... the acute effect of coffee ingestion on endothelial function in healthy individuals, and the potential role of caffeine. We studied 17 healthy young adults (28.9±3.0 years old; nine men), who were regular non-heavy coffee drinkers. The endothelial performance was estimated by endothelium-dependent FMD (flow...

...J.M. WATSON; R.S. SHERWIN; I.J. DEARY; L. SCOTT; D. KERR In patients with Type I diabetes and healthy volunteers, ingestion of modest amounts of caffeine augments the usual symptomatic and counter-regulatory responses to hypoglycaemia. The aim of the present study was to determine whether...

...D.G. SHIRLEY; S.J. WALTER; F.H. NOORMOHAMED In order to assess the intrarenal mechanisms responsible for the natriuretic action of caffeine, the renal clearances of 51 Cr-EDTA [used as a measure of glomerular filtration rate (GFR)] and lithium (used as an index of end-proximal fluid delivery) were...

... and caffeine; hypoglycaemia and placebo; and euglycaemia and caffeine. The latency of the P100 component of the pattern-reversal visual evoked potential increased significantly from rest to hypoglycaemia, but no effect of caffeine was found. Subjects were subsequently divided into two median groups based...

...Kwasi Debrah; Rob Haigh; Robert Sherwin; June Murphy; David Kerr 1. The effects of acute and chronic caffeine ingestion on supine- and tilt- (60 min at 70°) induced changes in middle cerebral artery velocity ( V mca ), heart rate, blood pressure and counter-regulatory hormone levels (catecholamines...

...Nigel R. Scott; Drago Stambuk; J. Chakraborty; Vincent Marks; Marsha Y. Morgan 1. The clearance and biotransformation of caffeine (1,3,7-trimethylxanthine) were investigated in eight healthy control subjects and 16 patients with cirrhosis, by measuring serial serum caffeine concentrations...

...A. P. Passmore; G. B. Kondowe; G. D. Johnston 1. The effects of increasing oral doses of caffeine (45, 90, 180 and 360 mg) on effective renal plasma flow (ERPF), plasma renin activity (PRA), serum electrolytes, plasma noradrenaline, blood pressure and heart rate were studied in eight healthy male...

...R. T. Jung; P. S. Shetty; W. P. T. James; M. A. Barrand; B. A. Callingham 1. The metabolic response of lean and obese women to caffeine was studied to see if caffeine could be used to demonstrate the subnormal thermogenesis in obesity previously shown after standard meals or intravenous infusions...