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Keyword: captopril
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Articles
Clin Sci (Lond) (1998) 94 (4): 373-381.
Published: 01 April 1998
.... The offspring from these pregnancies were administered captopril either between 2 and 4 weeks of age, or from 10 to 12 weeks of age. 3. The feeding of low protein diets in pregnancy had no effect upon the reproductive ability of female rats and the offspring generated were of normal birthweight. By 4...
Articles
Clin Sci (Lond) (1991) 80 (3): 241-247.
Published: 01 March 1991
...-treated with inhalation of either saline or a combination of the peptidase inhibitors phosphoramidon (0.1 mmol/l: 60 breaths; 7.5 nmol), to inhibit neutral endopeptidase, and captopril (4.6 mmol/l: 60 breaths; 350 nmol), to inhibit angiotensin-converting enzyme. 2. Airway microvascular leakage was...
Articles
Clin Sci (Lond) (1990) 79 (2): 123-129.
Published: 01 August 1990
... studied first after the administration of captopril, a manoeuvre that increased renal plasma flow without a significant change in glomerular filtration rate, and a second time after receiving combined therapy with captopril and ibuprofen, a manoeuvre that decreased glomerular filtration rate without a...
Articles
Clin Sci (Lond) (1989) 76 (4): 353-356.
Published: 01 April 1989
... purpose, we studied the effects of captopril (a thiol-containing angiotensin converting enzyme inhibitor), enalapril (an angiotensin converting enzyme inhibitor without a thiol group) and cysteine (a thiol-containing amino acid which has no angiotensin converting enzyme-inhibitory action) in adriamycin...
Articles
Clin Sci (Lond) (1987) 72 (2): 165-170.
Published: 01 February 1987
... investigated the effects of α-human atrial natriuretic polypeptide (α-hANP) on the plasma concentrations of renin (PRC) and aldosterone (PAC), as well as the effects of captopril pretreatment on the natriuresis and blood pressure reduction induced by α-hANP in rats. 2. Although α-hANP infused into conscious...
Articles
Clin Sci (Lond) (1986) 70 (5): 453-460.
Published: 01 May 1986
...Wann-Chu Huang 1. The effects of verapamil infusion alone and superimposed with captopril on arterial pressure and bilateral renal function were evaluated in 21 two-kidney, one-clip Goldblatt hypertensive rats and in 13 control rats. 2. Verapamil significantly decreased arterial pressure of both...
Articles
Clin Sci (Lond) (1985) 68 (1): 49-56.
Published: 01 January 1985
...B. C. Campbell; Alessandra Sturani; J. L. Reid 1. Captopril (50 mg orally) produced a significant fall in systolic and diastolic blood pressure in six normotensive sodium replete subjects, without a rise in heart rate. 2. On captopril, there was no change in the expected normal increase in heart...
Articles
Clin Sci (Lond) (1984) 67 (2): 195-203.
Published: 01 August 1984
... frusemide administration to six normal subjects. Subjects received 40 mg of frusemide for 3 days during three different protocols: Na + intake 270 mmol/day (high salt); Na + intake 20 mmol/day to stimulate the renin-angiotensin-aldosterone system (low salt); Na + intake 270 mmol/day plus captopril (25 mg/6...
Articles
Clin Sci (Lond) (1984) 66 (6): 725-731.
Published: 01 June 1984
... not due to free fluid endocytosis. 5 9 1983 19 12 1983 © 1984 The Biochemical Society and the Medical Research Society 1984 angiotensin II receptors captopril platelets Clinical Science (1984) 66, 125-131 725 Receptors for angiotensin I1 on platelets from man YU AN DING...
Articles
Clin Sci (Lond) (1984) 66 (5): 541-544.
Published: 01 May 1984
...P. J. Harris; L. G. Navar; D. W. Ploth 1. The effects of captopril on mean arterial blood pressure and proximal tubular fluid re-absorption ( J v ) were examined in anaesthetized normotensive rats and in the non-clipped kidneys of two-kidney, one-clip Goldblatt hypertensive rats. 2. In the...
Articles
Clin Sci (Lond) (1983) 65 (6): 589-598.
Published: 01 December 1983
...Sheila M. Gardiner; T. Bennett 1. The effects of the orally active converting enzyme inhibitor, captopril (SQ 14225), on blood pressures and intakes and urine outputs of water and electrolytes were studied in rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain) and in Long...
Articles
Clin Sci (Lond) (1983) 65 (1): 37-42.
Published: 01 July 1983
... increased. The plasma renin activity and plasma aldosterone were unchanged. However, the urinary excretions of prostaglandin E 2 (U PGE2 V ) and kallikrein ( U kall. V ) were markedly decreased throughout the experiment. 2. With concurrent administration of captopril, the elevation of blood pressure was...
Articles
Clin Sci (Lond) (1983) 64 (5): 463-470.
Published: 01 May 1983
...Y. Takata; A. E. Doyle; M. Veroni; S. G. Duffy 1. Blood pressure, the hypotensive effect of captopril, plasma renin activity, renal renin content and kidney weight were measured in the two-kidney—one-clip model, the one-kidney—one-clip model and the two-kidney—one-clip model with the ureter of the...
Articles
Clin Sci (Lond) (1982) 63 (s8): 335s-338s.
Published: 01 October 1982
... NaCl solution before and after pretreatment with either captopril or [Sar 1 , Ile 8 ]angiotensin II. 2. Mild pressor responses accompanied by a reflex decrease in renal sympathetic nerve activity were a characteristic before pretreatment, but after baroreceptor denervation the cardiovascular response...
Articles
Clin Sci (Lond) (1982) 63 (s8): 443s-445s.
Published: 01 October 1982
...Veterans Administration Cooperative Study Group on Antihypertensive Agents; Barry J. Materson 1. We randomized 475 men whose diastolic blood pressure was 92–109 mmHg to either placebo- or captopril-treated (37.5, 75 and 150 mg/day) groups for 7 weeks. 2. After 7 weeks, the placebo-treated patients...
Articles
Clin Sci (Lond) (1982) 63 (s8): 243s-246s.
Published: 01 October 1982
...M. S. Golub; M. E. Berger; N. D. Vlachakis; P. Eggena; M. P. Sambhi 1. Changes in plasma renin activity, plasma noradrenaline and adrenaline, and blood pressure were evaluated after mild haemorrhage (6 ml/kg) and subsequent intravenous captopril in conscious, restrained rabbits. Two protocols were...
Articles
Clin Sci (Lond) (1982) 63 (s8): 211s-213s.
Published: 01 October 1982
... abolish excretion from the contralateral kidney. 2. Plasma renin activity (PRA), renal renin content (RRC) and the response of blood pressure to captopril were examined. 3. The increase of blood pressure produced by the application of a clip to one renal artery was slightly accelerated by the ureteral...
Articles
Clin Sci (Lond) (1982) 63 (s8): 175s-177s.
Published: 01 October 1982
...W. A. Hsueh; R. Goldstone; E. J. Carlson; R. Horton 1. Administration of a single dose of captopril, 50 mg, to normal man (n = 7) on a low salt intake induced a 12.5 ± 0.9-fold rise in active renin. The rise in active renin was associated with a reciprocal decrease in circulating inactive renin to...
Articles
Clin Sci (Lond) (1982) 63 (s8): 261s-263s.
Published: 01 October 1982
...A. Salvetti; R. Pedrinelli; A. Magagna; P. Ugenti 1. The finding that sulindac, in contrast to indomethacin, does not inhibit renal prostaglandins synthesis in humans, prompted us to study the role that systemic and/or renal prostaglandins can play in the pharmacological responses to captopril...
Articles
Clin Sci (Lond) (1982) 63 (s8): 265s-267s.
Published: 01 October 1982
...H. Witzgall; B. Scherer; P. C. Weber 1. Haemodynamic and hormonal actions of 100 mg of captopril (SQ 14 225) orally were tested in 12 healthy volunteers with and without indomethacin pretreatment. 2. Without indomethacin, mean arterial blood pressure was reduced at 30 and 60 min after captopril ( P...
Articles
Clin Sci (Lond) (1982) 62 (6): 611-615.
Published: 01 June 1982
...H. Witzgall; F. Hirsch; B. Scherer; P. C. Weber 1. The acute haemodynamic and hormonal effects of 100 mg of captopril (SQ 14.225) orally were tested in twelve healthy men in the sodium replete state before and after indomethacin pre-treatment. 2. Without indomethacin, mean arterial blood pressure...
Articles
Clin Sci (Lond) (1982) 62 (2): 169-176.
Published: 01 February 1982
... unchanged by sodium meclofenamate, an inhibitor of prostaglandin synthesis, or captopril, an inhibitor of the angiotensin converting enzyme. 3. Haemorrhage doubled plasma adrenaline and noradrenaline levels. Plasma renin activity trebled after haemorrhage and was further elevated by captopril. 4. Renal...
Articles
Clin Sci (Lond) (1981) 61 (5): 521-526.
Published: 01 November 1981
.... The effects of nitroprusside on the above variables were also studied after pre-treatment with captopril, to allow assessment of the role of angiotensin II. 2. Nitroprusside given in doses ranging from 7.5 to 150 μg/min elicited dose-related decreases in resting blood pressure and rise in heart rate...
Articles
Clin Sci (Lond) (1981) 61 (3): 281-286.
Published: 01 September 1981
...M. G. Collis; J. R. Keddie 1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat mesenteric arteries...
Articles
Clin Sci (Lond) (1981) 61 (2): 175-180.
Published: 01 August 1981
...Hiromichi Suzuki; Kazuoki Kondo; Michiko Handa; Takao Saruta 1. To examine the possible participation of the brain iso-renin-angiotensin system in the control of blood pressure, as well as in the regulation of plasma renin activity, saralasin and captopril were injected into the cerebral ventricles...
Articles
Clin Sci (Lond) (1981) 61 (1): 97-105.
Published: 01 July 1981
...R. A. Banks; L. J. Beilin 1. Systemic and regional vascular changes were measured in conscious rabbits after intravenous sodium meclofenamate, captopril and phentolamine. These drugs were used respectively to inhibit prostaglandin synthesis and angiotensin-converting enzyme, and to block α...
Articles
Clin Sci (Lond) (1981) 60 (5): 591-593.
Published: 01 May 1981
...S. Rasmussen; M. Damkjaer Nielsen; J. Giese 1. We have measured plasma concentrations of renin, renin substrate and angiotensins I and II as well as plasma renin activity in nine patients with severe or malignant hypertension during treatment with captopril, hydrochlorothiazide and propranolol. 2...
Articles
Clin Sci (Lond) (1981) 60 (4): 387-392.
Published: 01 April 1981
...R. Vandongen; Anne Tunney; Patricia Martinez 1. Arterial plasma renin activity was significantly elevated in rats with one-kidney, one-clip hypertension of less than 3 weeks duration. 2. Intraperitoneal injection of the angiotensin-converting enzyme inhibitor SQ 14 225 (captopril) caused a dose...
Articles
Clin Sci (Lond) (1981) 61 (s7): 285s-287s.
Published: 01 January 1981
...A. Mimran; J. Ribstein 1. Systemic, humoral and renal responses to isotonic volume expansion (1800 ml in 3 h) were assessed in normal subjects before and during captopril administration. 2. Captopril, which otherwise induced a decrease in pre-saline mean arterial pressure (MAP), unmasked the volume...
Articles
Clin Sci (Lond) (1981) 61 (s7): 149s-152s.
Published: 01 January 1981
... < 0.05) and in UVP from 42 ± 7 to 67 ± 17 pmol/day ( P < 0.05). On the other hand, a single dose of captopril (1 mg/kg body weight) administered to the same patients did not alter PVP (1.68 ± 0.43 pmol/l) and UVP (40 ± 6 pmol/day) despite a similar blood pressure decrease. 4. In a group of 10...
Articles
Clin Sci (Lond) (1981) 61 (s7): 289s-293s.
Published: 01 January 1981
... rose by a similar extent in both groups. 3. In order to evaluate the role of endogenous angiotensin II, captopril, a converting enzyme inhibitor, was administered to six patients with APA and five patients with IHA at a dose of 75 mg/day for 1 week. There was a significant fall of mean blood pressure...
Articles
Clin Sci (Lond) (1981) 61 (s7): 441s-444s.
Published: 01 January 1981
...J. Staessen; R. Fagard; P. Lijnen; L. J. Verschueren; A. Amery 1. With a double-blind cross-over protocol, 20 hypertensive captopril-treated patients were studied by adding in a variable sequence a placebo and propranolol (80 mg three times a day) to their captopril regimen (200 mg three times a...
Articles
Clin Sci (Lond) (1981) 61 (s7): 395s-398s.
Published: 01 January 1981
.... Angiotensin converting enzyme inhibition with captopril appears to be the treatment of choice at present, but methyldopa or minoxidil may be successful in certain patients whose response to captopril is not satisfactory. © 1981 The Biochemical Society and the Medical Research Society 1981...
Articles
Clin Sci (Lond) (1981) 61 (s7): 223s-225s.
Published: 01 January 1981
... nerve activity from the right renal nerves were recorded in anaesthetized, spontaneously breathing, non diuretic rats, either with an intact spinal cord or with a spinal cord transected at the T6 level, before, during and after intravenous injections of 0.5–1.0 mg/kg of teprotide or captopril. 3. After...
Articles
Clin Sci (Lond) (1981) 61 (s7): 277s-280s.
Published: 01 January 1981
.... Teprotide was the least potent inhibitor with a K 1 of near 20 nmol/l whereas captopril (SQ 14 225) and SA 446 were both approximately 10 times and MK 421 approximately 20 times more potent. 5. Two inhibitors which lacked thiol groups [teprotide or SQ 20 881 and N -(1- S -1-carboxy-3-phenylpropyl)- l -Ala...
Articles
Clin Sci (Lond) (1980) 59 (6): 451-456.
Published: 01 December 1980
...M. Tree; J. J. Morton 1. Captopril infused into sodium-loaded dogs produced a fall in both blood pressure [117 ± 9.7 to 96.6 ± 11.4 (sd) mmHg] and plasma angiotensin II [11.0 ± 3.0 to 1.6 ± 1.3 (sd) pmol/l]. Plasma aldosterone fell while both blood angiotensin I and renin concentration rose. 2...
Articles
Clin Sci (Lond) (1980) 58 (6): 445-450.
Published: 01 June 1980
...J. J. Morton; M. Tree; J. Casals-Stenzel 1. Changes in arterial blood pressure, blood angiotensin I, plasma angiotensin II and plasma angiotensin III were measured in conscious sodium—depleted dogs after infusion of captopril, an orally active inhibitor of converting enzyme. 2. Angiotensins II and...
Articles
Clin Sci (Lond) (1980) 58 (1): 1-6.
Published: 01 January 1980
...E. S. Marks; R. F. Bing; H. Thurston; J. D. Swales 1. The peptide converting enzyme inhibitor captopril was given (1·25 mg/kg intravenously) to normal and nephrectomized rats and rats with renovascular and deoxycorticosterone hypertension. 2. Captopril lowered blood pressure to a small extent in...
Articles
Clin Sci (Lond) (1980) 59 (s6): 95s-99s.
Published: 01 January 1980
...G. A. MacGregor; N. D. Markandu; J. E. Roulston; J. C. Jones; J. J. Morton 1. Captopril given for 5 days caused a fall in blood pressure in normotensive subjects. The percentage fall in mean supine pressure was greatest on a low sodium diet (10 mmol/day), 19.6%, least on a high sodium diet (350...
Articles
Clin Sci (Lond) (1980) 59 (s6): 65s-69s.
Published: 01 January 1980
...J. A. Millar; D. J. Casey; C. I. Johnston 1. The effect of continuous infusion of captopril (80 μg/h) for up to 5 days on blood pressure, adrenal angiotensin II receptors and vascular reactivity to exogenous angiotensin II, arginine vasopressin and noradrenaline was studied in the rat. 2. In...
Articles
Clin Sci (Lond) (1980) 59 (s6): 71s-74s.
Published: 01 January 1980
...S. C. Textor; H. R. Brunner; H. Gavras 1. To investigate the non-angiotensin effects of converting enzyme inhibition, angiotensin II was infused intravenously at 30 ng/min for 9 days in conscious rats to produce moderate blood pressure elevation. One group was given captopril (SQ 14 225) by gavage...
Articles
Clin Sci (Lond) (1980) 59 (s6): 75s-78s.
Published: 01 January 1980
... restriction with appropriately elevated plasma angiotensin II levels (group 2) and in sodium-restricted subjects in whom plasma angiotensin II was suppressed by converting enzyme inhibition with captopril (group 3). 2. The action of saralasin was agonistic in group 3, antagonistic in group 2 and variable in...
Articles
Clin Sci (Lond) (1980) 59 (s6): 79s-82s.
Published: 01 January 1980
... min. 4. Saralasin or captopril also lowered blood pressure of spontaneously hypertensive rats, but progressively over a period of 3 h. 5. The results suggest that dopamine and angiotensin have opposite effects on the neurosecretion of vasopressin. 6. Vasopressin appears to be involved in maintenance...
Articles
Clin Sci (Lond) (1980) 59 (s6): 175s-178s.
Published: 01 January 1980
... dipeptidyl carboxypeptidase inhibitor captopril (250 μg) during continuous saralasin-induced angiotensin II blockade (10 μg/min). Dietary sodium restriction alone in sham-operated rats had no effect. 2. Acute bilateral adrenalectomy (18-24 h) did not preclude the demonstration of an augmented response to...
Articles
Clin Sci (Lond) (1980) 59 (s6): 83s-86s.
Published: 01 January 1980
...J. H. B. De Bruyn; G. J. Wenting; A. J. Man in 'T Veld; F. H. M. Derkx; M. A. D. H. Schalekamp 1. The haemodynamic effects of 100 mg of captopril in renovascular hypertension ( n = 11), essential hypertension ( n = 12) and the anephric state ( n = 7) were compared. Brachial artery pressure was...
Articles
Clin Sci (Lond) (1980) 59 (s6): 141s-144s.
Published: 01 January 1980
...Keishi Abe; Toru Ito; Makito Sato; Toshiaki Haruyama; KO Sato; Ken Omata; Masao Hiwatari; Yutaka Sakurai; Yutaka Imai; Kaoru Yoshinaga 1. The role of endogenous prostaglandins in the antihypertensive mechanism of the angiotensin converting enzyme inhibitor, captopril, was investigated. 2. An...
Articles
Clin Sci (Lond) (1979) 57 (s5): 145s-148s.
Published: 01 January 1979
...G. A. MacGregor; N. D. Markandu; J. E. Roulston 1. Propranolol, saralasin and captopril changed blood pressure in normotensive as well as hypertensive subjects. 2. The percentage change in blood pressure with these three drugs for a given plasma renin activity was similar in normotensive and...
Articles
Clin Sci (Lond) (1979) 57 (s5): 153s-155s.
Published: 01 January 1979
... angiotensin coverting enzyme inhibitor captopril (SQ 14 225) was given. Three hours later blood pressures were measured again. 3. During the first 3 weeks of psychosocial hypertension SQ 14 225 was without effect. But at 1 month and subsequently up to 7 months, SQ 14 225 reduced blood pressure to the normal...
Articles
Clin Sci (Lond) (1979) 57 (s5): 313s-316s.
Published: 01 January 1979
...D. B. Case; S. A. Atlas; J. H. Laragh 1. Saralasin and converting enzyme inhibitors SQ 20881 and captopril induced increases in plasma renin activity to greater than 14 ng h −1 ml −1 in 43 out of 44 patients with untreated renovascular hypertension when studied in the seated position and on normal...
Articles
Clin Sci (Lond) (1979) 57 (s5): 371s-373s.
Published: 01 January 1979
...Connie S. McCaa; H.G. Langford; W. C. Cushman; R. E. McCaa 1. The response of arterial blood pressure, plasma renin activity and plasma aldosterone concentration to inhibition of angiotensin I converting enzyme (kininase II) with captopril has been studied in patients with severe, treatment...