... and anxiety disorders, we increased fetal glucocorticoid exposure by administering the 11β-HSD inhibitor CBX (carbenoxolone; 12 mg·kg −1 of body weight·day −1 ) during the final week of murine gestation. We hypothesized that maternal antioxidant (tempol throughout pregnancy) would block glucocorticoid...

...]oxadiazolo[4,3-a]quinoxalin-1-one; 10 μ M) did not significantly alter the response to bradykinin (pEC 50 9.4±0.2; n = 9). The gap junction inhibitor carbenoxolone (100 μ M) did not affect the relaxation produced by bradykinin (pEC 50 , 9.7±0.1; R max , 100±3.2%; n = 6), but it significantly depressed R max...

... of the radioisotopes were monitored. Half of the rats received intravenous carbenoxolone to inhibit renal 11β-HSD activity. The urinary recovery of [ 14 C]inulin was complete in both groups of animals (101ŷ2% versus 101ŷ3%), but the recovery of 22 Na was lower in carbenoxolone-treated rats (34ŷ5%) than...

... glucocorticoids, has been suggested to underlie effects of low protein diets on fetal growth and blood pressure. 2. Pregnant rats were fed control (18% casein) or low protein (9% casein) diets throughout gestation. Animals fed the control diet were injected with carbenoxolone, an inhibitor of 11β-hydroxysteroid...

.... after liquorice ingestion) results in cortisol acting as a potent mineralocorticoid. We have evaluated the effect of the synthetic liquorice derivative, carbenoxolone, on this enzyme complex. 2. Carbenoxolone given to six volunteers in metabolic balance produced sodium retention with suppression...

...N. B. Roberts; W. H. Taylor 1. Carbenoxolone, in suspension at pH 4·0, inhibits swine pepsin A, and human pepsins 1, 3 and 5. Human pepsin 5 is the most readily inhibited, and human pepsin 1 the least. 2. Inhibition occurs by a process which is time-dependent, temperature-dependent and proportional...