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Keywords: cardiovascular disease
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (13): 817–850.
Published: 26 June 2024
... targeting from a clinical translational perspective. In summary, vascular remodelling, a coordinated modification of vascular structure and function, is crucial in cardiovascular disease pathology. In summary, various stressors stimulate pathological processes in the vessel wall, including proliferation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (7): 537–542.
Published: 13 April 2023
... tissue regeneration and pathology . Clin. Sci. (Lond.) 128 , 81 – 93 10.1042/CS20140278 25236972 9. Wang S. , Song P. and Zou M. ( 2012 ) AMP-activated protein kinase, stress responses and cardiovascular diseases . Clin. Sci. (Lond.) 122 , 555 – 573 10.1042...
Articles
Lauren T. May, Belinda A. Bartolo, David G. Harrison, Tomasz Guzik, Grant R. Drummond, Gemma A. Figtree, Rebecca H. Ritchie, Kerry-Anne Rye, Judy B. de Haan
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1731–1758.
Published: 02 December 2022
...Lauren T. May; Belinda A. Bartolo; David G. Harrison; Tomasz Guzik; Grant R. Drummond; Gemma A. Figtree; Rebecca H. Ritchie; Kerry-Anne Rye; Judy B. de Haan Cardiovascular disease (CVD) remains the leading cause of death worldwide. An ongoing challenge remains the development of novel...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1257–1280.
Published: 05 September 2022
... medical conditions. Patients with SMI have high levels of cardiovascular risk factors and are at increased risk of cardiovascular diseases, including ischemic heart disease, stroke and premature mortality [ 3–5 ]. Despite these patients exhibit higher rates of unnatural deaths, such as suicide...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (15): 1157–1178.
Published: 10 August 2022
...Denise Busscher; Reinier A. Boon; Rio P. Juni Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases...
Articles
Kurt Brassington, Stanley M.H. Chan, Simone N. De Luca, Aleksandar Dobric, Suleman A. Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 537–555.
Published: 21 April 2022
... destruction, primarily due to exposure to noxious gases and particulate matter inhaled from cigarette smoke (CS) [ 3 ]. COPD patients often experience various extrapulmonary comorbid diseases, with cardiovascular disease (CVD) causing approximately 50% of all COPD-related deaths [ 3 , 4 ]. People with COPD...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 431–434.
Published: 29 March 2022
...) (2021) 135 (24): 2667–2689. DOI: 10.1042/CS20210735). These findings support the notion that circulating SARS-CoV-2 S protein could contribute to cardiovascular disease independent of viral infection. Future studies are needed to determine the effect of the S protein on pericytes in other organs...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 435–454.
Published: 29 March 2022
... characterised in innate and adaptive immune cells, and discuss how macrophages’ and T cells’ metabolism may influence phenotypic changes in the plaque. Moreover, we discuss the potential of targeting immunometabolism to prevent and treat cardiovascular diseases (CVDs). Correspondence: Maria J. Forteza...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
... and oxygen availability to tissues, leading to life-threatening outcomes including myocardial infarction (MI) and stroke. Patients with COPD are most likely to die as a result of a cardiovascular event, with 30% of all COPD-related deaths being attributed to cardiovascular disease (CVD). Both atherosclerosis...
Articles
Inês Vasconcelos, Rui Adão, Miriam T. Rademaker, Adelino F. Leite-Moreira, Ana Patrícia Fontes-Sousa, Carmen Brás-Silva
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 1–14.
Published: 23 December 2021
... PAH rat model. One of the limitations of this study was the lack of categorization of PAH according to their RV phenotype and the low levels of plasma Ucn-2 in patients could be related to a compensated RV state [ 72 ]. biomarkers cardiovascular disease urocortin The urocortins (Ucns...
Articles
In Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2661–2663.
Published: 09 December 2021
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer cardiovascular disease pharmacology Recent decades have seen remarkable improvements in cancer survival...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
... cardiovascular disease COVID-19 placental biology pregnancy SARS-COV-2 It is noteworthy that the extensive expression of ACE2 in the uteroplacental unit throughout gestation also supports a higher placental susceptibility to SARS-CoV-2 infection, potentially enabling vertical transmission. Placental...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
...Timothy M. Palmer; Ian P. Salt Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade...
Articles
In Collection
Cardiovascular-Oncology
Sailaja Kamaraju, Meera Mohan, Svetlana Zaharova, Brianna Wallace, Joseph McGraw, James Lokken, John Tierney, Elizabeth Weil, Olubadewa Fatunde, Sherry-Ann Brown
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1333–1351.
Published: 02 June 2021
...Sailaja Kamaraju; Meera Mohan; Svetlana Zaharova; Brianna Wallace; Joseph McGraw; James Lokken; John Tierney; Elizabeth Weil; Olubadewa Fatunde; Sherry-Ann Brown Recent advances in treatment have transformed the management of cancer. Despite these advances, cardiovascular disease remains a leading...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
Published: 20 May 2021
.... Roks ( [email protected] ) 19 04 2021 06 05 2021 07 05 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cardiovascular disease cGMP mechanotransduction notch signalling pathway rho-associated protein kinases...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1165–1187.
Published: 14 May 2021
... under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis cardiovascular disease Epigenetics Atherosclerosis is characterized by a pathological build-up of plaque within the arterial vessel walls and is a major contributor to cardiovascular disease [ 1...
Articles
Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman, Ahmed F. El-Yazbi
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (8): 1015–1051.
Published: 21 April 2021
... Inhibitors. Specifically, we discuss the molecular evidence supporting such pleiotropic effects in the context of cardiovascular disease (CVD) including endothelial dysfunction (ED), atherosclerosis, cardiac injury, stroke, and arrhythmia. Importantly, we highlight the role of DOACs in mitigating metabolic...
Articles
In Collection
Cardiovascular-Oncology
Leanne Mooney, Carl S. Goodyear, Tamir Chandra, Kristina Kirschner, Mhairi Copland, Mark C. Petrie, Ninian N. Lang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 991–1007.
Published: 16 April 2021
...Leanne Mooney; Carl S. Goodyear; Tamir Chandra; Kristina Kirschner; Mhairi Copland; Mark C. Petrie; Ninian N. Lang Ageing is a major risk factor for the development of cardiovascular disease (CVD) and cancer. Whilst the cumulative effect of exposure to conventional cardiovascular risk factors...
Articles
In Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (5): 703–724.
Published: 09 March 2021
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 autoimmunity cardiovascular disease heart failure immunomodulation Adaptive immune responses are key contributors to both anti-tumor and autoimmune immune responses that are triggered by cancer...
Articles
In Collection
Celebrating 100 years of insulin research
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 589–591.
Published: 10 February 2021
... associated with the manuscript. DM diabetes mellitus References 1. Cosentino F. , Grant P.J. , Aboyans V. , Bailey C.J. , Ceriello A. , Delgado V. et al . ( 2020 ) 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... (CKD), a patient collective with extremely high risk of cardiovascular morbidity and mortality. Higher phosphate levels in serum have been associated with increased risk for cardiovascular disease (CVD) in CKD patients, but also in the general population. The causal connections between phosphate...
Articles
Jack D. Beazer, Patamat Patanapirunhakit, Jason M.R. Gill, Delyth Graham, Helen Karlsson, Stefan Ljunggren, Monique T. Mulder, Dilys J. Freeman
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2977–2986.
Published: 19 November 2020
... protection from atheroma. In spite of this, therapies aimed at increasing HDL concentration do not reduce the risk of cardiovascular disease (CVD), and as such focus has shifted towards other HDL functions protective of vascular health – including vasodilatory, anti-inflammatory, antioxidant and anti...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (20): 2707–2727.
Published: 23 October 2020
...) to maintain vascular homeostasis. Imbalances in endothelial and vascular smooth muscle cell COX, LO, and CYP metabolites in metabolic and cardiovascular diseases result in vascular dysfunction. Restoring the vascular balance of eicosanoids by genetic or pharmacological means can improve vascular function...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... evolution shows greater lethality in patients with antecedent cardiovascular disease, diabetes, or even obesity questioned the potential unfavorable contribution of angiotensin converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor blockers as facilitators of adverse outcomes due...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2399–2418.
Published: 16 September 2020
.... Collecting evidence and advancing knowledge on the mechanotransduction in the vessel wall can lead to a new direction of therapeutic interventions for vascular diseases. cardiovascular disease extracellular matrix flow-induced shear stress mechanical stimuli mechanotransduction vascular biology...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
... pathway as a novel therapeutic approach for cardiovascular diseases . Biochim. Biophys. Acta Mol. Basis Dis. 1863 , 1942 – 1950 10.1016/j.bbadis.2016.11.007 27825851 8. Kleinz M.J. and Davenport A.P. ( 2005 ) Emerging roles of Apelin in biology and medicine . Pharmacol. Ther...
Articles
Danlin Liu, Gavin Richardson, Fehmi M. Benli, Catherine Park, João V. de Souza, Agnieszka K. Bronowska, Ioakim Spyridopoulos
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Published: 03 September 2020
... molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1473–1474.
Published: 24 June 2020
... Limited on behalf of the Biochemical Society 2020 Adipose Biology Adipose tissue cardiometabolic disease cardiovascular disease Over the past decade, research in the field of adipose biology has grown exponentially offering new insights into the physiological and pathophysiological roles...
Articles
Manal Muin Fardoun, Dina Maaliki, Nabil Halabi, Rabah Iratni, Alessandra Bitto, Elias Baydoun, Ali H. Eid
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
... to progressive organ damage. Most of the vast endothelial surface area is part of the microcirculation, but most research in CKD-related cardiovascular disease (CVD) has been devoted to macrovascular complications. We have reviewed all publications evaluating structure and function of the microcirculation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (6): 657–676.
Published: 27 March 2020
...Xiao-Feng Chen; Xiangqi Chen; Xiaoqiang Tang Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies generally focused on the roles of long-chain fatty acids (LCFAs) in CVDs...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (4): 435–437.
Published: 28 February 2020
.... Touyz ( [email protected] ) 17 02 2020 17 02 2020 21 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease molecular mechanisms translational science Published by Portland Press...
Articles
Sarah R. Anthony, Adrienne R. Guarnieri, Anamarie Gozdiff, Robert N. Helsley, Albert Phillip Owens, III, Michael Tranter
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (22): 2329–2344.
Published: 28 November 2019
...), and epicardial adipose tissue (EAT) secretome on the development and progression of cardiovascular disease (CVD), with a particular focus on cardiac hypertrophy and fibrosis. Correspondence: Michael Tranter ( [email protected] ) 25 09 2019 08 11 2019 13 11 2019 © 2019 The Author...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2217–2220.
Published: 13 November 2019
... of cardiac fibrosis. A model system that is more closely related to humans could facilitate the study of fibrosis. Induced pluripotent stem cells offer a patient specific model of disease that has the potential to more reliably recapitulate the nuances of human cardiovascular disease [ 25 ]. Using iPSC...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... of diabetes are also recognized. The causes include genetic defects in β-cells and insulin action, diseases of the pancreas, endocrine pathologies, drug-induced reactions and infections [ 10 ]. cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes...
Articles
Siroon Bekkering, Albert P. Limawan, Maria U. Nguyen, Lisa K. Widiasmoko, Hui Lu, Salvatore Pepe, Michael M. Cheung, Trevelyan R. Menheniott, Megan J. Wallace, David P. Burgner, Timothy J. Moss
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (10): 1185–1196.
Published: 30 May 2019
.... Human and mechanistic studies are warranted to guide preventative strategies. cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and chronic...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1137–1143.
Published: 14 May 2019
... BY) . chronic disease cardiovascular disease multimorbidity precision medicine vascular biomedicine Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality worldwide [ 1 ]. It is often the vascular component of CVD that drives development of conditions such as myocardial...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... that cardiovascular-related comorbidities contribute to morbidity and mortality in COPD, with approximately 50% of deaths in COPD patients attributed to a cardiovascular event (e.g. myocardial infarction). Cardiovascular disease (CVD) and COPD share various risk factors including hypertension, sedentarism, smoking...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 205–224.
Published: 22 January 2019
... to lower the risk of cardiovascular disease, PCSK9 inhibitors represent an important therapeutic target, particularly in high-risk populations. Here, we summarise and update the science of PCSK9, including its discovery and the development of various inhibitors, including the now approved monoclonal...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 195–203.
Published: 18 January 2019
... abundant cell regulating plaque progression and stability. Recent studies have revealed a role for endogenous compounds related to atherosclerosis in the induction of trained immunity, which can enhance the expression of genes implicated in atherosclerosis and associated cardiovascular disease. Accelerated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... of RAAS blockade altered the association between circulating MPs and 24hUNa. cardiovascular disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality in people...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1699–1709.
Published: 16 August 2018
.... Correspondence: John R. Petrie ( [email protected] ) 26 06 2018 02 08 2018 03 08 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease clinical trials glucagon-like peptide-1 type 2 diabetes...
Articles
Clarissa P.C. Gomes, David de Gonzalo-Calvo, Rocio Toro, Tiago Fernandes, Daniel Theisen, Da-Zhi Wang, Yvan Devaux, on behalf of the Cardiolinc™ network
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
...Clarissa P.C. Gomes; David de Gonzalo-Calvo; Rocio Toro; Tiago Fernandes; Daniel Theisen; Da-Zhi Wang; Yvan Devaux; on behalf of the Cardiolinc™ network There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (7): 791–811.
Published: 16 April 2018
...-metabolism. The metabolic conditions reviewed here include obesity, a known risk factor for all of the other metabolic conditions, as well as, cardiovascular disease, diabetes and nonalcoholic fatty liver disease. Only by further understanding the cause and result of gut dysbiosis will an adequate solution...
Articles
Montserrat Baldan-Martin, Elena Rodríguez-Sánchez, Laura González-Calero, Luis M. Ruilope, Gloria Alvarez-Llamas, María G. Barderas, Gema Ruiz-Hurtado
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (7): 739–758.
Published: 06 April 2018
... are joint first authors. † These authors contributed equally to this work. 30 01 2018 09 03 2018 22 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 albuminuria cardiovascular disease metabolomics proteomics...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
...Asokan Devarajan The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging studies have revealed...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (5): 509–522.
Published: 09 March 2018
... chronic kidney disease cardiovascular disease microbiome mortality uremic toxins The intestinal microbiome is markedly altered in chronic kidney disease (CKD) and results in increased production of bacteria-derived uremic toxins such as indoxyl sulphate, p -cresyl sulphate, and trimethylamine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... risks [ 73 , 74 ]. It has been reported that adherence to the Mediterranean diet leads to a decrease in all the causes of mortality and in the incidence of cardiovascular diseases [ 75 ]. Moreover, dietary interventions can modify the microbiota composition by inducing rapid changes in certain nutrients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
... cardiovascular disease (CVD) risk. Currently, there is great interest in the role of the endothelin system in pre-eclampsia. Targetting the endothelin system, potentially by modulating upstream pathways to prevent ET B receptor dysfunction, may improve health outcomes for women and their offspring during pre...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2791–2794.
Published: 23 November 2017
...Michal Zeman; Monika Okuliarova Cardiovascular diseases (CVDs) are the leading cause of mortality and hypertension contributes substantially to the incidence of stroke, coronary artery disease, heart failure, atrial fibrillation and peripheral vascular disease. The origin of hypertension is clearly...
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