... reversed by a family of SUMO-specific proteases (SENPs), making SUMOylation an ideal regulatory mechanism for developing novel therapeutic strategies for promoting a cardiac regenerative response. However, the role of SUMOylation in cardiac regeneration remains unknown. In the present study, we assessed...

... cardiac regeneration let-7i-5p myocardial infarction The loss of cardiomyocytes (CMs) and their insufficient replacement is a major contributor to the pathogenesis of many cardiovascular diseases, such as myocardial infarction (MI), cardiovascular fibrosis, and heart failure [ 1 ]. Thus, CM...

... possibilities for cardiac regeneration. Correspondence: Dr Enzo R. Porrello (email [email protected] ). 3 1 2013 11 2 2013 15 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cardiac regeneration cardiovascular development cardiovascular disease...

... of the mechanisms involved in successful cardiac regeneration should direct future investigation in this area. Particular emphasis is placed on discussion of the general hypothesis that the benefits of cell therapy primarily result from stimulation of endogenous cardiac repair processes that have only recently been...