suggests that microparticles are not simply a consequence of disease, but that they themselves may contribute to pathological...
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Clin Sci (Lond) (2013) 124 (6): 389–390.
Published: 27 November 2012
... practice. 16 10 2012 19 10 2012 22 10 2012 22 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 body fluid biomarker diagnostics prognostics sepsis systems biology translational medicine Clinical manifestations and abnormal laboratory...
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Clin Sci (Lond) (2013) 124 (5): 289–306.
Published: 12 November 2012
... and lipid complement respectively, of a given system. Their application to ischaemic heart disease has demonstrated utilities in population profiling, identification of multivariate biomarkers and in monitoring of therapeutic response, as well as in basic mechanistic studies. Although advances in magnetic...
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Clin Sci (Lond) (2011) 120 (5): 183–193.
Published: 19 November 2010
...Junhao Gui; Yaping Tian; Xinyu Wen; Wenhui Zhang; Pengjun Zhang; Jing Gao; Wei Run; Liyuan Tian; Xingwang Jia; Yanhong Gao Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate the feasibility of using...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 120 (2): 51–63.
Published: 24 September 2010
... diseases. The revisited concept of a potential use of endogenous EPO levels as a predictor of CHF severity, as well as in the monitoring of responses to treatment, deserves appropriate investigation, as this may identify EPO as a useful biomarker in the clinical management of cardiovascular diseases...
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Clin Sci (Lond) (2010) 119 (5): 203–205.
Published: 02 June 2010
... the detection of very small areas of myocardial damage (probably only 10–50 mg of tissue) [ 4 ]. Correspondence: Professor Aldo Clerico (email clerico@ifc.cnr.it ). 29 4 2010 4 5 2010 4 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 biomarker...
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Clin Sci (Lond) (2010) 119 (2): 87–95.
Published: 20 April 2010
..., the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI. 1 These authors...
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Clin Sci (Lond) (2010) 118 (12): 717–725.
Published: 30 March 2010
... need to develop biomarkers for earlier detection of ovarian cancer. In the present study, we demonstrate for the first time that the previously reported metastasis-inducing protein AGR2 (anterior gradient protein 2) can be detected in the blood of ovarian cancer patients. Using a newly developed ELISA...
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Clin Sci (Lond) (2008) 114 (11): 661–677.
Published: 01 May 2008
... signalling pathways and control of the vessel wall matrix will be as important as those involved in the renin–angiotensin system, adrenergic and other vasoactive systems. Identifying the genes involved is important, since it may suggest new biomarkers as well as provide novel drug targets to reduce arterial...
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Clin Sci (Lond) (2005) 109 (5): 421–430.
Published: 24 October 2005
..., a major priority is the identification of disease-associated biomarkers. Proteomics, with its high-throughput and unbiased approach to the analysis of variations in protein expression patterns (actual phenotypic expression of genetic variation), promises to be the most suitable platform for biomarker...