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1-7 of 7
Keywords: blood brain barrier
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Articles
New evidence of vascular defects in neurodegenerative diseases revealed by single cell RNA sequencing
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (21): 1377–1394.
Published: 29 October 2024
... be primary drive the differentiation of human PCs, categorizing them into transport-type and ECM-rich [ 5 ]. Alzheimer's disease blood brain barrier Neurodegenerative disease ScRNA-seq Spinal muscular atrophy Vascular defects National Natural Science Foundation of China 32000841...
Articles
Michael F. Hammer, Collin T. Krzyzaniak, Erfan Bahramnejad, Kiran J. Smelser, Joshua B. Hack, Joseph C. Watkins, Patrick T. Ronaldson
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (4): 205–223.
Published: 21 February 2024
... the cellular mechanisms that underlie female resilience, we utilized blood–brain barrier (BBB) and hippocampal transcriptomic analyses in heterozygous mice before seizure onset (pre-TC) and in mice that experienced ∼20 TCs (post-TC). Results : In the pre-TC latent phase, both sexes exhibited leaky BBB; however...
Includes: Supplementary data
Articles
Blood–brain barrier lesion – a novel determinant of autonomic imbalance in heart failure and the effects of exercise training
Available to PurchaseHiviny de Ataides Raquel, Sany M. Pérego, Gustavo S. Masson, Leonardo Jensen, Alison Colquhoun, Lisete C. Michelini
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1049–1066.
Published: 02 August 2023
...) is effective to reduce neurohormonal activation but the mechanism underlying the autonomic dysfunction remains elusive. Knowing that blood–brain barrier (BBB) lesion contributes to autonomic imbalance, we sought now to investigate its involvement in HF- and exercise-induced changes of autonomic control. Wistar...
Articles
Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 907–910.
Published: 09 April 2021
...Carlos M. Ferrario; Leanne Groban; Hao Wang; Sarfaraz Ahmad AGT angiotensinogen ASO antisense oligonucleotide BBB blood–brain barrier DOCA deoxycorticosterone acetate GalNAc N-acetylgalactosamine RNAi RNA interference siRNA small interfering RNA...
Articles
Neurovascular dysfunction in dementia – human cellular models and molecular mechanisms
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (3): 399–418.
Published: 14 February 2018
... endothelial cells constitute the blood–brain barrier and in concert with pericytes or smooth muscle cells, glia and neurons, integrate into a functional neurovascular unit (NVU). This multicellular NVU maintains homoeostasis of the brain’s microenvironment by restricting the entry of systemic pathogens...
Articles
The pericyte–glia interface at the blood–brain barrier
Available to PurchasePatrizia Giannoni, Jerome Badaut, Cyril Dargazanli, Alexis Fayd’Herbe De Maudave, Wendy Klement, Vincent Costalat, Nicola Marchi
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (3): 361–374.
Published: 08 February 2018
... reorganization occurring at the outer wall of the blood-brain barrier (BBB) in response to an acute insult or a chronic disease could disclose novel disease mechanisms and therapeutic targets. Correspondence: Nicola Marchi ( [email protected] ) 15 12 2017 04 01 2018 04 01 2018...
Articles
Exacerbation of oxygen–glucose deprivation-induced blood–brain barrier disruption: potential pathogenic role of interleukin-9 in ischemic stroke
Available to PurchaseSha Tan, Yilong Shan, Yuge Wang, Yinyao Lin, Siyuan Liao, Zhezhi Deng, Li Zhou, Wei Cai, Qin Zeng, Lei Zhang, Bingjun Zhang, Xuejiao Men, Haiyan Li, Xueqiang Hu, Changyou Wu, Lisheng Peng, Zhengqi Lu
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1499–1513.
Published: 28 June 2017
... + CD4 + IL-9 + and CD3 + CD8 + IL-9 + cells, were determined in peripheral blood mononuclear cells (PBMCs) obtained from patients and control individuals. We also investigated the effects of IL-9 on the blood–brain barrier (BBB) following oxygen–glucose deprivation (OGD) and the potential downstream...
