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Keywords: carbon dioxide
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Articles

Impact of transient hypotension on regional cerebral blood flow in humans

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Nia C.S. Lewis, Kurt J. Smith, Anthony R. Bain, Kevin W. Wildfong, Tianne Numan, Philip N. Ainslie
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (2): 169–178.
https://doi.org/10.1042/CS20140751
Published: 24 April 2015
...-body negative pressure (LBNP) until pre-syncope to inflict hypotension. End-tidal carbon dioxide was clamped at baseline levels (isocapnic trial) or uncontrolled (poikilocapnic trial). Middle cerebral artery (MCA) and posterior cerebral artery (PCA) blood velocities (transcranial Doppler; TCD), heart...
View articletitled, Impact of transient hypotension on regional cerebral blood flow in humans
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Articles

Effects of breathing air containing 3% carbon dioxide, 35% oxygen or a mixture of 3% carbon dioxide/35% oxygen on cerebral and peripheral oxygenation at 150 m and 3459 m

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C.H.E. IMRAY, S. WALSH, T. CLARKE, C. TIIVAS, H. HOAR, T.C. HARVEY, C.W.M. CHAN, P.J.G. FORSTER, A.R. BRADWELL, A.D. WRIGHT
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (3): 203–210.
https://doi.org/10.1042/cs1040203
Published: 28 January 2003
...C.H.E. IMRAY; S. WALSH; T. CLARKE; C. TIIVAS; H. HOAR; T.C. HARVEY; C.W.M. CHAN; P.J.G. FORSTER; A.R. BRADWELL; A.D. WRIGHT The effects of gas mixtures comprising supplementary 3% carbon dioxide, 35% oxygen or a combination of 3% CO 2 plus 35% O 2 in ambient air have been compared on arterial blood...
View articletitled, Effects of breathing air containing 3% carbon dioxide, 35% oxygen or a mixture of 3% carbon dioxide/35% oxygen on cerebral and peripheral oxygenation at 150 m and 3459 m
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Articles

Inhibition of aquaporin-mediated CO2 diffusion and voltage-gated H+ channels by zinc does not alter rabbit lung CO2 and NO excretion

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Erik R. SWENSON, Steven DEEM, Mark E. KERR, Akhil BIDANI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (6): 567–575.
https://doi.org/10.1042/cs1030567
Published: 14 November 2002
... 2 elimination. Correspondence : Dr Erik R. Swenson (e-mail [email protected] ). 15 5 2002 8 8 2002 17 9 2002 The Biochemical Society and the Medical Research Society © 2002 2002 aquaporin carbon dioxide carbonic anhydrase gas exchange lungs nitric...
View articletitled, Inhibition of aquaporin-mediated CO2 diffusion and voltage-gated H+ channels by zinc does not alter rabbit lung CO2 and NO excretion
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Articles

Carbon dioxide, critical closing pressure and cerebral haemodynamics prior to vasovagal syncope in humans

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Brian J. CAREY, Penelope J. EAMES, Ronney B. PANERAI, John F. POTTER
Journal: Clinical Science
Clin Sci (Lond) (2001) 101 (4): 351–358.
https://doi.org/10.1042/cs1010351
Published: 04 September 2001
... blood flow velocities (CBFVs) were measured using transcranial Doppler ultrasound, along with simultaneous measures of MCA blood pressure, heart rate, and end-tidal and transcutaneous carbon dioxide concentrations. All 16 patients and 14 of the control subjects developed VVS during HUT. During pre...
View articletitled, Carbon dioxide, critical closing pressure and cerebral haemodynamics prior to vasovagal syncope in humans
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Articles

Carbon dioxide contributes to the beneficial effect of pressurization in a portable hyperbaric chamber at high altitude

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Christopher H. E. IMRAY, Timothy CLARKE, Peter J. G. FORSTER, Timothy C. HARVEY, Helen HOAR, Sarah WALSH, Alexander D. WRIGHT
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (2): 151–157.
https://doi.org/10.1042/cs1000151
Published: 02 January 2001
... pressurization. The effects of the accumulation of carbon dioxide within the chamber on r S O 2 and S p O 2 have also been investigated. Three studies of cerebral regional oxygenation were undertaken, using near-IR spectroscopy, in subjects who had ascended to 3475 m in the Alps, 4680 m in the Andes or 5005 m...
View articletitled, Carbon dioxide contributes to the beneficial effect of pressurization in a portable hyperbaric chamber at high altitude
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Articles

Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects

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N. CHAPMAN, G. HAIMES, A. V. STANTON, S. A. THOM, A. D. HUGHES
Journal: Clinical Science
Clin Sci (Lond) (2000) 99 (6): 483–488.
https://doi.org/10.1042/cs0990483
Published: 07 November 2000
... narrowed angles in hypertensive subjects could be explained by increased tone in the retinal arteriolar bed. blood pressure carbon dioxide optimality principles oxygen retinal vascular geometry 483Clinical Science (2000) 99, 483 488 (Printed in Great Britain) Acute effects of oxygen and carbon...
View articletitled, Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects
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Articles

Evaluation of potential factors affecting the measurement of cerebrovascular reactivity by near-infrared spectroscopy

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Rocco TOTARO, Giovanna BARATTELLI, Valentina QUARESIMA, Antonio CAROLEI, Marco FERRARI
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (4): 497–504.
https://doi.org/10.1042/cs0950497
Published: 01 October 1998
... reactivity and might be considered, after appropriate validation, for the assessment of patients with cerebrovascular disease. Correspondence : Dr V. Quaresima. 16 3 1998 15 5 1998 27 5 1998 The Biochemical Society and the Medical Research Society © 1998 1998 carbon dioxide...
View articletitled, Evaluation of potential factors affecting the measurement of cerebrovascular reactivity by near-infrared spectroscopy
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Articles

Recovery of 13 CO 2 and 14 CO 2 in Human Bicarbonate Studies: A Critical Review with Original Data

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D. P. C. Leijssen, M. Elia
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (6): 665–677.
https://doi.org/10.1042/cs0910665
Published: 01 December 1996
... 1996 carbon dioxide labelled carbon dioxide loss of label methodology recovery database Clinical Science (1996) 91, 665-677 (Printed in Great Britain) Recovery of I3CO2 and I4CO2 in human bicarbonate studies: a critical review with original data D. P. C. LEIJSSEN and M. ELlA Dunn Clinical...
View articletitled, Recovery of 13 CO 2 and 14 CO 2 in Human Bicarbonate Studies: A Critical Review with Original Data
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Articles

Recovery of 13 C in Breath from Infused NaH 13 CO 3 Increases During Euglycaemic Hyperinsulinaemia

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D. Reaich, K. A. Graham, B. G. Cooper, C. M. Scrimgeour, T. H. J. Goodship
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (4): 415–419.
https://doi.org/10.1042/cs0870415
Published: 01 October 1994
... committee of Newcastle Health Authority and the University of Newcastle upon Type. Isotopes and glucose NaHI3CO3 (99 mol% 13C) was purchased from Promochem, St Albans, Herts, U.K. It was diluted ~~ Key words bicarbonate, carbon dioxide, hyperinsulinaemic clamp, indirect calorimetry, stable isotopes...
View articletitled, Recovery of 13 C in Breath from Infused NaH 13 CO 3 Increases During Euglycaemic Hyperinsulinaemia
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Articles

Interpretation of Oxygen and Carbon Dioxide Exchange across Tissue Beds in vivo

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Keith N. Frayn, Patricia Lund, Mark Walker
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (4): 373–384.
https://doi.org/10.1042/cs0850373
Published: 01 October 1993
...Keith N. Frayn; Patricia Lund; Mark Walker © 1993 The Biochemical Society and the Medical Research Society 1993 adipose tissue arteriovenous differences carbon dioxide indirect calorimetry muscle oxygen respiratory quotient substrate oxidation Clinical S c i i e (1993) 85, 373...
View articletitled, Interpretation of Oxygen and Carbon Dioxide Exchange across Tissue Beds in vivo
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Articles

Effect of bicarbonate administration on skeletal muscle intracellular pH in the rat: implications for acute administration of bicarbonate in man

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Campbell H. Thompson, Paul D. Syme, E. Mark Williams, John G. G. Ledingham, George K. Radda
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (5): 559–564.
https://doi.org/10.1042/cs0820559
Published: 01 May 1992
... acidosis in rat skeletal muscle in vivo. When the bicarbonate was administered intravenously there was no such change in the pH of the skeletal muscle. 3. Bicarbonate administration by either route resulted in an elevated mixed venous partial pressure of carbon dioxide and an elevated arterial pH...
View articletitled, Effect of bicarbonate administration on skeletal muscle intracellular pH in the rat: implications for acute administration of bicarbonate in man
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Articles

Detection of Hypercapnia by Normal Subjects

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R. M. Schwartzstein, K. La Hive, A. Pope, R. A. Steinbrook, D. E. Leith, J. W. Weiss, V. Fencl, S. E. Weinberger
Journal: Clinical Science
Clin Sci (Lond) (1987) 73 (3): 333–335.
https://doi.org/10.1042/cs0730333
Published: 01 September 1987
... of ventilation. Key words: carbon dioxide, end-tidal Pco2, ventilation. Abbreviations: HCVR, ventilatory response to hyper- capnia; MVV, maximal voluntary ventilation; PETco2, end-tidal Pc02 *Present address: Department of Anesthesia, Brigham and Women's Hospital, Boston, MA 02115, U.S.A. t Present address...
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Articles

Influence of blood gases, Ca 2+ -entry blockade and angiotensin converting enzyme inhibition on pressor responses to α-adrenoceptor agonists: evidence in vivo for subtypes of response independent of receptor subtype?

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J. W. O'Brien, N. A. Flavahan, T. L. Grant, J. C. McGrath, R. J. Marshall
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 99s–104s.
https://doi.org/10.1042/cs068s099
Published: 01 January 1985
... them. © 1985 The Biochemical Society and the Medical Research Society 1985 α-adrenoceptor agonists angiotensin blood pressure Ca 2+ -entry blockade carbon dioxide nifedipine oxygen vascular smooth muscle Clinical Science (1985) 68 (Suppl. lo), 99s-104s 99s Influence of blood gases...
View articletitled, Influence of blood gases, Ca 2+ -entry blockade and angiotensin converting enzyme inhibition on pressor responses to α-adrenoceptor agonists: evidence in vivo for subtypes of response independent of receptor subtype?
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Articles

Role of Impaired Inspiratory Muscle Function in Limiting the Ventilatory Response to Carbon Dioxide in Chronic Airflow Obstruction

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H. R. Gribbin, I. T. Gardiner, G. J. Heinz, III, G. J. Gibson, N. B. Pride
Journal: Clinical Science
Clin Sci (Lond) (1983) 64 (5): 487–495.
https://doi.org/10.1042/cs0640487
Published: 01 May 1983
... Science (1983) 64,487495 487 Role of impaired inspiratory muscle function in limiting the ventilatory response to carbon dioxide in chronic airflow obstruction H. R. GRIBBIN, I. T. GARDINER, G. J. H E I N Z 111, G. J. GIBSON A N D N. B. P R I D E Department of Medicine, Royal Postgraduate Medical School...
View articletitled, Role of Impaired Inspiratory Muscle Function in Limiting the Ventilatory Response to Carbon Dioxide in Chronic Airflow Obstruction
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Articles

Recovery of Infused [ 14 C]Bicarbonate as Respiratory 14 CO 2 in Man

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Graeme A. Clugston, Peter J. Garlick
Journal: Clinical Science
Clin Sci (Lond) (1983) 64 (2): 231–233.
https://doi.org/10.1042/cs0640231
Published: 01 February 1983
... © 1983 The Biochemical Society and the Medical Research Society 1983 carbon dioxide [ 14 C]bicarbonate leucine oxidation protein turnover Clinical Science (1983) 64,23 1-233 SHORT COMMUNICATION 23 1 Recovery of infused [14C]bicarbonate as respiratory 14C02 in man GRAEME A. CLUGSTON...
View articletitled, Recovery of Infused [ 14 C]Bicarbonate as Respiratory 14 CO 2 in Man
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Articles

The Effects on Respiration in the Cat of the Sudden Excitation of Cerebral Vascular Nociceptors by Carbon Dioxide

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M. A. Hanson, P. C. G. Nye, R. W. Torrance
Journal: Clinical Science
Clin Sci (Lond) (1982) 63 (6): 505–511.
https://doi.org/10.1042/cs0630505
Published: 01 December 1982
... for headache. 15 6 1982 27 7 1982 © 1994 The Biochemical Society and the Medical Research Society 1994 respiratory timing vascular nociceptors cerebral arteries headache carbon dioxide phenyl diguanide meningeal blood vessels Clinical Science (1982) 63,505-5 11 505 The effects...
View articletitled, The Effects on Respiration in the Cat of the Sudden Excitation of Cerebral Vascular Nociceptors by Carbon Dioxide
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Articles

Chemosensitivity in Patients with Diabetic Neuropathy

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Ikuo Homma, Shigeru Kageyama, Takeshi Nagai, Ikuo Taniguchi, Toshio Sakai, Masakazu Abé
Journal: Clinical Science
Clin Sci (Lond) (1981) 61 (5): 599–603.
https://doi.org/10.1042/cs0610599
Published: 01 November 1981
... carbon dioxide chemosensitivity diabetic neuropathy rebreathing ventilation Clinical Science (198 1) 61,599-603 599 Chemosensitivity in patients with diabetic neuropathy I K U O H O M M A , S H I G E R U K A G E Y A M A * , T A K E S H I N A G A I , I K U O T A N I G U C H I * , T O S H I O S A K...
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Articles

Methods to Assess Breathlessness in Healthy Subjects: A Critical Evaluation and Application to Analyse the Acute Effects of Diazepam and Promethazine on Breathlessness Induced by Exercise or by Exposure to Raised Levels of Carbon Dioxide

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R. D. Stark, S. A. Gambles, J. A. Lewis
Journal: Clinical Science
Clin Sci (Lond) (1981) 61 (4): 429–439.
https://doi.org/10.1042/cs0610429
Published: 01 October 1981
... carbon dioxide in a double-blind study. 4. During exercise, diazepam and promethazine did not reduce breathlessness, although there was a minor trend with promethazine. During exposure to elevated levels of carbon dioxide, diazepam and promethazine had no effect on breathlessness. Diazepam...
View articletitled, Methods to Assess Breathlessness in Healthy Subjects: A Critical Evaluation and Application to Analyse the Acute Effects of Diazepam and Promethazine on Breathlessness Induced by Exercise or by Exposure to Raised Levels of Carbon Dioxide
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Articles

Estimation of Cardiac Output from the Rate of Change of Alveolar Carbon Dioxide Pressure during Rebreathing

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Mary Winsborough, J. N. Miller, D. W. Burgess, G. Laszlo
Journal: Clinical Science
Clin Sci (Lond) (1980) 58 (4): 263–270.
https://doi.org/10.1042/cs0580263
Published: 01 April 1980
... 1979 © 1980 The Biochemical Society and the Medical Research Society 1980 carbon dioxide cardiac output indirect Fick method nitrous oxide rebreathing Clinical Science (1980) 58,263-270 Estimation of cardiac output from the rate of change of alveolar carbon dioxide pressure during...
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Articles

Carbon Dioxide Equilibration in Canine Lungs during Rebreathing and Acute Alkalosis

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R. D. Latimer, G. Laszlo
Journal: Clinical Science
Clin Sci (Lond) (1979) 57 (5): 385–388.
https://doi.org/10.1042/cs0570385
Published: 01 November 1979
... 1 6 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 acid—base alkalosis alveolar—arterial difference carbon dioxide Clinical Science (1979) 51,385-388 Carbon dioxide equilibration in canine lungs during rebreathing and acute alkalosis R. D. LATIMER A N D...
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Articles

The Respiratory Response to Inhaled Carbon Dioxide in Man after 3 Hours Exposure to 3% Carbon Dioxide

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K. Prowse, C. Duvivier, R. Peslin, P. Sadoul
Journal: Clinical Science
Clin Sci Mol Med (1978) 55 (3): 309–316.
https://doi.org/10.1042/cs0550309
Published: 01 September 1978
... 1978 carbon dioxide environmental chamber hypercapnia pulmonary viscous work respiratory response to CO 2 ventilatory response to CO 2 Clinical Science and Molecular Medicine (1978), 55,309-3 16 The respiratory response to inhaled carbon dioxide in man after 3 hours exposure to 3% carbon...
View articletitled, The Respiratory Response to Inhaled Carbon Dioxide in Man after 3 Hours Exposure to 3% Carbon Dioxide
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Articles

Ventilatory Responses to Exercise and to Carbon Dioxide in Mitral Stenosis before and after Valvulotomy: Causes of Tachypnoea

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J. W. Reed, M. Ablett, J. E. Cotes
Journal: Clinical Science
Clin Sci Mol Med (1978) 54 (1): 9–16.
https://doi.org/10.1042/cs0540009
Published: 01 January 1978
...J. W. Reed; M. Ablett; J. E. Cotes 1. The ventilation and cardiac frequency during progressive exercise and the respiratory responses to breathing carbon dioxide have been measured in 33 female patients with mitral stenosis and in 31 control subjects. Compared with the control subjects...
View articletitled, Ventilatory Responses to Exercise and to Carbon Dioxide in Mitral Stenosis before and after Valvulotomy: Causes of Tachypnoea
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Articles

Intracellular pH and Bicarbonate Concentration as Determined in Biopsy Samples from the Quadriceps Muscle of Man at Rest

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K. Sahlin, A. Alvestrand, J. Bergström, E. Hultman
Journal: Clinical Science
Clin Sci Mol Med (1977) 53 (5): 459–466.
https://doi.org/10.1042/cs0530459
Published: 01 November 1977
...K. Sahlin; A. Alvestrand; J. Bergström; E. Hultman 1. A method for measuring intracellular pH and bicarbonate concentration of human muscle is described. 2. Muscle biopsies from the quadriceps muscle of 13 healthy subjects at rest were analysed for acid-labile carbon dioxide and volume of extra...
View articletitled, Intracellular pH and Bicarbonate Concentration as Determined in Biopsy Samples from the Quadriceps Muscle of Man at Rest
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Articles

Lack of Dependence of Urine P co 2 upon Reduction of Glomerular Filtration Rate in Alkalotic Dogs

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B. J. Stinebaugh, T. H. Hostetter, R. A. Peraino, F. X. Schloeder, W. N. Suki
Journal: Clinical Science
Clin Sci Mol Med (1977) 52 (2): 119–123.
https://doi.org/10.1042/cs0520119
Published: 01 February 1977
... appeared more important than their excretion rates in the maintenance of elevated U—B P co 2 values. 14 6 1976 24 8 1976 © 1977 The Biochemical Society and the Medical Research Society 1977 alkalosis carbon dioxide glomerular filtration rate P co 2 Clinical Science...
View articletitled, Lack of Dependence of Urine P co 2 upon Reduction of Glomerular Filtration Rate in Alkalotic Dogs
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Articles

Arterial Oxygenation and Carbon Dioxide Tensions in the Production of Hypoxic Electroencephalographic Changes in Man

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A. S. Rebuck, C. Davis, D. Longmire, A. R. M. Upton, A. C. P. Powles
Journal: Clinical Science
Clin Sci Mol Med (1976) 50 (4): 301–306.
https://doi.org/10.1042/cs0500301
Published: 01 April 1976
... dioxide electroencephalogram hypoxia oxygen Clinical Science and Molecular Medicine (1976) 50, 301-306. Arterial oxygenation and carbon dioxide tensions in the production of hypoxic electroencephalographic changes in man A. S. REBUCK, C. DAVIS, D. LONGMIRE, A. R. M. UPTON AND A. C. P. POWLES...
View articletitled, Arterial Oxygenation and Carbon Dioxide Tensions in the Production of Hypoxic Electroencephalographic Changes in Man
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Articles

Effect of Liver Failure on the Response of Ventilation and Cerebral Circulation to Carbon Dioxide in Man and in the Goat

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N. N. Stanley, B. G. Salisbury, L. C. McHenry, Jr, N. S. Cherniack
Journal: Clinical Science
Clin Sci Mol Med (1975) 49 (2): 157–169.
https://doi.org/10.1042/cs0490157
Published: 01 August 1975
... is increased. 7 1 1975 © 1975 The Biochemical Society and the Medical Research Society 1975 Clinical Science and Molecular Medicine (1975) 49, 157-169. Effect of liver failure on the response of ventilation and cerebral circulation to carbon dioxide in man and in the goat N. N. STANLEY, B. G...
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Articles

Effect of Ethanol on the Ventilatory Responses to Oxygen and Carbon Dioxide in Man

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S. A. Sahn, S. Lakshminarayan, D. J. Pierson, J. V. Weil
Journal: Clinical Science
Clin Sci Mol Med (1975) 49 (1): 33–38.
https://doi.org/10.1042/cs0490033
Published: 01 July 1975
... The Biochemical Society and the Medical Research Society 1975 carbon dioxide control of ventilation ethanol hypoxia Clinical Science and Molecular Medicine (1975) 49, 33-38. Effect of ethanol on the ventilatory responses to oxygen and carbon dioxide in man S. A. SAHN, S. LAKSHMINARAYAN, D. J. PIERSON...
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A New Method for Assessing States of Acute Acidaemia in Man

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J. B. Stoker, C. T. Kappagoda, V. A. Grimshaw, R. J. Linden
Journal: Clinical Science
Clin Sci (1972) 42 (4): 455–463.
https://doi.org/10.1042/cs0420455
Published: 01 April 1972
.... 3. A simple scheme based on the CO 2 titration curves in vivo has been proposed for the assessment of acute acidaemia in man. 20 8 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 carbon dioxide titration curves acidaemia Clinical Science (1972) 42, 45...
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