... that should be placed upon interpretation of bone mineral density changes in relation to treatment. New resorption inhibitors are being developed, based on mechanisms of action that are different from existing drugs. Some of these might offer resorption inhibition without reducing bone formation. More recent...

... © 1993 The Biochemical Society and the Medical Research Society 1993 bone formation calcium metabolism osteoporosis parathyroid hormone Clinical Science (1993) 85, 223-228 (Printed in Great Britain) 223 Modulation of the anabolic effect of synthetic human parathyroid hormone fragment+34...

...J. S. Wand; T. Smith; J. R. Green; R. Hesp; J. N. Bradbeer; J. Reeve 1. A new tracer method is described for the noninvasive measurement of bone formation in the proximal femur. The method is based on our previously described whole-body method using 85 Sr as the tracer (Reeve, J., Hesp, R...

... was found between calcium balance and the kinetically measured calcium accretion rate, which is the sum of the true rate of bone formation and various long-term exchange processes. 3. The more negative balances were associated with significantly greater early loss of tracer taken up into bone by ‘accretion...

... of the compounds were 0·01–10 mg of P kg body wt. −1 day −1 . 3. Cl 2 MDP caused a decrease in the rates of bone formation ( V 0+ ) and bone resorption ( V 0– ), and these effects were proportional to the logarithm of the dose of the compound. There was a small increase in the retention of calcium due...