1-14 of 14
Keywords: cardiomyopathy
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Clin Sci (Lond) (2021) 135 (10): 1311–1332.
Published: 28 May 2021
... result in cardiomyopathy and heart failure. Cardiomyocyte toxicity occurs via multiple molecular mechanisms, including topoisomerase II-mediated DNA double-strand breaks and reactive oxygen species (ROS) formation via effects on the mitochondrial electron transport chain, NADPH oxidases (NOXs...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (13): 1859–1885.
Published: 17 July 2020
... through its actions in the nucleus and formation of reactive oxygen species (ROS). And, despite the early use of dexrazoxane, no effective treatment strategy has emerged to prevent the development of cardiomyopathy, despite decades of study, suggesting that much more insight into the underlying mechanism...
Clin Sci (Lond) (2019) 133 (17): 1871–1881.
Published: 10 September 2019
... and potential molecular mechanisms. Through utilizing clinical samples and high fat diet-fed mice, we investigated the physiological roles of miR-122 in obesity-related cardiomyopathy. Besides, present study explored the mitochondrial function under exosomal miR-122 stimulation in mouse primary cardiomyocytes...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (13): 1375–1392.
Published: 23 June 2017
...Keith Dadson; Ludger Hauck; Filio Billia Cardiomyopathies represent a heterogeneous group of diseases that negatively affect heart function. Primary cardiomyopathies specifically target the myocardium, and may arise from genetic [hypertrophic cardiomyopathy (HCM), arrhythmogenic right ventricular...
Clin Sci (Lond) (2017) 131 (6): 439–448.
Published: 06 March 2017
... of paediatric heart failure is underestimated, as many individuals with heart failure remain asymptomatic for years without any cardiac events and present later when the illness reaches a critical threshold. The major causes of paediatric heart failure include CHD, cardiomyopathy (CMP), rhythm disorders...
Clin Sci (Lond) (2017) 131 (5): 395–409.
Published: 17 February 2017
...Natalie J. Galant; Per Westermark; Jeffrey N. Higaki; Avijit Chakrabartty Transthyretin (TTR) amyloidosis (ATTR amyloidosis) is an underdiagnosed and important type of cardiomyopathy and/or polyneuropathy that requires increased awareness within the medical community. Raising awareness among...
Clin Sci (Lond) (2015) 129 (10): 851–862.
Published: 28 August 2015
... of the existing strong associations between iron overload and iron deficiency with cardiomyopathy. Correspondence: Dr Gary Sweeney ( gsweeney@yorku.ca ). 26 1 2015 8 6 2015 14 7 2015 © 2015 Authors; published by Portland Press Limited 2015 24p3 autophagy cardiomyopathy ER...
Clin Sci (Lond) (2008) 114 (6): 431–440.
Published: 12 February 2008
... cardiomyopathy. However, the mechanisms whereby distinct mutations in the βMHC gene cause two kinds of cardiomyopathy are still unclear. In the present study we report a novel βMHC mutation found in a patient with isolated LVNC [LV (left ventricular) non-compaction] and the phenotype of a mouse mutant model...
Clin Sci (Lond) (2006) 111 (1): 53–59.
Published: 14 June 2006
... for calculating the Doppler variables. cardiomyopathy congestive heart failure hyperglycaemia hypertension systole Type II diabetes ventricular function Analysis of dichotomized data (treatment and increase/decrease in HbA 1c ) needed a sample size estimate of 34 participants...
Clin Sci (Lond) (2004) 106 (6): 653–659.
Published: 01 June 2004
...Nidal MAAROUF; Gavin ARNO; Nicholas D. CARTER; Petros SYRRIS; Shamil YUSUF; John A. CAMM; Jan POLEINIKI; Naab M. Al-SAADY Supraventricular tachycardias, including AF (atrial fibrillation), and mtDNA (mitochondrial DNA) deletions may lead to dilated cardiomyopathy. It is unknown whether mtDNA...
Includes: Supplementary data
Clin Sci (Lond) (2002) 103 (6): 623–632.
Published: 19 November 2002
... and the Medical Research Society © 2002 2002 cardiomyopathy gene expression myocarditis 623Clinical Science (2002) 103, 623 632 (Printed in Great Britain) Time course of gene expression in rat experimental autoimmune myocarditis Haruo HANAWA*, Satoru ABE*, Manabu HAYASHI*, Tsuyoshi YOSHIDA*, Kaori...
Clin Sci (Lond) (2001) 101 (6): 621–628.
Published: 29 October 2001
... in asymptomatic patients with cirrhosis. Levels of brain natriuretic peptide may prove to be useful as a marker for screening patients with cirrhosis for the presence of cirrhotic cardiomyopathy, and thereby identifying such patients for further investigations. Correspondence: Dr Florence Wong (e-mail...
Clin Sci (Lond) (1999) 97 (3): 259–267.
Published: 15 July 1999
...; and (iii) in ascitic patients, a reduced afterload, manifested as systemic arterial vasodilatation, compensates for a reduced pre-load and contractile dysfunction. Cirrhotic cardiomyopathy may well play a pathogenic role in the complications of cirrhosis. Correspondence: Dr Florence Wong, Room 220...
Clin Sci (Lond) (1995) 88 (3): 263–268.
Published: 01 March 1995
... for its pathogenesis. 17 10 1994 4 11 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 acetaldehyde adducts alcoholic heart muscle disease cardiomyopathy immunoblotting Clinical Science (1995) 88, 263-268 (Printed in Great Britain) 263 Circulating anti...