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Clin Sci (Lond) (2005) 108 (4): 357–363.
Published: 22 March 2005
... of reperfusion. Using a cross-over protocol, the subjects were randomized to oral administration of 500 mg of bosentan or placebo 2 h before ischaemia. Endothelium-dependent and -independent vasodilatation were determined by intra-brachial infusion of acetylcholine (1–10 μg/min) and nitroprusside...
Clin Sci (Lond) (1997) 92 (6): 579–585.
Published: 01 June 1997
... role in acute renal failure. In the present study we therefore investigated renal function and the renal ET system in rats on day 4 after bile-duct ligation (BDL) or sham-operation (SO), without ( n = 7 in each group) and with treatment with bosentan, a combined ET A /ET B receptor blocker, ( n = 5 in...
Clin Sci (Lond) (1995) 89 (6): 575–579.
Published: 01 December 1995
...Paddy A. Phillips; John Risvanis; Kathryn Aldred; Louise M. Burrell; Briony Bartholomeusz 1. We studied the effects of the non-selective, non-peptide, orally active endothelin (ET) receptor antagonist bosentan (Ro 47–0203) on rat hepatic and mesenteric vascular membrane 125 I-ET-1 binding...