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Keyword: cardiovascular disease
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Clin Sci (Lond) (2019) 133 (22): 2329-2344.
Published: 28 November 2019
... epicardial adipose tissue (EAT) secretome on the development and progression of cardiovascular disease (CVD), with a particular focus on cardiac hypertrophy and fibrosis. Correspondence: Michael Tranter ( trantemc@ucmail.uc.edu ) 25 09 2019 08 11 2019 13 11 2019 © 2019 The Author...
Clin Sci (Lond) (2019) 133 (21): 2217-2220.
Published: 13 November 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease fibrosis microRNA Cardiovascular disease (CVD) is the leading cause of death worldwide, with over 17.6 million deaths per year [ 1 ]. Cardiomyopathy is a type of CVD and cardiac fibrosis is an...
Clin Sci (Lond) (2019) 133 (21): 2121-2141.
Published: 06 November 2019
... Kantharidis ( phillip.kantharidis@monash.edu ) 12 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes...
Clin Sci (Lond) (2019) 133 (10): 1185-1196.
Published: 30 May 2019
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (9): 1137-1143.
Published: 14 May 2019
... 2019 07 05 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chronic disease cardiovascular disease multimorbidity...
Clin Sci (Lond) (2019) 133 (7): 885-904.
Published: 12 April 2019
... cardiovascular-related comorbidities contribute to morbidity and mortality in COPD, with approximately 50% of deaths in COPD patients attributed to a cardiovascular event (e.g. myocardial infarction). Cardiovascular disease (CVD) and COPD share various risk factors including hypertension, sedentarism, smoking...
Clin Sci (Lond) (2019) 133 (2): 205-224.
Published: 22 January 2019
... lower the risk of cardiovascular disease, PCSK9 inhibitors represent an important therapeutic target, particularly in high-risk populations. Here, we summarise and update the science of PCSK9, including its discovery and the development of various inhibitors, including the now approved monoclonal...
Clin Sci (Lond) (2019) 133 (2): 195-203.
Published: 18 January 2019
... atherosclerosis in patients with diabetes. Correspondence: Samuel T. Keating ( sam.keating@radboudumc.nl ) 16 10 2018 17 12 2018 21 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 Cardiovascular disease Diabetes...
Clin Sci (Lond) (2018) 132 (20): 2207-2220.
Published: 23 October 2018
... identifiable precursor to atherosclerosis with subsequent progression to cardiovascular disease [ 19 ], timelier identification, and intervention may improve outcomes. Underpinning the molecular mechanisms of endothelial dysfunction may be possible through the use of biomarkers, such as circulating...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (15): 1699-1709.
Published: 16 August 2018
... likely relevant. Correspondence: John R. Petrie ( john.petrie@glasgow.ac.uk ) 26 06 2018 02 08 2018 03 08 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease clinical trials glucagon-like...
Clin Sci (Lond) (2018) 132 (9): 925-942.
Published: 21 May 2018
...Clarissa P.C. Gomes; David de Gonzalo-Calvo; Rocio Toro; Tiago Fernandes; Daniel Theisen; Da-Zhi Wang; Yvan Devaux; on behalf of the Cardiolinc™ network There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death...
Clin Sci (Lond) (2018) 132 (7): 791-811.
Published: 16 April 2018
...-metabolism. The metabolic conditions reviewed here include obesity, a known risk factor for all of the other metabolic conditions, as well as, cardiovascular disease, diabetes and nonalcoholic fatty liver disease. Only by further understanding the cause and result of gut dysbiosis will an adequate solution...
Clin Sci (Lond) (2018) 132 (7): 739-758.
Published: 06 April 2018
... albuminuria cardiovascular disease metabolomics proteomics renal physiology Cardiovascular (CV) and renal disease are frequently interlinked and, correspondingly, the term ‘cardiorenal continuum’ has been used to extend the concept of the CV continuum, the chain of events linking CV risk factors...
Clin Sci (Lond) (2018) 132 (6): 615-626.
Published: 20 March 2018
...Asokan Devarajan; Asokan Devarajan The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging...
Clin Sci (Lond) (2018) 132 (5): 509-522.
Published: 09 March 2018
... progression of CKD. Correspondence: Wei Ling Lau ( wllau@uci.edu ) 20 12 2017 15 02 2018 19 02 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 chronic kidney disease cardiovascular disease microbiome mortality...
Clin Sci (Lond) (2018) 132 (1): 85-91.
Published: 11 January 2018
... Society 2018 cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics The human gut harbors more than 100 trillion microbial cells, and majority of them being classified into the phyla Firmicutes and Bacteroidetes . Additionally, these microbes are...
Clin Sci (Lond) (2018) 132 (1): 33-36.
Published: 02 January 2018
... cardiovascular disease (CVD) risk. Currently, there is great interest in the role of the endothelin system in pre-eclampsia. Targetting the endothelin system, potentially by modulating upstream pathways to prevent ET B receptor dysfunction, may improve health outcomes for women and their offspring during pre...
Clin Sci (Lond) (2017) 131 (23): 2791-2794.
Published: 23 November 2017
...Michal Zeman; Monika Okuliarova Cardiovascular diseases (CVDs) are the leading cause of mortality and hypertension contributes substantially to the incidence of stroke, coronary artery disease, heart failure, atrial fibrillation and peripheral vascular disease. The origin of hypertension is clearly...
Clin Sci (Lond) (2017) 131 (22): 2687-2699.
Published: 06 November 2017
...Allison B. Herman; Michael V. Autieri Cardiovascular disease remains a major medical and socioeconomic burden in developed and developing societies, and will increase with an aging and increasingly sedentary society. Vascular disease and atherosclerotic vascular syndromes are essentially...
Clin Sci (Lond) (2017) 131 (21): 2601-2609.
Published: 25 October 2017
... cardiovascular disease inflammation Klotho Cardiovascular disease (CVD) is highly prevalent and constitute the leading cause of death worldwide [ 1 , 2 ]. Nowadays, atherosclerosis, the main underlying process in CVD, is recognized as an inflammatory disorder of the arterial vessels, closely related to...
Clin Sci (Lond) (2017) 131 (18): 2397-2408.
Published: 08 September 2017
... Hypercholesterolaemia provokes reactive oxygen species (ROS) increase and is a major risk factor for cardiovascular disease (CVD) development. We previously showed that circulating miR-33a/b expression levels were up-regulated in children with familial hypercholesterolaemia (FH). miR-33a/b control cholesterol...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (15): 1941-1953.
Published: 13 July 2017
...@erasmusmc.nl ) * These authors contributed equally to this work. 11 01 2017 07 06 2017 15 06 2017 15 06 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Aging cardiovascular disease genetic association dietary...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (9): 833-846.
Published: 19 April 2017
...: Christine Maric-Bilkan ( christine.maric-bilkan@nih.gov ) 30 12 2016 24 1 2017 25 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 cardiovascular disease coronary heart disease endothelial dysfunction nephropathy...
Clin Sci (Lond) (2017) 131 (3): 225-226.
Published: 05 January 2017
... kidney disease cardiovascular disease fibrosis translational science Chronic kidney disease (CKD) is characterized by persisting renal damage and/or loss of renal function. The condition is associated with high morbidity and mortality throughout the continuum from early disease to advanced...
Clin Sci (Lond) (2017) 131 (1): 87-103.
Published: 09 December 2016
... Biochemical Society 2016 © 2016 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY-NC-ND) . angiogenesis angiopoietin Angpt Ang1 Ang2 cardiovascular...
Clin Sci (Lond) (2016) 130 (21): 1889-1899.
Published: 22 September 2016
...) antibodies could be a potential missing link between oxidative status, inflammation and cardiovascular disease (CVD) in rheumatoid arthritis (RA) patients. Therefore, they could represent an emerging clinical biomarker of CV risk in this condition. anti-paraoxonase 1 antibodies cardiovascular disease...
Clin Sci (Lond) (2016) 130 (19): 1677-1696.
Published: 23 August 2016
... are providing improved understanding of aging and disease and the basis for rational design of novel pharmaceuticals: glyoxalase 1 inducers for obesity, diabetes and cardiovascular disease and glyoxalase 1 inhibitors for multidrug-resistant tumours. The first clinical trial of a glyoxalase 1 inducer...
Clin Sci (Lond) (2016) 130 (15): 1285-1305.
Published: 29 June 2016
... cardiovascular disease diet epigenetic modification histones chromatin mitochondrial fusion–fission mitophagy Aerobic metabolism constitutes the energetic foundation of the great majority of living systems on Earth. By processing oxygen to harness the essential redox and phosphorylation energy...
Clin Sci (Lond) (2016) 130 (13): 1039-1050.
Published: 23 May 2016
... the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY-NC-ND) . cardiovascular disease chronic obstructive pulmonary disease (COPD) comorbidities oxidative stress stroke systemic inflammation Chronic obstructive pulmonary disease (COPD) is...
Clin Sci (Lond) (2016) 130 (10): 761-771.
Published: 01 April 2016
... cardiovascular disease hypertension sex differences The renin–angiotensin system (RAS) is a key regulator of arterial pressure and water and electrolyte balance in health and disease. The main effector peptide, angiotensin II (AngII), mediates the classic actions of the RAS, including vasoconstriction...
Clin Sci (Lond) (2016) 130 (7): 491-497.
Published: 17 February 2016
... with poor vascular function. However, maternal vascular function is enhanced in pregnancy. It is not understood how this is achieved in the face of the adverse metabolic and inflammatory environment. Research into cardiovascular disease demonstrates that plasma HDL (high-density lipoprotein), by merit...
Clin Sci (Lond) (2015) 129 (12): 989-999.
Published: 18 September 2015
... disease or cardiovascular diseases. The present review summarizes promising findings from basic research and shows which Nrf2-targeting therapies are currently being investigated in clinical trials and which agents have already entered clinical practice. Correspondence: Dr Othman Al-Sawaf (email...
Clin Sci (Lond) (2015) 129 (11): 963-972.
Published: 10 September 2015
...Francesco Martino; Fabrizio Carlomosti; Daniele Avitabile; Luca Persico; Mario Picozza; Francesco Barillà; Marcello Arca; Anna Montali; Eliana Martino; Cristina Zanoni; Sandro Parrotto; Alessandra Magenta Hypercholesterolaemia is one of the major causes of CVD (cardiovascular disease). It is...
Clin Sci (Lond) (2015) 129 (11): 915-931.
Published: 10 September 2015
...: Dr Lisa Ayers (email lisa.ayers@nhs.net ). 9 12 2014 29 6 2015 27 7 2015 © 2015 Authors; published by Portland Press Limited 2015 cardiovascular disease clinical studies microparticles microvesicles Interest in extracellular vesicles within cardiovascular...
Clin Sci (Lond) (2015) 129 (8): 769-784.
Published: 29 July 2015
...Maria U. Nguyen; Megan J. Wallace; Salvatore Pepe; Trevelyan R. Menheniott; Timothy J. Moss; Timothy J. Moss; David Burgner; David Burgner Cardiovascular disease continues to be the leading cause of global morbidity and mortality. Traditional risk factors account for only part of the attributable...
Clin Sci (Lond) (2015) 129 (2): 199-216.
Published: 30 April 2015
... Biochemical Society 2015 antioxidant therapy cardiovascular disease diabetes complications; reactive nitrogen species reactive oxygen species The pre-clinical evidence in support of a role for reactive oxygen and nitrogen species (ROS/RNS) in diabetic complications such as atherosclerosis...
Clin Sci (Lond) (2015) 129 (1): 1-25.
Published: 01 April 2015
... reduced prevalence of chronic diseases, particularly cardiovascular diseases (CVDs), as well as CVD-related mortality and risk factors. Recent data also link bilirubin to other chronic diseases, including cancer and Type 2 diabetes mellitus, and to all-cause mortality. Therefore, there is evidence to...
Clin Sci (Lond) (2015) 128 (9): 609-618.
Published: 11 February 2015
... been associated with glucose metabolism alterations and increased risk of cardiovascular disease (CVD). Primary IO is associated with mutations in the HFE gene. To which extent HFE gene mutations and metabolic alterations contribute to the presence of atherogenic lipoprotein modifications in primary IO...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (6): 379-385.
Published: 02 December 2014
... © The Authors Journal compilation © 2015 Biochemical Society 2015 Plasma PCSK9 and apoC-III concentrations were significantly associated with postprandial apoB-48 metabolism, favouring an inverse association with the catabolism of apoB-48 in obese subjects. cardiovascular disease...
Clin Sci (Lond) (2014) 127 (6): 367-373.
Published: 29 May 2014
... to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concept is that the mitochondrion can act as the ‘canary in the coal mine’ by serving as...
Clin Sci (Lond) (2014) 127 (6): 351-365.
Published: 21 May 2014
...Rick F. J. Kwekkeboom; Zhiyong Lei; Pieter A. Doevendans; René J. P. Musters; Joost P. G. Sluijter Dysregulation of miRNA expression has been associated with many cardiovascular diseases in animal models, as well as in patients. In the present review, we summarize recent findings on the role of...
Clin Sci (Lond) (2014) 127 (4): 209-216.
Published: 10 April 2014
... compilation © 2014 Biochemical Society 2014 animal model biomarker cardiovascular disease diabetes obesity obstructive sleep apnoea (OSA) OSA (obstructive sleep apnoea) is by far the most common respiratory disorder of sleep. OSA is caused by the loss of upper airway dilating muscle...
Clin Sci (Lond) (2014) 127 (4): 243-249.
Published: 10 April 2014
... II). Changes in the levels of ACE2 have been observed in a number of pathologies, including cardiovascular disease, but little is known of the mechanisms regulating its expression. In the present study, therefore, the potential role of miRNAs in the regulation of ACE2 expression in primary human...
Clin Sci (Lond) (2014) 126 (3): 183-194.
Published: 01 October 2013
...-regulatory processes and networks in both the cardiovascular system and cardiovascular diseases. Indeed, it has recently been shown that miRNAs are implicated in the regulation of many of the steps leading to the development of cardiovascular disease. These findings represent novel aspects in miRNA biology...
Clin Sci (Lond) (2014) 126 (2): 139-146.
Published: 19 September 2013
... velocity), AIx (augmentation index), CAP (central augmented pressure) and CSP (central-systolic pressure) were measured in 1367 CVD (cardiovascular disease)-free participants aged 50–70 years old. Cardiovascular events were validated after a mean follow-up of 3.8 years. AUC (area-under-the-curve) and NRI...
Clin Sci (Lond) (2014) 126 (1): 67-74.
Published: 03 September 2013
... disease) all of which may contribute to endothelial dysfunction, an early marker of CVD (cardiovascular disease) risk. Our objective was to examine the relationships between endothelial dysfunction in PCOS, the volume of AT (adipose tissue) compartments and the size of intracellular TAG (triacylglycerol...
Clin Sci (Lond) (2013) 125 (4): 151-166.
Published: 26 April 2013
... human diseases, including cardiovascular disease. In the present review, I discuss well-established and emerging roles of miRNAs in cardiac development, their relevance to congenital heart disease and unresolved questions in the field for future investigation, as well as emerging therapeutic...
Clin Sci (Lond) (2013) 125 (3): 109-119.
Published: 12 April 2013
... Brian R. Weil (email bweil@buffalo.edu ). 30 11 2012 31 1 2013 15 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cardiac regeneration cardiovascular disease cell therapy myocardial repair stem cell Despite significant advances in the...
Clin Sci (Lond) (2013) 124 (10): 617-626.
Published: 04 February 2013
... quantified and markers of atherogenesis were assessed using RT–PCR (reverse transcription–PCR) and ELISA. The association of sodium intake and adverse cardiovascular and mortality outcomes were explored in 2648 adults with Type 1 diabetes without prior CVD (cardiovascular disease) from the FinnDiane study. A...
Clin Sci (Lond) (2013) 124 (7): 423-441.
Published: 07 December 2012
... relating to the formation of microparticles and their biological effects are examined. Correspondence: Dr Dylan Burger (email dburger@uottawa.ca ). 12 6 2012 25 9 2012 2 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 biomarker cardiovascular...