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Keywords: calcium
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Articles
STIM1/Orai1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats
Available to PurchaseFernanda R. C. Giachini, Victor V. Lima, Fernando P. Filgueira, Anne M. Dorrance, Maria Helena C. Carvalho, Zuleica B. Fortes, R. Clinton Webb, Rita C. Tostes
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (5): 215–226.
Published: 28 October 2011
... Biochemical Society 2012 aorta calcium hypertension Orai1 stromal interaction molecule 1 (STIM1) sex difference vascular protection The coupling process between the ER (endoplasmic reticulum) and plasma membrane to mediate SOCE (store-operated Ca 2+ entry) remained a mechanistic mystery...
Articles
Phosphate toxicity: new insights into an old problem
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Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (3): 91–97.
Published: 14 October 2010
[email protected] ). 21 7 2010 17 8 2010 19 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 calcium fibroblast growth factor 23 (FGF23) klotho parathyroid hormone (PTH) sodium-dependent phosphate transporter vitamin D Phosphorus is an essential...
Articles
Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms
Available to PurchaseAlvaro Yogi, Glaucia E. Callera, Ulisses V. Hipólito, Catiane R. Silva, Rhian M. Touyz, Carlos R. Tirapelli
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (11): 657–668.
Published: 09 March 2010
... on the basis the H 2 O 2 standard curve. aorta calcium hydrogen peroxide prostanoid reactive oxygen species superoxide anion Several studies in animals and humans have demonstrated that ethanol consumption is associated with cardiovascular pathologies such as hypertension [ 1 – 3...
Articles
QT interval prolongation and decreased heart rate variability in cirrhotic patients: relevance of hepatic venous pressure gradient and serum calcium
Available to PurchaseSimonetta Genovesi, Daniela M. Prata Pizzala, Massimo Pozzi, Laura Ratti, Maria Milanese, Federico Pieruzzi, Antonio Vincenti, Andrea Stella, Giuseppe Mancia, Marco Stramba-Badiale
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (12): 851–859.
Published: 14 May 2009
... patients underwent a 24-h ECG Holter recording. The 24-h mean of QT intervals corrected for heart rate (termed QTc) and the slope of the regression line QT/RR were calculated. HRV (heart rate variability), plasma calcium and potassium concentration and HVPG (hepatic venous pressure gradient) were measured...
Articles
Role of endothelin-1 receptors in the sarcolemma membrane and the nuclear membrane in the modulation of basal cytosolic and nuclear calcium levels in heart cells
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Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 141S–147S.
Published: 01 September 2002
... and the confocal microscopy technique, our present results show that stimulation of endothelin-1 (ET-1) receptors at the sarcolemma membrane induced a dose-dependent sustained increase in basal cytosolic and nuclear calcium levels that was insensitive to the ET A and ET B receptor antagonists BQ123 and BQ788...
Articles
Genetic contribution to renal function and electrolyte balance: a twin study
Available to PurchaseDavid J. HUNTER, Marlies DE LANGE, Harold SNIEDER, Alex J. MAC GREGOR, R. SWAMINATHAN, Rajesh V. THAKKER, Tim D. SPECTOR
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (3): 259–265.
Published: 13 August 2002
...David J. HUNTER; Marlies DE LANGE; Harold SNIEDER; Alex J. MAC GREGOR; R. SWAMINATHAN; Rajesh V. THAKKER; Tim D. SPECTOR A classical twin study was performed to assess the relative contributions of genetic and environmental factors to serum levels of calcium, phosphate and magnesium, urinary levels...
Articles
Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics
Available to PurchaseJulia GORELIK, Sian E. HARDING, Andrew I. SHEVCHUK, Duleepa KORALAGE, Max LAB, Michael DE SWIET, Yuri KORCHEV, Catherine WILLIAMSON
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (2): 191–200.
Published: 17 July 2002
... and calcium transients with taurocholate. Our observations indicate that taurocholate affects calcium release from the sarcoplasmic reticulum and this parallels changes in contractile function. The relationship between the contraction amplitude and calcium transient is not linear, particularly at higher...
Articles
Asynchronous impairment of calcium homoeostasis in different acinar cells after pancreatic duct obstruction in rat
Available to PurchaseAránzazu URUÑUELA, Manuel A. MANSO, Ana Ma DE LA MANO, Sara SEVILLANO, Alberto ORFAO, Isabel DE DIOS
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (6): 615–622.
Published: 30 April 2002
... than R1 cells. Correspondence: Dr Isabel de Dios (e-mail [email protected] ). 29 5 2001 6 12 2001 14 2 2001 The Biochemical Society and the Medical Research Society © 2002 2002 acinar cells acute pancreatitis calcium rat 615Clinical Science (2002) 102, 615 622...
Articles
The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis
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Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (4): 363–369.
Published: 26 February 2001
...). Addition of taurocholate to a network of synchronously beating cells caused a similar decrease in the rate of contraction. Furthermore, the integrity of the network was destroyed, and cells ceased to beat synchronously. Taurocholate also resulted in altered calcium dynamics and loss of synchronous beating...
Articles
The hypomagnesaemic action of FK506: urinary excretion of magnesium and calcium and the role of parathyroid hormone
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Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (4): 285–292.
Published: 31 August 2000
... of FK506 employed did not decrease the glomerular filtration rate. FK506 elicited hypomagnesaemia in both sets of experiments, accompanied by inappropriately high fractional excretion of magnesium. There was also evidence of disruption of the normal renal reabsorption of calcium, but this did not result...
Articles
Change in Blood Pressure during Altered Sodium Intake is not Associated with Calciotropic Hormone Level
Available to PurchaseRyoji Ozono, Tetsuya Oshima, Hideo Matsuura, Katsuhiko Ishibashi, Mitsuaki Watanabe, Mitsuisa Yoshimura, Goro Kajiyama, Masayuki Kambe
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (2): 153–157.
Published: 01 August 1997
...Ryoji Ozono; Tetsuya Oshima; Hideo Matsuura; Katsuhiko Ishibashi; Mitsuaki Watanabe; Mitsuisa Yoshimura; Goro Kajiyama; Masayuki Kambe 1. We evaluated the effects of the dietary restriction of sodium chloride on blood pressure and systemic calcium metabolism in 19 in-patients with essential...
Articles
Plasma Ionized Magnesium during Acute Hyperventilation in Humans
Available to PurchaseGaudenz Hafen, Regula Laux-End, Anita C. Truttmann, Andreas Schibler, John A. S. McGuigan, Edgar Peheim, Mario G. Bianchetti
Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (3): 347–351.
Published: 01 September 1996
... of the syndrome of tetany and the cardiac complications that are precipitated by hyperventilation. 30 4 1996 24 5 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 alkalosis calcium hyperventilation magnesium potassium Clinical Science (1996) 91, 347-351...
Articles
Low Concentrations of Ouabain Increase Cytosolic Free Calcium Concentration in Rat Vascular Smooth Muscle Cells
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (1): 9–12.
Published: 01 January 1996
...Zhiming Zhu; Martin Tepel; Marcus Neusser; Walter Zidek 1. Low ouabain concentrations in the nanomolar range significantly increased cytosolic free calcium concentration. 2. The ouabain-induced cytosolic free calcium concentration increase was due to transplasmamembrane calcium influx, which could...
Articles
EMD 57033 Enhances Arrhythmias Associated with Increased Wall-Stress in the Working Rat Heart
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (1): 59–67.
Published: 01 July 1995
...Stephen J. Evans; Allan J. Levi; John A. Lee; John V. Jones 1. EMD 57033 produces a positive inotropic effect by increasing the sensitivity of cardiac muscle myofilaments to calcium. Since the elevation in intracellular calcium produced by conventional inotropic compounds is thought...
Articles
Role of Protein Kinase C in the Anti-Aggregatory Effects of Endothelin-1 on Human Platelets
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (3): 277–283.
Published: 01 March 1995
...R. M. Touyz; E. L. Schiffrin 1. Endothelin-1 has anti-aggregatory properties, but the mechanism underlying this inhibitory action is unknown. This in vitro study investigates effects of endothelin-1 on thrombin-stimulated aggregation and intracellular free calcium concentration in human platelets...
Articles
Acute Effect of Parathyroid Hormone on Urine Concentration in the Rat
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (2): 197–201.
Published: 01 February 1995
... in the group pretreated with parathyroid hormone. 4. Parathyroid hormone produced only a small increase in mean plasma calcium concentration, and glomerular filtration rate was not altered by either hormone. 5. These results demonstrate that high physiological concentrations of parathyroid hormone do have...
Articles
Atrial Natriuretic Peptide Inhibits Cyclosporin A-Induced Endothelin Production and Calcium Accumulation in Rat Vascular Smooth Muscle Cells
Available to PurchaseDirk Bokemeyer, Ursula Friedrichs, Angela Bäcker, Sabine Drechsler, Herbert J. Kramer, Harald Meyer-Lehnert
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (4): 383–387.
Published: 01 October 1994
...Dirk Bokemeyer; Ursula Friedrichs; Angela Bäcker; Sabine Drechsler; Herbert J. Kramer; Harald Meyer-Lehnert 1. As we have previously shown, cyclosporin A enhances the vasoconstrictor-induced rise in intracellular free calcium in vascular smooth muscle cells. This effect may contribute to important...
Articles
Hormonal and other Mechanisms Involved in the Pathogenesis of Cyclosporin-Induced Nephrotoxicity and Hypertension in Man
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Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (1): 1–9.
Published: 01 January 1994
..., prostaglandin imbalances, sympathetic ner- vous system activation and alterations in calcium handling have all been suggested. Of particular interest is the role of angiotensin I1 (ANG 11) and of vasodilatory prostaglandins, since these two hormonal systems are, in most other circumstances, critical...
Articles
Ionized and Total Magnesium Levels in Cyclosporin-Treated Renal Transplant Recipients: Relationship with Cholesterol and Cyclosporin Levels
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (3): 315–318.
Published: 01 September 1993
...M. S. Markell; B. T. Altura; R. L. Barbour; B. M. Altura 1. Ionized magnesium, measured using a newly developed ion-selective electrode, total magnesium, and ionized and total calcium were evaluated in 39 stable, long-term, cyclosporin-treated renal transplant recipients and compared with those...
Articles
A novel thiadiazinone derivative fully reverses acidosis-induced depression of force in cardiac muscle by a calcium-sensitizing effect
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (2): 141–144.
Published: 01 February 1993
..., unbranching papillary muscle of uniform diameter (mean = 0.7 & 0.07 mm) was identified. Small loops of silk Key words: acidosis, calcium, calcium sensitizers, cardiotonics, EMD 57033, myofilaments. Abbreviations: [Ca l l , , intracellular [Ca2 DMSO, dimethyl sulphoxide; PDE, phosphodiesterase. Correspondence...
Articles
Stimulatory action of parathyroid hormone on renin secretion in vitro : a study using isolated rat kidney, isolated rabbit glomeruli and superfused dispersed rat juxtaglomerular cells
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (1): 11–19.
Published: 01 January 1993
... hormone on renin release. 5. We also examined the effect of [Nle 8,18 , Tyr 34 ]parathyroid hormone-(l-34)amide during extracellular calcium buffering in the glomeruli. [Nle 8,18 ,Tyr 34 ]parathyroid hormone-(1–34)amide was uneffective in calcium-free medium. Increasing the extracellular ionized calcium...
Articles
Cellular and intrarenal control of renin secretion
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (1): 1–10.
Published: 01 January 1993
...Ole Skøtt; Boye L. Jensen © 1993 The Biochemical Society and the Medical Research Society 1993 angiotensin II baroreceptor calcium cyclic nucleotides endothelial factors juxtaglomerular apparatus macula densa osmotic forces prostaglandins renal nerves renin biosynthesis renin...
Articles
Effects of parathyroid hormone and calcium and their interrelationship on urinary acidification in the rat
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (6): 711–715.
Published: 01 December 1992
...F. Zaladek Gil; V. L. Costa Silva; M. F. Cavanal; G. Malnic 1. The influence of thyroparathyroidectomy on renal function and specifically on acid excretion was studied in rats with or without oral supplementation of calcium. 2. Thyroparathyroidectomy caused a significant decrease in glomerular...
Articles
Renal divalent cation excretion in secondary hypertension
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (5): 561–565.
Published: 01 November 1992
...Mario Barbagallo; Lawrence M. Resnick; R. Ernest Sosa; Mary Lou Corbett; John H. Laragh 1. To determine whether abnormal renal calcium excretion is unique to primary genetic hypertension, blood pressure and 24 h urinary excretion of calcium, magnesium, sodium and creatinine were measured...
Articles
Platelet cytosolic free calcium concentration, total plasma calcium concentration and blood pressure in human twins: a genetic analysis
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (5): 493–504.
Published: 01 May 1992
...P. D. Williams; I. B. Puddey; N. G. Martin; L. J. Beilin 1. We used path analysis and maximum-likelihood model fitting to evaluate the relative contributions of genetic and environmental factors to the relationships observed between level of blood pressure and both total plasma calcium...
Articles
Accumulation of calcium by normal and dystrophin-deficient mouse muscle during contractile activity in vitro
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (4): 455–459.
Published: 01 April 1992
...A. McArdle; R. H. T. Edwards; M. J. Jackson 1. Accumulation of calcium by extensor digitorum longus muscles from dystrophin-deficient mdx and control C57BL/10 mice has been studied in vitro by measurements of total muscle calcium and by following the retention of 45 Ca resulting from the incubation...
Articles
Metabolic balance studies of mineral supplementation in osteoporosis
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (6): 799–802.
Published: 01 December 1991
...Trevor Stamp; Monica Katakity; A. J. Goldstein; M. V. Jenkins; C. R. Kelsey; G. A. Rose 1. We studied the effect of mineral supplementation and its duration is osteoporosis by analysing the calcium and phosphorus balances of 49 treated osteoporotic patients whose median length of calcium treatment...
Articles
Calcium and phosphate metabolism in acute falciparum malaria
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (3): 297–304.
Published: 01 September 1991
... patients. 2. Mild, asymptomatic hypocalcaemia (corrected plasma calcium concentration 1.79–2.11 mmol/l) was found in 61 cross-sectional study patients (35.5%), with no difference between those with uncomplicated (2.16 ± 0.10 mmol/l, mean ± sd , n = 89) and severe (2.18 ± 0.15 mmol/l, n = 83, P = 0.36...
Articles
Glutathione depletion during experimental damage to rat skeletal muscle and its relevance to Duchenne muscular dystrophy
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 80 (6): 559–564.
Published: 01 June 1991
... is not directly related and that a reduction in muscle glutathione content does not occur before cytosolic enzyme release. 3. 2,4-Dinitrophenol-stimulated release of creatine kinase was significantly reduced by the omission of external calcium from the incubation media, but glutathione release and depletion...
Articles
A cross-sectional study of basal platelet intracellular free calcium concentration in normotensive and hypertensive primigravid pregnancies
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Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (1): 75–80.
Published: 01 January 1990
...M. D. Kilby; F. Broughton Pipkin; S. Cockbill; S. Heptinstall; E. M. Symonds 1. The intracellular free calcium concentration ([Ca 2+ ] i ) in washed human platelets was measured using the fluorescent indicator, fura-2, in a cross-sectional study of 36 normotensive, primigravid volunteers, 12...
Articles
Inhibitory Role of Ca 2+ in the Control of Renin Secretion: A Study Using Supervised Dispersed Rat Renal Cortical Cells
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Journal:
Clinical Science
Clin Sci (Lond) (1989) 77 (3): 273–279.
Published: 01 September 1989
... 2 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 adenosine 3′:5′-cyclic monophosphate calcium calcium channel blockers diltiazem kidney cortex renin Clinical Science ( 1 989) 77,273-279 273 Inhibitory role of Ca2 + in the control of renin secretion...
Articles
Atrial natriuretic peptide vascular receptor: regulation of low-affinity binding by calcium
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Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (1): 9–11.
Published: 01 January 1989
...J. J. Morton; Elisabeth C. Beattie; Fiona Lyall 1. In the presence of calcium, both high- [dissociation equilibrium constant ( K d ) 5.8 × 10 −11 mol/l] and low-( K d 1.2 × 10 −8 mol/l) affinity binding of atrial natriuretic peptide was detected on plasma membranes prepared from sodium-depleted...
Articles
Platelet intracellular free calcium concentration in normotensive and hypertensive pregnancies in the human
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Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (1): 67–71.
Published: 01 January 1989
...S. M. Barr; K. R. Lees; L. Butters; A. O'Donnell; P. C. Rubin 1. Basal and stimulated platelet intracellular free calcium concentrations were measured in non-pregnant women and in third trimester patients who were either normotensive or who had pregnancy-induced hypertension or pre-eclampsia...
Articles
Vasopressin-mediated contractions in mesenteric arteries from spontaneously hypertensive rats: Differences in response compared with Wistar–Kyoto animals
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Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (5): 449–453.
Published: 01 November 1988
... in all vessels from SHR and rarely in WKY vessels at activating concentrations of AVP. 3. AVP did not elicit a contractile response after noradrenaline-induced calcium depletion. 4. After vessels were depleted of calcium by using a combination of calcium-free media and noradrenaline stimulation...
Articles
Changes in calcium metabolic indices during long-term treatment of patients with essential hypertension
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Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (5): 543–549.
Published: 01 November 1988
...Andreas Hvarfner; Reinhold Bergström; Hans Lithell; Claes Mörlin; Leif Wide; Sverker Ljunghall 1. Disturbances of calcium metabolism, mimicking mild, compensated secondary hyperparathyroidism, accompany essential hypertension, but it is not known whether these alterations are primary or only...
Articles
Calcium and magnesium in essential hypertension
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Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (4): 395–402.
Published: 01 October 1988
...D. M. Tillman; P. F. Semple 1. Because disturbances of calcium metabolism have been described in hypertension, measurements of plasma and serum concentrations of ionized calcium, total calcium, magnesium and renin were made in 38 patients with essential hypertension and age- and sex-matched control...
Articles
Exercise and platelet intracellular free calcium concentration
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Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (2): 221–224.
Published: 01 August 1988
...Susan M. Barr; Kennedy R. Lees; Daniel D. McBryan; James Reid; Elizabeth Farish; Peter C. Rubin 1. A positive correlation between blood pressure and platelet intracellular free calcium concentration ([Ca 2+ ] i ) has been reported. We examined the effect of acute changes in blood pressure...
Articles
Magnesiuric and calciuric effects of terbutaline in man
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Journal:
Clinical Science
Clin Sci (Lond) (1988) 74 (6): 595–597.
Published: 01 June 1988
...W. J. W. Bos; D. S. Postma; J. J. van Doormaal 1. The effect of terbutaline infusion over 4 h on serum levels of potassium, ionized calcium, phosphate and magnesium and urinary excretion of potassium, calcium, magnesium and adenosine 3′:5′-cyclic monophosphate was studied in six healthy volunteers...
Articles
Effect of plasma from hypertensive subjects on Ca 2+ transport in permeabilized human neutrophils
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Journal:
Clinical Science
Clin Sci (Lond) (1988) 74 (1): 53–56.
Published: 01 January 1988
... in subcellular particles, so that under excitatory conditions Ca 2+ release in arterial smooth muscle might be enhanced. 01 6 1987 25 6 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 calcium essential hypertension neutrophils Clinical Science (1988) 74,53-56...
Articles
Specific binding of atrial natriuretic peptide to rat mesenteric artery: Effect of calcium and 5-guanylylimidodiphosphate
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Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (6): 573–579.
Published: 01 December 1987
... with either C- or N -terminal amino acids missing still competed, while peptides without an intact disulphide bridge did not compete. 4. Neither the addition nor the removal of calcium affected the affinity or density of binding sites. Also the non-hydrolysable guanosine triphosphate analogue 5...
Articles
Resting and stimulated cytosolic free calcium levels in neutrophils from patients with Bartter's syndrome
Available to PurchaseFrancesco Di Virgilio, Lorenzo Calò, Salvatore Cantaro, Silvana Favaro, Antonio Piccoli, Arturo Borsatti
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (4): 483–488.
Published: 01 April 1987
...Francesco Di Virgilio; Lorenzo Calò; Salvatore Cantaro; Silvana Favaro; Antonio Piccoli; Arturo Borsatti 1. Cytosolic free calcium concentrations ([a 2+ ] i ) were measured in resting and chemotactic peptide-activated neutrophils from eight patients with Bartter's syndrome and compared with levels...
Articles
Binding of glycosaminoglycans to sodium urate and uric acid crystals
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Journal:
Clinical Science
Clin Sci (Lond) (1986) 71 (1): 61–64.
Published: 01 July 1986
... and almost complete binding of heparin and chondroitin sulphate to sodium urate crystals did occur in the presence of calcium, whereas pentosan polysulphate bound incompletely. The binding was much less pronounced in the calcium-free conditions. 4. Uric acid crystals did not bind any of the three inhibitors...
Articles
Cytoplasmic free [Ca 2+ ] is not increased in the platelets of deoxycorticosterone–salt and spontaneously hypertensive rats
Available to PurchaseKoh-Ichi Murakawa, Yoshiharu Kanayama, Masakazu Kohno, Takahiko Kawarabayashi, Kenichi Yasunari, Tadanao Takeda, Atsushi Hyono
Journal:
Clinical Science
Clin Sci (Lond) (1986) 71 (1): 121–123.
Published: 01 July 1986
...Koh-Ichi Murakawa; Yoshiharu Kanayama; Masakazu Kohno; Takahiko Kawarabayashi; Kenichi Yasunari; Tadanao Takeda; Atsushi Hyono 1. The cytoplasmic free calcium concentration ([Ca 2+ ] i ) in the platelets of spontaneously hypertensive rats (SHR), Wistar–Kyoto rats (WKY), deoxycorticosterone–salt...
Articles
Human calcitonin gene related peptide: a potent endogenous vasodilator in man
Available to PurchaseA. D. Struthers, M. J. Brown, D. W. R. Macdonald, J. L. Beacham, J. C. Stevenson, H. R. Morris, I. Macintyre
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (4): 389–393.
Published: 01 April 1986
..., CGRP produces vasodilatation and complex changes in plasma calcium. 2. We have now assessed its biological activity in man by infusing human CGRP (hCGRP) into six normal volunteers. hCGRP (545 pmol/min) caused the diastolic pressure to fall from 64 ± 5 to 55 ± 7mmHg ( P < 0.05), the heart rate...
Articles
Changes in bone and muscle constituents during dieting for obesity
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Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (3): 285–293.
Published: 01 March 1986
...Michael W. J. Davie; Ralph R. Abraham; Belinda Hewins; Victor Wynn 1. The effects of dietary carbohydrate (CHO) content and of tri-iodothyronine (T 3 ) administration on calcium, zinc and phosphate balances and on urinary hydroxyproline output were examined in eight obese subjects undergoing...
Articles
Calmodulin levels in hypertensive rats
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Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (4): 407–410.
Published: 01 April 1985
... calcium-dependent regulatory systems are genetically disrupted in spontaneously hypertensive rats, but this is probably not an important factor in the development of hypertension. 25 7 1984 8 10 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 calcium...
Articles
Some problems associated with adenylate cyclase bioassays for parathyroid hormone
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Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (3): 311–319.
Published: 01 March 1985
... humans, dogs or rats. 2. Because of the presence of non-specific inhibitors and stimulators of adenylate cyclase in human serum, each serum sample was assayed in the presence and in the absence of a specific PTH inhibitor and the difference was used to calculate PTH activity. 3. Calcium, an inhibitor...
Articles
Effect of the Calcium Antagonist Verapamil on Human Leucocyte Sodium Transport in vitro
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Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (2): 239–241.
Published: 01 February 1985
...H. H. Gray; L. Poston; V. E. Johnson; P. J. Hilton 1. Sodium efflux rate constants and intracellular sodium were measured in leucocytes from healthy volunteers in the presence and absence of the calcium antagonist verapamil hydrochloride. 2. Verapamil stimulated sodium pump activity and this effect...
Articles
Ca 2+ sources mobilized by α 1 -receptor activation in vascular smooth muscle
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Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 47s–50s.
Published: 01 January 1985
.... In addition, Ca2+ from the free extracellular CaZ+ pool enters through receptor operated channels, supporting the maintained tension development. Key words: blood vessel, calcium, a-receptor, smooth muscle. Abbreviations: POC, potential operated channels; PSS, physiological salt solution; ROC, receptor...
Articles
Inositol lipid breakdown as a step in α-adrenergic stimulus-response coupling
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Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 43s–46s.
Published: 01 January 1985
... The Biochemical Society and the Medical Research Society 1985 α 1 -adrenoceptors calcium 1,2-diacyglycerol inositol inositol 1,4,5-trisphosphate phosphatidylinositol 4,5-bisphosphate Clinical Science (1985) 68 (Suppl. lo), 43s-46s 43s Inositol lipid breakdown as a step in a-adrenergic stimulus...
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