1-11 of 11
Keywords: cGMP
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
Published: 20 May 2021
...Anton J.M. Roks; Caroline Cheng; Catherine M. Shanahan Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3–Rho kinase–cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL...
Clin Sci (Lond) (2019) 133 (2): 239–252.
Published: 22 January 2019
... by excessive accumulation of myofibroblast-derived extracellular matrix. Natriuretic peptides have been demonstrated to have cyclic guanosine monophosphate (cGMP)-dependent anti-fibrotic properties likely due to interference with pro-fibrotic tissue growth factor β (TGF-β) signaling. However, in vivo...
Includes: Supplementary data
Clin Sci (Lond) (2002) 102 (2): 213–222.
Published: 14 January 2002
... suggests that inducible NO synthase attenuates ventricular contractility, mediated by cGMP. Another gas that transduces its signal through cGMP, carbon monoxide, is also likely to play a role in cirrhotic cardiomyopathy, but the nature of the interaction between NO and carbon monoxide in this syndrome...
Clin Sci (Lond) (2001) 100 (5): 473–479.
Published: 29 March 2001
... μ M), supporting the role of NO in maintenance of basal relaxation and vascular tone in females. We have examined the relative activity of the specific PKG subtypes 1α and 1β in vascular smooth muscle, based on relaxation of rat aortas by two cGMP analogues with different selectivity, β-phenyl-l- N...
Clin Sci (Lond) (2000) 99 (4): 255–260.
Published: 06 September 2000
... tissue levels of cGMP, and that could be beneficial for the treatment of cardiovascular conditions. Starting from zaprinast, a weak phosphodiesterase inhibitor, computer modelling guided rational medicinal chemistry to achieve significant increases in potency and selectivity for the 5-isoenzyme within...
Clin Sci (Lond) (1996) 91 (2): 225–231.
Published: 01 August 1996
... if inhaled nitric oxide influences platelet function in vivo in healthy subjects. 2. Platelet aggregability (filtragometry ex vivo , which reflects aggregability in vivo ), bleeding time and platelet secretion products and cGMP in plasma were studied during inhalation of two different doses of nitric oxide...