...Na Zhao; Li Zeng; Yang Liu; Dong Han; Haochen Liu; Jian Xu; Yuxi Jiang; Cuiying Li; Tao Cai; Hailan Feng; Yixiang Wang The underlying molecular mechanism of the increased bone mass phenotype in Tricho-dento-osseous (TDO) syndrome remains largely unknown. Our previous study has shown that the TDO...

...Darrell Green; Tamas Dalmay; William D. Fraser Bone is increasingly viewed as an endocrine organ with key biological functions. The skeleton produces hormones and cytokines, such as FGF23 and osteocalcin, which regulate an extensive list of homoeostatic functions. Some of these functions include...

... of the population. Smoking is a key lifestyle risk factor for bone loss and fractures that appears to be independent of other risk factors for fracture such as age, weight, sex and menopausal status. This review discusses the effects of smoking on bone health in pre-menopausal and post-menopausal women and men...

...Mark S. COOPER Glucocorticoids are used widely in a range of medical specialities, but their main limitation is an adverse impact on bone. Although physicians are increasingly aware of these deleterious effects, the marked variation in susceptibility between individuals makes it difficult...

...Rosemary BLAND The skeleton is a complex tissue, and hormonal control of bone remodelling is elaborate. The important role that steroid hormones play in bone cell development and in the maintenance of normal bone architecture is well established, but it is only relatively recently that it has...

...Jeffrey D. BRADY; Julia JU; Simon P. ROBINS An ELISA was developed for the measurement of N-telopeptides of the α2(I) collagen chain containing an isomerized Asp-Gly bond (β-peptide) using polyclonal antibodies raised against the synthetic peptide. The presence of this isomerized form in bone...

... concentration [5, 61. However, these results were not found universally, and a study by Galosy et al. [7] was not able to confirm the finding of increased oxa- Key words: bone, bone resorption, calcium oxalate, diet, urolithiasis. Abbreviations: FCD, freethoice diet; HC, hypercalciuria; ICaA%, fractional...

...Z. A. H. Yayha; D. Joe Millward 1. We report here studies of the interrelationship of bone and muscle growth in the rat and the regulatory role of dietary protein. Two experiments were undertaken. In experiment 1, growth inhibition was induced by ad libitum feeding of low protein diets containing 7...

.... The hypocalciuric effect of hydrochlorothiazide was not associated with significant changes in calcium deposition into or release from bone. 4. In thyroparathyroidectomized rats treated with 1,25(OH) 2 D 3 the hypocalciuric effect of hydrochlorothiazide was associated with a fall in intestinal calcium absorption...

...U. Elsasser; R. Hesp; L. Klenerman; R. Wootton 1. The mean attenuation coefficients of trabecular and cortical bone in the radius were measured in 32 female patients with fractured proximal femur, and in 28 age-matched female controls, with a special-purpose computed tomography-scanner. 2...

...B. A. Ashton; R. Smith 1. The plasma concentration of the α 2 HS-glycoprotein has been measured in 58 normal adults and in patients with Paget's disease of bone before (24) and during treatment (16). 2. The average plasma α 2 HS-glycoprotein was lower in the patients with Paget's disease than...

... admitted over the same period to the same orthopaedic wards. 2. A striking finding was the marked similarity of all variables measured in the fracture and control groups. The principal differences between the two populations were that the fracture patients had a lower mean forearm bone mineral content...

...P. Tothill; J. N. MaCpherson 1. The continued uptake of 18 F, 85 Sr and 47 Ca by bone after death has been studied in rats and rabbits after aortic injection followed by quick killing, a period of recirculation of tracer before death, and perfusion of the carcase. In each case an approximately...

.... However, the dose needed for this effect is known to affect bone turnover and mineralization. 22 6 1977 15 11 1977 © 1978 The Biochemical Society and the Medical Research Society 1978 Clinical Science and Molecular Medicine (1978) 54, 509-516 Biochemical and clinical effects of ethane...

...Sylvia Bisaz; A. Jung; H. Fleisch 1. The uptake of inorganic pyrophosphate (PPi) from blood to bone was investigated in the rat in vivo. 2. PPi is taken up by the bone, where it appears both as PPi and as inorganic orthophosphate (Pi). The latter is due at least partly to local hydrolysis. 3...

...R. Lindsay; D. M. Hart; D. Purdie; M. M. Ferguson; A. S. Clark; A. Kraszewski 1. The value of progestogen therapy in the prevention of postmenopausal bone loss was assessed in 30 women, by a preliminary randomized controlled trial of gestronol or mestranol, in comparison with a placebo. 2. When...

...J. M. Letteri; R. M. Biltz; K. J. Ellis; A. Martino; S. Yasumura; D. Brook; S. H. Cohn; E. D. Pellegrino 1. Young, sub-totally nephrectomized rats were used to study the altered mineral metabolism of renal failure and its effects on bone growth and mineral maturation. 2. Rats killed at 4 weeks...

... D 3 there was a substantial rise in the plasma concentration of 25-hydroxy vitamin D from initially abnormally low values. 3. Significant improvement in bone mineralization, intestinal calcium absorption and muscle strength occurred in the three patients with the greatest rise in plasma 25-hydroxy...

...A. C. Kennedy; R. Lindsay; W. W. Buchanan; B. F. Allam 1. Foetal rat hemi-calvaria were incubated in organ culture with sera from patients with active rheumatoid arthritis. 2. Increased 45 Ca resorption was produced by sera from patients who were hypercalcaemic. 3. This bone-resorbing effect could...

...U. Gebauer; R. G. G. Russell; M. Touabi; H. Fleisch 1. The diphosphonates, disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) and disodium dichloromethylene diphosphonate (Cl 2 MDP), inhibit bone resorption in animals and in explanted bone in tissue culture. The possibility that these effects might...

...%. 4. There was, however, no significant fall in cardiac output or change in oxygen transport during treatment. 5. Of the eight patients with bone pain who received treatment, five claimed complete pain relief. 5 2 1975 © 1975 The Biochemical Society and the Medical Research Society 1975...

...Jenifer Jowsey; P. Balasubramaniam 1. The short- and long-term effects of oral phosphate supplements were studied in two groups of adult rabbits. 2. In the short-term study, compared with control animals, the bones of phosphate-supplemented rabbits showed a greater degree of porosity, and defects...

... and probably man. It appears to be an initiating event in PTH action on bone. 3. Although calcitonin prevents PTH-induced bone resorption, it did not affect this early calcium shift. 4. This evidence is discussed in connection with the possibility of combining calcitonin with some other agent for the treatment...