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Keywords: biomarkers
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Clin Sci (Lond) (2023) 137 (6): 527–535.
Published: 29 March 2023
...: gene-related biomarkers and the use of humanized mice to search for biomarkers. First, the author provides an overview of the history of the establishment of hypertension and salt-sensitivity model rats, as well as advances in genetic analysis of causative genes of hypertension and the theory of renal...
Clin Sci (Lond) (2022) 136 (18): 1341–1346.
Published: 21 September 2022
... the diagnostic and therapeutic potential of miRNA. The identification of biomarkers for human disease progression remains an active area of research, and there is a growing number of miRNA and miRNA combinations that have been linked to the development and progression of numerous cardiovascular diseases...
Clin Sci (Lond) (2022) 136 (5): 323–328.
Published: 02 March 2022
... transcription. Large amount of clinical and experimental evidence provided the rationale for raising the intriguing question of whether miRNAs can mediate cell–cell communication. For those reasons, miRNAs have been considered as the ‘Holy Grail’ of biomarkers allowing non-invasive diagnostic screening...
Clin Sci (Lond) (2022) 136 (1): 1–14.
Published: 23 December 2021
... ) 16 07 2021 07 12 2021 08 12 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 biomarkers cardiovascular disease urocortin The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family, which...
Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...
Clin Sci (Lond) (2019) 133 (21): 2239–2244.
Published: 15 November 2019
... of CCA cell lines. Interestingly, exosomal-mediated circ-0000284 was reported to exhibit pro-oncogenic effects on surrounding normal cells. Altogether, these data highlight circRNAs not only as new players in CCA pathogenesis but also as promising molecules for innovative non-invasive biomarkers...
Clin Sci (Lond) (2019) 133 (12): 1321–1339.
Published: 20 June 2019
... suggests that a number of lncRNAs are centrally involved in development and progression of DKD either via direct pathogenic roles or as indirect mediators of some nephropathic pathways, like TGF-β1, NF-κB, STAT3 and GSK-3β signaling. Some lncRNAs are thus likely to serve as biomarkers for early diagnosis...
Clin Sci (Lond) (2019) 133 (10): 1145–1166.
Published: 16 May 2019
... on diabetic and non-diabetic kidney disease, in order to provide insights into their full clinical potential as biomarkers and/or therapeutic options against kidney disease. Table 1 Studies including the TNF-superfamily triad members TRAIL/OPG/TWEAK as biomarkers and/or therapeutic targets in renal...
Clin Sci (Lond) (2019) 133 (6): 777–788.
Published: 25 March 2019
... of SS, and the lower levels of lysine and glutamine are the metabolic characterization of the affected growth axes and stress state of SS, respectively. The significant changes of those serum metabolites are able to be regarded as potential biomarkers for the diagnosis of SS. Accordingly, supplemental...
Clin Sci (Lond) (2018) 132 (18): 2059–2069.
Published: 19 September 2018
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Biomarkers Cytomegalovirus Graft function Kidney transplant Long-Term graft function Proximal tubular disfunction Cytomegalovirus (CMV) infection is a frequent adverse event following kidney...
Clin Sci (Lond) (2018) 132 (17): 1937–1952.
Published: 05 September 2018
..., these investigations may soon be complemented by simpler screening tools such as retinal vasculature imaging, as well as novel biomarkers (e.g. heat shock protein 27). Hence, it is vital that robust, sex-specific cardiovascular imaging modalities and biomarkers continue to be developed and are incorporated...
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
... biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed...
Clin Sci (Lond) (2017) 131 (13): 1429–1436.
Published: 23 June 2017
... ) * Sandra Bodeau and Chloé Sauzay share first authorship. 16 02 2017 06 05 2017 24 05 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 biomarkers cyclosporin A post-transplant cancer unfolded protein response...
Clin Sci (Lond) (2017) 131 (8): 729–732.
Published: 06 April 2017
... Group designed to improve design, conduct and reporting of dementia biomarker studies. Correspondence: Terence J. Quinn ( terry.quinn@glasgow.ac.uk ) 24 2 2017 27 2 2017 28 2 2017 There are many potential approaches to the quantitative description of how a test performs...
Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
... with reduced lung tissue-specific L -carnitine in a clinically relevant mouse model. Furthermore, supplementing mice with this metabolite improved lung function and impaired disease progression. apoptosis biomarkers chronic obstructive pulmonary disease (COPD) metabolome • It is not clear...
Clin Sci (Lond) (2015) 128 (11): 751–760.
Published: 17 March 2015
... and specificity for diagnosis of AMI. Therefore, We concluded Rnf207 may be a novel biomarkers for AMI. Age-matched male wild-type (WT) C57BL/6 mice (weighing 20±1 g) and male Sprague–Dawley rats (weighing 200±10 g) were purchased from the Animal Center, Capital Medical University. All animals were kept 1 week...
Includes: Supplementary data