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Keywords: cardiovascular disease
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (13): 817–850.
Published: 26 June 2024
... targeting from a clinical translational perspective. In summary, vascular remodelling, a coordinated modification of vascular structure and function, is crucial in cardiovascular disease pathology. Correspondence: Tomasz J. Guzik ( [email protected] ) 26 09 2023 08 06 2024 10 06 2024...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (7): 537–542.
Published: 13 April 2023
... in cardiology and went on to establish a Clinical Research Center in St. Andrews, Scotland [ 2 ]. Both Lewis and Mackenzie were inducted as Fellows of the Royal Society, and both later succumbed to cardiovascular disease. Because of Lewis’s and Mackenzie’s expertise and notoriety, Heart served as a highly...
Articles
Lauren T. May, Belinda A. Bartolo, David G. Harrison, Tomasz Guzik, Grant R. Drummond, Gemma A. Figtree, Rebecca H. Ritchie, Kerry-Anne Rye, Judy B. de Haan
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1731–1758.
Published: 02 December 2022
...Lauren T. May; Belinda A. Bartolo; David G. Harrison; Tomasz Guzik; Grant R. Drummond; Gemma A. Figtree; Rebecca H. Ritchie; Kerry-Anne Rye; Judy B. de Haan Cardiovascular disease (CVD) remains the leading cause of death worldwide. An ongoing challenge remains the development of novel...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1257–1280.
Published: 05 September 2022
...: Antonio L. Teixeira ( [email protected] ) 11 04 2022 16 08 2022 22 08 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cardiovascular disease inflammation Mental disorder metabolic disorders Mood disorder...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (15): 1157–1178.
Published: 10 August 2022
...Denise Busscher; Reinier A. Boon; Rio P. Juni Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases...
Articles
Kurt Brassington, Stanley M.H. Chan, Simone N. De Luca, Aleksandar Dobric, Suleman A. Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 537–555.
Published: 21 April 2022
... antioxidant cardiovascular disease cigarette smoke endothelium vascular dysfunction Chronic obstructive pulmonary disease (COPD) is an incurable disease characterised by a progressive airflow limitation and irreversible decline in lung function. COPD is currently the third leading cause of death...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 431–434.
Published: 29 March 2022
...) (2021) 135 (24): 2667–2689. DOI: 10.1042/CS20210735). These findings support the notion that circulating SARS-CoV-2 S protein could contribute to cardiovascular disease independent of viral infection. Future studies are needed to determine the effect of the S protein on pericytes in other organs...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 435–454.
Published: 29 March 2022
... characterised in innate and adaptive immune cells, and discuss how macrophages’ and T cells’ metabolism may influence phenotypic changes in the plaque. Moreover, we discuss the potential of targeting immunometabolism to prevent and treat cardiovascular diseases (CVDs). Correspondence: Maria J. Forteza...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
... and oxygen availability to tissues, leading to life-threatening outcomes including myocardial infarction (MI) and stroke. Patients with COPD are most likely to die as a result of a cardiovascular event, with 30% of all COPD-related deaths being attributed to cardiovascular disease (CVD). Both atherosclerosis...
Articles
Inês Vasconcelos, Rui Adão, Miriam T. Rademaker, Adelino F. Leite-Moreira, Ana Patrícia Fontes-Sousa, Carmen Brás-Silva
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 1–14.
Published: 23 December 2021
...), relative LV wall thickness and body mass index (BMI). The positive relationship of Ucn-2 with LVMI is relevant given that LV hypertrophy is a potent predictor of cardiac events in hypertensive patients and an independent risk factor for cardiovascular diseases [ 61 ]. Walczewska et al. studied...
Articles
In Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2661–2663.
Published: 09 December 2021
... unwanted cardiovascular effects of anti-cancer therapies, cardioprotective strategies can be developed. Only by doing so, will patients be able to achieve optimal cancer treatment at the minimum cost to cardiovascular health. cancer cardiovascular disease pharmacology Recent decades have seen...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 cardiovascular disease COVID-19 placental biology pregnancy SARS-COV-2 The world is facing one of the greatest pandemics in history. The coronavirus disease 2019 (COVID...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
...Timothy M. Palmer; Ian P. Salt Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade...
Articles
In Collection
Cardiovascular-Oncology
Sailaja Kamaraju, Meera Mohan, Svetlana Zaharova, Brianna Wallace, Joseph McGraw, James Lokken, John Tierney, Elizabeth Weil, Olubadewa Fatunde, Sherry-Ann Brown
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1333–1351.
Published: 02 June 2021
...Sailaja Kamaraju; Meera Mohan; Svetlana Zaharova; Brianna Wallace; Joseph McGraw; James Lokken; John Tierney; Elizabeth Weil; Olubadewa Fatunde; Sherry-Ann Brown Recent advances in treatment have transformed the management of cancer. Despite these advances, cardiovascular disease remains a leading...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
Published: 20 May 2021
.... Correspondence: Anton J.M. Roks ( [email protected] ) 19 04 2021 06 05 2021 07 05 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cardiovascular disease cGMP mechanotransduction notch signalling pathway rho-associated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1165–1187.
Published: 14 May 2021
... 2021 08 04 2021 27 04 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis cardiovascular disease...
Articles
Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman, Ahmed F. El-Yazbi
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (8): 1015–1051.
Published: 21 April 2021
... Inhibitors. Specifically, we discuss the molecular evidence supporting such pleiotropic effects in the context of cardiovascular disease (CVD) including endothelial dysfunction (ED), atherosclerosis, cardiac injury, stroke, and arrhythmia. Importantly, we highlight the role of DOACs in mitigating metabolic...
Articles
In Collection
Cardiovascular-Oncology
Leanne Mooney, Carl S. Goodyear, Tamir Chandra, Kristina Kirschner, Mhairi Copland, Mark C. Petrie, Ninian N. Lang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 991–1007.
Published: 16 April 2021
...Leanne Mooney; Carl S. Goodyear; Tamir Chandra; Kristina Kirschner; Mhairi Copland; Mark C. Petrie; Ninian N. Lang Ageing is a major risk factor for the development of cardiovascular disease (CVD) and cancer. Whilst the cumulative effect of exposure to conventional cardiovascular risk factors...
Articles
In Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (5): 703–724.
Published: 09 March 2021
... ( [email protected] ) 28 12 2020 22 02 2021 24 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 autoimmunity cardiovascular disease heart failure immunomodulation Adaptive immune responses are key contributors...
Articles
In Collection
Celebrating 100 years of insulin research
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 589–591.
Published: 10 February 2021
... 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cardiovascular disease Metabolites type 2 diabetes Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and defect in metabolism of energy substrate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... (CKD), a patient collective with extremely high risk of cardiovascular morbidity and mortality. Higher phosphate levels in serum have been associated with increased risk for cardiovascular disease (CVD) in CKD patients, but also in the general population. The causal connections between phosphate...
Articles
Jack D. Beazer, Patamat Patanapirunhakit, Jason M.R. Gill, Delyth Graham, Helen Karlsson, Stefan Ljunggren, Monique T. Mulder, Dilys J. Freeman
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2977–2986.
Published: 19 November 2020
... protection from atheroma. In spite of this, therapies aimed at increasing HDL concentration do not reduce the risk of cardiovascular disease (CVD), and as such focus has shifted towards other HDL functions protective of vascular health – including vasodilatory, anti-inflammatory, antioxidant and anti...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (20): 2707–2727.
Published: 23 October 2020
...) to maintain vascular homeostasis. Imbalances in endothelial and vascular smooth muscle cell COX, LO, and CYP metabolites in metabolic and cardiovascular diseases result in vascular dysfunction. Restoring the vascular balance of eicosanoids by genetic or pharmacological means can improve vascular function...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... evolution shows greater lethality in patients with antecedent cardiovascular disease, diabetes, or even obesity questioned the potential unfavorable contribution of angiotensin converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor blockers as facilitators of adverse outcomes due...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2399–2418.
Published: 16 September 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease extracellular matrix flow-induced shear stress mechanical stimuli mechanotransduction vascular biology Deciphering the role of hemodynamic forces in homeostasis and disease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
... by a partial loss of apelin action [ 33 , 38 , 49 ]. angiotensin converting enzyme 2 apelin analogs apelin peptides cardiovascular disease pulmonary hypertension renin-angiotensin system The search for endogenous ligands for the orphan G-protein coupled APJ receptor, renamed...
Articles
Danlin Liu, Gavin Richardson, Fehmi M. Benli, Catherine Park, João V. de Souza, Agnieszka K. Bronowska, Ioakim Spyridopoulos
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Published: 03 September 2020
... molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1473–1474.
Published: 24 June 2020
... processes leading to cardiovascular disease. This is supported by a rich body of literature describing the impact of dysfunctional adipose depots on cardiac and vascular structure and function. Moreover, adipose tissue changes were shown to occur in a gradual, insidious manner that might precede systemic...
Articles
Manal Muin Fardoun, Dina Maaliki, Nabil Halabi, Rabah Iratni, Alessandra Bitto, Elias Baydoun, Ali H. Eid
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
... to progressive organ damage. Most of the vast endothelial surface area is part of the microcirculation, but most research in CKD-related cardiovascular disease (CVD) has been devoted to macrovascular complications. We have reviewed all publications evaluating structure and function of the microcirculation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (6): 657–676.
Published: 27 March 2020
...Xiao-Feng Chen; Xiangqi Chen; Xiaoqiang Tang Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies generally focused on the roles of long-chain fatty acids (LCFAs) in CVDs...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (4): 435–437.
Published: 28 February 2020
.... Touyz ( [email protected] ) 17 02 2020 17 02 2020 21 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease molecular mechanisms translational science Published by Portland Press...
Articles
Sarah R. Anthony, Adrienne R. Guarnieri, Anamarie Gozdiff, Robert N. Helsley, Albert Phillip Owens, III, Michael Tranter
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (22): 2329–2344.
Published: 28 November 2019
...), and epicardial adipose tissue (EAT) secretome on the development and progression of cardiovascular disease (CVD), with a particular focus on cardiac hypertrophy and fibrosis. Correspondence: Michael Tranter ( [email protected] ) 25 09 2019 08 11 2019 13 11 2019 © 2019 The Author...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2217–2220.
Published: 13 November 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease fibrosis microRNA Cardiovascular disease (CVD) is the leading cause of death worldwide, with over 17.6 million deaths per year [ 1 ]. Cardiomyopathy is a type of CVD and cardiac fibrosis is an important...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... ( [email protected] ) 12 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes The development...
Articles
Siroon Bekkering, Albert P. Limawan, Maria U. Nguyen, Lisa K. Widiasmoko, Hui Lu, Salvatore Pepe, Michael M. Cheung, Trevelyan R. Menheniott, Megan J. Wallace, David P. Burgner, Timothy J. Moss
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (10): 1185–1196.
Published: 30 May 2019
... Society 2019 cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and chronic inflammatory conditions, such as severe infections...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1137–1143.
Published: 14 May 2019
... 2019 07 05 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chronic disease cardiovascular disease multimorbidity...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... that cardiovascular-related comorbidities contribute to morbidity and mortality in COPD, with approximately 50% of deaths in COPD patients attributed to a cardiovascular event (e.g. myocardial infarction). Cardiovascular disease (CVD) and COPD share various risk factors including hypertension, sedentarism, smoking...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 205–224.
Published: 22 January 2019
... to lower the risk of cardiovascular disease, PCSK9 inhibitors represent an important therapeutic target, particularly in high-risk populations. Here, we summarise and update the science of PCSK9, including its discovery and the development of various inhibitors, including the now approved monoclonal...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 195–203.
Published: 18 January 2019
... abundant cell regulating plaque progression and stability. Recent studies have revealed a role for endogenous compounds related to atherosclerosis in the induction of trained immunity, which can enhance the expression of genes implicated in atherosclerosis and associated cardiovascular disease. Accelerated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... identifiable precursor to atherosclerosis with subsequent progression to cardiovascular disease [ 19 ], timelier identification, and intervention may improve outcomes. Underpinning the molecular mechanisms of endothelial dysfunction may be possible through the use of biomarkers, such as circulating...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1699–1709.
Published: 16 August 2018
.... Correspondence: John R. Petrie ( [email protected] ) 26 06 2018 02 08 2018 03 08 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease clinical trials glucagon-like peptide-1 type 2 diabetes...
Articles
Clarissa P.C. Gomes, David de Gonzalo-Calvo, Rocio Toro, Tiago Fernandes, Daniel Theisen, Da-Zhi Wang, Yvan Devaux, on behalf of the Cardiolinc™ network
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
...Clarissa P.C. Gomes; David de Gonzalo-Calvo; Rocio Toro; Tiago Fernandes; Daniel Theisen; Da-Zhi Wang; Yvan Devaux; on behalf of the Cardiolinc™ network There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (7): 791–811.
Published: 16 April 2018
...-metabolism. The metabolic conditions reviewed here include obesity, a known risk factor for all of the other metabolic conditions, as well as, cardiovascular disease, diabetes and nonalcoholic fatty liver disease. Only by further understanding the cause and result of gut dysbiosis will an adequate solution...
Articles
Montserrat Baldan-Martin, Elena Rodríguez-Sánchez, Laura González-Calero, Luis M. Ruilope, Gloria Alvarez-Llamas, María G. Barderas, Gema Ruiz-Hurtado
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (7): 739–758.
Published: 06 April 2018
... are joint first authors. † These authors contributed equally to this work. 30 01 2018 09 03 2018 22 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 albuminuria cardiovascular disease metabolomics proteomics...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
...Asokan Devarajan The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging studies have revealed...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (5): 509–522.
Published: 09 March 2018
... kidney disease cardiovascular disease microbiome mortality uremic toxins A healthy adult harbors approximately 100 trillion gut bacteria – this is ten-fold greater than the number of cells in the human body [ 1 ]. The genome of the gut microbiome encompasses 3.3 million genes [ 2 ] which...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics Correspondence: W.H. Wilson Tang ( [email protected] ) 02 09 2017 15 11 2017 20 11...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
... cardiovascular disease (CVD) risk. Currently, there is great interest in the role of the endothelin system in pre-eclampsia. Targetting the endothelin system, potentially by modulating upstream pathways to prevent ET B receptor dysfunction, may improve health outcomes for women and their offspring during pre...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2791–2794.
Published: 23 November 2017
...Michal Zeman; Monika Okuliarova Cardiovascular diseases (CVDs) are the leading cause of mortality and hypertension contributes substantially to the incidence of stroke, coronary artery disease, heart failure, atrial fibrillation and peripheral vascular disease. The origin of hypertension is clearly...
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