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Keyword: brain
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Articles
Clin Sci (Lond) (2018) 132 (2): 199–212.
Published: 19 January 2018
... leading to the release of pro-inflammatory cytokines which are considered important mediators of the liver–gut–brain communication. Although circulating cytokines are likely not the sole factors involved, they can induce liver inflammation/damage and reach the central nervous system where they favor...
Articles
Clin Sci (Lond) (2016) 130 (17): 1481–1497.
Published: 18 July 2016
...Neza Grgurevic; Gregor Majdic Although considerable progress has been made in our understanding of brain function, many questions remain unanswered. The ultimate goal of studying the brain is to understand the connection between brain structure and function and behavioural outcomes. Since sex...
Articles
Clin Sci (Lond) (2016) 130 (8): 565–574.
Published: 08 March 2016
...Katherine M. Davies; Julian F.B. Mercer; Nicholas Chen; Kay L. Double Copper is a biometal essential for normal brain development and function, thus copper deficiency or excess results in central nervous system disease. Well-characterized disorders of disrupted copper homoeostasis with neuronal...
Articles
Clin Sci (Lond) (2014) 127 (3): 135–148.
Published: 03 April 2014
...Ji Gao; Yannick Marc; Xavier Iturrioz; Vincent Leroux; Fabrice Balavoine; Catherine Llorens-Cortes Hypertension affects one-third of the adult population and is a growing problem due to the increasing incidence of obesity and diabetes. Brain RAS (renin–angiotensin system) hyperactivity has been...
Articles
Clin Sci (Lond) (2012) 123 (10): 567–590.
Published: 23 July 2012
...Juan M. Saavedra The effects of brain AngII (angiotensin II) depend on AT 1 receptor (AngII type 1 receptor) stimulation and include regulation of cerebrovascular flow, autonomic and hormonal systems, stress, innate immune response and behaviour. Excessive brain AT 1 receptor activity associates...
Articles
Clin Sci (Lond) (2011) 121 (1): 11–17.
Published: 18 March 2011
...Francisco Campos; Manuel Rodríguez-Yáñez; Mar Castellanos; Susana Arias; María Pérez-Mato; Tomás Sobrino; Miguel Blanco; Joaquín Serena; José Castillo Ischaemic stroke is associated with an excessive release of glutamate in brain. GOT (glutamate-oxaloacetate transaminase) and GPT (glutamate...
Articles
Clin Sci (Lond) (2002) 103 (3): 275–282.
Published: 14 August 2002
... Epo and its receptor, the regulation of their expression and, finally, the effects that this hormone has on the development and maturation of the brain. A further aim has been to investigate how it influences CNS homoeostasis and neurotransmission in adult brain. Attention has also been focused on the...
Articles
Clin Sci (Lond) (1999) 96 (3): 279–285.
Published: 01 March 1999
... carried out in the brain. Through gene hunting in fetal DS brain we found an overexpressed sequence homologous to the phosphoglycerate kinase (PGK) gene. This finding was studied further by investigating the activity levels of this key enzyme of carbohydrate metabolism in the brains of patients with DS...
Articles
Clin Sci (Lond) (1998) 94 (6): 677–685.
Published: 01 June 1998
...Michael Goggins; John M. Scott; Donald G. Weir 1. The aim of this study was to determine the pattern of protein carboxymethylation in different regions of the human brain. 2. The availability of protein methylation sites was determined by measurement of the incorporation of methyl- 3 H groups into...
Articles
Clin Sci (Lond) (1997) 92 (5): 519–525.
Published: 01 May 1997
...Tory A. Meyer; Jing Jing Wang; Gregory M. Tiao; Cora K. Ogle; Josef E. Fischer; Per-Olof Hasselgren 1. In previous studies, experimental endotoxaemia was found to stimulate cytokine production in the central nervous system. The effect of sepsis on brain cytokines is not fully known. We compared the...
Articles
Clin Sci (Lond) (1996) 91 (5): 539–550.
Published: 01 November 1996
... changes take place in the heart, kidneys and blood vessels. These may reinforce, augment and even conceal the initially neurogenic background. The cause of the increased sympathetic activity remains in dispute, but it is probably not psychological in most cases. 2. The brain has a high requirement for...
Articles
Clin Sci (Lond) (1996) 90 (1): 81–85.
Published: 01 January 1996
...Eduardo Garrido; Ramón Segura; Antoni Capdevila; Jesús Pujol; Casimiro Javierre; Josep Li Ventura 1. The potential risk of brain damage when low-landers attempt to climb the highest summits is a well-known fact. However, very little is known about what occurs to Himalayan natives, perfectly adapted...
Articles
Clin Sci (Lond) (1995) 88 (4): 471–477.
Published: 01 April 1995
... normal. It also only occurred when the S -adenosylmethionine level fell. 4. Rats maintained in nitrous oxide for 4 months showed a marked reduction of methionine synthase but no reduction in the methylation ratio or in brain hypomethylation. None of the rats became clinically ataxic. 5. Using an...
Articles
Clin Sci (Lond) (1995) 88 (1): 73–79.
Published: 01 January 1995
... . 8 8 1994 12 8 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 Brain folate vitamin B 12 hypomethylation methionine synthase methyltransferases methylation ratio nitrous oxide S -adenosylhomocysteine S -adenosylmethionine Clinical Science...
Articles
Clin Sci (Lond) (1994) 87 (5): 481–485.
Published: 01 November 1994
... intellectual handicaps and brain tumours. The gene responsible for neurofibromatosis (the NF1 gene) codes for a protein of 2818 amino acids, termed neurofibromin, which has a domain related to mammalian ras GTPase-activating protein. 2. The NF1 gene gives rise to multiple transcripts generated by alternative...
Articles
Clin Sci (Lond) (1989) 77 (5): 529–534.
Published: 01 November 1989
...Helmut Geiger; Udo Bahner; Miklos Palkovits; Jürgen Hupe; August Heidland 1. The influence of deoxycorticosterone acetate (DOCA)–salt hypertension on brain atrial natriuretic factor (ANF) in rats was investigated to elucidate the role of central ANF in a renin-independent model of experimental...
Articles
Clin Sci (Lond) (1982) 63 (s8): 149s–152s.
Published: 01 October 1982
... activity were significantly increased in the cerebral cortex, cerebellum, hypothalamus and brain stem of the DOC-salt-treated rats 30 days after the initiation of the experiment. 3. Influence of plasma contamination on the former results was evaluated by the determination of (a) plasma angiotensinogen...
Articles
Clin Sci (Lond) (1982) 63 (s8): 159s–161s.
Published: 01 October 1982
... a decreased sympathetic outflow is suggested. 4. The present data indicate that the brain renin-angiotensin system contributes to the development of hypertension in the spontaneously hypertensive rat. © 1982 The Biochemical Society and the Medical Research Society 1982 N -acetyl-pepstatin...
Articles
Clin Sci (Lond) (1982) 63 (s8): 323s–326s.
Published: 01 October 1982
... populations within the nucleus tractus solitarius may be neurochemically and functionally differentiated. © 1982 The Biochemical Society and the Medical Research Society 1982 brain glutamate metergoline nucleus tractus solitarius serotonin Clinical Science (1982) 63,3239-326s 323s Serotonergic...
Articles
Clin Sci (Lond) (1982) 62 (3): 285–293.
Published: 01 March 1982
... determined in the basal state and during intravenous infusion of α-oxoisocaproate (300 μmol/min) for 150 min. The exchanges of amino acids and substrates across the splanchnic region, the brain and the leg were examined in the healthy subjects by a catheter technique. 2. Basal α-oxoisocaproate levels were...
Articles
Clin Sci (Lond) (1981) 61 (2): 175–180.
Published: 01 August 1981
...Hiromichi Suzuki; Kazuoki Kondo; Michiko Handa; Takao Saruta 1. To examine the possible participation of the brain iso-renin-angiotensin system in the control of blood pressure, as well as in the regulation of plasma renin activity, saralasin and captopril were injected into the cerebral ventricles...
Articles
Clin Sci (Lond) (1981) 61 (s7): 53s–55s.
Published: 01 January 1981
... Research Society 1981 brain catecholaminergic neurons Dahl S rats paraventricular nuclei salt CIinicalScience (1981) 61,53s-S5s 53s Brain lesions in the paraventricular nuclei and catecholaminergic neurons minimize salt hypertension in Dahl salt-sensitive rats A T S U O G O T O , T O S H I O I...
Articles
Clin Sci (Lond) (1980) 59 (3): 173–181.
Published: 01 September 1980
...L. Hagenfeldt; S. Eriksson; J. Wahren 1. l -Leucine was given to healthy, post-absorptive subjects as a continuous intravenous infusion (300 μmol/min) during 2 1/2 h. Arterial blood concentrations and regional exchange of amino acids were measured across the splanchnic region, the brain and a leg...
Articles
Clin Sci (Lond) (1980) 58 (4): 311–316.
Published: 01 April 1980
... significantly between the groups. 3. In cerebrospinal fluid and brain about 80% of HMPG was free and of the conjugated HMPG in these two tissues most was in the glucuronide form. 4. It is concluded from these data that both HMPG sulphate and HMPG glucuronide have a substantial peripheral origin and that...
Articles
Clin Sci (Lond) (1980) 59 (s6): 53s–56s.
Published: 01 January 1980
...B. A. Schölkens; W. Jung; W. Rascher; A. Schömig; D. Ganten 1. The mechanisms of central angiotensin II blood pressure effects in conscious dogs on normal or sodium-deficient diets were examined. 2. The biosynthesis of brain angiotensin II in cerebrospinal fluid from its local precursor...
Articles
Clin Sci (Lond) (1980) 59 (s6): 299s–302s.
Published: 01 January 1980
... pathogenesis of hypertension. The effector pathways appear to be different from angiotensin. © 1980 The Biochemical Society and the Medical Research Society 1980 baclofen baroreceptor reflex blood pressure brain substance P Clinical Science (1980) 59,299s-302s 299s Blood pressure and heart rate...
Articles
Clin Sci (Lond) (1980) 59 (s6): 271s–273s.
Published: 01 January 1980
... resulted in an exaggerated pressor response. © 1980 The Biochemical Society and the Medical Research Society 1980 behaviour brain catecholamines ClinicalScience (1980) 59,271s-273s 271s A hierarchical organization of blood pressure during natural behaviour in rat and the effects of central...
Articles
Clin Sci (Lond) (1979) 56 (6): 585–589.
Published: 01 June 1979
... after injections of angiotensin I and II into the brain ventricles was observed after oral SQ 14225. 3. Intracerebroventricular infusions of SQ 14225 in spontaneously hypertensive rats abolished the central pressor responses to angiotensin I. 4. The results show that SQ 14225 effectively blocked the...
Articles
Clin Sci (Lond) (1979) 57 (s5): 111s–113s.
Published: 01 January 1979
...Claire Baxter; J. Horvath; G. Duggin; D. Tiller 1. Angiotensin II receptor binding was studied in specific regions of rat brain at different ages from birth to 14 weeks. 2. The number of specific angiotensin II receptors increased in all regions during the first 2 weeks of life and then decreased...
Articles
Clin Sci (Lond) (1979) 57 (s5): 271s–274s.
Published: 01 January 1979
...B. Schölkens; R. Steinbach; D. Ganten 1. In Sprague—Dawley rats experiments were carried out to evaluate the influence of prostaglandins (PG) on the local generation of angiotensin (ANG) from brain angiotensinogen in cerebrospinal fluid and on the blood pressure effects of brain ANG. 2. In rats...
Articles
Clin Sci Mol Med (1978) 55 (s4): 237s–241s.
Published: 01 January 1978
...W. Simon; K. Schaz; U. Ganten; G. Stock; K. H. Schlör; D. Ganten 1. The cardiovascular effects of enkephalins have been tested in normotensive Wistar—Kyoto rats. Methionine—enkephalin and leucine—enkephalin increased blood pressure and heart rate after infusion into the brain ventricles. 2. After...
Articles
Clin Sci Mol Med (1978) 55 (s4): 121s–123s.
Published: 01 January 1978
...Tadashi Inagami; Hideyoshi Yokosawa; Shigehisa Hirose 1. Angiotensin I-generating activity of rat brain extract was separated into two components by affinity chromatography on a casein—Sepharose gel column. 2. The component without affinity to the gel was identified as true renin on the basis of...
Articles
Clin Sci Mol Med (1976) 51 (s3): 117s–120s.
Published: 01 January 1976
... kidney renin and of extrarenal tissue iso-renin are similar. 2. Results indicate that tissue iso-renins are part of a complex enzyme system with mainly local function. A possible biological role has been demonstrated in brain, adrenal gland and tissue culture. © 1976 The Biochemical Society and the...
Articles
Clin Sci Mol Med (1976) 50 (1): 15–23.
Published: 01 January 1976
... values, which were much higher than the critical threshold values for producing hypoxic CMRo 2 depression in health. 4. It is concluded that the brain becomes more vulnerable to the adverse effects of hypoxia during liver failure. This may be of practical importance in the management of patients with...
Articles
Clin Sci Mol Med (1975) 48 (1): 33–37.
Published: 01 January 1975
...B. Hindfelt 1. The distribution of ammonia between extra- and intra-cellular compartments of the brain was evaluated in anaesthetized rats exposed to sustained hyperammonaemia and superimposed acute hypo- or hyper-capnia. 2. It is concluded that the concentration gradient for ammonia between...