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Keywords: cardiomyocytes
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Articles
Clin Sci (Lond) (2024) 138 (21): 1395–1419.
Published: 04 November 2024
...Doris M.T. Adao; Crizza Ching; Jason E. Fish; Craig A. Simmons; Filio Billia To maintain homeostasis in the heart, endothelial cells and cardiomyocytes engage in dynamic cross-talk through paracrine signals that regulate both cardiac development and function. Here, we review the paracrine signals...
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Clin Sci (Lond) (2022) 136 (22): 1661–1681.
Published: 21 November 2022
.... with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hypertension) is associated with additional features including increased fibrosis and can lead to heart failure. RAF kinases (ARAF/BRAF/RAF1) integrate signals into the extracellular signal-regulated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (17): 1281–1301.
Published: 05 September 2022
... and quantified rat ASC-exosome miRNAs and used bioinformatics to select uncharacterized miRNAs down-regulated in post-MI related to cardiac repair. We selected and validated miR-196a-5p and miR-425-5p as candidates for the concerted response in neonatal cardiomyocytes, cardiac fibroblasts, endothelial cells...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
... © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 biomarkers cancer therapy-related cardiac dysfunction cardiomyocytes endothelium extracellular vesicles microRNA In circumstances where vascular homeostasis is perturbed, functional...
Articles
Clin Sci (Lond) (2019) 133 (13): 1387–1399.
Published: 02 July 2019
...Fei Xu; Jingcheng Yang; Jun Shang; Feng Lan; Miaomiao Li; Leming Shi; Li Shen; Yongming Wang; Junbo Ge Recent evidence has shown that cardiomyocytes (CMs) can proliferate at a low level after myocardial infarction (MI), but it is insufficient to reestablish heart function. Several microRNAs (miRNAs...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (2): 225–238.
Published: 22 January 2019
... TOF patients, two of which (Y42D and L659P) are novel and not found in the Exome Aggregation Consortium (ExAC) database. Point mutation knock-in (KI) and ADAM17 knock-out (KO) human embryonic stem cells (hESCs) were generated by CRISPR/Cas9 and programmed to differentiate into cardiomyocytes (CMs...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (20): 2163–2167.
Published: 19 October 2018
...Hannah A. Cooper; Satoru Eguchi Ischemia reperfusion (I/R) injury is a common event following myocardial infarction (MI) resulting in excessive oxidative stress, calcium overload, inflammation, and cardiomyocyte death. Mitochondrial homeostasis including their dynamics are imbalanced in cardiac I/R...
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Articles
Clin Sci (Lond) (2017) 131 (18): 2319–2345.
Published: 25 August 2017
... in the left ventricle (LV) in response to internal or external cardiovascular damage or influence by pathogenic risk factors, and is a precursor of clinical heart failure (HF). Pathological remodelling is associated with fibrosis, inflammation and cellular dysfunction (e.g. abnormal cardiomyocyte/non...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 148S–151S.
Published: 01 September 2002
... the influence of various agonists or physical stress that, in the long term, also lead to development of hypertrophy. Previously, we identified three different Cl - channel activities in neonatal rat cardiomyocytes: (i) Ca 2+ regulated, (ii) cAMP regulated (cystic fibrosis transmembrane conductance regulator Cl...
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Articles
Clin Sci (Lond) (1996) 90 (5): 403–407.
Published: 01 May 1996
... of newborn genetically hypertensive rats. The present study was designed to investigate the participation of phospholipase A 2 in these modifications. 2. Phospholipase A 2 activity of cultured cardiomyocytes of neonate spontaneously hypertensive rats and normotensive control Wistar—Kyoto rats was compared...
Articles
Clin Sci (Lond) (1980) 59 (s6): 207s–209s.
Published: 01 December 1980
...S. N. Orlov; Yu. V. Postnov 1. The ability of isolated membrane fractions of cardiomyocytes, aortic smooth muscle and erythrocytes from spontaneously hypertensive rats to bind calcium was investigated isotopically. 2. Plasma membranes of aortic smooth muscle and erythrocytes of spontaneously...