... features of WM changes in SVDs. The most widely held view is that SVD-associated WM lesions are caused by chronic hypoperfusion, impaired cerebrovascular reactivity (CVR) or blood–brain barrier (BBB) leakage. Here, we assess the arguments for and against each of these mechanisms based on population...

...). We found that des-acylated ghrelin (1 mg/kg) improved neurological and functional performance, reduced infarct and swelling, and decreased apoptosis. In addition, it reduced blood-brain barrier (BBB) disruption in vivo and attenuated the hyper-permeability of mouse cerebral microvascular endothelial...

.... Alzheimer's disease blood–brain barrier endothelium lipids statins Therefore, we have examined the hypothesis that systemic oxLDL affects the function of microvascular endothelial cells to secrete inflammatory mediators into the brain compartment pre-disposing to AD and that statin intervention...

...-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. bacterial meningitis blood–brain barrier colonization Neisseria meningitidis outer...

... the signals for the formation of endothelial tight junctions both during development and after blood–brain barrier breakdown provoked by tissue injury [ 22 ]. In addition to engulfing blood vessels, astrocytes enwrap neuronal synapses and have, therefore, been proposed to shuffle nutrients and metabolites...

... concentrations. © 1980 The Biochemical Society and the Medical Research Society 1980 adrenoreceptor blood-brain barrier metoprolol propranolol Clinical Science (1980) 5 9 , 4 5 3 ~ 4 5 5 ~ 453s P-Adrenoreceptor-blocking agents and the blood-brain barrier J. M. CRUICKSHANK*, G. NEIL-DWYER?, M. M...

... blood—brain barrier converting-enzyme inhibitor YS 980 enkephalins kallikrein—kinin system Clinical Science (1979) 57 ,157~160s A novel orally active converting-enzyme inhibitor Y S 980: effects on blood pressure in spontaneously hypertensive rats TH. U N G E R , R. W. R O C K H O L D , K . S C H...

... Research Society 1976 angiotensin blood—brain barrier hypercapnia hypertension hyperventilation Clinical Science and Molecular Medicine (1976) 51,419-43s. Some factors Muencing the damaging effect of acute arterial hypertension on cerebral vessels in rats B. B. J O H A N S S O N Deportment...

.... Key words : angiotensin analogue, blood-brain barrier, central blood pressure regulation, cerebro- spinal fluid, diabetes insipidus rats, intrinsic brain iso-renin-angiotensin system, spontaneously hyper- tensive rats. Introduction Two different lines of investigation have led to the concept...