...Claudiu T. Supuran Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) was clinically exploited for decades, as most modern diuretics were obtained considering as lead molecule acetazolamide, the prototypical CA inhibitor (CAI). The discovery and characterization of multiple human CA (hCA) isoforms...

... , an inhibitor of both AQ-mediated CO 2 diffusion and voltage-gated H + channels. For comparison, red cell and lung carbonic anhydrases (CAs) were inhibited by 0.1mM methazolamide. ZnCl 2 had no effect on CO 2 exchange when inspired CO 2 was altered between 2% and 5% in 5-min intervals. Pulmonary vascular...

... treatment resulted in gastric acid hypersecretion, which was largely abolished by concurrent cimetidine administration. 2. Activities of enzymes implicated in bicarbonate secretion, HCO − 3 -activated ATPase, carbonic anhydrase and Na + + K + -activated ATPase, were measured in the duodenal mucosa...