...Doris M.T. Adao; Crizza Ching; Jason E. Fish; Craig A. Simmons; Filio Billia To maintain homeostasis in the heart, endothelial cells and cardiomyocytes engage in dynamic cross-talk through paracrine signals that regulate both cardiac development and function. Here, we review the paracrine signals...

.... with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hypertension) is associated with additional features including increased fibrosis and can lead to heart failure. RAF kinases (ARAF/BRAF/RAF1) integrate signals into the extracellular signal-regulated...

... and quantified rat ASC-exosome miRNAs and used bioinformatics to select uncharacterized miRNAs down-regulated in post-MI related to cardiac repair. We selected and validated miR-196a-5p and miR-425-5p as candidates for the concerted response in neonatal cardiomyocytes, cardiac fibroblasts, endothelial cells...

... © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 biomarkers cancer therapy-related cardiac dysfunction cardiomyocytes endothelium extracellular vesicles microRNA In circumstances where vascular homeostasis is perturbed, functional...

...Fei Xu; Jingcheng Yang; Jun Shang; Feng Lan; Miaomiao Li; Leming Shi; Li Shen; Yongming Wang; Junbo Ge Recent evidence has shown that cardiomyocytes (CMs) can proliferate at a low level after myocardial infarction (MI), but it is insufficient to reestablish heart function. Several microRNAs (miRNAs...

... TOF patients, two of which (Y42D and L659P) are novel and not found in the Exome Aggregation Consortium (ExAC) database. Point mutation knock-in (KI) and ADAM17 knock-out (KO) human embryonic stem cells (hESCs) were generated by CRISPR/Cas9 and programmed to differentiate into cardiomyocytes (CMs...

...Hannah A. Cooper; Satoru Eguchi Ischemia reperfusion (I/R) injury is a common event following myocardial infarction (MI) resulting in excessive oxidative stress, calcium overload, inflammation, and cardiomyocyte death. Mitochondrial homeostasis including their dynamics are imbalanced in cardiac I/R...

...Yang Li; Xiaoyi Zhang; Lu Li; Xiang Wang; Zhidan Chen; Xingxu Wang; Ying Wang; Le Kang; Yong Ye; Jianguo Jia; Guoping Zhang; Chunjie Yang; Jie Yuan; Jingmin Zhou; Junbo Ge; Hui Gong; Yunzeng Zou By employing a proteomic analysis on supernatant of mechanically stretched cardiomyocytes, we found...

... in the left ventricle (LV) in response to internal or external cardiovascular damage or influence by pathogenic risk factors, and is a precursor of clinical heart failure (HF). Pathological remodelling is associated with fibrosis, inflammation and cellular dysfunction (e.g. abnormal cardiomyocyte/non...

... the influence of various agonists or physical stress that, in the long term, also lead to development of hypertrophy. Previously, we identified three different Cl - channel activities in neonatal rat cardiomyocytes: (i) Ca 2+ regulated, (ii) cAMP regulated (cystic fibrosis transmembrane conductance regulator Cl...

... in vivo , as demonstrated by the developmental switching of the major isoform of myosin heavy chain (MHC) from β to α. However, the β-MHC isoform predominates in monocrotaline-induced pulmonary hypertension, a model of right ventricular hypertrophy in vivo . Cultured cardiomyocytes showed a predominance...

... of newborn genetically hypertensive rats. The present study was designed to investigate the participation of phospholipase A 2 in these modifications. 2. Phospholipase A 2 activity of cultured cardiomyocytes of neonate spontaneously hypertensive rats and normotensive control Wistar—Kyoto rats was compared...

...S. N. Orlov; Yu. V. Postnov 1. The ability of isolated membrane fractions of cardiomyocytes, aortic smooth muscle and erythrocytes from spontaneously hypertensive rats to bind calcium was investigated isotopically. 2. Plasma membranes of aortic smooth muscle and erythrocytes of spontaneously...