...F. Njuki; C. G. Nicholl; A. Howard; J. C. W. Mak; P. J. Barnes; S. I. Girgis; S. Legon 1. Two rat clones have been isolated which are similar to known calcitonin-receptor sequences. One of these does not have the distribution expected of a calcitonin receptor. It is widely distributed...

...D. P. O'Doherty; D. R. Bickerstaff; E. V. McCloskey; R. Atkins; N. A. T. Hamdy; A. Kanis 1. We studied the acute effects of intranasal and subcutaneous calcitonin in 40 patients with active Paget's disease of bone. Patients received a single dose of either 400 units of calcitonin delivered...

...A. D. Struthers; M. J. Brown; D. W. R. Macdonald; J. L. Beacham; J. C. Stevenson; H. R. Morris; I. Macintyre 1. In addition to calcitonin and katacalcin, it is now known that the human calcitonin gene encodes a novel peptide called calcitonin gene related peptide (CGRP). In experimental animals...

... excretion of both calcium and hydroxyproline with both treatments, indicating reduced bone resorption. This was apparent after 1 week of therapy but became more marked after 3 weeks. 3. These changes were not accompanied by any changes in plasma levels of calcitonin or parathyroid hormone. 4. Patients...

... in the normal adults and was inversely related to plasma alkaline phosphatase activity ( r = −0.55, n = 24, P <0.001). 3. When the patients with Paget's disease were treated with either diphosphonate or calcitonin, the plasma α 2 HS-glycoprotein concentration increased towards normal. In those patients...

.... There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal...

...R. Shainkin-Kestenbaum; R. Lerman; A. Reuben; G. M. Berlyne 1. Plasma concentrations of human calcitonin were measured in groups of patients with chronic renal failure, treated either conservatively or by haemodialysis, and compared with a normal group of persons. 2. Plasma calcitonin...

...J. A. Kanis; G. Heynen; R. J. Walton 1. Plasma levels of immunoreactive calcitonin were measured in 22 patients with untreated Paget's disease of bone and in 22 control subjects matched for age and sex. 2. No significant differences in plasma calcitonin were found between patients and control...

...A. Caniggia; C. Gennari; A. Vattimo; P. Nardi; R. Nuti 1. The effect of calcitonin, a large amount of calcium given orally, pentagastrin and glucagon on plasma 47 Ca radioactivity curves in subjects pretreated with 47 Ca was examined. 2. A sudden increase of plasma radioactivity after intravenous...

... be inhibited by calcitonin. 26 3 1976 © 1976 The Biochemical Society and the Medical Research Society 1976 bone calcitonin calcium hypercalcaemia rheumatoid arthritis Clinical Science and Molecular Medicine (1976) 51,205-207. SHORT COMMUNICATION Boneresorbing activity in the sera...

...R. Ardaillou; M. Beaufils; Marie-Paule Nivez; R. Isaac; C. Mayaud; J.-D. Sraer 1. High plasma immunoreactive calcitonin concentrations were observed in ten of eleven patients with acute renal failure, particularly in the oliguric phase. 2. Immunoreactive calcitonin decreased progressively with time...

...W. A. Crosbie; S. M. Mohamedally; N. J. Y. Woodhouse 1. Twelve patients with symptomatic Paget's disease were studied before starting treatment with salmon calcitonin (12.5 μg) subcutaneously twice daily. Eleven of them were studied again after 3 months on this therapy. 2. Although pretreatment...

...A. Caniggia; C. Gennari; F. Piantelli; A. Vattimo 1. An intravenous infusion of calcitonin produced a sudden increase of plasma radioactivity after intravenous administration of 47 Ca in man. 2. This effect was noted a few minutes before the well-known decrease of plasma calcium concentration. 3...

...C. C. Williams; E. W. Matthews; Jane M. Moseley; I. MacIntyre 1. The effects on renal electrolyte excretion of human and salmon synthetic calcitonins were studied in the rat. 2. As little as 50 ng of salmon calcitonin produced an increase in sodium excretion, but human calcitonin in doses up to 15...

... and probably man. It appears to be an initiating event in PTH action on bone. 3. Although calcitonin prevents PTH-induced bone resorption, it did not affect this early calcium shift. 4. This evidence is discussed in connection with the possibility of combining calcitonin with some other agent for the treatment...