... Increased O- GlcNAcylation ( O- GlcNAc) in cerebral arteries, as a result of a high-fat diet (HFD), augments reactivity to constrictor stimuli as well as increases mitogen-activated protein kinases (MAPKs) activity. Increased O -GlcNAc levels may represent a new mechanism to cerebral vasculature...

.... the basilar artery) is approx. 80% of aortic pressure and pressure in pial arteries on the cerebrum [e.g. the MCA (middle cerebral artery)] is approx. 50% of systemic pressure [ 3 ]. In addition, extracranial arteries, such as the carotid or vertebral arteries, are major sites of resistance to blood flow [ 3...

... was to determine vasoconstrictor potency (EC 50 ) of triptans in human coronary and cerebral arteries and to examine whether there was any relationship with the maximal plasma concentrations ( C max ; nM) of the drugs achieved following oral administration of clinically relevant doses to man using values reported...