...Yiming Bo; Xin Zhao; Liliang Li Drug-induced cardiotoxicity has become one of the most common and detrimental health concerns, which causes significant loss to public health and drug resources. Cannabinoid receptors (CBRs) have recently achieved great attention for their vital roles...

... exposure of isolated mouse islets to cannabinoid receptor agonists on islet gene expression and function. Quantitative RT–PCR (reverse transcription–PCR) indicated that mRNAs encoding synthesis [NAPE-PLD ( N -acyl-phosphatidyl ethanolamide-hydrolysing phospholipase D)] and degradation [FAAH (fatty acid...

... on the intrahepatic microcirculation were, at least partly, mediated by the inhibition of hepatic TGF-β 1 activity, which was associated with decreased hepatic collagen deposition and the activated PLA 2 /eicosanoid cascade in cirrhotic livers. cannabinoid receptor cirrhosis eicosanoid increased intrahepatic...