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Keywords: blood–brain barrierClose
Clin Sci (Lond) (2017) 131 (8): 635–651.
Published: 28 March 2017
... features of WM changes in SVDs. The most widely held view is that SVD-associated WM lesions are caused by chronic hypoperfusion, impaired cerebrovascular reactivity (CVR) or blood–brain barrier (BBB) leakage. Here, we assess the arguments for and against each of these mechanisms based on population...
Jacqueline M. Ku, Mohammadali Taher, Kai Yee Chin, Tom Barsby, Victoria Austin, Connie H.Y. Wong, Zane B. Andrews, Sarah J. Spencer, Alyson A. Miller
Clin Sci (Lond) (2016) 130 (17): 1545–1558.
Published: 26 July 2016
...). We found that des-acylated ghrelin (1 mg/kg) improved neurological and functional performance, reduced infarct and swelling, and decreased apoptosis. In addition, it reduced blood-brain barrier (BBB) disruption in vivo and attenuated the hyper-permeability of mouse cerebral microvascular endothelial...
Clin Sci (Lond) (2015) 129 (12): 1195–1206.
Published: 11 November 2015
.... Alzheimer's disease blood–brain barrier endothelium lipids statins • We have explored why patients who have been prescribed lipid-lowering drugs in mid-life are at a lower risk of dementia. We identified a novel anti-inflammatory effect for statins in patients with hypercholesterolaemia...
Includes: Supplementary data
Clin Sci (Lond) (2010) 118 (9): 547–564.
Published: 09 February 2010
...-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. bacterial meningitis blood–brain barrier colonization Neisseria meningitidis outer...
Includes: Multimedia, Supplementary data
Clin Sci (Lond) (2007) 112 (1): 1–25.
Published: 01 December 2006
... endothelial cells by the basal lamina, they seem to provide the signals for the formation of endothelial tight junctions both during development and after blood–brain barrier breakdown provoked by tissue injury [ 22 ]. In addition to engulfing blood vessels, astrocytes enwrap neuronal synapses and have...
Clin Sci (Lond) (1980) 59 (s6): 453s–455s.
Published: 01 December 1980
... concentrations. © 1980 The Biochemical Society and the Medical Research Society 1980 adrenoreceptor blood-brain barrier metoprolol propranolol Clinical Science (1980) 5 9 , 4 5 3 ~ 4 5 5 ~ 453s P-Adrenoreceptor-blocking agents and the blood-brain barrier J. M. CRUICKSHANK*, G. NEIL-DWYER?, M. M...
Clin Sci (Lond) (1979) 57 (s5): 157s–160s.
Published: 01 December 1979
... blood—brain barrier converting-enzyme inhibitor YS 980 enkephalins kallikrein—kinin system Clinical Science (1979) 57 ,157~160s A novel orally active converting-enzyme inhibitor Y S 980: effects on blood pressure in spontaneously hypertensive rats TH. U N G E R , R. W. R O C K H O L D , K . S C H...
Clin Sci Mol Med (1976) 51 (s3): 41s–43s.
Published: 01 December 1976
... Research Society 1976 angiotensin blood—brain barrier hypercapnia hypertension hyperventilation Clinical Science and Molecular Medicine (1976) 51,419-43s. Some factors Muencing the damaging effect of acute arterial hypertension on cerebral vessels in rats B. B. J O H A N S S O N Deportment...
Clin Sci Mol Med (1975) 48 (s2): 265s–268s.
Published: 01 January 1975
... hypertensive rats. © 1975 The Biochemical Society and the Medical Research Society 1975 angiotensin analogue blood-brain barrier central blood pressure regulation cerebrospinal fluid diabetes insipidus rats intrinsic brain iso-renin-angiotensin system spontaneously hypertensive rats Clinical...