... suggests that inducible NO synthase attenuates ventricular contractility, mediated by cGMP. Another gas that transduces its signal through cGMP, carbon monoxide, is also likely to play a role in cirrhotic cardiomyopathy, but the nature of the interaction between NO and carbon monoxide in this syndrome...

...C. D. R. Borland; Y. Cox 1. To examine the effect of varying oxygen partial pressure ( P ao 2 ) on nitric oxide (DLNO) and carbon monoxide (DLCO) diffusing capacity (transfer factor), 10 subjects performed combined DLCO/DLNO measurements with the inspired mixture made up with three different oxygen...

...Andrew J. T. Kirkham; Andrew R. Guyatt; Gordon Cumming 1. We have compared rebreathing, breath-hold and mean alveolar methods of measuring alveolar carbon monoxide (CO), at levels similar to those found in smokers, as a preliminary to using them as indirect measures of carboxyhaemoglobin levels...

...Andrew R. Guyatt; Andrew J. T. Kirkham; Derek C. Mariner; Gordon Cumming 1. We measured alveolar carbon monoxide (CO) after a 20 s breath-holding period and carboxyhaemoglobin both before and after smoking a cigarette on 500 occasions (101 individuals). The two measurements were closely correlated...

...G. Woodman; D. M. Wintoniuk; R. G. Taylor; S. W. Clarke 1. Fifteen asymptomatic habitual smokers each smoked one of their usual cigarettes, not having smoked for 2 h. End-expired carbon monoxide concentration (EECO) was measured with an Ecolyzer 2000 series analyser before smoking (pre-S value), 1...

... smoking analyser and flowhead/cigarette holder. The expired air carbon monoxide concentration was measured immediately before and within 5 min of finishing smoking. 3. The inhaled smoke percentage (total inhaled smoke volume/total puff volume) averaged 46% to 85% in different subjects. 4. Neither the mean...

... carbon monoxide levels were measured before and after smoking each cigarette, and the cigarette butt was analysed for nicotine. 4. While smoking behaviour varied considerably between the various subjects only small differences were seen between the different cigarette types in puff volume and duration...

...A. P. Greening; J. M. B. Hughes 1. Serial estimations of the diffusing capacity for carbon monoxide, with a standard single-breath technique, were used to assist the monitoring of disease activity in patients at risk from intrapulmonary haemorrhage. 2. A reversible rise in diffusing capacity...

...Elizabeth H. Clark; R. L. Woods; J. M. B. Hughes 1. Ten studies were performed on nine patients with haematological disorders but with normal lungs, who required intermittent blood transfusions. The transfer factor for carbon monoxide and uptake of carbon monoxide per unit lung volume ( K CO ) were...

...J. A. Milne; R. J. Mills; J. R. T. Coutts; M. C. Macnaughton; F. Moran; A. I. Pack 1. The pulmonary transfer factor for carbon monoxide was measured by the single-breath method in 21 pregnant women with no previous history of cardiac or respiratory disease. Measurements were made at monthly...

...J. M. Ramsey 1. Twenty normal subjects, twenty patients with emphysema and twenty with anaemia breathed 0·03% carbon monoxide for 45 min. For all sixty the mean increase in carboxyhaemoglobin (COHb) was 4·5%. Patients with emphysema showed a significantly smaller increase than did the other two...