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Keywords: cardiopulmonary blood volume
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Articles
Alterations in Cardiac Function and Cardiopulmonary Blood Volume in Chronic Sodium Depletion in Dogs
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 393s–395s.
Published: 01 December 1980
... restriction together with frusemide. 2. Sodium depletion was associated with significant decreases in cardiac output, ejection fraction and total blood volume; the cardiopulmonary blood volume increased but the change was not statistically significant ( P <0.2). These changes were accompanied by a...
Abstract
1. Chronic sodium depletion in dogs is associated with a blunting of the pressor response to carotid occlusion. After section of the vagus nerves this pressor response reverts to normal although atropine is without effect, suggesting a possible role for increased activity of cardiopulmonary vagal afferents in suppressing sympathetic outflow. Since increases in central blood volume stimulate vagal afferents, cardiopulmonary haemodynamics were studied by radioisotope dilution before and after 3 and 4 weeks of dietary sodium restriction together with frusemide. 2. Sodium depletion was associated with significant decreases in cardiac output, ejection fraction and total blood volume; the cardiopulmonary blood volume increased but the change was not statistically significant ( P <0.2). These changes were accompanied by a significant increase in the ratio cardiopulmonary blood volume/total blood volume and a decrease in the ratio cardiac output/cardiopulmonary blood volume. 3. Results indicate that sodium depletion may be accompanied by a paradoxical translocation of blood to the cardiopulmonary region in part due to depressed ventricular performance.
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1975) 49 (6): 573–579.
Published: 01 December 1975
... in sixty-three apparently healthy subjects. 2. Mean DBH values were not significantly different between the groups. 3. Cardiac output, cardiopulmonary blood volume and the cardiopulmonary blood volume/total blood volume ratio (CPBV/TBV) were significantly higher in borderline than in permanent...
Abstract
1. Resting plasma dopamine β-hydroxylase (DBH) activity and haemodynamic parameters were studied in untreated borderline (twenty-nine) and permanent (twenty-seven) essential hypertensive patients. DBH was also measured in sixty-three apparently healthy subjects. 2. Mean DBH values were not significantly different between the groups. 3. Cardiac output, cardiopulmonary blood volume and the cardiopulmonary blood volume/total blood volume ratio (CPBV/TBV) were significantly higher in borderline than in permanent hypertensive patients. 4. In borderline hypertensive patients, plasma DBH activity was directly correlated with diastolic arterial pressure and with values of cardiac output, cardiopulmonary blood volume and CPBV/TBV ratio. No such correlations could be observed in the permanent hypertensive group. 5. These results suggest that plasma DBH activities in borderline hypertension mainly depend on the sympathetic activity responsible for the haemodynamic variations. Contrariwise, plasma DBH activities in permanent essential hypertensive patients appear to reflect other factors.
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1974) 47 (2): 153–164.
Published: 01 August 1974
...M. E. Safar; Y. A. Weiss; G. M. London; R. F. Frackowiak; P. L. Milliez 1. A haemodynamic study which included estimation of cardiopulmonary blood volume (CPBV), total blood volume (TBV) and vascular reactivity to noradrenaline was performed in seventeen borderline and sixteen permanent...
Abstract
1. A haemodynamic study which included estimation of cardiopulmonary blood volume (CPBV), total blood volume (TBV) and vascular reactivity to noradrenaline was performed in seventeen borderline and sixteen permanent hypertensive patients. 2. Borderline hypertensive patients had higher values of cardiac index, stroke index and heart rate when compared with the permanent hypertensive patients, and lower values of blood pressure and total peripheral resistance. 3. The CPBV/TBV ratio was significantly higher in borderline hypertensive patients. In that group, this ratio was directly correlated with cardiac index, stroke index and the pressor dose of noradrenaline ( P < 0.01). 4. In permanent hypertensive patients, none of these correlations was observed. Only the total blood volume was correlated directly with cardiac index and inversely with total peripheral resistance. 5. The study suggests that a redistribution of intravascular volume from peripheral veins to the cardiopulmonary capacitance bed occurs in borderline hypertension when compared with permanent hypertension and that hypertension is related to a neural mechanism in the borderline state and to a volume mechanism in the permanent state.