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Keyword: blood pressure
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Clin Sci (Lond) (2019) 133 (23): 2401-2413.
Published: 04 December 2019
...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide (NO...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (8): 939-951.
Published: 29 April 2019
...; p.o., 9 weeks)-treated groups. After 2 weeks of treatment, rats were subjected to 30-min left coronary artery occlusion or sham operation. Systolic blood pressure (SBP) and echocardiography (ECHO) measurements were performed at the beginning of study, 4 days before, and 7 weeks after MI. At the end of...
Clin Sci (Lond) (2016) 130 (5): 337-348.
Published: 26 January 2016
... blood pressure led to the hypothesis that slow growth during fetal life increased blood pressure and the risk for cardiovascular disease in later life. It is now recognized that growth during infancy and childhood, in addition to exposure to adverse influences during fetal life, contributes to the...
Clin Sci (Lond) (2016) 130 (1): 9-18.
Published: 30 November 2015
... mechanisms involved in the ability of hypertensive risk factors to increase SNA and blood pressure. Understanding the mechanisms by which oestrogen acts at key sites in the brain for the regulation of SNA is important for the development of novel, sex-specific therapies for treating hypertension...
Clin Sci (Lond) (2015) 129 (12): 1061-1075.
Published: 13 October 2015
... associated with markers of cellular senescence. Conversely, PDE1 inhibition lowered expression of these markers. Human genetic studies revealed significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure (DBP; β =0.28, P =2.47×10 −5 ) and carotid intima–media thickness...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (6): 505-513.
Published: 22 June 2015
... reduce blood pressure in separate groups of conscious spontaneously hypertensive rats. Whereas Ang III alone increased mean arterial pressure (MAP), β-Pro 7 Ang III had no effect. During low-level AT 1 R blockade, both Ang III and β-Pro 7 Ang III, but not Ang II, lowered MAP (by ∼30 mmHg) at equimolar...
Clin Sci (Lond) (2015) 129 (2): 169-178.
Published: 24 April 2015
... rate, blood pressure and end-tidal carbon dioxide were obtained continuously. Measurements of internal carotid artery (ICA) and vertebral artery (VA) blood flow (ICA BF and VA BF respectively) were also obtained. Overall, blood pressure was reduced by ∼20% from baseline in both trials ( P <0.001...
Clin Sci (Lond) (2015) 129 (1): 81-92.
Published: 15 April 2015
...Sofie Brouwers; Ilse Smolders; Richard D. Wainford; Alain G. Dupont The type 2 angiotensin receptor (AT 2 R) has been suggested to counterbalance the type 1 angiotensin receptor (AT 1 R) in the central regulation of blood pressure and sympathetic tone. In the present study we investigated the blood...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (5): 307-313.
Published: 07 May 2014
...Naoki Wada; Wolfgang Singer; Tonette L. Gehrking; David M. Sletten; James D. Schmelzer; Phillip A. Low The baroreflex plays a key role in human BP (blood pressure) regulation. Its efferent limb consists of a vagal and a sympathetic component. The Valsalva manoeuvre is widely used to quantify vagal...
Clin Sci (Lond) (2014) 126 (6): 401-415.
Published: 15 November 2013
... activity) by 12–30%. Reports concerning the effect of statin therapy on HRV (heart rate variability) are less consistent. Because of their implications for BP (blood pressure) control, insulin sensitivity, arrhythmogenesis and sudden cardiac death, these autonomic nervous system actions should be...
Clin Sci (Lond) (2014) 126 (4): 267-274.
Published: 14 October 2013
... hypertensive rat. How activation of immunity is triggered remains unknown, but neo-antigens could be generated by elevated blood pressure through damage-associated molecular pattern receptors or other mechanisms. Once activated, Th1 cells may contribute to blood pressure elevation by affecting the kidney...
Clin Sci (Lond) (2014) 126 (1): 41-53.
Published: 30 August 2013
... pharmacologically, they are not widely used in clinical practice, leaving the SNS unopposed in many patients. The recent introduction of catheter-based renal denervation as an alternative approach to target the SNS therapeutically has been demonstrated to result in a clinically relevant blood pressure reduction in...
Clin Sci (Lond) (2013) 125 (12): 543-553.
Published: 02 August 2013
... normotensive individuals. The complex acute physiological responses to water immersion suggest swimming may affect BP (blood pressure) differently than other forms of aerobic exercises. We tested the hypothesis that an acute bout of swimming would fail to elicit a PEH BP response compared with an equivalent...
Clin Sci (Lond) (2012) 123 (2): 53-72.
Published: 23 March 2012
... later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring...
Clin Sci (Lond) (2012) 122 (12): 581-590.
Published: 05 March 2012
...Peter C. Papageorgiou; Erik L. Yeo; Peter H. Backx; John S. Floras By inducing BK (bradykinin)-stimulated adrenomedullary catecholamine release, bolus injection of the β-fragment of activated plasma coagulation Factor XII (β-FXIIa) transiently elevates BP (blood pressure) and HR (heart rate) of...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (6): 271-279.
Published: 11 November 2011
... dysfunction. The magnitude of the postprandial fall in BP (blood pressure) appears to be dependent on the rate of nutrient entry into the small intestine and may be related to changes in splanchnic blood flow and sympathetic nerve activity. We aimed at determining the comparative effects of different ID...
Clin Sci (Lond) (2012) 122 (1): 25-31.
Published: 12 September 2011
...) and BP (blood pressure) are known to exhibit diurnal variability, but the role of diurnal variability in orthostatic changes of HR and BP is not known. In the present study, we tested the hypothesis that there is diurnal variation of orthostatic HR and BP in patients with POTS and healthy controls...
Clin Sci (Lond) (2010) 119 (4): 151-161.
Published: 14 May 2010
... between obesity, uric acid level, dietary sodium intake, inflammation, inheritance and other factors, which lead to increased risk of developing HTN in childhood and adulthood. The detection and monitoring of HTN has significantly improved with the use of ABPM (ambulatory blood pressure monitoring), which...
Clin Sci (Lond) (2009) 118 (2): 137-145.
Published: 19 October 2009
... =0.0001), end-systolic diameter (β=−0.09, P =0.0007), mass (β=−0.11, P <0.0001) and indexed mass (β=−0.12, P <0.0001). These effects were independent of conventional factors, including gender, age, body surface area, blood pressure, diabetes, cigarette smoking and alcohol consumption. The...
Includes: Supplementary data
Clin Sci (Lond) (2010) 118 (1): 43-45.
Published: 02 October 2009
... yielded conflicting results with regards to a sympathetically mediated association between NEFAs and elevated arterial blood pressure. In the present issue of Clinical Science , Florian and Pawelczyk present some interesting results obtained from a small number of healthy normotensive lean volunteers who...
Clin Sci (Lond) (2010) 118 (1): 61-69.
Published: 02 October 2009
...John P. Florian; James A. Pawelczyk Previous studies have shown that acute increases in plasma NEFAs (non-esterified fatty acids) raise SVR (systemic vascular resistance) and BP (blood pressure). However, these studies have failed to distinguish between CNS (central nervous system) mechanisms that...
Clin Sci (Lond) (2009) 117 (6): 229-236.
Published: 14 August 2009
...Sharleet Mahal; W. David Strain; M. Elena Martinez-Perez; Simon A. McG. Thom; Nish Chaturvedi; Alun D. HUGHES Diabetes aggravates the impact of elevated BP (blood pressure) on the microcirculation, and people of African ancestry with diabetes are more susceptible to microvascular damage than...
Clin Sci (Lond) (2009) 116 (6): 513-520.
Published: 12 February 2009
...Fiona G. Brodie; Emily R. Atkins; Thompson G. Robinson; Ronney B. Panerai Spontaneous fluctuations in BP (blood pressure) and subsequent change in CBFV (cerebral blood flow velocity) in the MCA (middle cerebral artery) can be used to assess dynamic cerebral autoregulation using transfer function...
Clin Sci (Lond) (2009) 116 (5): 391-399.
Published: 02 February 2009
...Steven Gu; Carlo Cifelli; Sean Wang; Scott P. Heximer Understanding the mechanisms that underlie BP (blood pressure) variation in humans and animal models may provide important clues for reducing the burden of uncontrolled hypertension in industrialized societies. High BP is often associated with...
Clin Sci (Lond) (2009) 116 (5): 433-441.
Published: 02 February 2009
... interventions on arterial BP (blood pressure) and vascular function has not been studied in older humans. Thus in six older (71±2 years) mildly hypertensive men, arterial BP was evaluated non-invasively at rest and during small muscle mass (knee-extensor) exercise with and without a pharmacological dose of oral...
Clin Sci (Lond) (2009) 116 (4): 315-316.
Published: 15 January 2009
... (email macdonmj@mcmaster.ca ). 9 12 2008 10 12 2008 10 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 adolescent aerobic interval training blood pressure cardiovascular risk factor endothelial function obesity In the present issue of...
Clin Sci (Lond) (2009) 116 (4): 317-326.
Published: 15 January 2009
... compared with MTG in reducing BMI (body mass index), percentage of fat, MAP (mean arterial blood pressure) and increasing peak oxygen pulse. In addition, AIT induced a more favourable regulation of blood glucose and insulin compared with MTG. In conclusion, the novel findings of the present proof-of...
Clin Sci (Lond) (2009) 116 (1): 61-70.
Published: 28 November 2008
... ). 4 2 2008 4 4 2008 7 5 2008 7 5 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 blood pressure diabetes eicosanoid inflammation nephropathy soluble epoxide hydrolase Hypertension is a major risk factor for the development of nephropathy...
Clin Sci (Lond) (2008) 115 (10): 317-326.
Published: 15 October 2008
... relationship between birthweight and arterial elasticity in 472 children between 5 and 8 years of age was assessed. LAEI (large artery elasticity index), SAEI (small artery elasticity index) and BP (blood pressure) were assessed using the HDI/PulseWave™ CR-2000 CardioVascular Profiling System. Blood...
Clin Sci (Lond) (2008) 115 (8): 255-262.
Published: 12 September 2008
..., reduced in subjects with DM− (40±6 °; P <0.01 compared with CTRL subjects) and impaired in subjects with DM+ (30±5 °; P <0.01 compared with subjects with DM−), indicating less dampening of blood pressure oscillations by affected dynamic cerebral autoregulation. The steady-state response of MCA V...
Clin Sci (Lond) (2008) 114 (10): 625-634.
Published: 14 April 2008
... decrease in BP (blood pressure) in patients with EH. A randomized double-blind placebo-controlled clinical trial was conducted in 110 men with grade 1 EH (35–60 years of age without obesity, dyslipidaemia and diabetes mellitus, non-smokers, not undergoing vigorous physical exercise, without the use of any...
Clin Sci (Lond) (2008) 114 (6): 441-447.
Published: 12 February 2008
... 2007 8 10 2007 8 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 arterial elasticity blood pressure B-mode cardiovascular risk distensibility coefficient M-mode tissue Doppler imaging (TDI) Assessment of IMT (intima-medial thickness) in the...
Clin Sci (Lond) (2008) 114 (5): 375-380.
Published: 01 February 2008
... investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66...
Clin Sci (Lond) (2008) 114 (4): 305-311.
Published: 15 January 2008
..., while the role of genetic factors for this phenotype is unknown. In the present study, we show that, compared with resistant SHRs (spontaneously hypertensive rats), both male and female MWF rats develop a significant increase in UAE at 24 weeks of age ( P <0.0001), although blood pressures were lower...
Clin Sci (Lond) (2008) 114 (1): 1-17.
Published: 30 November 2007
... studies and experimental models have revealed underlying the adult cardiovascular phenotype dictated by the perinatal experience, as well as the probable key causal or triggering elements. Programmed elevated blood pressure in the adult human or animal is characterized by vascular dysfunction and...
Clin Sci (Lond) (2007) 113 (10): 401-407.
Published: 12 October 2007
...) rose from squatting twice, once with LBMT and once without. In addition, seven healthy volunteers (five men; median age, 27 years) were studied in a cross-over study design. They stood up from the squatting position three times, once combined with LBMT. Blood pressure (Finometer) was measured...
Clin Sci (Lond) (2007) 113 (7): 329-337.
Published: 03 September 2007
... (blood pressure) decline due to a diminished baroreflex-buffering capacity. The purpose of the present study was to examine the effect of NTG on baroreflex control of BP in patients with distinct age-related vasovagal collapse patterns. The study groups consisted of 29 patients (16–71 years old, 17...
Clin Sci (Lond) (2007) 113 (5): 251-258.
Published: 01 August 2007
... influence of the α-adducin Gly460Trp polymorphism on PEH (postexercise hypotension) has not been studied. In the present study we examined the effects of the α-adducin Gly460Trp polymorphism on PEH among 48 men (42.6±1.6 years; mean±S.E.M.) with high BP (blood pressure; 144.0±1.7/84.7±1.1 mmHg). Subjects...
Clin Sci (Lond) (2007) 113 (2): 83-91.
Published: 13 June 2007
...Renate T. de Jongh; Richard G. Ijzerman; Erik H. Serné; Mirjam M. van Weissenbruch; Jasper J. Voordouw; Henriette A. Delemarre-van de Waal; Coen D. A. Stehouwer The relationships of cortisol with elevated blood pressure and insulin resistance are likely to be the result of a complex interplay of...
Clin Sci (Lond) (2007) 112 (12): 583-597.
Published: 14 May 2007
... with the renin–angiotensin and sympathetic nervous systems. Dopamine receptors are classified into D 1 -like (D 1 and D 5 ) and D 2 -like (D 2 , D 3 and D 4 ) subtypes based on their structure and pharmacology. Each of the dopamine receptor subtypes participates in the regulation of blood pressure by...
Clin Sci (Lond) (2007) 112 (7): 375-384.
Published: 01 March 2007
... mortality. Lowering elevated blood pressure in diabetic hypertensive individuals decreases cardiovascular events. In patients with hypertension and diabetes, the pathophysiology of cardiovascular disease is multifactorial, but recent evidence points toward the presence of an important component dependent on...
Clin Sci (Lond) (2007) 112 (7): 403-409.
Published: 01 March 2007
...Cheri L. Mcgowan; Andrew S. Levy; Neil Mccartney; Maureen J. Macdonald Isometric HG (handgrip) training lowers resting arterial BP (blood pressure), yet the mechanisms are elusive. In the present study, we investigated improved systemic endothelial function as a mechanism of arterial BP...
Clin Sci (Lond) (2007) 112 (6): 337-344.
Published: 12 February 2007
...Antoinette Pechere-Bertschi; Gordana Sunaric-Megevand; Ivan Haefliger; Francesca Panarello; Marc Maillard; Michel Burnier Low BP (blood pressure) is a recognized risk factor for some patients with NPG (normal pressure glaucoma). We have shown previously that patients with orthostasis have impaired...
Clin Sci (Lond) (2007) 112 (3): 157-165.
Published: 03 January 2007
...Wouter Wieling; C. T. Paul Krediet; Nynke van Dijk; Mark Linzer; Michael E. Tschakovsky Several studies have shown that standing up is a frequent (3–10%) trigger of loss of consciousness both in young and old subjects. An exaggerated transient BP (blood pressure) fall upon standing is the...
Clin Sci (Lond) (2006) 111 (6): 365-372.
Published: 14 November 2006
...Wolfgang Lieb; Juliane Bolbrinker; Angela Döring; Hans-Werner Hense; Jeanette Erdmann; Heribert Schunkert; Reinhold Kreutz A polymorphism in the cytochrome P450 3A CYP3A5 enzyme has been implicated in BP (blood pressure) control and arterial hypertension. Carriers of the CYP3A5 * 1 allele had high...
Clin Sci (Lond) (2006) 110 (3): 315-326.
Published: 10 February 2006
... that EH is heritable. Owing to the fact that blood pressure is controlled by cardiac output and total peripheral resistance, many molecular pathways are believed to be involved in the disease. In this review, recent genetic studies investigating the molecular basis of EH, including different molecular...
Clin Sci (Lond) (2005) 109 (5): 431-437.
Published: 24 October 2005
... family has long been known to include presynaptic inhibition of neurotransmitter release, diminished sympathetic efferent traffic, vasodilation and vasoconstriction. This complex response is mediated by one of three subtypes which all uniquely affect blood pressure and blood flow. All three subtypes are...
Clin Sci (Lond) (2005) 108 (6): 547-552.
Published: 24 May 2005
...He-Hui XIE; Fu-Ming SHEN; Yong-Bing CAO; Hui-Lin LI; Ding-Feng SU The present study was designed to investigate the effects of low-dose ketanserin on BPV (blood pressure variability), BRS (baroreflex sensitivity) and organ damage in SHR (spontaneously hypertensive rats). Ketanserin was mixed in rat...
Clin Sci (Lond) (2005) 108 (5): 399-412.
Published: 22 April 2005
...Stephanie W. WATTS Since its discovery by Erspamer in the 1930s and identification by Page in the 1950s, 5-HT (5-hydroxytryptamine; serotonin) has been an elusive candidate as a substance that plays a role in the disease of high blood pressure, also known as hypertension. In both animal and human...
Clin Sci (Lond) (2004) 107 (2): 205-211.
Published: 27 July 2004
... index blood pressure radial artery tonometry Over recent years there has been increasing interest in the technique of reconstruction of central aortic pressure waveforms by the application of a generalized arterial transfer function to non-invasively acquired radial artery pressure waveforms...