... the mutation rate is low, and screens have failed to detect PLN mutations [ 39 , 40 ]. arrhythmogenic right ventricular (ARVC) cardiomyocyte cardiomyopathy dilated cardiomyopathy (DCM) heart failure hypertrophic cardiomyopathy (HCM) hypertrophy primary cardiomyopathy restrictive cardiomyopathy...

... sensitivity and cardiomyocyte responsiveness to βAR stimulation. Strikingly, baseline cardiac contractility was enhanced in V1AR KO mice and they experienced a greater loss in contractile function than control mice following acute ischaemic injury, although the absolute levels of cardiac dysfunction...

...-dependent autophagy plays an important role in the elimination of pathogens by phagocytes and in the regulation of vascular- and cancer-cell survival. Interestingly, we recently found that Nox is also important for autophagy regulation in cardiomyocytes. We found that Nox4, but not Nox2, promotes...

... and adipose tissues. The aim of the present study was to assess the role of NOD1 in the progression of diabetic cardiomyopathy. We have measured NOD1 protein in cardiac tissue from Type 2 diabetic ( db ) mice. Heart and isolated cardiomyocytes from db mice revealed a significant increase in NOD1, together...

... old. Genetic variations and molecular adaptations are the primary contributors to the onset of cardiovascular disease; however, molecular links between age and heart syndromes are complex and involve much more than the passage of time. Changes in CM (cardiomyocyte) structure and function occur...

... ) or Dr Yu-Hsun Kao (e-mail [email protected] ). 29 10 2010 28 2 2011 19 4 2011 19 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cardiomyocyte diabetes mellitus hypertension NADPH oxidase peroxisome-proliferator-activated receptor (PPAR...

... of synchronous beating, bradycardia and cessation of contraction in cultured rat cardiomyocytes [Williamson, Gorelik, Eaton, Lab, de Swiet and Korchev (2001) Clin. Sci. 100 , 363–369]. The aim of the present study was to investigate the effect of taurocholate on cardiomyocytes further. We demonstrated a reduced...

... in vivo was evaluated by echocardiography and cardiac catheterization. Cardiomyocyte apoptosis was detected by the TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling) method. The gene expression of Bax, Bcl-2 and Bcl-xL was analysed by Northern blotting. The TUNEL method...

... rate abnormalities have been reported in obstetric cholestasis, we hypothesized that intra-uterine death is caused by impaired fetal cardiomyocyte function, resulting in fetal cardiac arrest. Obstetric cholestasis is associated with raised levels of maternal and fetal serum bile acids, and we propose...

...Leanne M. D. DELBRIDGE; Pamela J. CONNELL; Peter J. HARRIS; Trefor O. MORGAN Little is known about the direct cardiac effects of socially common sub-intoxication levels of ethanol. Previous studies evaluating the responses of normal cardiomyocytes to short-term ethanol exposure have utilized...