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Keywords: cardiomyocytes
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Articles
Clin Sci (Lond) (2022) 136 (17): 1281–1301.
Published: 05 September 2022
... and quantified rat ASC-exosome miRNAs and used bioinformatics to select uncharacterized miRNAs down-regulated in post-MI related to cardiac repair. We selected and validated miR-196a-5p and miR-425-5p as candidates for the concerted response in neonatal cardiomyocytes, cardiac fibroblasts, endothelial cells...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
... , 4 ]. For example, cancer therapy has off-target effects and can directly affect the myocardium leading to cardiomyocyte damage and heart failure [ 2 , 5 ]. Other common manifestations of cancer therapy include hypertension, coronary disease, myocarditis, and arrhythmia which can arise during...
Articles
Clin Sci (Lond) (2019) 133 (13): 1387–1399.
Published: 02 July 2019
...Fei Xu; Jingcheng Yang; Jun Shang; Feng Lan; Miaomiao Li; Leming Shi; Li Shen; Yongming Wang; Junbo Ge Recent evidence has shown that cardiomyocytes (CMs) can proliferate at a low level after myocardial infarction (MI), but it is insufficient to reestablish heart function. Several microRNAs (miRNAs...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (2): 225–238.
Published: 22 January 2019
... TOF patients, two of which (Y42D and L659P) are novel and not found in the Exome Aggregation Consortium (ExAC) database. Point mutation knock-in (KI) and ADAM17 knock-out (KO) human embryonic stem cells (hESCs) were generated by CRISPR/Cas9 and programmed to differentiate into cardiomyocytes (CMs...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (20): 2163–2167.
Published: 19 October 2018
...Hannah A. Cooper; Satoru Eguchi Ischemia reperfusion (I/R) injury is a common event following myocardial infarction (MI) resulting in excessive oxidative stress, calcium overload, inflammation, and cardiomyocyte death. Mitochondrial homeostasis including their dynamics are imbalanced in cardiac I/R...
Articles
Clin Sci (Lond) (2018) 132 (16): 1855–1874.
Published: 30 August 2018
...Yang Li; Xiaoyi Zhang; Lu Li; Xiang Wang; Zhidan Chen; Xingxu Wang; Ying Wang; Le Kang; Yong Ye; Jianguo Jia; Guoping Zhang; Chunjie Yang; Jie Yuan; Jingmin Zhou; Junbo Ge; Hui Gong; Yunzeng Zou By employing a proteomic analysis on supernatant of mechanically stretched cardiomyocytes, we found...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (18): 2319–2345.
Published: 25 August 2017
... in the left ventricle (LV) in response to internal or external cardiovascular damage or influence by pathogenic risk factors, and is a precursor of clinical heart failure (HF). Pathological remodelling is associated with fibrosis, inflammation and cellular dysfunction (e.g. abnormal cardiomyocyte/non...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 148S–151S.
Published: 01 September 2002
... the influence of various agonists or physical stress that, in the long term, also lead to development of hypertrophy. Previously, we identified three different Cl - channel activities in neonatal rat cardiomyocytes: (i) Ca 2+ regulated, (ii) cAMP regulated (cystic fibrosis transmembrane conductance regulator Cl...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 210S–214S.
Published: 01 September 2002
... in vivo , as demonstrated by the developmental switching of the major isoform of myosin heavy chain (MHC) from β to α. However, the β-MHC isoform predominates in monocrotaline-induced pulmonary hypertension, a model of right ventricular hypertrophy in vivo . Cultured cardiomyocytes showed a predominance...
Articles
Clin Sci (Lond) (1996) 90 (5): 403–407.
Published: 01 May 1996
... of newborn genetically hypertensive rats. The present study was designed to investigate the participation of phospholipase A 2 in these modifications. 2. Phospholipase A 2 activity of cultured cardiomyocytes of neonate spontaneously hypertensive rats and normotensive control Wistar—Kyoto rats was compared...
Articles
Clin Sci (Lond) (1980) 59 (s6): 207s–209s.
Published: 01 December 1980
...S. N. Orlov; Yu. V. Postnov 1. The ability of isolated membrane fractions of cardiomyocytes, aortic smooth muscle and erythrocytes from spontaneously hypertensive rats to bind calcium was investigated isotopically. 2. Plasma membranes of aortic smooth muscle and erythrocytes of spontaneously...