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Keywords: cerebrospinal fluid
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Articles

Perivascular spaces, glymphatic dysfunction, and small vessel disease

Humberto Mestre, Serhii Kostrikov, Rupal I. Mehta, Maiken Nedergaard
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (17): 2257–2274.
https://doi.org/10.1042/CS20160381
Published: 10 August 2017
... ) * These authors contributed equally to this work. 17 03 2017 09 07 2017 24 07 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Cerebrospinal fluid CNS clearance Glymphatic Perivascular space Small vessel disease...
View article titled, Perivascular spaces, glymphatic dysfunction, and small vessel disease
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Articles

T helper 9 cells induced by plasmacytoid dendritic cells regulate interleukin-17 in multiple sclerosis

Gabriella Ruocco, Silvia Rossi, Caterina Motta, Giulia Macchiarulo, Francesca Barbieri, Marco De Bardi, Giovanna Borsellino, Annamaria Finardi, Maria Grazia Grasso, Serena Ruggieri, Claudio Gasperini, Roberto Furlan, Diego Centonze, Luca Battistini, Elisabetta Volpe
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (4): 291–303.
https://doi.org/10.1042/CS20140608
Published: 21 May 2015
... in Th17-polarized cells. Moreover, in the cerebrospinal fluid (CSF) of 107 RR-MS patients, IL-9 inversely correlated with indexes of inflammatory activity, neurodegeneration and disability progression of MS. High levels of IL-9 were associated with the absence of IL-17 in the CSF of RR-MS patients. Our...
View article titled, T helper 9 cells induced by plasmacytoid dendritic cells regulate interleukin-17 in multiple sclerosis
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Includes: Supplementary data
Articles

Dopamine β -Hydroxylase Immunoreactivity in Human Cerebrospinal Fluid: Properties, Relationship to Central Noradrenergic Neuronal Activity and Variation in Parkinson's Disease and Congenital Dopamine β -Hydroxylase Deficiency

Daniel T. O'Connor, Justine H. Cervenka, Richard A. Stone, Gail L. Levine, Robert J. Parmer, Rebecca E. Franco-Bourland, Ignacio Madrazo, Philip J. Langlais, David Robertson, Italo Biaggioni
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (2): 149–158.
https://doi.org/10.1042/cs0860149
Published: 01 February 1994
... in noradrenergic neurons and chromaffin cells. Although dopamine β-hydroxylase enzymic activity is measurable in cerebrospinal fluid, such activity is unstable, and its relationship to central noradrenergic neuronal activity in humans is not clearly established. To explore the significance of cerebrospinal fluid...
View article titled, Dopamine β -Hydroxylase Immunoreactivity in Human <span class="search-highlight">Cerebrospinal</span> <span class="search-highlight">Fluid</span>: Properties, Relationship to Central Noradrenergic Neuronal Activity and Variation in Parkinson&#x27;s Disease and Congenital Dopamine β -Hydroxylase Deficiency
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Articles

Cerebrospinal fluid levels of substance P and calcitonin-gene-related peptide: Correlation with sural nerve levels and neuropathic signs in sensory diabetic polyneuropathy

C. Tsigos, L. T. Diemel, A. White, D. R. Tomlinson, R. J. Young
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (3): 305–311.
https://doi.org/10.1042/cs0840305
Published: 01 March 1993
...C. Tsigos; L. T. Diemel; A. White; D. R. Tomlinson; R. J. Young 1. Lumbar spinal substance P and calcitonin-gene-related peptide derive from spillage out of the dorsal horns associated with activity of small primary sensory afferents (C- and Aδ-fibres). Cerebrospinal fluid and sural nerve levels...
View article titled, <span class="search-highlight">Cerebrospinal</span> <span class="search-highlight">fluid</span> levels of substance P and calcitonin-gene-related peptide: Correlation with sural nerve levels and neuropathic signs in sensory diabetic polyneuropathy
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Articles

Possible long-lasting inhibition of converting enzyme by enalapril in human cerebrospinal fluid

Marcello Fanciullacci, Massimo Alessandri, Maria Nicolodi, Sergio Michelacci, Federigo Sicuteri
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (3): 313–317.
https://doi.org/10.1042/cs0840313
Published: 01 March 1993
...Marcello Fanciullacci; Massimo Alessandri; Maria Nicolodi; Sergio Michelacci; Federigo Sicuteri 1. Converting enzyme and neutral endopeptidase activities were both measured every 3 h by a fluorimetric method in plasma and cerebrospinal fluid of patients diagnosed as migraineurs with aura after...
View article titled, Possible long-lasting inhibition of converting enzyme by enalapril in human <span class="search-highlight">cerebrospinal</span> <span class="search-highlight">fluid</span>
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Articles

Effects of the Fab fragment of digoxin antibody on the natriuresis and increase in blood pressure induced by intracerebroventricular infusion of hypertonic saline solution in rats

Kaoru YAMADA, Atsuo GOTO, Chen HUI, Noriko YAGI, Tsuneaki SUGIMOTO
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (6): 625–630.
https://doi.org/10.1042/cs0820625
Published: 01 June 1992
... or pressor response to digoxin in guinea-pigs. 3. Infusion of high-sodium cerebrospinal fluid, but not normal-sodium cerebrospinal fluid, into the lateral brain ventricle of rats caused marked increases in blood pressure, urine volume and urinary sodium excretion. 4. Digibind did not significantly affect...
View article titled, Effects of the Fab fragment of digoxin antibody on the natriuresis and increase in blood pressure induced by intracerebroventricular infusion of hypertonic saline solution in rats
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Articles

Central bradykininergic system in normotensive and hypertensive rats

Azucena L. Alvarez, Alejandro Delorenzi, Daniel Santajuliana, Samuel Finkielman, Victor E. Nahmod, Carlos J. Pirola
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (5): 513–519.
https://doi.org/10.1042/cs0820513
Published: 01 May 1992
... cerebrospinal fluid depressor effect kinin antagonist kinin receptor spontaneously hypertensive rats Clinical Science (I 992) 82, 5 13-5 I 9 (Printed in Great Britain) 513 Central bradykininergic system in normotensive and hypertensive rats Azucena L. ALVAREZ, Alejandro DELORENZI, Daniel SANTAJULIANA...
View article titled, Central bradykininergic system in normotensive and hypertensive rats
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Articles

Ferrous ions detected in cerebrospinal fluid by using bleomycin and DNA damage

John M. C. Gutteridge
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (3): 315–320.
https://doi.org/10.1042/cs0820315
Published: 01 March 1992
...-ion-oxidizing activity of caeruloplasmin rapidly converts ferrous ions back to the less reactive ferric state so that they can bind to available binding sites on transferrin. 4. Cerebrospinal fluids, however, often appear to contain low-molecular-mass iron, high levels of ascorbate and low levels...
View article titled, Ferrous ions detected in <span class="search-highlight">cerebrospinal</span> <span class="search-highlight">fluid</span> by using bleomycin and DNA damage
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Articles

Correlation of the ratio of S-adenosyl-l-methionine to S-adenosyl-l-homocysteine in the brain and cerebrospinal fluid of the pig: implications for the determination of this methylation ratio in human brain

D. G. Weir, A. M. Molloy, J. N. Keating, P. B. Young, S. Kennedy, D. G. Kennedy, J. M. Scott
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (1): 93–97.
https://doi.org/10.1042/cs0820093
Published: 01 January 1992
... of cerebrospinal fluid, cortex, cerebellum and spinal cord were then extracted and analysed for S -adenosyl- l -methionine and S -adenosyl- l -homocysteine. Regression analyses were carried out on values obtained in cerebrospinal fluid and in neural tissues. 2. Highly significant correlations were obtained between...
View article titled, Correlation of the ratio of S-adenosyl-l-methionine to S-adenosyl-l-homocysteine in the brain and <span class="search-highlight">cerebrospinal</span> <span class="search-highlight">fluid</span> of the pig: implications for the determination of this methylation ratio in human brain
Open the PDF for Correlation of the ratio of S-adenosyl-l-methionine to S-adenosyl-l-homocysteine in the brain and <span class="search-highlight">cerebrospinal</span> <span class="search-highlight">fluid</span> of the pig: implications for the determination of this methylation ratio in human brain in another window
Articles

Alterations in Cerebrospinal Fluid Angiotensin II by Sodium Intake in Patients with Essential Hypertension

Minoru Kawamura, Yuhei Kawano, Kaoru Yoshida, Masahito Imanishi, Satoshi Akabane, Yohkazu Matsushima, Morio Kuramochi, Kazuaki Shimamoto, Keiichi Ito, Teruo Omae
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (4): 389–394.
https://doi.org/10.1042/cs0770389
Published: 01 October 1989
...Minoru Kawamura; Yuhei Kawano; Kaoru Yoshida; Masahito Imanishi; Satoshi Akabane; Yohkazu Matsushima; Morio Kuramochi; Kazuaki Shimamoto; Keiichi Ito; Teruo Omae 1. Angiotensin (ANG) levels were measured in the cerebrospinal fluid of 15 patients with essential hypertension on a high sodium diet...
View article titled, Alterations in <span class="search-highlight">Cerebrospinal</span> <span class="search-highlight">Fluid</span> Angiotensin II by Sodium Intake in Patients with Essential Hypertension
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Articles

Influence of sodium concentration in cerebrospinal fluid on plasma atrial natriuretic peptide in conscious rats

Yuhei Kawano, Kaoru Yoshida, Yukio Hirata, Hiroki Yoshimi, Morio Kuramochi, Keiichi Ito, Teruo Omae
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (1): 49–52.
https://doi.org/10.1042/cs0740049
Published: 01 January 1988
... of high Na + artificial cerebrospinal fluid (CSF) on blood pressure, urinary Na + excretion and plasma ANP levels in conscious Wistar rats. 2. Infusion of high Na + (0.6 mol/1) CSF into the lateral ventricle at a rate of 1 μl/min for 60 min significantly increased mean blood pressure and urinary Na...
View article titled, Influence of sodium concentration in <span class="search-highlight">cerebrospinal</span> <span class="search-highlight">fluid</span> on plasma atrial natriuretic peptide in conscious rats
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Articles

High resolution proton nuclear magnetic resonance studies of human cerebrospinal fluid

Jimmy D. Bell, Judith C. C. Brown, Peter J. Sadler, Andrew F. MacLeod, Peter H. Sönksen, Robin D. Hughes, Roger Williams
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (5): 563–570.
https://doi.org/10.1042/cs0720563
Published: 01 May 1987
...Jimmy D. Bell; Judith C. C. Brown; Peter J. Sadler; Andrew F. MacLeod; Peter H. Sönksen; Robin D. Hughes; Roger Williams 1. One- and two-dimensional (correlated shift spectroscopy) high resolution proton n.m.r. spectra of human cerebrospinal fluid (CSF) are reported. The merits of water suppression...
View article titled, High resolution proton nuclear magnetic resonance studies of human <span class="search-highlight">cerebrospinal</span> <span class="search-highlight">fluid</span>
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Articles

δ-Aminolaevulinic acid in plasma, cerebrospinal fluid, saliva and erythrocytes: Studies in normal, uraemic and porphyric subjects

A. Gorchein, R. Webber
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (1): 103–112.
https://doi.org/10.1042/cs0720103
Published: 01 January 1987
...A. Gorchein; R. Webber 1. ô-Aminolaevulinic acid (ALA) was determined by g.l.c. with electron-capture detection. Normal plasma level was 92 nmol/l ( sd = 39, n = 89, range 24–270 nmol/l). 2. ALA was undetectable in 35 of 53 samples of normal cerebrospinal fluid (limit of assay 2 nmol/l). The mean...
View article titled, δ-Aminolaevulinic acid in plasma, <span class="search-highlight">cerebrospinal</span> <span class="search-highlight">fluid</span>, saliva and erythrocytes: Studies in normal, uraemic and porphyric subjects
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Articles

Cerebrospinal fluid γ-aminobutyric acid levels in dogs with chronic portosystemic encephalopathy

J. E. Maddison, D. Yau, P. Stewart, G. C. Farrell
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (6): 749–753.
https://doi.org/10.1042/cs0710749
Published: 01 December 1986
...J. E. Maddison; D. Yau; P. Stewart; G. C. Farrell 1. Cerebrospinal fluid (CSF) γ-aminobutyric acid (GABA) levels were measured in a dog model of spontaneous chronic portosystemic encephalopathy. 2. Dogs with congenital portacaval shunts (intra- or extra-hepatic) develop neurological features...
View article titled, <span class="search-highlight">Cerebrospinal</span> <span class="search-highlight">fluid</span> γ-aminobutyric acid levels in dogs with chronic portosystemic encephalopathy
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Articles

Superoxide dismutase isoenzymes in cerebrospinal fluid and plasma from patients with neuronal ceroid-lipofuscinoses

Stefan L. Marklund, Hannu Heiskala, Tuomas Westermarck, Pirkko Santavuori
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (1): 57–60.
https://doi.org/10.1042/cs0710057
Published: 01 July 1986
... that cerebrospinal fluid from patients with infantile and juvenile neuronal ceroid-lipofuscinosis were less protective against superoxide radical-induced hydroxyl radical formation compared with controls [3]. 2. The content of superoxide dismutase isoenzymes in cerebrospinal fluid and in plasma from patients...
View article titled, Superoxide dismutase isoenzymes in <span class="search-highlight">cerebrospinal</span> <span class="search-highlight">fluid</span> and plasma from patients with neuronal ceroid-lipofuscinoses
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Articles

Elevation of sodium levels in the cerebral ventricles of anaesthetized dogs triggers the release of an inhibitor of ouabain-sensitive sodium, potassium-ATPase into the circulation

Bhagavan S. Jandhyala, Ahmad F. Ansari
Journal: Clinical Science
Clin Sci (Lond) (1986) 70 (1): 103–110.
https://doi.org/10.1042/cs0700103
Published: 01 January 1986
... + −pump activity was estimated in the plantar and dorsal branches of the lateral saphenous veins by using the 86 Rb-uptake method. 2. Infusion of the cerebral ventricles with the artificial cerebrospinal fluid (CSF) containing normal Na + (0.15 mol/l) for over 120 min resulted in significant increases...
View article titled, Elevation of sodium levels in the cerebral ventricles of anaesthetized dogs triggers the release of an inhibitor of ouabain-sensitive sodium, potassium-ATPase into the circulation
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Articles

Changes of Plasma and Cerebrospinal Fluid Noradrenaline during Frusemide Administration and Acute Renal Artery Constriction in Dogs

Yoshiaki Masuyama, Yuji Ueno, Mikio Arita, Hidetoshi Suruda, Osamu Mohara
Journal: Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 343s–345s.
https://doi.org/10.1042/cs063343s
Published: 01 October 1982
...Yoshiaki Masuyama; Yuji Ueno; Mikio Arita; Hidetoshi Suruda; Osamu Mohara 1. The effects of circulating angiotensin II on cerebrospinal fluid and plasma noradrenaline during frusemide administration and acute renal artery constriction were studied in dogs. 2. The administration of frusemide...
View article titled, Changes of Plasma and <span class="search-highlight">Cerebrospinal</span> <span class="search-highlight">Fluid</span> Noradrenaline during Frusemide Administration and Acute Renal Artery Constriction in Dogs
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Articles

Dissociation between Central and Peripheral Noradrenergic Activity in Essential Hypertension

C. R. Lake, R. J. Polinsky, H.-G. Gullner, M. H. Ebert, M. G. Ziegler, F. C. Bartter, I. J. Kopin
Journal: Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 229s–233s.
https://doi.org/10.1042/cs059229s
Published: 01 December 1980
...C. R. Lake; R. J. Polinsky; H.-G. Gullner; M. H. Ebert; M. G. Ziegler; F. C. Bartter; I. J. Kopin 1. Eleven patients with essential hypertension and nine healthy normotensive volunteer subjects, all without a neurological disorder, had blood drawn and cerebrospinal fluid sampled for analysis...
View article titled, Dissociation between Central and Peripheral Noradrenergic Activity in Essential Hypertension
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Articles

Characterization of Immunoreactive Angiotensin in Canine Cerebrospinal Fluid as Des-Asp 1 -Angiotensin II

J. S. Hutchinson, J. Csicsmann, P. I. Korner, C. I. Johnston
Journal: Clinical Science
Clin Sci Mol Med (1978) 54 (2): 147–151.
https://doi.org/10.1042/cs0540147
Published: 01 February 1978
...J. S. Hutchinson; J. Csicsmann; P. I. Korner; C. I. Johnston 1. Immunoreactive angiotensin II was measured in cerebrospinal fluid of four normal dogs. 2. The migration of this immunoreactive angiotensin II on polyacrylamide-slab gel electrophoresis was identical with the migration...
View article titled, Characterization of Immunoreactive Angiotensin in Canine <span class="search-highlight">Cerebrospinal</span> <span class="search-highlight">Fluid</span> as Des-Asp 1 -Angiotensin II
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Articles

Effect of Anticonvulsants on the Uptake of 5-Methyltetrahydrofolic Acid by the Choroid Plexus in Rabbits

H. Taguchi, Z. Abdul-Cader, J. Perry, E. H. Reynolds, I. Chanarin
Journal: Clinical Science
Clin Sci Mol Med (1977) 53 (1): 75–80.
https://doi.org/10.1042/cs0530075
Published: 01 July 1977
... anticonvulsant drugs cerebrospinal fluid choroid plexus methyltetrahydrofolic acid Clinical Science and Molecular Medicine (1977) 53, 75-80. Effect of anticonvulsants on the uptake of Smethyltetrahydrofolic acid by the choroid plexus in rabbits H. TAGUCHI,* Z. ABDUL-CADER, J. PERRY, E. H. REYNOLDS AND I...
View article titled, Effect of Anticonvulsants on the Uptake of 5-Methyltetrahydrofolic Acid by the Choroid Plexus in Rabbits
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Articles

Effect of Intraventricular Perfusion of Angiotensin II in Conscious Normal Rats and in Rats with Hereditary Hypothalamic Diabetes Insipidus

J. S. Hutchinson, P. Schelling, J. Möhring, D. Ganten
Journal: Clinical Science
Clin Sci Mol Med (1976) 51 (s3): 391s–394s.
https://doi.org/10.1042/cs051391s
Published: 01 December 1976
...J. S. Hutchinson; P. Schelling; J. Möhring; D. Ganten 1. Artificial cerebrospinal fluid was perfused through the cerebral ventricles of conscious rats. A basal secretion rate of 16 ± 3 × 10 —15 mol of immunoreactive angiotensin 11/min was calculated for intact rats. 2. Most of the immunoreactive...
View article titled, Effect of Intraventricular Perfusion of Angiotensin II in Conscious Normal Rats and in Rats with Hereditary Hypothalamic Diabetes Insipidus
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Articles

The Encephalopathic Action of Five-carbon-atom Fatty Acids in the Rabbit

P. F. Teychenne, I. Walters, L. E. Claveria, D. B. Calne, Jane Price, B. B. Macgillivary, D. Gompertz
Journal: Clinical Science
Clin Sci Mol Med (1976) 50 (6): 463–472.
https://doi.org/10.1042/cs0500463
Published: 01 June 1976
...). The concentration of the acids in the cerebrospinal fluid (CSF) perfusate have been compared with changes in integrated low-frequency activity in the EEG. 2. The C-5 acids investigated were those accumulating in inborn errors of metabolism, i.e. isovaleric acid, β-methylcrotonic acid, tiglic acid and α-keto- and α...
View article titled, The Encephalopathic Action of Five-carbon-atom Fatty Acids in the Rabbit
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Articles

Effect of Liver Failure on the Response of Ventilation and Cerebral Circulation to Carbon Dioxide in Man and in the Goat

N. N. Stanley, B. G. Salisbury, L. C. McHenry, Jr, N. S. Cherniack
Journal: Clinical Science
Clin Sci Mol Med (1975) 49 (2): 157–169.
https://doi.org/10.1042/cs0490157
Published: 01 August 1975
...N. N. Stanley; B. G. Salisbury; L. C. McHenry, Jr; N. S. Cherniack 1. The acid-base state of arterial blood and cerebrospinal fluid, and the ventilatory response to CO 2 , were measured in twelve patients with liver disease. The CO 2 response was also measured in eight goats before and after...
View article titled, Effect of Liver Failure on the Response of Ventilation and Cerebral Circulation to Carbon Dioxide in Man and in the Goat
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Articles

The Intrinsic Brain Iso-Renin-Angiotensin System in the Rat: Its Possible Role in Central Mechanisms of Blood Pressure Regulation

D. Ganten, J. S. Hutchinson, P. Schelling
Journal: Clinical Science
Clin Sci Mol Med (1975) 48 (s2): 265s–268s.
https://doi.org/10.1042/cs048265s
Published: 01 January 1975
...D. Ganten; J. S. Hutchinson; P. Schelling 1. Angiotensin is produced by the intrinsic iso-renin-angiotensin system. 2. Angiotensin is secreted into the cerebrospinal fluid of nephrectomized rats. 3. Angiotensin in cerebrospinal fluid elevates systemic blood pressure. 4. Rats with hereditary...
View article titled, The Intrinsic Brain Iso-Renin-Angiotensin System in the Rat: Its Possible Role in Central Mechanisms of Blood Pressure Regulation
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Articles

Transport of 5-Methyltetrahydrofolic Acid into the Cerebrospinal Fluid in Man

I. Chanarin, Janet Perry, E. H. Reynolds
Journal: Clinical Science
Clin Sci Mol Med (1974) 46 (3): 369–373.
https://doi.org/10.1042/cs0460369
Published: 01 March 1974
... Society 1974 cerebrospinal fluid methyltetrahydrofolic acid Clinical Science and Molecular Medicine (1974) 46, 369-373. TRANSPORT O F 5-METHYLTETRAHYDROFOLIC ACID INTO THE CEREBROSPINAL F L U I D IN M A N I. CHANARIN, JANET PERRY AND E. H. REYNOLDS Northwick Park Hospital and Clinical Research...
View article titled, Transport of 5-Methyltetrahydrofolic Acid into the <span class="search-highlight">Cerebrospinal</span> <span class="search-highlight">Fluid</span> in Man
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