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Keywords: cerebrospinal fluid
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Clin Sci (Lond) (2017) 131 (17): 2257–2274.
Published: 10 August 2017
... ) * These authors contributed equally to this work. 17 03 2017 09 07 2017 24 07 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Cerebrospinal fluid CNS clearance Glymphatic Perivascular space Small vessel disease...
Clin Sci (Lond) (2015) 129 (4): 291–303.
Published: 21 May 2015
... in Th17-polarized cells. Moreover, in the cerebrospinal fluid (CSF) of 107 RR-MS patients, IL-9 inversely correlated with indexes of inflammatory activity, neurodegeneration and disability progression of MS. High levels of IL-9 were associated with the absence of IL-17 in the CSF of RR-MS patients. Our...
Includes: Supplementary data
Clin Sci (Lond) (1994) 86 (2): 149–158.
Published: 01 February 1994
... in noradrenergic neurons and chromaffin cells. Although dopamine β-hydroxylase enzymic activity is measurable in cerebrospinal fluid, such activity is unstable, and its relationship to central noradrenergic neuronal activity in humans is not clearly established. To explore the significance of cerebrospinal fluid...
Clin Sci (Lond) (1993) 84 (3): 305–311.
Published: 01 March 1993
...C. Tsigos; L. T. Diemel; A. White; D. R. Tomlinson; R. J. Young 1. Lumbar spinal substance P and calcitonin-gene-related peptide derive from spillage out of the dorsal horns associated with activity of small primary sensory afferents (C- and Aδ-fibres). Cerebrospinal fluid and sural nerve levels...
Clin Sci (Lond) (1993) 84 (3): 313–317.
Published: 01 March 1993
...Marcello Fanciullacci; Massimo Alessandri; Maria Nicolodi; Sergio Michelacci; Federigo Sicuteri 1. Converting enzyme and neutral endopeptidase activities were both measured every 3 h by a fluorimetric method in plasma and cerebrospinal fluid of patients diagnosed as migraineurs with aura after...
Clin Sci (Lond) (1992) 82 (6): 625–630.
Published: 01 June 1992
... or pressor response to digoxin in guinea-pigs. 3. Infusion of high-sodium cerebrospinal fluid, but not normal-sodium cerebrospinal fluid, into the lateral brain ventricle of rats caused marked increases in blood pressure, urine volume and urinary sodium excretion. 4. Digibind did not significantly affect...
Clin Sci (Lond) (1992) 82 (5): 513–519.
Published: 01 May 1992
... cerebrospinal fluid depressor effect kinin antagonist kinin receptor spontaneously hypertensive rats Clinical Science (I 992) 82, 5 13-5 I 9 (Printed in Great Britain) 513 Central bradykininergic system in normotensive and hypertensive rats Azucena L. ALVAREZ, Alejandro DELORENZI, Daniel SANTAJULIANA...
Clin Sci (Lond) (1992) 82 (3): 315–320.
Published: 01 March 1992
...-ion-oxidizing activity of caeruloplasmin rapidly converts ferrous ions back to the less reactive ferric state so that they can bind to available binding sites on transferrin. 4. Cerebrospinal fluids, however, often appear to contain low-molecular-mass iron, high levels of ascorbate and low levels...
Clin Sci (Lond) (1992) 82 (1): 93–97.
Published: 01 January 1992
... of cerebrospinal fluid, cortex, cerebellum and spinal cord were then extracted and analysed for S -adenosyl- l -methionine and S -adenosyl- l -homocysteine. Regression analyses were carried out on values obtained in cerebrospinal fluid and in neural tissues. 2. Highly significant correlations were obtained between...
Clin Sci (Lond) (1989) 77 (4): 389–394.
Published: 01 October 1989
...Minoru Kawamura; Yuhei Kawano; Kaoru Yoshida; Masahito Imanishi; Satoshi Akabane; Yohkazu Matsushima; Morio Kuramochi; Kazuaki Shimamoto; Keiichi Ito; Teruo Omae 1. Angiotensin (ANG) levels were measured in the cerebrospinal fluid of 15 patients with essential hypertension on a high sodium diet...
Clin Sci (Lond) (1988) 74 (1): 49–52.
Published: 01 January 1988
... of high Na + artificial cerebrospinal fluid (CSF) on blood pressure, urinary Na + excretion and plasma ANP levels in conscious Wistar rats. 2. Infusion of high Na + (0.6 mol/1) CSF into the lateral ventricle at a rate of 1 μl/min for 60 min significantly increased mean blood pressure and urinary Na...
Clin Sci (Lond) (1987) 72 (5): 563–570.
Published: 01 May 1987
...Jimmy D. Bell; Judith C. C. Brown; Peter J. Sadler; Andrew F. MacLeod; Peter H. Sönksen; Robin D. Hughes; Roger Williams 1. One- and two-dimensional (correlated shift spectroscopy) high resolution proton n.m.r. spectra of human cerebrospinal fluid (CSF) are reported. The merits of water suppression...
Clin Sci (Lond) (1987) 72 (1): 103–112.
Published: 01 January 1987
...A. Gorchein; R. Webber 1. ô-Aminolaevulinic acid (ALA) was determined by g.l.c. with electron-capture detection. Normal plasma level was 92 nmol/l ( sd = 39, n = 89, range 24–270 nmol/l). 2. ALA was undetectable in 35 of 53 samples of normal cerebrospinal fluid (limit of assay 2 nmol/l). The mean...
Clin Sci (Lond) (1986) 71 (6): 749–753.
Published: 01 December 1986
...J. E. Maddison; D. Yau; P. Stewart; G. C. Farrell 1. Cerebrospinal fluid (CSF) γ-aminobutyric acid (GABA) levels were measured in a dog model of spontaneous chronic portosystemic encephalopathy. 2. Dogs with congenital portacaval shunts (intra- or extra-hepatic) develop neurological features...
Clin Sci (Lond) (1986) 71 (1): 57–60.
Published: 01 July 1986
... that cerebrospinal fluid from patients with infantile and juvenile neuronal ceroid-lipofuscinosis were less protective against superoxide radical-induced hydroxyl radical formation compared with controls [3]. 2. The content of superoxide dismutase isoenzymes in cerebrospinal fluid and in plasma from patients...
Clin Sci (Lond) (1986) 70 (1): 103–110.
Published: 01 January 1986
... + −pump activity was estimated in the plantar and dorsal branches of the lateral saphenous veins by using the 86 Rb-uptake method. 2. Infusion of the cerebral ventricles with the artificial cerebrospinal fluid (CSF) containing normal Na + (0.15 mol/l) for over 120 min resulted in significant increases...
Clin Sci (Lond) (1982) 63 (s8): 343s–345s.
Published: 01 October 1982
...Yoshiaki Masuyama; Yuji Ueno; Mikio Arita; Hidetoshi Suruda; Osamu Mohara 1. The effects of circulating angiotensin II on cerebrospinal fluid and plasma noradrenaline during frusemide administration and acute renal artery constriction were studied in dogs. 2. The administration of frusemide...
Clin Sci (Lond) (1980) 59 (s6): 229s–233s.
Published: 01 December 1980
...C. R. Lake; R. J. Polinsky; H.-G. Gullner; M. H. Ebert; M. G. Ziegler; F. C. Bartter; I. J. Kopin 1. Eleven patients with essential hypertension and nine healthy normotensive volunteer subjects, all without a neurological disorder, had blood drawn and cerebrospinal fluid sampled for analysis...
Clin Sci Mol Med (1978) 54 (2): 147–151.
Published: 01 February 1978
...J. S. Hutchinson; J. Csicsmann; P. I. Korner; C. I. Johnston 1. Immunoreactive angiotensin II was measured in cerebrospinal fluid of four normal dogs. 2. The migration of this immunoreactive angiotensin II on polyacrylamide-slab gel electrophoresis was identical with the migration...
Clin Sci Mol Med (1977) 53 (1): 75–80.
Published: 01 July 1977
... of pteroylglutamic acid on the uptake of 5-methyltetrahydrofolate by the choroid plexus may explain the effect of long-term folic acid therapy in aggravating vitamin B 12 neuropathy in pernicious anaemia. anticonvulsant drugs cerebrospinal fluid choroid plexus methyltetrahydrofolic acid 26 10 1976...
Clin Sci Mol Med (1976) 51 (s3): 391s–394s.
Published: 01 December 1976
...J. S. Hutchinson; P. Schelling; J. Möhring; D. Ganten 1. Artificial cerebrospinal fluid was perfused through the cerebral ventricles of conscious rats. A basal secretion rate of 16 ± 3 × 10 —15 mol of immunoreactive angiotensin 11/min was calculated for intact rats. 2. Most of the immunoreactive...
Clin Sci Mol Med (1976) 50 (6): 463–472.
Published: 01 June 1976
...). The concentration of the acids in the cerebrospinal fluid (CSF) perfusate have been compared with changes in integrated low-frequency activity in the EEG. 2. The C-5 acids investigated were those accumulating in inborn errors of metabolism, i.e. isovaleric acid, β-methylcrotonic acid, tiglic acid and α-keto- and α...
Clin Sci Mol Med (1975) 49 (2): 157–169.
Published: 01 August 1975
...N. N. Stanley; B. G. Salisbury; L. C. McHenry, Jr; N. S. Cherniack 1. The acid-base state of arterial blood and cerebrospinal fluid, and the ventilatory response to CO 2 , were measured in twelve patients with liver disease. The CO 2 response was also measured in eight goats before and after...
Clin Sci Mol Med (1975) 48 (s2): 265s–268s.
Published: 01 January 1975
...D. Ganten; J. S. Hutchinson; P. Schelling 1. Angiotensin is produced by the intrinsic iso-renin-angiotensin system. 2. Angiotensin is secreted into the cerebrospinal fluid of nephrectomized rats. 3. Angiotensin in cerebrospinal fluid elevates systemic blood pressure. 4. Rats with hereditary...
Clin Sci Mol Med (1974) 46 (3): 369–373.
Published: 01 March 1974
... Society 1974 cerebrospinal fluid methyltetrahydrofolic acid Clinical Science and Molecular Medicine (1974) 46, 369-373. TRANSPORT O F 5-METHYLTETRAHYDROFOLIC ACID INTO THE CEREBROSPINAL F L U I D IN M A N I. CHANARIN, JANET PERRY AND E. H. REYNOLDS Northwick Park Hospital and Clinical Research...