... ]. The observation that human bone marrow (BM) contains fat cells dates to over a century ago. Surprisingly, BM adipose tissue (BMAT) has attracted much less clinical attention than classical fat storing tissues. In the last 20 years, however, there has been an increasing number of publications on BMAT. Searching...

... (IS) mice to address whether MDSCs acquired their suppressive ability in the bone marrow (BM) and whether they could migrate to lymph nodes (LNs) to exert their suppressive function. Our results showed that Gr-1 + CD11b + cells of IS mice already had the potential to inhibit T-cell proliferation in the BM...

... medicine after renal injury. Correspondence : Dr Anton J.M. Roks (email [email protected] ) 26 1 2015 27 1 2015 27 1 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 acute kidney injury bone marrow renin–angiotensin system Stem...

... bone-marrow-derived stromal cells (BMSCs) have shown therapeutic promise in treatment of AKI, the impact of pathological RAS on BMSC functionality has remained unresolved. RAS and its local components in the bone marrow are involved in several key steps of cell maturation processes. This may also...

...Ibrahim C. Haznedaroglu; Yavuz Beyazit The locally active ligand peptides, mediators, receptors and signalling pathways of the haematopoietic BM (bone marrow) autocrine/paracrine RAS (renin–angiotensin system) affect the essential steps of definitive blood cell production. Haematopoiesis...

... by stimulation of the AT 2 receptor (angiotensin II type 2 receptor) and the Ang-(1–7) receptor encoded by the Mas proto-oncogene. In recent years, this view has been broadened with the observation that the RAS regulates bone marrow stromal cells and stem cells, thus involving haematopoiesis and tissue...

... the progress made and the pitfalls encountered to date, and critically assesses the evidence for the use of stem cells in lung disease. airway bone marrow gene therapy lung disease epithelial cell progenitor stem cell These experimental findings led to the notion that adult bone marrow stem cells...

...Leora B. Balsam; Robert C. Robbins HSCs (haematopoietic stem cells) are multipotent stem cells that give rise to all cells of the blood cell lineage. In recent years, it has been proposed that bone marrow serves as a reservoir for cardiomyogenic precursors and that, following cardiac injury...

...Claus Orloff Juhl; Lars Vinter-Jensen; Olaf Myhre-Jensen; Lone Susanne Jensen; Esam Zapher Dajani 1. From two independent experimental studies conducted in 48 minipigs with oesophageal sclerotherapy and concomitant treatment with epidermal growth factor, blood samples together with bone marrow...

...J. Hodgetts; T. G. Hoy; A. Jacobs 1. The erythroblasts from four normal bone marrows were enriched by using an anti-myeloid monoclonal antibody (TG-1), and a polyclonal antibody against mononuclear cells to effect complement mediated lysis of unwanted cells. 2. The erythroblasts were cultured...

...J. Hodgetts; S. W. Peters; T. G. Hoy; A. Jacobs 1. Erythroblasts were enriched from human bone marrow samples and fractionated on Percoll gradients according to maturity. 2. Heart-type and spleen-type ferritin was measured in each fraction by an immunoradiometric assay. 3. In normal marrow, heart...