...Szu-Yu Chien; Chun-Yin Huang; Chun-Hao Tsai; Shih-Wei Wang; Yu-Min Lin; Chih-Hsin Tang Arthritis is a process of chronic inflammation that results in joint damage. IL (interleukin)-1β is an inflammatory cytokine that acts as a key mediator of cartilage degradation, and is abundantly expressed...

... was significantly amplified [ 47 ]. The findings suggest that these miRNAs work in synergy to promote normal skeletal development, or miR-140 has a key role in chondrogenesis and the generation of cartilage. Correspondence: Darrell Green (email d.green@uea.ac.uk ). 26 3 2015 17 7 2015...

... process that leads to increases in proteoglycan synthesis. 18 9 1995 19 9 1995 © 1996 The Biochemical Society and the Medical Research Society 1996 articular cartilage cells ion channels mechanoreceptors membrane potential Clinical Science (1996) Qo, 61-71 (Printed in Great...

... cytokines that influence the metabolism of articular cartilage may have a similar effect, we have investigated whether tumour necrosis factor-α also modulates the stimulation of the production of prostaglandin E 2 in these cells by ATP. 2. Tumour necrosis factor-α enhanced the response of cultured human...

... of collagenase in the early days of culture, similar to that previously described for rabbit tissues. in contrast, no free inhibitor could be detected in the media of rheumatoid synovial cultures. 4. Explants of normal human articular cartilage produced latent collagenase and free inhibitor in culture. 5...

...R. H. Pryce-Jones; J. Saklatvala; G. C. Wood 1. The cartilage-proteoglycan-degrading activity of synovial fluid cells from rheumatoid patients is primarily due to neutral protease activity; hyaluronidase does not contribute significantly. Evidence for these conclusions is adduced from...

...Jennifer M. Dehnel; M. J. O. Francis 1. Homocystine (10 mg/100 ml) has a significant effect on the incorporation of inorganic sulphate by rat costal cartilage in vitro. 2. The characteristic skeletal changes associated with homocystinuria due to defective cystathionine synthetase could therefore...