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Keywords: brain
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Clin Sci (Lond) (2018) 132 (2): 199–212.
Published: 19 January 2018
... leading to the release of pro-inflammatory cytokines which are considered important mediators of the liver–gut–brain communication. Although circulating cytokines are likely not the sole factors involved, they can induce liver inflammation/damage and reach the central nervous system where they favor...
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Clin Sci (Lond) (2016) 130 (17): 1481–1497.
Published: 18 July 2016
...Neza Grgurevic; Gregor Majdic Although considerable progress has been made in our understanding of brain function, many questions remain unanswered. The ultimate goal of studying the brain is to understand the connection between brain structure and function and behavioural outcomes. Since sex...
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Clin Sci (Lond) (2016) 130 (8): 565–574.
Published: 08 March 2016
...Katherine M. Davies; Julian F.B. Mercer; Nicholas Chen; Kay L. Double Copper is a biometal essential for normal brain development and function, thus copper deficiency or excess results in central nervous system disease. Well-characterized disorders of disrupted copper homoeostasis with neuronal...
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Clin Sci (Lond) (2012) 123 (10): 567–590.
Published: 23 July 2012
...Juan M. Saavedra The effects of brain AngII (angiotensin II) depend on AT 1 receptor (AngII type 1 receptor) stimulation and include regulation of cerebrovascular flow, autonomic and hormonal systems, stress, innate immune response and behaviour. Excessive brain AT 1 receptor activity associates...
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Clin Sci (Lond) (2002) 103 (3): 275–282.
Published: 14 August 2002
... of Epo and its receptor, the regulation of their expression and, finally, the effects that this hormone has on the development and maturation of the brain. A further aim has been to investigate how it influences CNS homoeostasis and neurotransmission in adult brain. Attention has also been focused...
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Clin Sci (Lond) (1998) 94 (6): 677–685.
Published: 01 June 1998
...Michael Goggins; John M. Scott; Donald G. Weir 1. The aim of this study was to determine the pattern of protein carboxymethylation in different regions of the human brain. 2. The availability of protein methylation sites was determined by measurement of the incorporation of methyl- 3 H groups...
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Clin Sci (Lond) (1997) 92 (5): 519–525.
Published: 01 May 1997
...Tory A. Meyer; Jing Jing Wang; Gregory M. Tiao; Cora K. Ogle; Josef E. Fischer; Per-Olof Hasselgren 1. In previous studies, experimental endotoxaemia was found to stimulate cytokine production in the central nervous system. The effect of sepsis on brain cytokines is not fully known. We compared...
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Clin Sci (Lond) (1996) 91 (5): 539–550.
Published: 01 November 1996
... changes take place in the heart, kidneys and blood vessels. These may reinforce, augment and even conceal the initially neurogenic background. The cause of the increased sympathetic activity remains in dispute, but it is probably not psychological in most cases. 2. The brain has a high requirement...
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Clin Sci (Lond) (1996) 90 (1): 81–85.
Published: 01 January 1996
...Eduardo Garrido; Ramón Segura; Antoni Capdevila; Jesús Pujol; Casimiro Javierre; Josep Li Ventura 1. The potential risk of brain damage when low-landers attempt to climb the highest summits is a well-known fact. However, very little is known about what occurs to Himalayan natives, perfectly adapted...
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Clin Sci (Lond) (1989) 77 (5): 529–534.
Published: 01 November 1989
...Helmut Geiger; Udo Bahner; Miklos Palkovits; Jürgen Hupe; August Heidland 1. The influence of deoxycorticosterone acetate (DOCA)–salt hypertension on brain atrial natriuretic factor (ANF) in rats was investigated to elucidate the role of central ANF in a renin-independent model of experimental...
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Clin Sci (Lond) (1982) 63 (s8): 149s–152s.
Published: 01 October 1982
... activity were significantly increased in the cerebral cortex, cerebellum, hypothalamus and brain stem of the DOC-salt-treated rats 30 days after the initiation of the experiment. 3. Influence of plasma contamination on the former results was evaluated by the determination of (a) plasma angiotensinogen...
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Clin Sci (Lond) (1982) 63 (s8): 159s–161s.
Published: 01 October 1982
... of a decreased sympathetic outflow is suggested. 4. The present data indicate that the brain renin-angiotensin system contributes to the development of hypertension in the spontaneously hypertensive rat. © 1982 The Biochemical Society and the Medical Research Society 1982 N -acetyl-pepstatin brain...
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Clin Sci (Lond) (1982) 63 (s8): 323s–326s.
Published: 01 October 1982
... populations within the nucleus tractus solitarius may be neurochemically and functionally differentiated. © 1982 The Biochemical Society and the Medical Research Society 1982 brain glutamate metergoline nucleus tractus solitarius serotonin Clinical Science (1982) 63,3239-326s 323s Serotonergic...
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Clin Sci (Lond) (1982) 62 (3): 285–293.
Published: 01 March 1982
... determined in the basal state and during intravenous infusion of α-oxoisocaproate (300 μmol/min) for 150 min. The exchanges of amino acids and substrates across the splanchnic region, the brain and the leg were examined in the healthy subjects by a catheter technique. 2. Basal α-oxoisocaproate levels were...
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Clin Sci (Lond) (1981) 61 (2): 175–180.
Published: 01 August 1981
...Hiromichi Suzuki; Kazuoki Kondo; Michiko Handa; Takao Saruta 1. To examine the possible participation of the brain iso-renin-angiotensin system in the control of blood pressure, as well as in the regulation of plasma renin activity, saralasin and captopril were injected into the cerebral ventricles...
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Clin Sci (Lond) (1980) 59 (s6): 299s–302s.
Published: 01 December 1980
... of hypertension. The effector pathways appear to be different from angiotensin. baclofen baroreceptor reflex blood pressure brain substance P Clinical Science (1980) 59,299s-302s 299s Blood pressure and heart rate responses to centrally administered substance P are increased in spontaneously...
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Clin Sci (Lond) (1980) 59 (3): 173–181.
Published: 01 September 1980
...L. Hagenfeldt; S. Eriksson; J. Wahren 1. l -Leucine was given to healthy, post-absorptive subjects as a continuous intravenous infusion (300 μmol/min) during 2 1/2 h. Arterial blood concentrations and regional exchange of amino acids were measured across the splanchnic region, the brain and a leg...
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Clin Sci (Lond) (1979) 57 (s5): 111s–113s.
Published: 01 December 1979
...Claire Baxter; J. Horvath; G. Duggin; D. Tiller 1. Angiotensin II receptor binding was studied in specific regions of rat brain at different ages from birth to 14 weeks. 2. The number of specific angiotensin II receptors increased in all regions during the first 2 weeks of life and then decreased...
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Clin Sci (Lond) (1979) 57 (s5): 271s–274s.
Published: 01 December 1979
...B. Schölkens; R. Steinbach; D. Ganten 1. In Sprague—Dawley rats experiments were carried out to evaluate the influence of prostaglandins (PG) on the local generation of angiotensin (ANG) from brain angiotensinogen in cerebrospinal fluid and on the blood pressure effects of brain ANG. 2. In rats...
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Clin Sci Mol Med (1978) 55 (s4): 237s–241s.
Published: 01 December 1978
...W. Simon; K. Schaz; U. Ganten; G. Stock; K. H. Schlör; D. Ganten 1. The cardiovascular effects of enkephalins have been tested in normotensive Wistar—Kyoto rats. Methionine—enkephalin and leucine—enkephalin increased blood pressure and heart rate after infusion into the brain ventricles. 2. After...
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Clin Sci Mol Med (1978) 55 (s4): 121s–123s.
Published: 01 December 1978
...Tadashi Inagami; Hideyoshi Yokosawa; Shigehisa Hirose 1. Angiotensin I-generating activity of rat brain extract was separated into two components by affinity chromatography on a casein—Sepharose gel column. 2. The component without affinity to the gel was identified as true renin on the basis...
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Clin Sci Mol Med (1976) 51 (s3): 117s–120s.
Published: 01 December 1976
... of kidney renin and of extrarenal tissue iso-renin are similar. 2. Results indicate that tissue iso-renins are part of a complex enzyme system with mainly local function. A possible biological role has been demonstrated in brain, adrenal gland and tissue culture. adrenal gland angiotensin brain tissue...
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Clin Sci Mol Med (1976) 50 (1): 15–23.
Published: 01 January 1976
... values, which were much higher than the critical threshold values for producing hypoxic CMRo 2 depression in health. 4. It is concluded that the brain becomes more vulnerable to the adverse effects of hypoxia during liver failure. This may be of practical importance in the management of patients...
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Clin Sci Mol Med (1975) 48 (1): 33–37.
Published: 01 January 1975
...B. Hindfelt 1. The distribution of ammonia between extra- and intra-cellular compartments of the brain was evaluated in anaesthetized rats exposed to sustained hyperammonaemia and superimposed acute hypo- or hyper-capnia. 2. It is concluded that the concentration gradient for ammonia between...