... bleomycin administration. Inflammatory and fibrotic markers, as well as neurotrophin levels, were assessed in bronchoalveolar lavage fluid and/or lung tissue. Cough sensitivity to citric acid, capsaicin and allylisothiocyanate was evaluated in conscious animals at days 14 and 21 after bleomycin...

... occur with fenspiride was investigated in anaesthetized guinea pigs. Capsaicin (30 μmol/l) was used to increase baseline R aw through bronchoconstriction. Fenspiride gave a dose-dependent partial reversal of the raised R aw , and its administration by aerosol proved as efficacious as the intravenous...

... + fibres by neonatal treatment with capsaicin resulted in a marked increase in the number of RMCPII + and RMCPI/II + cells in lung and, even more, in spleen of adult rats. 3. The interaction of mast cells with CGRP + C-fibres was assessed pharmacologically by evaluation of the effects of histamine H 3...

...M. J. Barros; S. L. Zammattio; P. J. Rees 1. Twelve non-smoking subjects inhaled capsaicin at three different inspiratory flow rates: 50, 100 and 150 litres/min. Capsaicin was delivered by a breath-actuated dosimeter; inhalations consisted of 0.21–13.6 nmol of capsaicin in doubling amounts given...

...A. J. Winning; R. D. Hamilton; S. A. Shea; A. Guz 1. The respiratory and cardiovascular effects of capsaicin injection into the superior vena cava and an arm vein were studied in three normal subjects. 2. No changes were seen in tidal volume, inspiratory time or expiratory time after capsaicin...

... reflex. 4. Capsaicin, which is known to release substance P from primary afferents, mimicked the sympatho-inhibitory and cardiovascular effects of substance P when applied locally to the nucleus of the solitary tract. 5. The results are compatible with a transmitter or neuromodulatory role for substance...