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Keywords: blood pressure
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Articles
Metabolically stable apelin analogs: development and functional role in water balance and cardiovascular function
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (02): 131–149.
Published: 29 January 2025
... on the regulation of blood pressure (BP). Angiotensin II, by binding to AT1 receptors present in VSMCs, induces intracellular calcium mobilization and vasoconstriction, while apelin, by binding to Apelin-R present on vascular endothelium, increases nitric oxide production and induces vasodilation. Apelin also plays...
Articles
NaHCO 3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease
Available to PurchaseElinor C. Mannon, P. Robinson Muller, Jingping Sun, Weston B. Bush, Alex Coleman, Hiram Ocasio, Aaron J. Polichnowski, Michael W. Brands, Paul M. O'Connor
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (4): 189–203.
Published: 19 February 2024
...). While increased dietary sodium chloride (NaCl) is known to promote volume retention and increase blood pressure, the effects of NaHCO 3 loading on blood pressure and volume retention in CKD remain unclear. In the present study, we compared the effects of NaCl and NaHCO 3 loading on volume retention...
Articles
Correction: The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension
Open Access
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (23): 1787.
Published: 14 December 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . blood pressure digoxin migraine stroke The authors of the review...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (20): 1595–1618.
Published: 25 October 2023
... 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Correspondence: Christian Staehr ( [email protected] ) blood pressure...
Articles
Revisiting blood pressure and body fluid status
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (9): 755–767.
Published: 18 May 2023
... and/or water. Various concerns remain unclear, and the regulatory mechanism of body sodium, fluid, and blood pressure needs to be readdressed. In the present review article, we discuss novel concepts regarding the regulation of body sodium, water, and blood pressure with a particular focus on the systemic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (18): 1341–1346.
Published: 21 September 2022
...—original draft, Writing—review & editing. Correspondence: Jennifer C. Sullivan ( [email protected] ) 24 07 2022 31 08 2022 01 09 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 biomarkers blood pressure...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 599–620.
Published: 22 April 2022
...Theodore W. Kurtz; Michal Pravenec; Stephen E. DiCarlo High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to reduce the risk for salt-induced increases in blood pressure and CV events...
Articles
Sheon Mary, Philipp Boder, Giacomo Rossitto, Lesley Graham, Kayley Scott, Arun Flynn, David Kipgen, Delyth Graham, Christian Delles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2749–2761.
Published: 17 December 2021
... maintained on 1% NaCl for 3 weeks. A subset of salt-loaded SHRSP was treated with nifedipine. Salt-loading in SHRSP increased blood pressure (ΔSBP 35 ± 5 mmHg, P <0.0001) and kidney injury markers such as kidney injury marker-1 (KIM-1; fold change, FC 3.4; P =0.003), neutrophil gelatinase-associated...
Includes: Supplementary data
Articles
The acute pressure natriuresis response is suppressed by selective ET A receptor blockade
Open Access
Journal:
Clinical Science
Clin Sci (Lond) (2021) CS20210937.
Published: 17 December 2021
... impaired vascular function or disruption to the relationship between blood pressure (BP) and renal salt-handling (pressure natriuresis, PN). Endothelin-1 (ET-1) regulates BP via ET A and ET B receptor subtypes. Blockade of ET A receptors reduces BP, but promotes sodium retention by an unknown mechanism. ET...
Articles
Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis
Available to PurchaseAndré Felipe Rodrigues, Mihail Todiras, Fatimunnisa Qadri, Maria Jose Campagnole-Santos, Natalia Alenina, Michael Bader
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1353–1367.
Published: 02 June 2021
...André Felipe Rodrigues; Mihail Todiras; Fatimunnisa Qadri; Maria Jose Campagnole-Santos; Natalia Alenina; Michael Bader In spite of the fact that the modulatory effects of angiotensin II (Ang II) on the sympathetic nerve activity to targeted organs involved in blood pressure (BP) regulation is well...
Includes: Supplementary data
Articles
CRIP1 expression in monocytes related to hypertension
Available to PurchaseOlga Schweigert, Julia Adler, Natalie Längst, Dylan Aïssi, Jorge Duque Escobar, Teng Tong, Christian Müller, David-Alexandre Trégouët, Robert Lukowski, Tanja Zeller
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
... cells, and CRIP1 mRNA expression in monocytes associates with blood pressure (BP) and is up-regulated by proinflammatory modulation suggesting a link between CRIP1 and BP regulation through the immune system. To address this functional link, we studied CRIP1 expression in immune cells in relation to BP...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
... Commons Attribution License 4.0 (CC BY-NC-ND) . Open access for this article was enabled by the participation of Monash University in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. blood pressure placenta...
Includes: Supplementary data
Articles
Angiotensin II inhibits DDAH1–nNOS signaling via AT1R and μOR dimerization to modulate blood pressure control in the central nervous system
Available to PurchaseGwo-Ching Sun, Tzyy-Yue Wong, Hsin-Hung Chen, Chiu-Yi Ho, Tung-Chen Yeh, Wen-Yu Ho, Ching-Jiunn Tseng, Pei-Wen Cheng
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (23): 2401–2413.
Published: 04 December 2019
...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide...
Includes: Supplementary data
Articles
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats
Available to PurchaseJan Neckář, Md. Abdul Hye Khan, Garrett J. Gross, Michaela Cyprová, Jaroslav Hrdlička, Alena Kvasilová, John R. Falck, William B. Campbell, Lenka Sedláková, Šárka Škutová, Veronika Olejníčková, Martina Gregorovičová, David Sedmera, František Kolář, John D. Imig
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (8): 939–951.
Published: 29 April 2019
... weeks)-treated groups. After 2 weeks of treatment, rats were subjected to 30-min left coronary artery occlusion or sham operation. Systolic blood pressure (SBP) and echocardiography (ECHO) measurements were performed at the beginning of study, 4 days before, and 7 weeks after MI. At the end of the study...
Articles
Gender differences in developmental programming of cardiovascular diseases
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (5): 337–348.
Published: 26 January 2016
... and blood pressure led to the hypothesis that slow growth during fetal life increased blood pressure and the risk for cardiovascular disease in later life. It is now recognized that growth during infancy and childhood, in addition to exposure to adverse influences during fetal life, contributes...
Articles
Sex, the brain and hypertension: brain oestrogen receptors and high blood pressure risk factors
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (1): 9–18.
Published: 30 November 2015
... in the ability of hypertensive risk factors to increase SNA and blood pressure. Understanding the mechanisms by which oestrogen acts at key sites in the brain for the regulation of SNA is important for the development of novel, sex-specific therapies for treating hypertension. Hypertension is a worldwide...
Articles
Phosphodiesterase 1 regulation is a key mechanism in vascular aging
Available to PurchasePaula K. Bautista Niño, Matej Durik, A.H. Jan Danser, René de Vries, Usha M. Musterd-Bhaggoe, Marcel E. Meima, Maryam Kavousi, Mohsen Ghanbari, Jan H. Hoeijmakers, Christopher J. O'Donnell, Nora Franceschini, Ger M.J. Janssen, Jo G.R. De Mey, Yiwen Liu, Catherine M. Shanahan, Oscar H. Franco, Abbas Dehghan, Anton J.M. Roks
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1061–1075.
Published: 13 October 2015
... associated with markers of cellular senescence. Conversely, PDE1 inhibition lowered expression of these markers. Human genetic studies revealed significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure (DBP; β =0.28, P =2.47×10 −5 ) and carotid intima–media thickness...
Includes: Supplementary data
Articles
β-Pro 7 Ang III is a novel highly selective angiotensin II type 2 receptor (AT 2 R) agonist, which acts as a vasodepressor agent via the AT 2 R in conscious spontaneously hypertensive rats
Available to PurchaseMark Del Borgo, Yan Wang, Sanja Bosnyak, Morimer Khan, Pia Walters, Iresha Spizzo, Patrick Perlmutter, Lucinda Hilliard, Kate Denton, Marie-Isabel Aguilar, Robert E. Widdop, Emma S. Jones
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (6): 505–513.
Published: 22 June 2015
... to reduce blood pressure in separate groups of conscious spontaneously hypertensive rats. Whereas Ang III alone increased mean arterial pressure (MAP), β-Pro 7 Ang III had no effect. During low-level AT 1 R blockade, both Ang III and β-Pro 7 Ang III, but not Ang II, lowered MAP (by ∼30 mmHg) at equimolar...
Articles
Impact of transient hypotension on regional cerebral blood flow in humans
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (2): 169–178.
Published: 24 April 2015
... rate, blood pressure and end-tidal carbon dioxide were obtained continuously. Measurements of internal carotid artery (ICA) and vertebral artery (VA) blood flow (ICA BF and VA BF respectively) were also obtained. Overall, blood pressure was reduced by ∼20% from baseline in both trials ( P <0.001...
Articles
Hypotensive and sympathoinhibitory responses to selective central AT 2 receptor stimulation in spontaneously hypertensive rats
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Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (1): 81–92.
Published: 15 April 2015
...Sofie Brouwers; Ilse Smolders; Richard D. Wainford; Alain G. Dupont The type 2 angiotensin receptor (AT 2 R) has been suggested to counterbalance the type 1 angiotensin receptor (AT 1 R) in the central regulation of blood pressure and sympathetic tone. In the present study we investigated the blood...
Includes: Supplementary data
Articles
Comparison of baroreflex sensitivity with a fall and rise in blood pressure induced by the Valsalva manoeuvre
Available to PurchaseNaoki Wada, Wolfgang Singer, Tonette L. Gehrking, David M. Sletten, James D. Schmelzer, Phillip A. Low
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (5): 307–313.
Published: 07 May 2014
...Naoki Wada; Wolfgang Singer; Tonette L. Gehrking; David M. Sletten; James D. Schmelzer; Phillip A. Low The baroreflex plays a key role in human BP (blood pressure) regulation. Its efferent limb consists of a vagal and a sympathetic component. The Valsalva manoeuvre is widely used to quantify vagal...
Articles
Statins and the autonomic nervous system
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (6): 401–415.
Published: 15 November 2013
... activity) by 12–30%. Reports concerning the effect of statin therapy on HRV (heart rate variability) are less consistent. Because of their implications for BP (blood pressure) control, insulin sensitivity, arrhythmogenesis and sudden cardiac death, these autonomic nervous system actions should...
Articles
Immune mechanisms in hypertension and vascular injury
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (4): 267–274.
Published: 14 October 2013
... hypertensive rat. How activation of immunity is triggered remains unknown, but neo-antigens could be generated by elevated blood pressure through damage-associated molecular pattern receptors or other mechanisms. Once activated, Th1 cells may contribute to blood pressure elevation by affecting the kidney...
Articles
Renal denervation: current implications and future perspectives
Available to PurchaseJianzhong Xu, Dagmara Hering, Yusuke Sata, Antony Walton, Henry Krum, Murray D. Esler, Markus P. Schlaich
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (1): 41–53.
Published: 30 August 2013
... pharmacologically, they are not widely used in clinical practice, leaving the SNS unopposed in many patients. The recent introduction of catheter-based renal denervation as an alternative approach to target the SNS therapeutically has been demonstrated to result in a clinically relevant blood pressure reduction...
Articles
Effects of moderate-intensity aerobic cycling and swim exercise on post-exertional blood pressure in healthy young untrained and triathlon-trained men and women
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (12): 543–553.
Published: 02 August 2013
... in normotensive individuals. The complex acute physiological responses to water immersion suggest swimming may affect BP (blood pressure) differently than other forms of aerobic exercises. We tested the hypothesis that an acute bout of swimming would fail to elicit a PEH BP response compared with an equivalent...
Articles
Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
Open AccessEsther F. Davis, Laura Newton, Adam J. Lewandowski, Merzaka Lazdam, Brenda A. Kelly, Theodosios Kyriakou, Paul Leeson
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (2): 53–72.
Published: 23 March 2012
... of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (12): 581–590.
Published: 05 March 2012
...Peter C. Papageorgiou; Erik L. Yeo; Peter H. Backx; John S. Floras By inducing BK (bradykinin)-stimulated adrenomedullary catecholamine release, bolus injection of the β-fragment of activated plasma coagulation Factor XII (β-FXIIa) transiently elevates BP (blood pressure) and HR (heart rate...
Includes: Supplementary data
Articles
Effects of variations in duodenal glucose load on blood pressure, heart rate, superior mesenteric artery blood flow and plasma noradrenaline in healthy young and older subjects
Available to PurchaseLaurence G. Trahair, Lora Vanis, Diana Gentilcore, Kylie Lange, Christopher K. Rayner, Michael Horowitz, Karen L. Jones
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (6): 271–279.
Published: 11 November 2011
... dysfunction. The magnitude of the postprandial fall in BP (blood pressure) appears to be dependent on the rate of nutrient entry into the small intestine and may be related to changes in splanchnic blood flow and sympathetic nerve activity. We aimed at determining the comparative effects of different ID...
Articles
Diurnal variability in orthostatic tachycardia: implications for the postural tachycardia syndrome
Available to PurchaseJordan A. Brewster, Emily M. Garland, Italo Biaggioni, Bonnie K. Black, John F. Ling, Cyndya A. Shibao, David Robertson, Satish R. Raj
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (1): 25–31.
Published: 12 September 2011
...) and BP (blood pressure) are known to exhibit diurnal variability, but the role of diurnal variability in orthostatic changes of HR and BP is not known. In the present study, we tested the hypothesis that there is diurnal variation of orthostatic HR and BP in patients with POTS and healthy controls...
Articles
Hypertension in children: new trends and challenges
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (4): 151–161.
Published: 14 May 2010
... between obesity, uric acid level, dietary sodium intake, inflammation, inheritance and other factors, which lead to increased risk of developing HTN in childhood and adulthood. The detection and monitoring of HTN has significantly improved with the use of ABPM (ambulatory blood pressure monitoring), which...
Articles
The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension
Available to PurchaseXiaojian Wang, Xu Yang, Kai Sun, Jingzhou Chen, Xiaodong Song, Hu Wang, Zhe Liu, Changxin Wang, Channa Zhang, Rutai Hui
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (2): 137–145.
Published: 19 October 2009
...-systolic diameter (β=−0.09, P =0.0007), mass (β=−0.11, P <0.0001) and indexed mass (β=−0.12, P <0.0001). These effects were independent of conventional factors, including gender, age, body surface area, blood pressure, diabetes, cigarette smoking and alcohol consumption. The transcription activity...
Includes: Supplementary data
Articles
Central sympathetic outflow to skeletal muscle: the major link between non-esterified fatty acids and elevated blood pressure?
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (1): 43–45.
Published: 02 October 2009
... yielded conflicting results with regards to a sympathetically mediated association between NEFAs and elevated arterial blood pressure. In the present issue of Clinical Science , Florian and Pawelczyk present some interesting results obtained from a small number of healthy normotensive lean volunteers who...
Articles
Non-esterified fatty acids increase arterial pressure via central sympathetic activation in humans
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (1): 61–69.
Published: 02 October 2009
...John P. Florian; James A. Pawelczyk Previous studies have shown that acute increases in plasma NEFAs (non-esterified fatty acids) raise SVR (systemic vascular resistance) and BP (blood pressure). However, these studies have failed to distinguish between CNS (central nervous system) mechanisms...
Articles
Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes
Available to PurchaseSharleet Mahal, W. David Strain, M. Elena Martinez-Perez, Simon A. McG. Thom, Nish Chaturvedi, Alun D. HUGHES
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (6): 229–236.
Published: 14 August 2009
...Sharleet Mahal; W. David Strain; M. Elena Martinez-Perez; Simon A. McG. Thom; Nish Chaturvedi; Alun D. HUGHES Diabetes aggravates the impact of elevated BP (blood pressure) on the microcirculation, and people of African ancestry with diabetes are more susceptible to microvascular damage than...
Articles
Reliability of dynamic cerebral autoregulation measurement using spontaneous fluctuations in blood pressure
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (6): 513–520.
Published: 12 February 2009
...Fiona G. Brodie; Emily R. Atkins; Thompson G. Robinson; Ronney B. Panerai Spontaneous fluctuations in BP (blood pressure) and subsequent change in CBFV (cerebral blood flow velocity) in the MCA (middle cerebral artery) can be used to assess dynamic cerebral autoregulation using transfer function...
Articles
RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (5): 391–399.
Published: 02 February 2009
...Steven Gu; Carlo Cifelli; Sean Wang; Scott P. Heximer Understanding the mechanisms that underlie BP (blood pressure) variation in humans and animal models may provide important clues for reducing the burden of uncontrolled hypertension in industrialized societies. High BP is often associated...
Articles
Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (5): 433–441.
Published: 02 February 2009
... of these interventions on arterial BP (blood pressure) and vascular function has not been studied in older humans. Thus in six older (71±2 years) mildly hypertensive men, arterial BP was evaluated non-invasively at rest and during small muscle mass (knee-extensor) exercise with and without a pharmacological dose of oral...
Articles
Interval exercise is a path to good health, but how much, how often and for whom?
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (4): 315–316.
Published: 15 January 2009
... activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial JAMA, J. Am. Med. Assoc. 2007 297 2081 2091 © The Authors Journal compilation © 2009 Biochemical Society 2009 adolescent aerobic...
Articles
Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents
Available to PurchaseArnt E. Tjønna, Tomas O. Stølen, Anja Bye, Marte Volden, Stig A. Slørdahl, Rønnaug Ødegård, Eirik Skogvoll, Ulrik Wisløff
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (4): 317–326.
Published: 15 January 2009
... compared with MTG in reducing BMI (body mass index), percentage of fat, MAP (mean arterial blood pressure) and increasing peak oxygen pulse. In addition, AIT induced a more favourable regulation of blood glucose and insulin compared with MTG. In conclusion, the novel findings of the present proof...
Articles
Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto–Kakizaki rats
Available to PurchaseJeffrey J. Olearczyk, Jeffrey E. Quigley, Bradford C. Mitchell, Tatsuo Yamamoto, In-Hae Kim, John W. Newman, Ayala Luria, Bruce D. Hammock, John D. Imig
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (1): 61–70.
Published: 28 November 2008
... Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, U.S.A. (email [email protected] ). 4 2 2008 4 4 2008 7 5 2008 7 5 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 blood pressure diabetes eicosanoid inflammation...
Articles
Relationship between birthweight and arterial elasticity in childhood
Available to PurchasePatricia H.C. Rondó, Jesuana O. Lemos, Joilane A. Pereira, Julicristie M. Oliveira, Luiz Roberto Innocente
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (10): 317–326.
Published: 15 October 2008
..., the relationship between birthweight and arterial elasticity in 472 children between 5 and 8 years of age was assessed. LAEI (large artery elasticity index), SAEI (small artery elasticity index) and BP (blood pressure) were assessed using the HDI/PulseWave™ CR-2000 CardioVascular Profiling System. Blood...
Articles
Dynamic cerebral autoregulatory capacity is affected early in Type 2 diabetes
Available to PurchaseYu-Sok Kim, Rogier V. Immink, Wim J. Stok, John M. Karemaker, Niels H. Secher, Johannes J. van Lieshout
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (8): 255–262.
Published: 12 September 2008
..., reduced in subjects with DM− (40±6 °; P <0.01 compared with CTRL subjects) and impaired in subjects with DM+ (30±5 °; P <0.01 compared with subjects with DM−), indicating less dampening of blood pressure oscillations by affected dynamic cerebral autoregulation. The steady-state response of MCA V...
Articles
Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (10): 625–634.
Published: 14 April 2008
... with a decrease in BP (blood pressure) in patients with EH. A randomized double-blind placebo-controlled clinical trial was conducted in 110 men with grade 1 EH (35–60 years of age without obesity, dyslipidaemia and diabetes mellitus, non-smokers, not undergoing vigorous physical exercise, without the use of any...
Articles
Derivation of the distensibility coefficient using tissue Doppler as a marker of arterial function
Available to PurchaseBrian A. Haluska, Leanne Jeffriess, Joseph Brown, Melodie Downey, Stephane G. Carlier, Thomas H. Marwick
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (6): 441–447.
Published: 12 February 2008
... that has prognostic value [ 1 , 2 ]. Increased arterial stiffness is an important contributor to increased SBP [systolic BP (blood pressure)] and PP (pulse pressure) [ 3 , 4 ], which are important determinants of the risk of cardiovascular disease [ 5 , 6 ]. However, although the measurement of arterial...
Articles
Circulating renin–angiotensin system and catecholamines in childhood: is there a role for birthweight?
Available to PurchaseMaria C. P. Franco, Dulce E. Casarini, Marcela S. Carneiro-Ramos, Ana L. Sawaya, Maria L. M. Barreto-Chaves, Ricardo Sesso
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (5): 375–380.
Published: 01 February 2008
... was to investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66...
Articles
Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL
Available to PurchaseAngela Schulz, Maria Schlesener, Judith Weiss, Jonna Hänsch, Norbert Wendt, Peter Kossmehl, Daniela Grimm, Roland Vetter, Reinhold Kreutz
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (4): 305–311.
Published: 15 January 2008
..., while the role of genetic factors for this phenotype is unknown. In the present study, we show that, compared with resistant SHRs (spontaneously hypertensive rats), both male and female MWF rats develop a significant increase in UAE at 24 weeks of age ( P <0.0001), although blood pressures were lower...
Articles
Mechanisms underlying developmental programming of elevated blood pressure and vascular dysfunction: evidence from human studies and experimental animal models
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (1): 1–17.
Published: 30 November 2007
... studies and experimental models have revealed underlying the adult cardiovascular phenotype dictated by the perinatal experience, as well as the probable key causal or triggering elements. Programmed elevated blood pressure in the adult human or animal is characterized by vascular dysfunction...
Articles
Management of initial orthostatic hypotension: lower body muscle tensing attenuates the transient arterial blood pressure decrease upon standing from squatting
Available to PurchaseC. T. Paul Krediet, Ingeborg K. Go-Schön, Yu-Sok Kim, Mark Linzer, Johannes J. Van Lieshout, Wouter Wieling
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (10): 401–407.
Published: 12 October 2007
...) rose from squatting twice, once with LBMT and once without. In addition, seven healthy volunteers (five men; median age, 27 years) were studied in a cross-over study design. They stood up from the squatting position three times, once combined with LBMT. Blood pressure (Finometer) was measured...
Articles
Impact of age on the vasovagal response provoked by sublingual nitroglycerine in routine tilt testing
Available to PurchaseBart Verheyden, Janneke Gisolf, Frank Beckers, John M. Karemaker, Karel H. Wesseling, André E. Aubert, Wouter Wieling
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (7): 329–337.
Published: 03 September 2007
... (blood pressure) decline due to a diminished baroreflex-buffering capacity. The purpose of the present study was to examine the effect of NTG on baroreflex control of BP in patients with distinct age-related vasovagal collapse patterns. The study groups consisted of 29 patients (16–71 years old, 17...
Articles
The α-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure
Available to PurchaseLinda S. Pescatello, Bruce E. Blanchard, Gregory J. Tsongalis, Carl M. Maresh, Ann O'Connell, Paul D. Thompson
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (5): 251–258.
Published: 01 August 2007
..., the influence of the α-adducin Gly460Trp polymorphism on PEH (postexercise hypotension) has not been studied. In the present study we examined the effects of the α-adducin Gly460Trp polymorphism on PEH among 48 men (42.6±1.6 years; mean±S.E.M.) with high BP (blood pressure; 144.0±1.7/84.7±1.1 mmHg). Subjects...
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