... by Portland Press Limited on behalf of the Biochemical Society 2020 Cardiac myocyte Ischemia-reperfusion injury Mitochondrial dynamics Mitochondrial fusion Myocardial infarction Heart attacks are a leading cause of death worldwide with no effective pharmacological strategies to limit permanent...

..., SRF and the ERK pathway and these findings suggest that hypoxia induces hypertrophy via MURC expression. cardiac myocyte hypoxia muscle-restricted coiled-coil protein (MURC) signalling pathway transforming growth factor-β (TGF-β) • The expression of MURC, a hypertrophy-regulated...

... with increased signalling via G-protein-coupled receptors. Three members of the RGS (regulator of G-protein signalling) superfamily RGS2, RGS4 and RGS5 have been implicated in the attenuation of G-protein signalling pathways in vascular and cardiac myocytes, as well as cells of the kidney and autonomic nervous...

..., and autocrine and paracrine functions. Laminar shear stress exerts anti-apoptotic, anti-atherosclerotic and antithrombotic effects on ECs (endothelial cells). Mechanical stretch of cardiac myocytes can modulate growth, apoptosis, electric remodelling, alterations in gene expression, and autocrine and paracrine...