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Keywords: calpain
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Articles

Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis

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Maria Klaude, Maiko Mori, Inga Tjäder, Thomas Gustafsson, Jan Wernerman, Olav Rooyackers
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (3): 133–142.
https://doi.org/10.1042/CS20110233
Published: 11 October 2011
... protein degradation rates are dramatically increased (up to 160%). Of the major proteolytic enzyme systems both the proteasome and the lysosomal systems had higher activities in the patients, whereas calpain and caspase activities were not changed. Gene expression of several genes related...
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Articles

Abnormalities in primary granule exocytosis in neutrophils from Type I diabetic patients with nephropathy

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Nicholas J.M. FARDON, Robert WILKINSON, Trevor H. THOMAS
Journal: Clinical Science
Clin Sci (Lond) (2002) 102 (1): 69–75.
https://doi.org/10.1042/cs1020069
Published: 10 December 2001
... incubation. The protein kinase C (PKC) inhibitor, bisindolylmaleimide (BIM), showed that a larger proportion of neutrophils from DN, compared with DC or NC, exocytosed primary granules independent of PKC. The calpain inhibitor, E64d, showed that a larger proportion of neutrophils from both groups of diabetic...
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