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Keywords: blood brain barrierClose
Clin Sci (Lond) (2021) 135 (7): 907–910.
Published: 09 April 2021
... angiotensinogen blood brain barrier hypertension neural Dear Editor We read with great interest the article by Uijl et al. [ 1 ] who reported that liver-directed small interfering RNA (siRNA) targeted to angiotensinogen (AGT) does not reverse the hypertension induced in male Sprague–Dawley rats by the...
Clin Sci (Lond) (2018) 132 (3): 399–418.
Published: 14 February 2018
... endothelial cells constitute the blood–brain barrier and in concert with pericytes or smooth muscle cells, glia and neurons, integrate into a functional neurovascular unit (NVU). This multicellular NVU maintains homoeostasis of the brain’s microenvironment by restricting the entry of systemic pathogens and...
Patrizia Giannoni, Jerome Badaut, Cyril Dargazanli, Alexis Fayd’Herbe De Maudave, Wendy Klement, Vincent Costalat, Nicola Marchi
Clin Sci (Lond) (2018) 132 (3): 361–374.
Published: 08 February 2018
... reorganization occurring at the outer wall of the blood-brain barrier (BBB) in response to an acute insult or a chronic disease could disclose novel disease mechanisms and therapeutic targets. Correspondence: Nicola Marchi ( firstname.lastname@example.org ) 15 12 2017 04 01 2018 04 01 2018...
Sha Tan, Yilong Shan, Yuge Wang, Yinyao Lin, Siyuan Liao, Zhezhi Deng, Li Zhou, Wei Cai, Qin Zeng, Lei Zhang, Bingjun Zhang, Xuejiao Men, Haiyan Li, Xueqiang Hu, Changyou Wu, Lisheng Peng, Zhengqi Lu
Clin Sci (Lond) (2017) 131 (13): 1499–1513.
Published: 28 June 2017
... + CD4 + IL-9 + and CD3 + CD8 + IL-9 + cells, were determined in peripheral blood mononuclear cells (PBMCs) obtained from patients and control individuals. We also investigated the effects of IL-9 on the blood–brain barrier (BBB) following oxygen–glucose deprivation (OGD) and the potential downstream...